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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064108
UUCD1 version UUC-MuM-00812
Ensembl Protein ID ENSMUSP00000099502.3
UniProt Accession Q8VEJ4; B1ARD5; NLE1_MOUSE
Genbank Protein ID CAI25495.1; AAH18399.1
Protein Name Notchless protein homolog 1
Genbank Nucleotide ID AL603745; BC018399
Gene Name Nle1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000020692.14 ENSMUST00000103213.9 ENSMUSP00000099502.3
ENSMUSG00000020692.14 ENSMUST00000167196.1 ENSMUSP00000128341.1
ENSMUSG00000020692.14 ENSMUST00000126202.7 ENSMUSP00000130605.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.70e-66 217.2 197 240
UBD/Beta-Prp 1.40e-78 265.2 106 304
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 197  GHSKWITGLSWeplhmnPEcRYVASSSKDGSVRVWDTTAGRCER 240
           8***************9889**********************86 PP
   

   UBD/Beta-Prp
   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+s+sp+g+kl+sG +   + +wd +tg  +  t
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRT 194
           6799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           **********8762222267889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlvsg 240
           tl+gh  +v+ +++s  d  l +g
   Q: 282  TLQGHGHWVNTMALS-TDYALRTG 304
           **************9.44444444 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival.
 Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival.
Protein Sequence
(Fasta)
MAAAVVEEAA AGDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDKLQLVCNA LLAQEEPLPL 60
AFYVHDAEIV SSLGKTLESQ SVETEKIVDI IYQPQAVFRV RAVTRCTSSL EGHSEAVISV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064108|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGATTTAA CGCTCCGTCT TTCCGCCTCG GTTCTCCTCC ACGTGGGGAC GCAGGATGGC 60
GGCGGCGGTG GTGGTAGGTG TACGCGCACG GGGCGGGGAT GCCGGGTCTC CGCGTGGGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064108|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005840--C:ribosome
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0000027--P:ribosomal large subunit assembly
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis
KEGG mmu:217011
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000437 Aegilops tauschii 58.58 4.00e-169 587.00
IUUC-Aml-001793 Ailuropoda melanoleuca 95.77 0.00e+00 939.00
IUUC-Atr-002507 Amborella trichopoda 58.64 2.00e-167 582.00
IUUC-Apl-003964 Anas platyrhynchos 84.14 0.00e+00 812.00
IUUC-Aly-006396 Arabidopsis lyrata 54.68 8.00e-161 560.00
IUUC-Ath-007278 Arabidopsis thaliana 54.89 8.00e-161 560.00
IUUC-Ago-007951 Ashbya gossypii 47.23 3.00e-128 451.00
IUUC-Acl-008298 Aspergillus clavatus 47.72 1.00e-120 426.00
IUUC-Afl-008581 Aspergillus flavus 52.65 4.00e-109 387.00
IUUC-Afu-008906 Aspergillus fumigatus 47.51 2.00e-119 422.00
IUUC-Ani-009189 Aspergillus nidulans 45.45 1.00e-116 413.00
IUUC-Ang-009630 Aspergillus niger 48.91 4.00e-124 438.00
IUUC-Aor-010038 Aspergillus oryzae 47.62 6.00e-127 447.00
IUUC-Ate-010278 Aspergillus terreus 47.80 4.00e-122 431.00
IUUC-Ame-011890 Astyanax mexicanus 81.01 0.00e+00 827.00
IUUC-Bgr-012011 Blumeria graminis 48.45 2.00e-129 456.00
IUUC-Bta-012964 Bos taurus 95.35 0.00e+00 937.00
IUUC-Bci-013592 Botrytis cinerea 44.74 9.00e-120 423.00
IUUC-Bdi-015035 Brachypodium distachyon 58.89 4.00e-171 594.00
IUUC-Bol-015501 Brassica oleracea 55.56 5.00e-161 560.00
IUUC-Bra-017642 Brassica rapa 55.34 1.00e-160 559.00
IUUC-Cel-018430 Caenorhabditis elegans 57.73 2.00e-166 578.00
IUUC-Cja-019125 Callithrix jacchus 95.98 0.00e+00 937.00
IUUC-Cfa-021013 Canis familiaris 94.00 0.00e+00 849.00
IUUC-Cpo-021743 Cavia porcellus 95.77 0.00e+00 941.00
IUUC-Cre-022973 Chlamydomonas reinhardtii 47.13 3.00e-121 428.00
IUUC-Csa-024270 Chlorocebus sabaeus 96.19 0.00e+00 940.00
IUUC-Cin-025795 Ciona intestinalis 67.16 0.00e+00 690.00
IUUC-Csv-025953 Ciona savignyi 67.16 0.00e+00 682.00
IUUC-Cgl-026517 Colletotrichum gloeosporioides 51.99 2.00e-109 389.00
IUUC-Cne-026901 Cryptococcus neoformans 49.20 2.00e-138 486.00
IUUC-Cme-027281 Cyanidioschyzon merolae 48.34 7.00e-116 411.00
IUUC-Dre-028515 Danio rerio 77.64 0.00e+00 801.00
IUUC-Dno-029596 Dasypus novemcinctus 95.98 0.00e+00 938.00
IUUC-Dor-030494 Dipodomys ordii 96.39 0.00e+00 934.00
IUUC-Dse-031538 Dothistroma septosporum 48.24 3.00e-129 455.00
IUUC-Dme-031974 Drosophila melanogaster 59.39 9.00e-168 583.00
IUUC-Ete-032948 Echinops telfairi 97.61 4.00e-118 418.00
IUUC-Eca-033399 Equus caballus 96.82 0.00e+00 943.00
IUUC-Eeu-035013 Erinaceus europaeus 95.22 2.00e-116 412.00
IUUC-Fca-035860 Felis catus 95.14 0.00e+00 933.00
IUUC-Fal-037069 Ficedula albicollis 87.60 2.00e-131 461.00
IUUC-Fox-038059 Fusarium oxysporum 46.61 2.00e-126 445.00
IUUC-Fso-038445 Fusarium solani 46.41 2.00e-126 446.00
IUUC-Gmo-039319 Gadus morhua 76.22 0.00e+00 738.00
IUUC-Ggr-040095 Gaeumannomyces graminis 47.60 1.00e-122 433.00
IUUC-Gga-040303 Gallus gallus 86.00 9.00e-131 459.00
IUUC-Gac-042267 Gasterosteus aculeatus 79.11 0.00e+00 768.00
IUUC-Gma-043974 Glycine max 57.02 9.00e-169 586.00
IUUC-Ggo-044637 Gorilla gorilla 95.75 0.00e+00 931.00
IUUC-Hsa-046128 Homo sapiens 95.98 0.00e+00 941.00
IUUC-Hvu-047373 Hordeum vulgare 57.63 2.00e-168 585.00
IUUC-Itr-048070 Ictidomys tridecemlineatus 96.03 0.00e+00 941.00
IUUC-Kpa-049274 Komagataella pastoris 44.79 2.00e-124 439.00
IUUC-Lch-049907 Latimeria chalumnae 82.98 0.00e+00 825.00
IUUC-Lpe-050778 Leersia perrieri 53.81 6.00e-152 530.00
IUUC-Loc-051889 Lepisosteus oculatus 80.59 0.00e+00 828.00
IUUC-Lma-053041 Leptosphaeria maculans 51.00 8.00e-116 410.00
IUUC-Laf-053598 Loxodonta africana 96.41 0.00e+00 944.00
IUUC-Mcc-055660 Macaca mulatta 95.98 0.00e+00 938.00
IUUC-Meu-056197 Macropus eugenii 79.79 0.00e+00 774.00
IUUC-Mor-056949 Magnaporthe oryzae 46.58 4.00e-120 425.00
IUUC-Mpo-057571 Magnaporthe poae 45.42 3.00e-64 239.00
IUUC-Mtr-058530 Medicago truncatula 58.09 9.00e-166 576.00
IUUC-Mla-059133 Melampsora laricipopulina 45.47 1.00e-122 433.00
IUUC-Mga-059252 Meleagris gallopavo 84.66 0.00e+00 663.00
IUUC-Mvi-060522 Microbotryum violaceum 50.00 7.00e-137 480.00
IUUC-Mmr-061117 Microcebus murinus 95.36 0.00e+00 932.00
IUUC-Mdo-062892 Monodelphis domestica 89.03 0.00e+00 890.00
IUUC-Mac-064430 Musa acuminata 59.10 3.00e-172 597.00
IUUC-Mpu-065882 Mustela putorius furo 95.36 0.00e+00 935.00
IUUC-Mlu-068123 Myotis lucifugus 95.35 0.00e+00 940.00
IUUC-Nfi-068484 Neosartorya fischeri 47.82 3.00e-120 425.00
IUUC-Ncr-068649 Neurospora crassa 44.58 2.00e-116 412.00
IUUC-Nle-069140 Nomascus leucogenys 95.54 0.00e+00 931.00
IUUC-Opr-070220 Ochotona princeps 88.72 0.00e+00 817.00
IUUC-Ont-072643 Oreochromis niloticus 80.38 0.00e+00 819.00
IUUC-Ocu-074007 Oryctolagus cuniculus 96.19 0.00e+00 912.00
IUUC-Oba-075904 Oryza barthii 58.89 1.00e-171 596.00
IUUC-Obr-076280 Oryza brachyantha 58.46 1.00e-170 592.00
IUUC-Ogl-077425 Oryza glaberrima 58.89 9.00e-172 596.00
IUUC-Ogu-078586 Oryza glumaepatula 58.89 1.00e-171 595.00
IUUC-Oin-079489 Oryza indica 56.75 1.00e-162 565.00
IUUC-Olo-080766 Oryza longistaminata 58.76 2.00e-171 595.00
IUUC-Ome-081905 Oryza meridionalis 58.89 1.00e-171 596.00
IUUC-Oni-083022 Oryza nivara 58.89 7.00e-172 596.00
IUUC-Opu-083615 Oryza punctata 58.89 8.00e-172 596.00
IUUC-Oru-085076 Oryza rufipogon 58.89 7.00e-172 597.00
IUUC-Osa-085516 Oryza sativa 58.89 7.00e-172 597.00
IUUC-Ola-087290 Oryzias latipes 78.48 0.00e+00 803.00
IUUC-Olu-087898 Ostreococcus lucimarinus 51.78 1.00e-142 499.00
IUUC-Oga-088980 Otolemur garnettii 95.75 0.00e+00 937.00
IUUC-Oar-089580 Ovis aries 95.11 0.00e+00 812.00
IUUC-Ptr-090845 Pan troglodytes 95.12 0.00e+00 926.00
IUUC-Pan-092836 Papio anubis 95.98 0.00e+00 941.00
IUUC-Psi-093965 Pelodiscus sinensis 83.48 3.00e-57 213.00
IUUC-Pno-095052 Phaeosphaeria nodorum 46.71 1.00e-121 430.00
IUUC-Ppa-095432 Physcomitrella patens 58.21 6.00e-170 590.00
IUUC-Pfo-096963 Poecilia formosa 71.94 0.00e+00 702.00
IUUC-Pab-097716 Pongo abelii 91.72 0.00e+00 885.00
IUUC-Pop-099224 Populus trichocarpa 58.30 1.00e-170 592.00
IUUC-Pca-100682 Procavia capensis 91.83 0.00e+00 674.00
IUUC-Ppe-101819 Prunus persica 57.36 5.00e-167 580.00
IUUC-Pva-102338 Pteropus vampyrus 95.24 0.00e+00 711.00
IUUC-Pgr-103583 Puccinia graminis 54.50 2.00e-130 459.00
IUUC-Ptt-103737 Puccinia triticina 44.11 2.00e-97 349.00
IUUC-Pte-104150 Pyrenophora teres 52.21 1.00e-120 426.00
IUUC-Pyt-104606 Pyrenophora triticirepentis 51.96 2.00e-120 425.00
IUUC-Rno-105987 Rattus norvegicus 98.94 0.00e+00 960.00
IUUC-Sce-106315 Saccharomyces cerevisiae 46.75 1.00e-127 450.00
IUUC-Sha-107273 Sarcophilus harrisii 89.87 0.00e+00 898.00
IUUC-Sja-107677 Schizosaccharomyces japonicus 45.91 2.00e-118 419.00
IUUC-Spo-108092 Schizosaccharomyces pombe 48.05 3.00e-122 431.00
IUUC-Ssl-108442 Sclerotinia sclerotiorum 44.81 6.00e-116 410.00
IUUC-Smo-108855 Selaginella moellendorffii 55.65 2.00e-163 568.00
IUUC-Sit-110329 Setaria italica 58.89 9.00e-171 593.00
IUUC-Sly-111830 Solanum lycopersicum 59.53 2.00e-173 601.00
IUUC-Stu-112603 Solanum tuberosum 59.53 3.00e-173 601.00
IUUC-Sar-113504 Sorex araneus 89.36 3.00e-72 265.00
IUUC-Sbi-114560 Sorghum bicolor 58.46 7.00e-169 587.00
IUUC-Sre-115133 Sporisorium reilianum 37.69 1.00e-99 357.00
IUUC-Ssc-115903 Sus scrofa 95.77 0.00e+00 935.00
IUUC-Tgu-116798 Taeniopygia guttata 85.20 0.00e+00 856.00
IUUC-Tru-118361 Takifugu rubripes 79.32 0.00e+00 806.00
IUUC-Tsy-118849 Tarsius syrichta 96.59 0.00e+00 936.00
IUUC-Tni-120094 Tetraodon nigroviridis 79.32 0.00e+00 806.00
IUUC-Tca-121634 Theobroma cacao 58.30 1.00e-167 583.00
IUUC-Tre-122051 Trichoderma reesei 46.93 4.00e-121 428.00
IUUC-Tvi-122322 Trichoderma virens 47.54 5.00e-125 441.00
IUUC-Tae-123133 Triticum aestivum 58.05 6.00e-170 590.00
IUUC-Tur-126766 Triticum urartu 51.89 3.00e-161 561.00
IUUC-Tme-127175 Tuber melanosporum 51.16 5.00e-131 461.00
IUUC-Tbe-127779 Tupaia belangeri 94.61 0.00e+00 826.00
IUUC-Ttr-128224 Tursiops truncatus 90.65 0.00e+00 806.00
IUUC-Uma-129537 Ustilago maydis 42.04 1.00e-124 440.00
IUUC-Vda-129927 Verticillium dahliae 45.40 7.00e-112 397.00
IUUC-Vpa-130658 Vicugna pacos 83.83 0.00e+00 791.00
IUUC-Vvi-131659 Vitis vinifera 58.21 8.00e-170 590.00
IUUC-Xtr-132918 Xenopus tropicalis 77.22 0.00e+00 788.00
IUUC-Xma-133700 Xiphophorus maculatus 80.38 0.00e+00 816.00
IUUC-Yli-134478 Yarrowia lipolytica 49.59 3.00e-137 482.00
IUUC-Zma-135835 Zea mays 55.98 6.00e-166 577.00
Created Date 25-Jun-2017

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