iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046068

UUCD1 version

UUC-HoS-01206

Ensembl Protein ID

ENSP00000246548.3

UniProt Accession

Q9UBT2; B3KWB9; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UED2; SAE2_HUMAN

Genbank Protein ID

AAD12784.1; AAD23914.1; AAD24434.1; AAC99992.1; CAB66839.1; BAG54081.1; AAP88783.1; CAG33037.1; AAH03153.1; BAD92109.1; BAA34795.1

Protein Name

SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2

Genbank Nucleotide ID

AF090384; AF079566; AF110957; U35832; AL136905; AK124730; BT009781; CR456756; AC008747; AB208872; AB015337

Gene Name

UBA2; SAE2; UBLE1B; HRIHFB2115

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000126261.12	ENST00000607361.5	ENSP00000475565.1
ENSG00000126261.12	ENST00000586313.1	ENSP00000468538.1
ENSG00000126261.12	ENST00000246548.8	ENSP00000246548.3
ENSG00000126261.12	ENST00000590048.6	ENSP00000467433.2
ENSG00000126261.12	ENST00000591016.1	ENSP00000468756.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB	SCOP
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	9920803; 20682785

Classification

Family	E-value	Score	Start	End
E1	3.30e-138	463.1	10	421

Active Site

Position(s)	Description	Evidence
173	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU10132, ECO:0000269\|PubMed:15660128, ECO:0000269\|PubMed:20164921}

Domain Profile

   S: 11   eaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitelee 102
           e  e++   +vl+vGagg+GcEllKnLvl+G+++i ++D dt++vsnlnrqFLf++++vg+sKA+va+e++ ++ p+ n++a+++si+++++
   Q: 10   ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDY 101
           56799999************************************************************************************ PP
   S: 103  eivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.vlf 193
           +++Ff++f +V++aldnr+ar++vnr+cl+a+vpliesgt G+lGqv++i kg+tecy+c+++p+q+t+P+ct+++tp+++ h+i+wa +lf
   Q: 102  NVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAkYLF 193
           ******************************************************************************************** PP
   S: 194  nklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv.......... 274
           n+l++ee++++ev++  d++++e++++++++e+++++++++ ++++i++k++ak+t ++ +k ++k f++di++  ++++++          
   Q: 194  NQLFGEEDADQEVSP--DRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDpVKLFTKLFKDDIRYLLTMDKLWrkrkppvpld 283
           ***************..799************************************************************************ PP
   S: 275  ........sfcsnaealqvpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkl 353
                   +  + ++++++p+ ++kd++v++++++     +++++++++++ek +g    el ++kdd+sa+d+vt+aanlr++ +++++  
   Q: 284  waevqsqgEETNASDQQNEPQLGLKDQQVLDVKSYarlfsKSIETLRVHLAEKGDGA---ELIWDKDDPSAMDFVTSAANLRMHIFSMNM-K 371
           *******999999********************************************...68****************************.* PP
   S: 354  dddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfda 403
           ++++ik++agniipaiattnav++Gl+++E +K++sgk ++++++fl+++
   Q: 372  SRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQ 421
           **********************************************9965 PP

Organism

Homo sapiens

Functional Description
(View)

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Protein Sequence
(Fasta)

MALSRGLPRE LAEAVAGGRV LVVGAGGIGC ELLKNLVLTG FSHIDLIDLD TIDVSNLNRQ 60
FLFQKKHVGR SKAQVAKESV LQFYPKANIV AYHDSIMNPD YNVEFFRQFI LVMNALDNRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCGCCCTT CCCCCACCCG CTTCCGGCCG CGGCTCGGTT CTCCCGCCTC CGCCTCCGCC 60
GCGGCTCGTG GTTGTCCCGC CATGGCACTG TCGCGGGGGC TGCCCCGGGA GCTGGCTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR016040--NAD(P)-bd_dom
IPR030661--SAE2/Uba2
IPR000594--ThiF_NAD_FAD-bd
IPR028077--UAE_UbL_dom
IPR032426--UBA2_C
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF00899--ThiF
PF14732--UAE_UbL
PF16195--UBA2_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0031510--C:SUMO activating enzyme complex
GO:0005524--F:ATP binding
GO:0008047--F:enzyme activator activity
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0019948--F:SUMO activating enzyme activity
GO:0016925--P:protein sumoylation

KEGG

hsa:10054

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000112	Aegilops tauschii	40.81	4.00e-108	385.00
IUUC-Aml-001662	Ailuropoda melanoleuca	97.50	0.00e+00	1249.00
IUUC-Atr-002636	Amborella trichopoda	40.00	4.00e-113	402.00
IUUC-Apl-003369	Anas platyrhynchos	89.23	0.00e+00	1028.00
IUUC-Aca-004490	Anolis carolinensis	83.39	0.00e+00	924.00
IUUC-Aly-006359	Arabidopsis lyrata	41.76	9.00e-105	374.00
IUUC-Ath-007667	Arabidopsis thaliana	42.31	3.00e-108	386.00
IUUC-Ago-007844	Ashbya gossypii	34.63	3.00e-85	309.00
IUUC-Acl-008270	Aspergillus clavatus	43.60	1.00e-105	377.00
IUUC-Afl-008674	Aspergillus flavus	43.29	3.00e-112	399.00
IUUC-Afu-008883	Aspergillus fumigatus	41.87	7.00e-107	381.00
IUUC-Ani-009500	Aspergillus nidulans	45.16	2.00e-116	413.00
IUUC-Ang-009535	Aspergillus niger	43.65	6.00e-111	394.00
IUUC-Aor-010223	Aspergillus oryzae	44.24	3.00e-114	405.00
IUUC-Ate-010282	Aspergillus terreus	43.93	8.00e-90	324.00
IUUC-Ame-011736	Astyanax mexicanus	78.16	0.00e+00	993.00
IUUC-Bgr-012166	Blumeria graminis	42.26	1.00e-98	353.00
IUUC-Bta-012589	Bos taurus	97.97	0.00e+00	1256.00
IUUC-Bci-013802	Botrytis cinerea	43.21	6.00e-101	362.00
IUUC-Bdi-014697	Brachypodium distachyon	39.56	3.00e-112	399.00
IUUC-Bol-016315	Brassica oleracea	42.22	4.00e-110	392.00
IUUC-Bra-017009	Brassica rapa	40.06	6.00e-111	394.00
IUUC-Cel-018708	Caenorhabditis elegans	46.48	4.00e-133	468.00
IUUC-Cja-019120	Callithrix jacchus	99.53	0.00e+00	1228.00
IUUC-Cfa-021061	Canis familiaris	97.97	0.00e+00	1256.00
IUUC-Cpo-021842	Cavia porcellus	97.81	0.00e+00	1212.00
IUUC-Csa-024104	Chlorocebus sabaeus	99.84	0.00e+00	1192.00
IUUC-Cho-024332	Choloepus hoffmanni	86.52	0.00e+00	874.00
IUUC-Cin-025363	Ciona intestinalis	61.87	0.00e+00	683.00
IUUC-Cgl-026419	Colletotrichum gloeosporioides	43.39	3.00e-99	356.00
IUUC-Cne-026888	Cryptococcus neoformans	53.05	1.00e-72	268.00
IUUC-Cme-027315	Cyanidioschyzon merolae	34.42	7.00e-60	225.00
IUUC-Dre-028420	Danio rerio	76.11	0.00e+00	918.00
IUUC-Dno-030041	Dasypus novemcinctus	97.19	0.00e+00	1207.00
IUUC-Dor-031039	Dipodomys ordii	82.27	0.00e+00	650.00
IUUC-Dse-031504	Dothistroma septosporum	42.76	3.00e-94	339.00
IUUC-Dme-031771	Drosophila melanogaster	50.24	2.00e-148	519.00
IUUC-Ete-033037	Echinops telfairi	91.41	0.00e+00	1083.00
IUUC-Eca-033774	Equus caballus	98.15	0.00e+00	1211.00
IUUC-Eeu-035074	Erinaceus europaeus	97.13	0.00e+00	973.00
IUUC-Fca-036508	Felis catus	98.32	0.00e+00	1213.00
IUUC-Fal-036813	Ficedula albicollis	86.99	0.00e+00	1023.00
IUUC-Fox-038056	Fusarium oxysporum	43.95	5.00e-106	378.00
IUUC-Fso-038223	Fusarium solani	42.70	5.00e-104	372.00
IUUC-Gmo-038526	Gadus morhua	75.04	0.00e+00	900.00
IUUC-Ggr-039767	Gaeumannomyces graminis	44.12	4.00e-101	362.00
IUUC-Gga-040981	Gallus gallus	87.97	0.00e+00	1052.00
IUUC-Gac-041437	Gasterosteus aculeatus	76.18	0.00e+00	927.00
IUUC-Gma-044072	Glycine max	37.97	3.00e-114	405.00
IUUC-Ggo-045358	Gorilla gorilla	96.44	0.00e+00	1135.00
IUUC-Hvu-047646	Hordeum vulgare	38.25	8.00e-109	387.00
IUUC-Itr-047887	Ictidomys tridecemlineatus	97.50	0.00e+00	1202.00
IUUC-Lch-049565	Latimeria chalumnae	81.96	0.00e+00	1045.00
IUUC-Lpe-050884	Leersia perrieri	40.82	4.00e-109	388.00
IUUC-Loc-052493	Lepisosteus oculatus	81.75	0.00e+00	1026.00
IUUC-Lma-053117	Leptosphaeria maculans	44.20	1.00e-101	364.00
IUUC-Laf-054518	Loxodonta africana	94.23	0.00e+00	1182.00
IUUC-Mcc-055334	Macaca mulatta	99.53	0.00e+00	1192.00
IUUC-Mor-057137	Magnaporthe oryzae	43.14	2.00e-95	343.00
IUUC-Mpo-057449	Magnaporthe poae	41.48	5.00e-102	365.00
IUUC-Mtr-058045	Medicago truncatula	39.41	3.00e-118	419.00
IUUC-Mla-058864	Melampsora laricipopulina	45.72	3.00e-96	345.00
IUUC-Mga-059422	Meleagris gallopavo	83.03	0.00e+00	932.00
IUUC-Mvi-060536	Microbotryum violaceum	42.44	6.00e-87	315.00
IUUC-Mmr-061161	Microcebus murinus	96.47	0.00e+00	1210.00
IUUC-Mdo-061802	Monodelphis domestica	93.14	0.00e+00	1146.00
IUUC-Mmu-064357	Mus musculus	94.06	0.00e+00	1197.00
IUUC-Mac-065475	Musa acuminata	38.69	1.00e-110	393.00
IUUC-Mpu-066895	Mustela putorius furo	98.12	0.00e+00	1256.00
IUUC-Mlu-067862	Myotis lucifugus	97.04	0.00e+00	1247.00
IUUC-Nfi-068385	Neosartorya fischeri	44.02	3.00e-110	392.00
IUUC-Ncr-068885	Neurospora crassa	41.67	3.00e-107	382.00
IUUC-Nle-069524	Nomascus leucogenys	99.22	0.00e+00	1178.00
IUUC-Opr-071038	Ochotona princeps	97.50	0.00e+00	1249.00
IUUC-Ont-071719	Oreochromis niloticus	76.27	0.00e+00	983.00
IUUC-Oan-072877	Ornithorhynchus anatinus	90.74	0.00e+00	997.00
IUUC-Ocu-074080	Oryctolagus cuniculus	97.34	0.00e+00	1202.00
IUUC-Oba-075936	Oryza barthii	37.97	2.00e-109	390.00
IUUC-Obr-076841	Oryza brachyantha	38.29	2.00e-111	396.00
IUUC-Ogl-077686	Oryza glaberrima	38.03	4.00e-111	395.00
IUUC-Ogu-078597	Oryza glumaepatula	37.09	1.00e-106	380.00
IUUC-Oin-079791	Oryza indica	37.97	2.00e-109	390.00
IUUC-Olo-081009	Oryza longistaminata	37.97	2.00e-109	389.00
IUUC-Ome-081327	Oryza meridionalis	35.50	1.00e-103	370.00
IUUC-Oni-082334	Oryza nivara	37.27	8.00e-107	381.00
IUUC-Opu-083447	Oryza punctata	38.29	5.00e-111	395.00
IUUC-Oru-084977	Oryza rufipogon	37.96	6.00e-109	388.00
IUUC-Osa-086160	Oryza sativa	43.98	4.00e-96	345.00
IUUC-Ola-087415	Oryzias latipes	75.59	0.00e+00	937.00
IUUC-Olu-087850	Ostreococcus lucimarinus	40.41	3.00e-101	362.00
IUUC-Oga-088434	Otolemur garnettii	97.97	0.00e+00	1216.00
IUUC-Oar-089872	Ovis aries	97.48	0.00e+00	1199.00
IUUC-Ptr-091212	Pan troglodytes	100.00	0.00e+00	1196.00
IUUC-Pan-092708	Papio anubis	99.61	6.00e-133	467.00
IUUC-Psi-093703	Pelodiscus sinensis	90.91	0.00e+00	1053.00
IUUC-Pno-094953	Phaeosphaeria nodorum	46.06	7.00e-106	378.00
IUUC-Ppa-095963	Physcomitrella patens	44.28	1.00e-108	387.00
IUUC-Pfo-097515	Poecilia formosa	75.04	0.00e+00	934.00
IUUC-Pab-097951	Pongo abelii	99.82	0.00e+00	1039.00
IUUC-Pop-099703	Populus trichocarpa	36.63	2.00e-96	346.00
IUUC-Pca-100426	Procavia capensis	95.00	0.00e+00	1213.00
IUUC-Ppe-101152	Prunus persica	39.22	6.00e-113	401.00
IUUC-Pva-102792	Pteropus vampyrus	93.09	0.00e+00	1159.00
IUUC-Pgr-103592	Puccinia graminis	44.15	8.00e-101	361.00
IUUC-Ptt-103805	Puccinia triticina	41.92	5.00e-87	315.00
IUUC-Pte-104215	Pyrenophora teres	44.91	9.00e-113	400.00
IUUC-Pyt-104634	Pyrenophora triticirepentis	46.24	5.00e-111	395.00
IUUC-Rno-106117	Rattus norvegicus	94.53	0.00e+00	1204.00
IUUC-Sce-106177	Saccharomyces cerevisiae	33.59	2.00e-76	280.00
IUUC-Sha-107006	Sarcophilus harrisii	93.30	0.00e+00	1150.00
IUUC-Sja-107967	Schizosaccharomyces japonicus	43.96	2.00e-94	340.00
IUUC-Spo-108020	Schizosaccharomyces pombe	44.38	7.00e-96	344.00
IUUC-Ssl-108509	Sclerotinia sclerotiorum	43.45	1.00e-103	370.00
IUUC-Smo-109264	Selaginella moellendorffii	43.75	8.00e-108	384.00
IUUC-Sit-110581	Setaria italica	40.84	1.00e-109	390.00
IUUC-Sly-111870	Solanum lycopersicum	39.41	7.00e-112	397.00
IUUC-Stu-112283	Solanum tuberosum	39.70	2.00e-109	389.00
IUUC-Sar-113432	Sorex araneus	72.39	0.00e+00	798.00
IUUC-Sbi-114075	Sorghum bicolor	38.28	5.00e-110	392.00
IUUC-Sre-114926	Sporisorium reilianum	43.41	2.00e-104	373.00
IUUC-Ssc-116281	Sus scrofa	98.62	3.00e-118	417.00
IUUC-Tgu-117247	Taeniopygia guttata	85.71	0.00e+00	1019.00
IUUC-Tru-118075	Takifugu rubripes	71.32	0.00e+00	896.00
IUUC-Tsy-119398	Tarsius syrichta	81.88	0.00e+00	936.00
IUUC-Tni-120771	Tetraodon nigroviridis	66.10	0.00e+00	808.00
IUUC-Tca-121651	Theobroma cacao	39.52	5.00e-111	395.00
IUUC-Tre-122224	Trichoderma reesei	43.58	4.00e-96	345.00
IUUC-Tvi-122634	Trichoderma virens	43.40	4.00e-96	345.00
IUUC-Tae-125665	Triticum aestivum	40.93	7.00e-106	377.00
IUUC-Tur-126417	Triticum urartu	39.96	1.00e-106	380.00
IUUC-Tme-127016	Tuber melanosporum	44.59	4.00e-97	348.00
IUUC-Tbe-127678	Tupaia belangeri	82.25	3.00e-179	622.00
IUUC-Ttr-128598	Tursiops truncatus	93.91	0.00e+00	1192.00
IUUC-Uma-129612	Ustilago maydis	41.77	4.00e-97	349.00
IUUC-Vda-129811	Verticillium dahliae	39.31	1.00e-102	367.00
IUUC-Vpa-130732	Vicugna pacos	83.91	0.00e+00	1036.00
IUUC-Vvi-130832	Vitis vinifera	40.70	7.00e-107	381.00
IUUC-Xtr-132823	Xenopus tropicalis	76.46	0.00e+00	927.00
IUUC-Xma-133552	Xiphophorus maculatus	74.88	0.00e+00	933.00
IUUC-Yli-134666	Yarrowia lipolytica	37.66	3.00e-76	279.00
IUUC-Zma-135547	Zea mays	38.35	2.00e-108	386.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence