iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000052934.14	ENSMUST00000059018.13	ENSMUSP00000057573.5
ENSMUSG00000052934.14	ENSMUST00000212985.1	ENSMUSP00000148763.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	4.70e-06	27.8	11	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 65   gpsaaakpkaglrseaaaapapapaptp....tpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwkt 145
           gp+  ++ +   r  a +a a + a t       e gp + +l +lp e+lvei+  l++++l ++a+vc r++++ +++++w++
   Q: 11   GPARGCRRRQQRRGPAETAAADSEADTDpeeeRIEAGPARCSLLELPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIWRR 95
           55555555556666555555666665540011345699************************************99999999986 PP

Organism

Mus musculus

Functional Description
(View)

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).

Protein Sequence
(Fasta)

MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR CSLLELPPEL 60
LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE YGVCENLRKL EITGVSCRDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGCGCTGT GCGTGCGCGT CCGCGTGCGC GCCTCCGCGG TGGTGACGGG CATGGCGGTG 60
TGTGCTCGGC TCTGCGGCGT GGGCCCCGCG CGTGGGTGCC GCCGCCGCCA GCAGCGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR026941--FBXO31

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX

Gene Ontology

GO:0005813--C:centrosome
GO:0043025--C:neuronal cell body
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030332--F:cyclin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:2001224--P:positive regulation of neuron migration
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

mmu:76454

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000641	Aegilops tauschii	34.33	1.00e-03	37.40
IUUC-Aml-001283	Ailuropoda melanoleuca	78.69	0.00e+00	738.00
IUUC-Atr-003100	Amborella trichopoda	29.67	9.00e-05	42.40
IUUC-Apl-003209	Anas platyrhynchos	75.17	0.00e+00	652.00
IUUC-Aca-004894	Anolis carolinensis	75.62	0.00e+00	707.00
IUUC-Aly-005512	Arabidopsis lyrata	32.89	5.00e-04	39.70
IUUC-Ath-007284	Arabidopsis thaliana	30.63	6.00e-06	46.20
IUUC-Ame-011867	Astyanax mexicanus	65.04	0.00e+00	658.00
IUUC-Bta-012497	Bos taurus	79.70	0.00e+00	717.00
IUUC-Bdi-014535	Brachypodium distachyon	36.54	5.00e-03	36.20
IUUC-Cja-019896	Callithrix jacchus	82.35	0.00e+00	830.00
IUUC-Cfa-020183	Canis familiaris	85.71	0.00e+00	706.00
IUUC-Cpo-022420	Cavia porcellus	89.28	0.00e+00	861.00
IUUC-Cre-022968	Chlamydomonas reinhardtii	35.00	2.00e-04	41.20
IUUC-Csa-023606	Chlorocebus sabaeus	77.62	0.00e+00	821.00
IUUC-Dre-028579	Danio rerio	71.08	0.00e+00	653.00
IUUC-Dno-030013	Dasypus novemcinctus	84.24	1.00e-149	523.00
IUUC-Dor-030865	Dipodomys ordii	85.36	0.00e+00	800.00
IUUC-Eca-033625	Equus caballus	87.86	0.00e+00	712.00
IUUC-Eeu-034639	Erinaceus europaeus	71.09	0.00e+00	641.00
IUUC-Fca-036551	Felis catus	76.55	0.00e+00	707.00
IUUC-Fal-037031	Ficedula albicollis	81.49	0.00e+00	742.00
IUUC-Gmo-039215	Gadus morhua	65.65	1.00e-169	589.00
IUUC-Gga-040962	Gallus gallus	81.68	0.00e+00	742.00
IUUC-Gac-041683	Gasterosteus aculeatus	65.22	0.00e+00	635.00
IUUC-Ggo-044776	Gorilla gorilla	84.43	0.00e+00	828.00
IUUC-Hsa-046605	Homo sapiens	85.34	0.00e+00	830.00
IUUC-Hvu-047259	Hordeum vulgare	31.88	7.00e-03	35.80
IUUC-Itr-048607	Ictidomys tridecemlineatus	91.24	0.00e+00	714.00
IUUC-Lch-050047	Latimeria chalumnae	65.65	0.00e+00	690.00
IUUC-Lpe-051286	Leersia perrieri	32.65	7.00e-03	35.80
IUUC-Loc-052230	Lepisosteus oculatus	71.52	1.00e-179	623.00
IUUC-Laf-053797	Loxodonta africana	84.18	0.00e+00	826.00
IUUC-Mcc-055189	Macaca mulatta	82.83	1.00e-170	592.00
IUUC-Meu-055993	Macropus eugenii	70.29	6.00e-155	540.00
IUUC-Mga-059198	Meleagris gallopavo	76.98	0.00e+00	660.00
IUUC-Mvi-060509	Microbotryum violaceum	34.92	7.00e-02	32.70
IUUC-Mmr-061738	Microcebus murinus	89.45	0.00e+00	790.00
IUUC-Mdo-062753	Monodelphis domestica	86.98	3.00e-178	618.00
IUUC-Mpu-066236	Mustela putorius furo	84.86	0.00e+00	704.00
IUUC-Mlu-068199	Myotis lucifugus	83.08	0.00e+00	813.00
IUUC-Nle-069835	Nomascus leucogenys	86.38	0.00e+00	705.00
IUUC-Opr-071142	Ochotona princeps	86.17	0.00e+00	793.00
IUUC-Ont-071669	Oreochromis niloticus	69.32	0.00e+00	650.00
IUUC-Oan-072716	Ornithorhynchus anatinus	82.90	0.00e+00	696.00
IUUC-Ocu-074345	Oryctolagus cuniculus	87.10	0.00e+00	719.00
IUUC-Oba-075322	Oryza barthii	31.91	1.20e-02	35.00
IUUC-Obr-076323	Oryza brachyantha	27.14	2.00e-03	36.20
IUUC-Ogu-078551	Oryza glumaepatula	31.91	1.30e-02	34.70
IUUC-Oin-079844	Oryza indica	39.58	2.40e-02	33.90
IUUC-Olo-080388	Oryza longistaminata	30.00	6.00e-03	34.70
IUUC-Ome-081606	Oryza meridionalis	31.91	1.70e-02	34.70
IUUC-Oni-082615	Oryza nivara	39.58	2.60e-02	33.90
IUUC-Opu-083870	Oryza punctata	32.61	1.50e-02	34.70
IUUC-Osa-086248	Oryza sativa	39.58	2.60e-02	33.90
IUUC-Ola-087311	Oryzias latipes	73.44	5.00e-169	587.00
IUUC-Oga-089001	Otolemur garnettii	79.04	0.00e+00	820.00
IUUC-Oar-089350	Ovis aries	80.72	0.00e+00	672.00
IUUC-Ptr-090976	Pan troglodytes	82.50	0.00e+00	825.00
IUUC-Pan-092129	Papio anubis	81.77	0.00e+00	835.00
IUUC-Psi-093747	Pelodiscus sinensis	79.09	4.00e-138	484.00
IUUC-Pma-094219	Petromyzon marinus	72.76	3.00e-98	351.00
IUUC-Pfo-096548	Poecilia formosa	70.22	0.00e+00	647.00
IUUC-Pab-098720	Pongo abelii	82.32	0.00e+00	847.00
IUUC-Pop-099194	Populus trichocarpa	22.78	2.00e-03	37.70
IUUC-Pca-101114	Procavia capensis	72.44	3.00e-112	398.00
IUUC-Pva-102268	Pteropus vampyrus	90.94	5.00e-167	580.00
IUUC-Pgr-103461	Puccinia graminis	45.45	4.00e-05	43.10
IUUC-Ptt-103780	Puccinia triticina	41.30	8.00e-04	38.90
IUUC-Rno-105274	Rattus norvegicus	97.04	0.00e+00	896.00
IUUC-Sha-107258	Sarcophilus harrisii	78.00	0.00e+00	668.00
IUUC-Sit-110285	Setaria italica	34.69	1.80e-02	34.30
IUUC-Stu-112846	Solanum tuberosum	26.32	3.70e-02	33.50
IUUC-Ssc-115393	Sus scrofa	79.05	0.00e+00	799.00
IUUC-Tgu-116622	Taeniopygia guttata	79.92	0.00e+00	771.00
IUUC-Tru-118647	Takifugu rubripes	66.53	0.00e+00	640.00
IUUC-Tni-120516	Tetraodon nigroviridis	70.35	0.00e+00	652.00
IUUC-Tae-122758	Triticum aestivum	34.33	1.00e-03	38.50
IUUC-Tur-126040	Triticum urartu	34.33	1.00e-03	36.60
IUUC-Tme-127118	Tuber melanosporum	41.30	9.00e-05	41.60
IUUC-Tbe-127269	Tupaia belangeri	82.79	0.00e+00	666.00
IUUC-Ttr-129258	Tursiops truncatus	87.09	0.00e+00	699.00
IUUC-Vpa-130056	Vicugna pacos	71.43	1.00e-39	157.00
IUUC-Vvi-131420	Vitis vinifera	32.58	3.00e-03	37.40
IUUC-Xtr-132268	Xenopus tropicalis	68.80	0.00e+00	691.00
IUUC-Xma-134200	Xiphophorus maculatus	70.00	0.00e+00	644.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence