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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063811
UUCD1 version UUC-MuM-00291
Ensembl Protein ID ENSMUSP00000125291.1
UniProt Accession O88879; A2RRK8; APAF_MOUSE
Genbank Protein ID AAC62458.1; AAI31684.1; AAI31685.1
Protein Name Apoptotic protease-activating factor 1
Genbank Nucleotide ID AF064071; BC131683; BC131684
Gene Name Apaf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000019979.12 ENSMUST00000159110.7 ENSMUSP00000125291.1
ENSMUSG00000019979.12 ENSMUST00000162618.7 ENSMUSP00000124134.1
ENSMUSG00000019979.12 ENSMUST00000161987.7 ENSMUSP00000124422.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.90e-66 216.5 741 776
UBD/Beta-Prp 5.90e-93 312.4 610 784
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d  ll+s+s Dgt+++WD+r+ +
   Q: 741  GHTNSVNHCRFsPDdELLASCSADGTLRLWDVRSAN 776
           8***********777*****************9876 PP
   

   UBD/Beta-Prp
   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           +++ h+d v+   fs++g++++s ++d+t++v++ etg++l ++++ +d+v +c+ +++d+++++++s+D++v++Wd++tgkl++t  +
   Q: 610  VVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCA-FSSDDSYIATCSADKKVKIWDSATGKLVHTYDE 697
           4557888888888888888888888888888888888888887777666665555.555588888888888888888888888888887 PP
   S: 178  ghtdsvyslsfdsngke..lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
            h ++v++  f+ ++++  l++gs+d  +klwdl ++ec +t+ ght+ v+  rfsp+de+l+s+s+Dg++r+Wd+rs +  k+++ +
   Q: 698  -HSEQVNCCHFTNKSNHllLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSINVK 784
           .888888888888885511568888888888888888888888888888888888888888888888888888888888888888765 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).
 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).
Protein Sequence
(Fasta)
MDAKARNCLL QHREALEKDI KTSYIMDHMI SNGVLSVIEE EKVKSQATQY QRAAALIKMI 60
LNKDNCAYIS FYNALLHEGY KDLAALLQSG LPLVSSSSGK DTDGGITSFV RTVLCEGGVP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063811|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGAATTTGC GTGCCCGGGC GCGCGCTGTG TGGACTGGGC GGGCCCAGCG GTGTTTGAGT 60
GCTCCGCGGT CCTGAGGCAG AGACCAGGAG GCAGCTAGAG GAGCAGACGT CTCACTCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063811|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR017251--Apaf-1
IPR024977--Apc4_WD40_dom
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00619--CARD
PF00931--NB-ARC
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0043293--C:apoptosome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042802--F:identical protein binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0007568--P:aging
GO:0007420--P:brain development
GO:0010659--P:cardiac muscle cell apoptotic process
GO:0030154--P:cell differentiation
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0030900--P:forebrain development
GO:0034349--P:glial cell apoptotic process
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0007275--P:multicellular organism development
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0051260--P:protein homooligomerization
GO:1902510--P:regulation of apoptotic DNA fragmentation
GO:0001666--P:response to hypoxia
GO:0007584--P:response to nutrient
KEGG mmu:11783
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001432 Ailuropoda melanoleuca 87.14 0.00e+00 2261.00
IUUC-Apl-004201 Anas platyrhynchos 69.94 0.00e+00 1816.00
IUUC-Aca-004638 Anolis carolinensis 67.44 0.00e+00 1795.00
IUUC-Ani-009285 Aspergillus nidulans 26.33 1.00e-68 255.00
IUUC-Ame-011062 Astyanax mexicanus 54.60 0.00e+00 1374.00
IUUC-Bta-012865 Bos taurus 87.43 0.00e+00 2305.00
IUUC-Cel-018376 Caenorhabditis elegans 21.69 3.00e-27 118.00
IUUC-Cja-018815 Callithrix jacchus 77.41 0.00e+00 1985.00
IUUC-Cfa-020222 Canis familiaris 82.49 0.00e+00 2115.00
IUUC-Cpo-021524 Cavia porcellus 86.15 0.00e+00 2247.00
IUUC-Csa-023861 Chlorocebus sabaeus 87.27 0.00e+00 2264.00
IUUC-Cho-024484 Choloepus hoffmanni 77.06 0.00e+00 1196.00
IUUC-Dre-028006 Danio rerio 53.58 0.00e+00 1276.00
IUUC-Dno-029591 Dasypus novemcinctus 87.51 0.00e+00 2308.00
IUUC-Dor-030237 Dipodomys ordii 73.97 0.00e+00 1077.00
IUUC-Ete-032620 Echinops telfairi 82.26 0.00e+00 1073.00
IUUC-Eca-033569 Equus caballus 87.03 0.00e+00 2272.00
IUUC-Eeu-035354 Erinaceus europaeus 63.41 4.00e-175 608.00
IUUC-Fca-036337 Felis catus 87.36 0.00e+00 2297.00
IUUC-Fal-037077 Ficedula albicollis 69.58 0.00e+00 1819.00
IUUC-Gmo-039687 Gadus morhua 51.16 0.00e+00 928.00
IUUC-Ggr-039828 Gaeumannomyces graminis 23.64 2.00e-42 168.00
IUUC-Gga-040299 Gallus gallus 68.59 0.00e+00 1823.00
IUUC-Gac-041762 Gasterosteus aculeatus 52.40 0.00e+00 1281.00
IUUC-Ggo-045563 Gorilla gorilla 87.83 0.00e+00 2283.00
IUUC-Hsa-046771 Homo sapiens 87.35 0.00e+00 2275.00
IUUC-Lch-050200 Latimeria chalumnae 64.42 0.00e+00 1634.00
IUUC-Loc-052090 Lepisosteus oculatus 60.19 0.00e+00 1526.00
IUUC-Laf-053861 Loxodonta africana 86.80 0.00e+00 2270.00
IUUC-Mcc-055543 Macaca mulatta 87.83 0.00e+00 2278.00
IUUC-Meu-056688 Macropus eugenii 78.75 0.00e+00 2040.00
IUUC-Mga-059243 Meleagris gallopavo 69.19 0.00e+00 1840.00
IUUC-Mmr-061134 Microcebus murinus 83.30 0.00e+00 1965.00
IUUC-Mdo-062913 Monodelphis domestica 78.04 0.00e+00 2048.00
IUUC-Mpu-066780 Mustela putorius furo 87.28 0.00e+00 2250.00
IUUC-Mlu-067276 Myotis lucifugus 86.96 0.00e+00 2281.00
IUUC-Nfi-068459 Neosartorya fischeri 26.96 2.00e-59 225.00
IUUC-Nle-069129 Nomascus leucogenys 87.11 0.00e+00 2270.00
IUUC-Opr-071007 Ochotona princeps 65.34 0.00e+00 1116.00
IUUC-Ont-071348 Oreochromis niloticus 55.33 0.00e+00 1412.00
IUUC-Oan-072717 Ornithorhynchus anatinus 79.95 0.00e+00 2105.00
IUUC-Ocu-074286 Oryctolagus cuniculus 87.84 0.00e+00 1962.00
IUUC-Ola-086895 Oryzias latipes 50.91 0.00e+00 1212.00
IUUC-Oga-088678 Otolemur garnettii 87.99 0.00e+00 2291.00
IUUC-Oar-089359 Ovis aries 87.11 0.00e+00 2279.00
IUUC-Ptr-091062 Pan troglodytes 87.59 0.00e+00 2279.00
IUUC-Pan-092528 Papio anubis 89.55 0.00e+00 1336.00
IUUC-Psi-093430 Pelodiscus sinensis 72.49 0.00e+00 1910.00
IUUC-Pma-094690 Petromyzon marinus 39.03 3.00e-153 535.00
IUUC-Pfo-097204 Poecilia formosa 55.04 0.00e+00 1394.00
IUUC-Pab-097690 Pongo abelii 87.75 0.00e+00 2283.00
IUUC-Pca-100778 Procavia capensis 68.50 0.00e+00 1168.00
IUUC-Pva-102870 Pteropus vampyrus 85.16 0.00e+00 2055.00
IUUC-Pyt-104620 Pyrenophora triticirepentis 28.71 1.00e-62 235.00
IUUC-Rno-104889 Rattus norvegicus 96.08 0.00e+00 2467.00
IUUC-Sha-107465 Sarcophilus harrisii 78.25 0.00e+00 2087.00
IUUC-Sar-113268 Sorex araneus 85.47 0.00e+00 644.00
IUUC-Ssc-115654 Sus scrofa 87.03 0.00e+00 2291.00
IUUC-Tgu-117302 Taeniopygia guttata 70.14 0.00e+00 1837.00
IUUC-Tru-118363 Takifugu rubripes 54.85 0.00e+00 1390.00
IUUC-Tsy-119007 Tarsius syrichta 84.07 0.00e+00 2184.00
IUUC-Tni-120910 Tetraodon nigroviridis 53.88 0.00e+00 1340.00
IUUC-Tbe-127413 Tupaia belangeri 75.25 0.00e+00 1390.00
IUUC-Ttr-129213 Tursiops truncatus 80.30 0.00e+00 2075.00
IUUC-Vpa-130146 Vicugna pacos 82.04 0.00e+00 1584.00
IUUC-Xtr-132559 Xenopus tropicalis 60.54 0.00e+00 1554.00
Created Date 25-Jun-2017

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