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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Cel-018129
UUCD1 version UUC-CaE-00279
Ensembl Protein ID K06H7.6
UniProt Accession P34514; P34513; ANC2_CAEEL
Genbank Protein ID CCD64457.1
Protein Name Anaphase-promoting complex subunit 2; Cyclosome subunit 2
Genbank Nucleotide ID BX284603
Gene Name apc-2; K06H7.6/K06H7.5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000143 K06H7.6 K06H7.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Cullin 29.56 9.00e-49 193.00 IUUC-Hsa-045663
E3 adaptor/Cullin RING/APC_C/APC_C 29.56 9.00e-49 193.00 IUUC-Hsa-045663
E3 adaptor/Cullin RING/APC_C/APC_C 19.35 1.00e-06 50.40 IUUC-Sce-106292
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis.
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis.
Protein Sequence
(Fasta)
MSIFDRMTTS KEAAMKYRQF CVSKKKEVWD ALIYHAKYAK NIEKVYDMTT VLQRVQQECL 60
MFALEKGVGQ PDIRDAAELI FPLAMQKVVI KVLRPYFMSH FTNYRLAMYL PHRKIDHGID 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cel-018129|E3,Cullin;E3,APC_C|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTCGTATCC TTGCTGAAAT TATTTTAACC ATTTCGAAAA TGTCCATTTT TGACAGAATG 60
ACTACTTCGA AAGAGGCTGC GATGAAGTAC AGGTATGGAA TTTTTGAAAA TGAGTTCCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018129|E3,Cullin;E3,APC_C|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014786--APC_su2_C
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2

Pfam

PF08672--ANAPC2
PF00888--Cullin

SMART

SM01013--APC2
SM00182--CULLIN

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0051301--P:cell division
GO:0051321--P:meiotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0007275--P:multicellular organism development
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG cel:CELE_K06H7.6
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000110 Aegilops tauschii 26.13 1.00e-40 160.00
IUUC-Aml-001248 Ailuropoda melanoleuca 30.38 8.00e-48 184.00
IUUC-Atr-002679 Amborella trichopoda 26.48 1.00e-44 174.00
IUUC-Apl-003362 Anas platyrhynchos 27.35 4.00e-44 171.00
IUUC-Aca-004655 Anolis carolinensis 28.28 4.00e-49 188.00
IUUC-Aly-006274 Arabidopsis lyrata 27.94 5.00e-49 188.00
IUUC-Ath-007394 Arabidopsis thaliana 27.43 8.00e-49 187.00
IUUC-Acl-008276 Aspergillus clavatus 29.46 3.00e-36 145.00
IUUC-Afl-008425 Aspergillus flavus 29.27 4.00e-33 135.00
IUUC-Afu-008876 Aspergillus fumigatus 26.64 2.00e-36 146.00
IUUC-Ani-009501 Aspergillus nidulans 30.26 3.00e-31 129.00
IUUC-Ang-009519 Aspergillus niger 28.18 4.00e-33 135.00
IUUC-Aor-009911 Aspergillus oryzae 29.27 5.00e-33 135.00
IUUC-Ate-010350 Aspergillus terreus 29.72 1.00e-31 131.00
IUUC-Ame-011184 Astyanax mexicanus 29.30 3.00e-42 166.00
IUUC-Bgr-011977 Blumeria graminis 24.51 5.00e-30 125.00
IUUC-Bta-013406 Bos taurus 34.65 5.00e-38 151.00
IUUC-Bci-013817 Botrytis cinerea 30.79 3.00e-30 125.00
IUUC-Bdi-014198 Brachypodium distachyon 26.10 4.00e-42 165.00
IUUC-Bol-015673 Brassica oleracea 28.68 2.00e-46 179.00
IUUC-Bra-017485 Brassica rapa 26.88 2.00e-47 183.00
IUUC-Cja-019940 Callithrix jacchus 30.08 2.00e-49 189.00
IUUC-Cfa-020113 Canis familiaris 30.41 2.00e-48 186.00
IUUC-Cpo-021669 Cavia porcellus 30.28 2.00e-49 189.00
IUUC-Cre-022990 Chlamydomonas reinhardtii 29.70 4.00e-09 55.50
IUUC-Csa-023060 Chlorocebus sabaeus 29.88 2.00e-49 189.00
IUUC-Cin-025736 Ciona intestinalis 24.90 7.00e-44 170.00
IUUC-Csv-026175 Ciona savignyi 22.45 6.00e-05 39.30
IUUC-Cgl-026442 Colletotrichum gloeosporioides 27.19 8.00e-26 111.00
IUUC-Cne-026902 Cryptococcus neoformans 26.72 7.00e-34 137.00
IUUC-Cme-027318 Cyanidioschyzon merolae 23.32 2.00e-07 50.40
IUUC-Dre-028318 Danio rerio 31.12 1.00e-57 216.00
IUUC-Dno-029026 Dasypus novemcinctus 28.57 1.00e-39 157.00
IUUC-Dor-031148 Dipodomys ordii 32.98 1.00e-45 176.00
IUUC-Dse-031458 Dothistroma septosporum 25.00 1.00e-16 80.50
IUUC-Dme-032025 Drosophila melanogaster 27.51 6.00e-47 181.00
IUUC-Ete-033154 Echinops telfairi 29.36 2.00e-30 126.00
IUUC-Eca-033812 Equus caballus 32.52 4.00e-42 164.00
IUUC-Eeu-035246 Erinaceus europaeus 37.16 9.00e-19 87.80
IUUC-Fca-035890 Felis catus 29.74 6.00e-47 181.00
IUUC-Fal-037639 Ficedula albicollis 27.24 1.00e-44 173.00
IUUC-Fox-037792 Fusarium oxysporum 26.95 5.00e-28 118.00
IUUC-Fso-038191 Fusarium solani 26.52 6.00e-26 111.00
IUUC-Gmo-039138 Gadus morhua 29.07 4.00e-53 201.00
IUUC-Ggr-040106 Gaeumannomyces graminis 27.14 8.00e-23 101.00
IUUC-Gga-040327 Gallus gallus 27.37 7.00e-46 177.00
IUUC-Gac-042053 Gasterosteus aculeatus 34.18 2.00e-35 142.00
IUUC-Gma-043658 Glycine max 29.72 2.00e-49 189.00
IUUC-Ggo-045094 Gorilla gorilla 29.88 2.00e-49 189.00
IUUC-Hsa-045663 Homo sapiens 29.88 2.00e-49 189.00
IUUC-Hvu-047677 Hordeum vulgare 27.63 1.00e-40 160.00
IUUC-Itr-047927 Ictidomys tridecemlineatus 30.28 2.00e-49 189.00
IUUC-Kpa-049177 Komagataella pastoris 22.04 1.00e-30 127.00
IUUC-Lch-049435 Latimeria chalumnae 30.36 2.00e-53 202.00
IUUC-Lpe-050728 Leersia perrieri 27.51 1.00e-42 166.00
IUUC-Loc-052561 Lepisosteus oculatus 30.97 5.00e-51 194.00
IUUC-Lma-052995 Leptosphaeria maculans 26.16 7.00e-22 98.20
IUUC-Laf-053447 Loxodonta africana 30.48 2.00e-51 196.00
IUUC-Mcc-054960 Macaca mulatta 29.88 2.00e-49 189.00
IUUC-Meu-056836 Macropus eugenii 29.82 2.00e-41 162.00
IUUC-Mor-057155 Magnaporthe oryzae 24.65 3.00e-23 103.00
IUUC-Mpo-057560 Magnaporthe poae 25.83 2.00e-22 100.00
IUUC-Mtr-058784 Medicago truncatula 29.97 3.00e-48 185.00
IUUC-Mla-058965 Melampsora laricipopulina 25.67 2.00e-23 102.00
IUUC-Mga-059511 Meleagris gallopavo 27.37 8.00e-45 174.00
IUUC-Mvi-060393 Microbotryum violaceum 27.63 2.00e-40 159.00
IUUC-Mmr-061594 Microcebus murinus 30.68 8.00e-51 194.00
IUUC-Mdo-063009 Monodelphis domestica 30.22 3.00e-41 162.00
IUUC-Mmu-063535 Mus musculus 30.28 9.00e-45 174.00
IUUC-Mac-065167 Musa acuminata 24.85 7.00e-42 164.00
IUUC-Mpu-065758 Mustela putorius furo 30.22 3.00e-49 189.00
IUUC-Nfi-068614 Neosartorya fischeri 27.20 4.00e-36 145.00
IUUC-Ncr-068900 Neurospora crassa 31.72 5.00e-21 95.50
IUUC-Nle-069236 Nomascus leucogenys 26.88 8.00e-33 134.00
IUUC-Opr-070724 Ochotona princeps 29.66 4.00e-40 158.00
IUUC-Ont-072662 Oreochromis niloticus 28.19 5.00e-35 141.00
IUUC-Oan-073106 Ornithorhynchus anatinus 29.49 4.00e-15 75.10
IUUC-Oba-075268 Oryza barthii 26.80 6.00e-41 161.00
IUUC-Obr-076594 Oryza brachyantha 25.26 3.00e-41 162.00
IUUC-Ogl-077092 Oryza glaberrima 25.47 3.00e-41 162.00
IUUC-Ogu-078791 Oryza glumaepatula 27.11 3.00e-41 162.00
IUUC-Oin-079065 Oryza indica 25.47 5.00e-41 161.00
IUUC-Olo-080300 Oryza longistaminata 27.03 4.00e-40 158.00
IUUC-Ome-081502 Oryza meridionalis 26.65 2.00e-41 162.00
IUUC-Oni-082212 Oryza nivara 26.80 6.00e-41 161.00
IUUC-Opu-083508 Oryza punctata 27.32 8.00e-43 167.00
IUUC-Oru-084815 Oryza rufipogon 27.11 3.00e-41 162.00
IUUC-Osa-085494 Oryza sativa 25.47 5.00e-41 161.00
IUUC-Ola-087495 Oryzias latipes 28.00 2.00e-43 169.00
IUUC-Olu-087578 Ostreococcus lucimarinus 32.78 2.00e-32 133.00
IUUC-Oga-088026 Otolemur garnettii 30.28 3.00e-52 199.00
IUUC-Oar-089448 Ovis aries 31.21 7.00e-15 74.70
IUUC-Ptr-090626 Pan troglodytes 25.86 7.00e-32 131.00
IUUC-Pan-092841 Papio anubis 29.88 2.00e-49 189.00
IUUC-Psi-093519 Pelodiscus sinensis 28.15 3.00e-28 119.00
IUUC-Pno-094923 Phaeosphaeria nodorum 23.33 6.00e-05 42.00
IUUC-Ppa-095741 Physcomitrella patens 24.17 2.00e-38 152.00
IUUC-Pfo-096798 Poecilia formosa 29.88 2.00e-50 192.00
IUUC-Pab-097600 Pongo abelii 29.88 2.00e-49 189.00
IUUC-Pop-099171 Populus trichocarpa 27.91 5.00e-44 171.00
IUUC-Pca-101085 Procavia capensis 28.49 8.00e-41 160.00
IUUC-Ppe-101600 Prunus persica 28.42 1.00e-45 177.00
IUUC-Pva-102210 Pteropus vampyrus 30.62 1.00e-49 189.00
IUUC-Pgr-103279 Puccinia graminis 27.62 2.00e-28 119.00
IUUC-Ptt-103707 Puccinia triticina 28.94 2.00e-27 115.00
IUUC-Pte-104344 Pyrenophora teres 26.23 1.00e-20 94.40
IUUC-Pyt-104781 Pyrenophora triticirepentis 31.88 9.00e-20 91.30
IUUC-Rno-104923 Rattus norvegicus 28.49 8.00e-41 160.00
IUUC-Sce-106292 Saccharomyces cerevisiae 19.89 1.00e-03 37.70
IUUC-Sha-107256 Sarcophilus harrisii 29.82 2.00e-41 162.00
IUUC-Sja-107869 Schizosaccharomyces japonicus 24.47 3.00e-28 118.00
IUUC-Spo-108218 Schizosaccharomyces pombe 29.50 5.00e-17 81.60
IUUC-Smo-108710 Selaginella moellendorffii 25.15 2.00e-39 155.00
IUUC-Sit-110252 Setaria italica 27.64 2.00e-43 169.00
IUUC-Sly-111678 Solanum lycopersicum 27.35 1.00e-46 180.00
IUUC-Stu-112740 Solanum tuberosum 27.97 7.00e-47 181.00
IUUC-Sbi-114620 Sorghum bicolor 27.64 2.00e-42 166.00
IUUC-Sre-115165 Sporisorium reilianum 23.70 3.00e-14 72.40
IUUC-Tgu-116996 Taeniopygia guttata 27.32 2.00e-44 173.00
IUUC-Tru-118128 Takifugu rubripes 29.80 4.00e-45 174.00
IUUC-Tni-120443 Tetraodon nigroviridis 29.69 3.00e-47 182.00
IUUC-Tca-121062 Theobroma cacao 28.12 5.00e-45 175.00
IUUC-Tre-121916 Trichoderma reesei 28.12 3.00e-29 122.00
IUUC-Tvi-122395 Trichoderma virens 28.48 1.00e-28 120.00
IUUC-Tae-122865 Triticum aestivum 25.98 1.00e-40 160.00
IUUC-Tme-126929 Tuber melanosporum 28.16 8.00e-30 123.00
IUUC-Ttr-128180 Tursiops truncatus 31.01 1.00e-49 190.00
IUUC-Uma-129453 Ustilago maydis 24.38 4.00e-13 68.90
IUUC-Vda-129887 Verticillium dahliae 27.19 1.00e-14 73.90
IUUC-Vvi-130919 Vitis vinifera 28.91 2.00e-47 182.00
IUUC-Xtr-132418 Xenopus tropicalis 27.52 3.00e-53 202.00
IUUC-Xma-133612 Xiphophorus maculatus 30.08 1.00e-51 196.00
IUUC-Yli-134637 Yarrowia lipolytica 25.86 3.00e-29 122.00
IUUC-Zma-135885 Zea mays 27.64 2.00e-42 166.00
Created Date 25-Jun-2017

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