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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063338
Ensembl Protein ID ENSMUSP00000115184.1
UniProt Accession Q99KY4; Q6P1I8; Q6P9S5; Q8BM74; Q8K0Q4; GAK_MOUSE
Genbank Protein ID BAC28779.1; BAE38941.1; AAH03958.1; AAH30859.1; AAH60622.1; AAH65052.1
Protein Name Cyclin-G-associated kinase
Genbank Nucleotide ID AK034637; AK166682; BC003958; BC030859; BC060622; BC065052
Gene Name Gak
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000062234.14 ENSMUST00000156110.7 ENSMUSP00000115184.1
ENSMUSG00000062234.14 ENSMUST00000046603.14 ENSMUSP00000036705.8
ENSMUSG00000062234.14 ENSMUST00000199048.4 ENSMUSP00000142931.1
ENSMUSG00000062234.14 ENSMUST00000200204.1 ENSMUSP00000143359.1
ENSMUSG00000062234.14 ENSMUST00000139303.1 ENSMUSP00000116862.1
ENSMUSG00000062234.14 ENSMUST00000199662.1 ENSMUSP00000143646.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 42.59 2.00e-16 82.00 IUUC-Spo-108127
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (By similarity).
 Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (By similarity).
Protein Sequence
(Fasta)
XGGRLQAKMA SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL FQVNLEVEVE 60
PRDRPSREAP PWENTSLRGL NPKILFSNRE EQQDILSKFE EKEPETGLDN TSPKESQSVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063338|UBD,UBA|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATTTACGTC ACGGCGCGGG CGGAAGATGG CCGGGTTGTT CGCCCGCAGC TGCTAACCCG 60
GCAGTGCGGA GCTGGAGCCT GGCTCCCGCT GCCGCGGAGC GGCCGACGCC ATGTCGCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063338|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR000008--C2_dom
IPR001623--DnaJ_domain
IPR011009--Kinase-like_dom
IPR029021--Prot-tyrosine_phosphatase-like
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR014020--Tensin_C2-dom
IPR029023--Tensin_phosphatase
PROSITE

PS51182--C2_TENSIN
PS50076--DNAJ_2
PS51181--PPASE_TENSIN
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00226--DnaJ
PF00069--Pkinase
PF10409--PTEN_C2
SMART

SM00271--DnaJ
SM01326--PTEN_C2
SM00220--S_TKc
Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0007049--P:cell cycle
GO:0048468--P:cell development
GO:0072318--P:clathrin coat disassembly
GO:1905224--P:clathrin-coated pit assembly
GO:0072583--P:clathrin-dependent endocytosis
GO:0007029--P:endoplasmic reticulum organization
GO:0009913--P:epidermal cell differentiation
GO:0072600--P:establishment of protein localization to Golgi
GO:0090002--P:establishment of protein localization to plasma membrane
GO:0061436--P:establishment of skin barrier
GO:0048853--P:forebrain morphogenesis
GO:0007030--P:Golgi organization
GO:0090160--P:Golgi to lysosome transport
GO:0035622--P:intrahepatic bile duct development
GO:0010977--P:negative regulation of neuron projection development
GO:2000179--P:positive regulation of neural precursor cell proliferation
GO:0006898--P:receptor-mediated endocytosis
KEGG mmu:231580
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000572 Aegilops tauschii 47.67 1.00e-15 79.00
IUUC-Ago-007899 Ashbya gossypii 40.35 2.00e-03 37.70
IUUC-Acl-008209 Aspergillus clavatus 43.18 5.00e-14 73.60
IUUC-Afl-008687 Aspergillus flavus 41.49 2.00e-15 77.80
IUUC-Afu-009038 Aspergillus fumigatus 44.32 5.00e-14 73.60
IUUC-Ani-009386 Aspergillus nidulans 40.00 4.00e-15 77.00
IUUC-Ang-009793 Aspergillus niger 39.80 1.00e-14 75.50
IUUC-Aor-009993 Aspergillus oryzae 41.49 2.00e-15 77.80
IUUC-Ate-010348 Aspergillus terreus 41.84 1.00e-15 78.60
IUUC-Bdi-014164 Brachypodium distachyon 43.10 2.00e-18 88.60
IUUC-Cel-018193 Caenorhabditis elegans 51.15 1.00e-35 145.00
IUUC-Cne-027019 Cryptococcus neoformans 38.95 2.00e-12 68.20
IUUC-Gma-043549 Glycine max 41.38 1.00e-17 85.50
IUUC-Hvu-047859 Hordeum vulgare 43.10 3.00e-19 90.90
IUUC-Kpa-049310 Komagataella pastoris 46.24 7.00e-17 82.40
IUUC-Lpe-050789 Leersia perrieri 42.24 5.00e-18 87.00
IUUC-Lma-053081 Leptosphaeria maculans 43.43 6.00e-15 76.60
IUUC-Laf-054525 Loxodonta africana 62.95 0.00e+00 661.00
IUUC-Nfi-068286 Neosartorya fischeri 44.32 5.00e-14 73.60
IUUC-Oba-075068 Oryza barthii 44.12 7.00e-18 86.30
IUUC-Obr-076494 Oryza brachyantha 41.38 1.00e-17 85.50
IUUC-Ogl-077765 Oryza glaberrima 41.38 1.00e-17 85.50
IUUC-Ogu-078409 Oryza glumaepatula 42.24 3.00e-18 87.40
IUUC-Oin-079736 Oryza indica 41.38 9.00e-18 85.90
IUUC-Olo-080812 Oryza longistaminata 47.67 1.00e-16 81.60
IUUC-Ome-081515 Oryza meridionalis 41.67 7.00e-18 86.30
IUUC-Oni-083001 Oryza nivara 42.24 4.00e-18 87.00
IUUC-Opu-083298 Oryza punctata 41.67 9.00e-18 85.90
IUUC-Oru-084203 Oryza rufipogon 42.24 4.00e-18 87.40
IUUC-Osa-085672 Oryza sativa 41.38 9.00e-18 85.90
IUUC-Olu-087759 Ostreococcus lucimarinus 38.82 2.00e-11 64.30
IUUC-Pno-095073 Phaeosphaeria nodorum 44.21 1.00e-14 75.90
IUUC-Pgr-103508 Puccinia graminis 49.23 1.00e-12 68.90
IUUC-Ptt-104005 Puccinia triticina 49.23 4.00e-12 67.00
IUUC-Pte-104104 Pyrenophora teres 43.16 2.00e-14 75.10
IUUC-Pyt-104479 Pyrenophora triticirepentis 43.16 2.00e-14 74.70
IUUC-Spo-108127 Schizosaccharomyces pombe 42.59 1.00e-16 82.00
IUUC-Sit-109875 Setaria italica 42.24 3.00e-18 87.40
IUUC-Stu-111986 Solanum tuberosum 42.59 4.00e-19 90.50
IUUC-Sbi-114622 Sorghum bicolor 42.24 5.00e-18 86.70
IUUC-Tca-121218 Theobroma cacao 41.38 2.00e-17 85.10
IUUC-Tae-124301 Triticum aestivum 42.24 2.00e-18 87.80
IUUC-Tur-126241 Triticum urartu 42.24 3.00e-18 87.00
IUUC-Tme-127081 Tuber melanosporum 37.63 2.00e-13 72.00
IUUC-Uma-129632 Ustilago maydis 37.78 9.00e-13 69.30
IUUC-Yli-134359 Yarrowia lipolytica 42.27 1.00e-14 75.50
Created Date 25-Jun-2017

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