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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045788
UUCD1 version UUC-HoS-00548
Ensembl Protein ID ENSP00000357858.4
UniProt Accession O43684; A6NJ42; B2R6E7; D3DRE9; O43685; BUB3_HUMAN
Genbank Protein ID AAC28438.1; AAC28439.1; AAC06258.1; AAC36307.1; BAG35444.1; EAW49284.1; EAW49285.1; EAW49286.1; AAH05138.1; AAH22438.1
Protein Name Mitotic checkpoint protein BUB3
Genbank Nucleotide ID AF047472; AF047473; AF053304; AF081496; AK312546; AC012391; CH471066; CH471066; BC005138; BC022438
Gene Name BUB3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000154473.17 ENST00000368865.8 ENSP00000357858.4
ENSG00000154473.17 ENST00000368859.6 ENSP00000357852.1
ENSG00000154473.17 ENST00000368858.9 ENSP00000357851.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.90e-29 99.8 95 128
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           H ++++c+++ ++ + +v+Gs+D t+k+WD+rt 
   Q: 95   HDAPIRCVEYcPEvNVMVTGSWDQTVKLWDPRTP 128
           999********999****************9985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
 Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Protein Sequence
(Fasta)
MTGSNEFKLN QPPEDGISSV KFSPNTSQFL LVSSWDTSVR LYDVPANSMR LKYQHTGAVL 60
DCAFYDPTHA WSGGLDHQLK MHDLNTDQEN LVGTHDAPIR CVEYCPEVNV MVTGSWDQTV 120
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Protein Fasta Sequence


>IUUC-Hsa-045788|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGTTGACCG ATGCTGGGCA GCTGAGCGGA CCAATCGGCC CCCTAGACTG AGACGTTGGC 60
GTTTGAAATC AGCCAATGGC AGGTCTACAC TGGAGCTTCC TCTCCGCCTC CTTCGCCTAG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045788|E3,WD_repeat|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0013--ADP-ribosylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0995--Kinetochore
KW-0469--Meiosis
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005654--C:nucleoplasm
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0008608--P:attachment of spindle microtubules to kinetochore
GO:0051301--P:cell division
GO:0051321--P:meiotic cell cycle
GO:0000070--P:mitotic sister chromatid segregation
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051983--P:regulation of chromosome segregation
GO:0007062--P:sister chromatid cohesion
GO:0071173--P:spindle assembly checkpoint
KEGG hsa:9184
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000710 Aegilops tauschii 50.00 7.00e-65 241.00
IUUC-Aml-002418 Ailuropoda melanoleuca 99.69 0.00e+00 686.00
IUUC-Atr-002511 Amborella trichopoda 53.42 3.00e-103 368.00
IUUC-Apl-003201 Anas platyrhynchos 96.00 0.00e+00 665.00
IUUC-Aca-004657 Anolis carolinensis 98.15 0.00e+00 676.00
IUUC-Aly-005707 Arabidopsis lyrata 55.66 6.00e-105 374.00
IUUC-Ath-007454 Arabidopsis thaliana 55.03 7.00e-104 370.00
IUUC-Acl-008120 Aspergillus clavatus 38.07 2.00e-69 256.00
IUUC-Afu-009061 Aspergillus fumigatus 38.18 1.00e-70 260.00
IUUC-Ani-009457 Aspergillus nidulans 39.15 7.00e-72 264.00
IUUC-Ang-009848 Aspergillus niger 37.64 5.00e-68 251.00
IUUC-Aor-009886 Aspergillus oryzae 36.86 5.00e-64 238.00
IUUC-Ate-010388 Aspergillus terreus 38.35 8.00e-69 253.00
IUUC-Ame-011039 Astyanax mexicanus 88.00 7.00e-178 616.00
IUUC-Bgr-012134 Blumeria graminis 37.25 2.00e-68 253.00
IUUC-Bta-012959 Bos taurus 100.00 0.00e+00 687.00
IUUC-Bci-013818 Botrytis cinerea 39.70 3.00e-69 255.00
IUUC-Bdi-014928 Brachypodium distachyon 53.42 9.00e-104 370.00
IUUC-Bol-016443 Brassica oleracea 55.80 3.00e-105 374.00
IUUC-Bra-016981 Brassica rapa 55.66 3.00e-106 378.00
IUUC-Cel-018211 Caenorhabditis elegans 43.64 2.00e-77 282.00
IUUC-Cja-018807 Callithrix jacchus 99.70 0.00e+00 694.00
IUUC-Cfa-020279 Canis familiaris 100.00 3.00e-151 527.00
IUUC-Cpo-022411 Cavia porcellus 100.00 0.00e+00 694.00
IUUC-Cre-022964 Chlamydomonas reinhardtii 46.48 6.00e-79 287.00
IUUC-Csa-024046 Chlorocebus sabaeus 100.00 9.00e-153 532.00
IUUC-Cho-024930 Choloepus hoffmanni 99.09 0.00e+00 687.00
IUUC-Cin-025561 Ciona intestinalis 70.37 6.00e-141 493.00
IUUC-Csv-026129 Ciona savignyi 69.14 2.00e-139 488.00
IUUC-Cgl-026764 Colletotrichum gloeosporioides 37.82 1.00e-66 247.00
IUUC-Cne-026832 Cryptococcus neoformans 39.08 3.00e-54 206.00
IUUC-Dre-028257 Danio rerio 86.15 4.00e-165 573.00
IUUC-Dno-029433 Dasypus novemcinctus 99.70 0.00e+00 692.00
IUUC-Dor-030318 Dipodomys ordii 99.70 0.00e+00 692.00
IUUC-Dme-031609 Drosophila melanogaster 60.56 1.00e-116 412.00
IUUC-Ete-032903 Echinops telfairi 82.57 4.00e-156 543.00
IUUC-Eca-034333 Equus caballus 100.00 0.00e+00 694.00
IUUC-Fca-035848 Felis catus 100.00 0.00e+00 694.00
IUUC-Fal-037239 Ficedula albicollis 96.62 0.00e+00 672.00
IUUC-Fox-037712 Fusarium oxysporum 36.52 4.00e-65 241.00
IUUC-Fso-038165 Fusarium solani 37.10 1.00e-64 239.00
IUUC-Gmo-039586 Gadus morhua 85.76 6.00e-172 596.00
IUUC-Gga-040565 Gallus gallus 96.91 0.00e+00 670.00
IUUC-Gac-041299 Gasterosteus aculeatus 85.98 5.00e-175 606.00
IUUC-Gma-042865 Glycine max 53.77 3.00e-102 364.00
IUUC-Ggo-045135 Gorilla gorilla 100.00 0.00e+00 694.00
IUUC-Itr-048845 Ictidomys tridecemlineatus 100.00 0.00e+00 686.00
IUUC-Lch-050423 Latimeria chalumnae 93.54 0.00e+00 652.00
IUUC-Lpe-051670 Leersia perrieri 55.28 3.00e-107 381.00
IUUC-Loc-052148 Lepisosteus oculatus 90.15 0.00e+00 630.00
IUUC-Lma-053147 Leptosphaeria maculans 39.71 2.00e-68 253.00
IUUC-Laf-054429 Loxodonta africana 99.08 0.00e+00 677.00
IUUC-Mcc-055649 Macaca mulatta 100.00 0.00e+00 694.00
IUUC-Meu-056019 Macropus eugenii 85.76 8.00e-163 565.00
IUUC-Mtr-058803 Medicago truncatula 53.73 2.00e-103 369.00
IUUC-Mla-059131 Melampsora laricipopulina 39.94 5.00e-69 254.00
IUUC-Mga-059227 Meleagris gallopavo 96.32 0.00e+00 665.00
IUUC-Mmr-060811 Microcebus murinus 100.00 0.00e+00 694.00
IUUC-Mdo-062582 Monodelphis domestica 95.52 0.00e+00 672.00
IUUC-Mmu-064048 Mus musculus 100.00 0.00e+00 687.00
IUUC-Mac-064572 Musa acuminata 54.46 4.00e-104 370.00
IUUC-Mpu-066592 Mustela putorius furo 100.00 0.00e+00 694.00
IUUC-Mlu-067466 Myotis lucifugus 98.15 0.00e+00 671.00
IUUC-Nfi-068486 Neosartorya fischeri 38.22 1.00e-69 256.00
IUUC-Ncr-068899 Neurospora crassa 38.35 1.00e-69 256.00
IUUC-Nle-069273 Nomascus leucogenys 100.00 0.00e+00 694.00
IUUC-Opr-070473 Ochotona princeps 94.21 0.00e+00 654.00
IUUC-Ont-072515 Oreochromis niloticus 87.38 9.00e-178 615.00
IUUC-Oan-073344 Ornithorhynchus anatinus 99.64 1.00e-169 588.00
IUUC-Ocu-073931 Oryctolagus cuniculus 99.39 0.00e+00 692.00
IUUC-Oba-075450 Oryza barthii 55.28 3.00e-107 381.00
IUUC-Obr-076202 Oryza brachyantha 55.28 2.00e-107 382.00
IUUC-Ogl-077809 Oryza glaberrima 55.28 3.00e-107 381.00
IUUC-Ogu-078034 Oryza glumaepatula 51.60 1.00e-102 366.00
IUUC-Oin-079586 Oryza indica 55.28 3.00e-107 381.00
IUUC-Olo-080351 Oryza longistaminata 50.96 8.00e-94 337.00
IUUC-Ome-081913 Oryza meridionalis 44.95 4.00e-79 288.00
IUUC-Oni-082048 Oryza nivara 55.28 3.00e-107 381.00
IUUC-Opu-083951 Oryza punctata 55.28 3.00e-107 381.00
IUUC-Oru-084904 Oryza rufipogon 55.28 5.00e-107 380.00
IUUC-Osa-085399 Oryza sativa 55.28 2.00e-107 381.00
IUUC-Ola-086605 Oryzias latipes 87.65 3.00e-177 614.00
IUUC-Oga-088115 Otolemur garnettii 100.00 0.00e+00 694.00
IUUC-Oar-089301 Ovis aries 99.70 0.00e+00 692.00
IUUC-Pan-092156 Papio anubis 100.00 0.00e+00 694.00
IUUC-Psi-094031 Pelodiscus sinensis 97.85 0.00e+00 678.00
IUUC-Pma-094724 Petromyzon marinus 81.85 2.00e-167 581.00
IUUC-Pno-094848 Phaeosphaeria nodorum 40.08 8.00e-52 196.00
IUUC-Ppa-096018 Physcomitrella patens 57.83 3.00e-109 388.00
IUUC-Pfo-096256 Poecilia formosa 87.38 6.00e-177 612.00
IUUC-Pab-097757 Pongo abelii 100.00 0.00e+00 694.00
IUUC-Pop-099511 Populus trichocarpa 55.17 2.00e-105 375.00
IUUC-Pca-100326 Procavia capensis 99.16 1.00e-144 505.00
IUUC-Ppe-101462 Prunus persica 55.35 2.00e-104 372.00
IUUC-Pva-102523 Pteropus vampyrus 100.00 0.00e+00 694.00
IUUC-Pgr-103482 Puccinia graminis 40.29 1.00e-56 213.00
IUUC-Ptt-103911 Puccinia triticina 39.09 1.00e-65 243.00
IUUC-Pte-104350 Pyrenophora teres 38.82 5.00e-68 251.00
IUUC-Pyt-104538 Pyrenophora triticirepentis 38.82 4.00e-68 251.00
IUUC-Rno-105388 Rattus norvegicus 64.92 2.00e-108 386.00
IUUC-Sha-106976 Sarcophilus harrisii 99.08 0.00e+00 687.00
IUUC-Sja-107725 Schizosaccharomyces japonicus 37.20 4.00e-55 208.00
IUUC-Spo-108103 Schizosaccharomyces pombe 37.88 1.00e-54 206.00
IUUC-Ssl-108521 Sclerotinia sclerotiorum 35.78 5.00e-37 147.00
IUUC-Smo-109187 Selaginella moellendorffii 54.06 7.00e-104 370.00
IUUC-Sit-110412 Setaria italica 52.55 1.00e-98 352.00
IUUC-Sly-111541 Solanum lycopersicum 54.49 1.00e-102 366.00
IUUC-Stu-112371 Solanum tuberosum 54.17 3.00e-102 365.00
IUUC-Sar-113159 Sorex araneus 78.24 2.00e-107 381.00
IUUC-Sbi-114880 Sorghum bicolor 54.97 3.00e-106 378.00
IUUC-Sre-115205 Sporisorium reilianum 31.28 4.00e-46 178.00
IUUC-Ssc-116399 Sus scrofa 100.00 0.00e+00 694.00
IUUC-Tgu-117029 Taeniopygia guttata 96.28 0.00e+00 665.00
IUUC-Tru-118385 Takifugu rubripes 87.35 2.00e-176 611.00
IUUC-Tsy-118842 Tarsius syrichta 99.09 0.00e+00 689.00
IUUC-Tni-120539 Tetraodon nigroviridis 86.20 3.00e-174 604.00
IUUC-Tca-121027 Theobroma cacao 55.03 2.00e-103 369.00
IUUC-Tre-122098 Trichoderma reesei 37.10 3.00e-62 232.00
IUUC-Tvi-122569 Trichoderma virens 37.39 1.00e-64 239.00
IUUC-Tae-123002 Triticum aestivum 54.66 4.00e-106 377.00
IUUC-Tur-126282 Triticum urartu 51.36 2.00e-66 245.00
IUUC-Tme-127210 Tuber melanosporum 48.10 5.00e-83 301.00
IUUC-Tbe-128159 Tupaia belangeri 69.21 1.00e-124 439.00
IUUC-Ttr-128743 Tursiops truncatus 100.00 0.00e+00 694.00
IUUC-Uma-129496 Ustilago maydis 32.69 4.00e-40 159.00
IUUC-Vda-129882 Verticillium dahliae 39.94 2.00e-69 256.00
IUUC-Vpa-130790 Vicugna pacos 100.00 4.00e-161 560.00
IUUC-Vvi-131671 Vitis vinifera 54.35 2.00e-103 369.00
IUUC-Xtr-132887 Xenopus tropicalis 82.41 5.00e-158 550.00
IUUC-Xma-134127 Xiphophorus maculatus 87.38 7.00e-177 612.00
IUUC-Yli-134366 Yarrowia lipolytica 40.60 2.00e-53 202.00
Created Date 25-Jun-2017

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