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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064187
UUCD1 version UUC-MuM-00671
Ensembl Protein ID ENSMUSP00000023159.8
UniProt Accession Q9D074; Q3U5V9; Q3UDA1; Q6ZQ97; Q8BZM9; MGRN1_MOUSE
Genbank Protein ID BAB27816.2; BAC28587.1; BAC40408.1; BAE29360.1; BAE31967.1; AAH46830.1; BAC97971.1
Protein Name E3 ubiquitin-protein ligase MGRN1; Mahogunin RING finger protein 1; RING-type E3 ubiquitin transferase MGRN1
Genbank Nucleotide ID AK011747; AK034100; AK088533; AK150176; AK153407; BC046830; AK129161
Gene Name Mgrn1; Kiaa0544
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022517.16 ENSMUST00000070658.14 ENSMUSP00000068314.8
ENSMUSG00000022517.16 ENSMUST00000023159.8 ENSMUSP00000023159.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 35.58 7.00e-30 129.00 IUUC-Ath-007579
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity).
 E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity).
Protein Sequence
(Fasta)
MGSILSRRIA GVEDIDIQAN SAYRYPPKSA GNYFASHFFM GGEKFDTPHP EGYLFGENMD 60
LNFLGSRPVQ FPYVTPAPHE PVKTLRSLVN IRKDSLRLVR YKEDADSPTE DGEKPRVLYS 120
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Protein Fasta Sequence


>IUUC-Mmu-064187|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GGTGGTGGTG GTGGTGGTGG TGGCAAGCTT GGGAAGCGTA GTACGCAGGC GCATTGGCTG 60
CCTGGCCTGG ACTCCATTTC CCCTGGAACT GCGGGGCGGG GGCGGGGGCG GGGCGCCGGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064187|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001370--BIR_rpt
IPR001841--Znf_RING
PROSITE

PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0008333--P:endosome to lysosome transport
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0045744--P:negative regulation of G-protein coupled receptor protein signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
KEGG mmu:17237
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000903 Aegilops tauschii 34.81 1.00e-37 149.00
IUUC-Atr-002864 Amborella trichopoda 34.75 2.00e-38 153.00
IUUC-Apl-004187 Anas platyrhynchos 76.55 0.00e+00 786.00
IUUC-Aca-005114 Anolis carolinensis 79.60 0.00e+00 822.00
IUUC-Aly-006409 Arabidopsis lyrata 36.19 6.00e-33 134.00
IUUC-Ath-007579 Arabidopsis thaliana 35.07 7.00e-31 128.00
IUUC-Afl-008422 Aspergillus flavus 36.71 6.00e-09 53.50
IUUC-Ame-011921 Astyanax mexicanus 69.05 2.00e-180 625.00
IUUC-Bdi-014817 Brachypodium distachyon 35.64 9.00e-38 150.00
IUUC-Bol-015790 Brassica oleracea 34.64 2.00e-31 130.00
IUUC-Cfa-021099 Canis familiaris 85.24 0.00e+00 847.00
IUUC-Cpo-021611 Cavia porcellus 86.00 0.00e+00 853.00
IUUC-Cre-022780 Chlamydomonas reinhardtii 29.10 8.00e-27 114.00
IUUC-Csa-023582 Chlorocebus sabaeus 85.97 0.00e+00 918.00
IUUC-Cne-026964 Cryptococcus neoformans 36.49 2.00e-11 64.30
IUUC-Dno-029086 Dasypus novemcinctus 84.14 0.00e+00 904.00
IUUC-Dor-030120 Dipodomys ordii 78.72 0.00e+00 764.00
IUUC-Ete-032561 Echinops telfairi 66.86 7.00e-164 570.00
IUUC-Eca-033875 Equus caballus 90.48 0.00e+00 868.00
IUUC-Eeu-034497 Erinaceus europaeus 74.14 0.00e+00 710.00
IUUC-Fca-036132 Felis catus 84.98 0.00e+00 847.00
IUUC-Fal-036855 Ficedula albicollis 85.50 0.00e+00 859.00
IUUC-Gmo-039258 Gadus morhua 72.86 0.00e+00 774.00
IUUC-Gga-040695 Gallus gallus 79.82 0.00e+00 831.00
IUUC-Gac-041714 Gasterosteus aculeatus 73.08 0.00e+00 778.00
IUUC-Gma-044140 Glycine max 36.78 6.00e-38 151.00
IUUC-Ggo-045064 Gorilla gorilla 84.92 0.00e+00 915.00
IUUC-Hsa-046606 Homo sapiens 86.33 0.00e+00 925.00
IUUC-Lpe-050811 Leersia perrieri 33.44 7.00e-39 154.00
IUUC-Laf-054217 Loxodonta africana 86.76 0.00e+00 832.00
IUUC-Mcc-055466 Macaca mulatta 86.87 0.00e+00 929.00
IUUC-Meu-056424 Macropus eugenii 75.37 0.00e+00 725.00
IUUC-Mtr-058351 Medicago truncatula 33.58 6.00e-36 144.00
IUUC-Mga-060123 Meleagris gallopavo 90.12 0.00e+00 751.00
IUUC-Mmr-060947 Microcebus murinus 89.69 0.00e+00 803.00
IUUC-Mdo-061853 Monodelphis domestica 86.02 0.00e+00 900.00
IUUC-Mac-065591 Musa acuminata 34.34 2.00e-37 149.00
IUUC-Mpu-066218 Mustela putorius furo 85.61 0.00e+00 904.00
IUUC-Mlu-067226 Myotis lucifugus 85.48 0.00e+00 907.00
IUUC-Opr-070507 Ochotona princeps 81.43 0.00e+00 840.00
IUUC-Oan-073619 Ornithorhynchus anatinus 81.50 0.00e+00 775.00
IUUC-Oba-075139 Oryza barthii 36.40 2.00e-34 139.00
IUUC-Obr-076291 Oryza brachyantha 35.69 9.00e-39 154.00
IUUC-Ogl-077178 Oryza glaberrima 35.10 1.00e-39 157.00
IUUC-Ogu-078712 Oryza glumaepatula 36.12 1.00e-40 160.00
IUUC-Oin-080016 Oryza indica 36.12 2.00e-40 160.00
IUUC-Olo-081031 Oryza longistaminata 34.84 3.00e-39 156.00
IUUC-Ome-081566 Oryza meridionalis 35.76 6.00e-39 155.00
IUUC-Oni-082100 Oryza nivara 36.12 2.00e-40 160.00
IUUC-Opu-084142 Oryza punctata 34.26 2.00e-39 156.00
IUUC-Oru-084936 Oryza rufipogon 36.12 2.00e-40 160.00
IUUC-Osa-086062 Oryza sativa 36.12 2.00e-40 160.00
IUUC-Oga-088990 Otolemur garnettii 88.79 0.00e+00 904.00
IUUC-Oar-090173 Ovis aries 70.98 0.00e+00 643.00
IUUC-Pan-091797 Papio anubis 86.58 0.00e+00 907.00
IUUC-Psi-093844 Pelodiscus sinensis 89.80 0.00e+00 710.00
IUUC-Pno-094880 Phaeosphaeria nodorum 36.73 6.00e-05 42.40
IUUC-Ppa-095271 Physcomitrella patens 28.36 2.00e-26 113.00
IUUC-Pab-097992 Pongo abelii 86.06 0.00e+00 902.00
IUUC-Pop-099592 Populus trichocarpa 35.36 3.00e-34 139.00
IUUC-Pca-100998 Procavia capensis 75.68 0.00e+00 758.00
IUUC-Ppe-101577 Prunus persica 35.27 6.00e-40 157.00
IUUC-Pva-102362 Pteropus vampyrus 87.13 0.00e+00 902.00
IUUC-Rno-105572 Rattus norvegicus 92.97 0.00e+00 964.00
IUUC-Sha-107374 Sarcophilus harrisii 86.20 0.00e+00 899.00
IUUC-Smo-109530 Selaginella moellendorffii 32.71 2.00e-32 132.00
IUUC-Sit-110038 Setaria italica 36.40 9.00e-38 150.00
IUUC-Sly-110839 Solanum lycopersicum 34.23 2.00e-34 139.00
IUUC-Stu-112804 Solanum tuberosum 33.85 1.00e-33 137.00
IUUC-Sre-115067 Sporisorium reilianum 30.95 1.00e-04 42.00
IUUC-Ssc-116415 Sus scrofa 84.53 0.00e+00 895.00
IUUC-Tgu-116526 Taeniopygia guttata 84.53 0.00e+00 839.00
IUUC-Tru-118173 Takifugu rubripes 73.97 0.00e+00 768.00
IUUC-Tni-119781 Tetraodon nigroviridis 74.95 0.00e+00 773.00
IUUC-Tca-121153 Theobroma cacao 33.58 2.00e-32 133.00
IUUC-Tae-123450 Triticum aestivum 34.67 4.00e-38 152.00
IUUC-Tur-126214 Triticum urartu 34.67 2.00e-38 153.00
IUUC-Tme-127014 Tuber melanosporum 32.20 9.00e-08 47.80
IUUC-Tbe-127685 Tupaia belangeri 67.41 3.00e-131 461.00
Created Date 25-Jun-2017

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