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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Sce-106416
UUCD1 version UUC-SaC-00238
Ensembl Protein ID YHR134W
UniProt Accession P38838; D3DL83; WSS1_YEAST
Genbank Protein ID AAB68404.1; DAA06827.1
Protein Name DNA-dependent metalloprotease WSS1; DNA damage response protein WSS1; SUMO-dependent isopeptidase WSS1; Weak suppressor of SMT3 protein 1
Genbank Nucleotide ID U10398; BK006934
Gene Name WSS1; YHR134W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YHR134W YHR134W YHR134W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/Other DUB/Other 20516210
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
Protein Sequence
(Fasta)
MKTEGIKSPS AKYHDMAGSQ RIPHKNPHIQ KVAVLQSKPN KEDALNLIKE IAHKVSYLMK 60
ENHFKVTNLV EFYPRDQRLL GMNVNHGSKI MLRLRCSTDE FQFLPMECIM GTMLHELTHN 120
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Protein Fasta Sequence



>IUUC-Sce-106416|DUB,DUB/Other|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAAGACAG AAGGAATAAA AAGCCCATCG GCAAAATACC ATGATATGGC GGGCTCCCAG 60
AGAATCCCTC ACAAGAACCC GCACATTCAA AAAGTGGCTG TTTTGCAAAG TAAGCCCAAT 120
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Nucleotide Fasta Sequence



>IUUC-Sce-106416|DUB,DUB/Other|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR013536--WLM_dom

PROSITE

PS51397--WLM
PS00142--ZINC_PROTEASE

Pfam

PF08325--WLM

Gene Ontology

GO:0000324--C:fungal-type vacuole
GO:0005635--C:nuclear envelope
GO:0046872--F:metal ion binding
GO:0004222--F:metalloendopeptidase activity
GO:0008237--F:metallopeptidase activity
GO:0032183--F:SUMO binding
GO:0061665--F:SUMO ligase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:1990466--P:protein autosumoylation
GO:0016925--P:protein sumoylation
GO:1990414--P:replication-born double-strand break repair via sister chromatid exchange
GO:0010224--P:response to UV-B
GO:0010225--P:response to UV-C
GO:0019985--P:translesion synthesis

KEGG sce:YHR134W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000592 Aegilops tauschii 43.40 4.00e-17 79.70
IUUC-Atr-003051 Amborella trichopoda 31.25 2.00e-16 77.80
IUUC-Aly-006462 Arabidopsis lyrata 36.06 5.00e-28 116.00
IUUC-Ath-007657 Arabidopsis thaliana 37.02 5.00e-29 120.00
IUUC-Ago-007734 Ashbya gossypii 62.20 1.00e-46 177.00
IUUC-Acl-008308 Aspergillus clavatus 42.86 4.00e-26 110.00
IUUC-Afl-008658 Aspergillus flavus 37.70 1.00e-28 118.00
IUUC-Afu-008913 Aspergillus fumigatus 31.80 1.00e-28 118.00
IUUC-Ani-009308 Aspergillus nidulans 30.41 1.00e-26 111.00
IUUC-Ang-009619 Aspergillus niger 31.51 5.00e-26 109.00
IUUC-Aor-009946 Aspergillus oryzae 37.70 1.00e-28 118.00
IUUC-Ate-010393 Aspergillus terreus 33.00 5.00e-27 113.00
IUUC-Bgr-012175 Blumeria graminis 29.38 9.00e-10 55.50
IUUC-Bci-013702 Botrytis cinerea 35.89 5.00e-29 119.00
IUUC-Bdi-014770 Brachypodium distachyon 38.97 7.00e-24 102.00
IUUC-Bol-015716 Brassica oleracea 36.06 2.00e-28 117.00
IUUC-Bra-017928 Brassica rapa 37.57 3.00e-25 107.00
IUUC-Cja-019118 Callithrix jacchus 31.82 1.30e+00 26.20
IUUC-Cpo-022142 Cavia porcellus 27.16 2.30e-01 28.10
IUUC-Cre-022670 Chlamydomonas reinhardtii 40.00 2.00e-16 77.00
IUUC-Cin-025462 Ciona intestinalis 32.69 2.60e-02 30.00
IUUC-Cgl-026567 Colletotrichum gloeosporioides 34.57 2.00e-08 51.20
IUUC-Cne-026853 Cryptococcus neoformans 25.71 5.00e-10 57.00
IUUC-Cme-027193 Cyanidioschyzon merolae 28.85 7.00e-12 62.40
IUUC-Dse-031270 Dothistroma septosporum 46.08 4.00e-22 97.40
IUUC-Eca-033788 Equus caballus 25.16 2.30e-02 33.90
IUUC-Fox-037769 Fusarium oxysporum 37.05 9.00e-30 122.00
IUUC-Fso-038248 Fusarium solani 34.60 5.00e-25 105.00
IUUC-Ggr-040026 Gaeumannomyces graminis 43.75 1.00e-23 101.00
IUUC-Gac-041842 Gasterosteus aculeatus 50.00 9.60e-02 30.00
IUUC-Gma-043646 Glycine max 33.47 7.00e-30 122.00
IUUC-Hvu-047699 Hordeum vulgare 39.71 2.00e-21 94.70
IUUC-Kpa-049326 Komagataella pastoris 38.83 4.00e-31 126.00
IUUC-Lpe-050735 Leersia perrieri 36.64 1.00e-31 128.00
IUUC-Lma-053304 Leptosphaeria maculans 29.87 1.00e-23 102.00
IUUC-Laf-053605 Loxodonta africana 28.38 1.70e-02 31.60
IUUC-Mor-057018 Magnaporthe oryzae 35.96 1.00e-24 105.00
IUUC-Mpo-057432 Magnaporthe poae 28.00 4.00e-07 47.80
IUUC-Mtr-058133 Medicago truncatula 34.56 1.00e-26 112.00
IUUC-Mla-058977 Melampsora laricipopulina 35.19 4.00e-06 43.50
IUUC-Mvi-060474 Microbotryum violaceum 33.20 7.00e-29 119.00
IUUC-Mac-064717 Musa acuminata 33.33 2.00e-25 107.00
IUUC-Nfi-068513 Neosartorya fischeri 32.26 1.00e-28 118.00
IUUC-Ncr-068633 Neurospora crassa 44.14 1.00e-22 99.00
IUUC-Nle-069378 Nomascus leucogenys 36.96 3.20e-02 30.00
IUUC-Ocu-074551 Oryctolagus cuniculus 29.31 1.20e+00 26.20
IUUC-Oba-075102 Oryza barthii 35.19 9.00e-25 105.00
IUUC-Obr-076781 Oryza brachyantha 34.91 1.00e-21 95.10
IUUC-Ogl-077291 Oryza glaberrima 35.19 4.00e-25 106.00
IUUC-Ogu-078856 Oryza glumaepatula 28.05 1.00e-07 49.70
IUUC-Oin-079800 Oryza indica 35.19 2.00e-24 104.00
IUUC-Olo-080556 Oryza longistaminata 46.15 2.00e-11 57.40
IUUC-Ome-081262 Oryza meridionalis 35.19 4.00e-25 106.00
IUUC-Oni-082829 Oryza nivara 35.19 2.00e-24 104.00
IUUC-Opu-083275 Oryza punctata 35.19 4.00e-25 106.00
IUUC-Oru-084564 Oryza rufipogon 35.19 3.00e-25 107.00
IUUC-Osa-085600 Oryza sativa 35.19 3.00e-25 107.00
IUUC-Olu-087608 Ostreococcus lucimarinus 44.44 8.00e-05 38.10
IUUC-Pno-095010 Phaeosphaeria nodorum 30.17 6.00e-25 106.00
IUUC-Ppa-095486 Physcomitrella patens 38.12 1.00e-24 105.00
IUUC-Pop-099256 Populus trichocarpa 32.93 5.00e-30 122.00
IUUC-Ppe-101337 Prunus persica 36.84 2.00e-30 124.00
IUUC-Pgr-103380 Puccinia graminis 34.78 1.00e-10 58.20
IUUC-Ptt-103766 Puccinia triticina 34.29 7.00e-09 53.10
IUUC-Pte-104280 Pyrenophora teres 31.06 3.00e-24 103.00
IUUC-Pyt-104755 Pyrenophora triticirepentis 43.12 5.00e-20 89.40
IUUC-Sja-107738 Schizosaccharomyces japonicus 30.40 8.00e-10 55.50
IUUC-Spo-108238 Schizosaccharomyces pombe 38.46 4.00e-11 60.10
IUUC-Ssl-108588 Sclerotinia sclerotiorum 37.09 3.00e-23 100.00
IUUC-Smo-109380 Selaginella moellendorffii 38.07 3.00e-25 107.00
IUUC-Sit-110033 Setaria italica 35.10 1.00e-21 95.10
IUUC-Sly-111119 Solanum lycopersicum 32.08 5.00e-27 113.00
IUUC-Stu-112451 Solanum tuberosum 33.97 9.00e-27 112.00
IUUC-Sbi-113896 Sorghum bicolor 37.02 2.00e-21 94.00
IUUC-Sre-114932 Sporisorium reilianum 31.39 6.00e-08 50.40
IUUC-Ssc-115613 Sus scrofa 26.92 4.20e-02 29.30
IUUC-Tru-118177 Takifugu rubripes 50.00 6.30e-02 30.80
IUUC-Tsy-119033 Tarsius syrichta 34.09 6.20e-01 26.90
IUUC-Tni-119660 Tetraodon nigroviridis 33.33 8.00e-03 32.30
IUUC-Tca-121382 Theobroma cacao 36.06 2.00e-20 90.90
IUUC-Tre-121881 Trichoderma reesei 41.33 2.00e-25 107.00
IUUC-Tvi-122470 Trichoderma virens 37.12 1.00e-27 115.00
IUUC-Tae-125350 Triticum aestivum 38.97 8.00e-22 95.50
IUUC-Tur-126703 Triticum urartu 34.91 3.00e-21 93.20
IUUC-Tme-127206 Tuber melanosporum 37.02 7.00e-27 112.00
IUUC-Uma-129542 Ustilago maydis 31.78 9.00e-07 46.20
IUUC-Vda-130005 Verticillium dahliae 38.30 4.00e-24 103.00
IUUC-Vvi-131427 Vitis vinifera 36.68 1.00e-26 112.00
IUUC-Xma-133947 Xiphophorus maculatus 50.00 2.10e-01 28.90
IUUC-Yli-134425 Yarrowia lipolytica 46.67 3.00e-28 116.00
IUUC-Zma-135771 Zea mays 35.62 4.00e-30 123.00
Created Date 25-Jun-2017

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