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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106363
UUCD1 version UUC-SaC-00173
Ensembl Protein ID YGL213C
UniProt Accession Q02793; D6VTU2; SKI8_YEAST
Genbank Protein ID AAA35050.1; CAA96930.1; DAA07903.1
Protein Name Antiviral protein SKI8; Superkiller protein 8
Genbank Nucleotide ID M96058; Z72736; BK006941
Gene Name SKI8; REC103; YGL213C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGL213C YGL213C YGL213C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.80e-14 50.5 290 322
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           H+++v +l+f ++  +l+s+++Dg+++ WD++t
   Q: 290  HSSWVMSLSFnDSgETLCSAGWDGKLRFWDVKT 322
           **********733699**************987 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology.
 Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology.
Protein Sequence
(Fasta)
MSKVFIATAN AGKAHDADIF SVSACNSFTV SCSGDGYLKV WDNKLLDNEN PKDKSYSHFV 60
HKSGLHHVDV LQAIERDAFE LCLVATTSFS GDLLFYRITR EDETKKVIFE KLDLLDSDMK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106363|E3,WD_repeat|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGTCCAAAG TGTTTATTGC CACAGCAAAT GCAGGTAAAG CTCATGACGC TGATATTTTC 60
TCGGTTTCTG CTTGCAATTC ATTTACGGTA AGTTGTTCAG GTGACGGTTA CTTAAAGGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106363|E3,WD_repeat|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0051--Antiviral defense
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0469--Meiosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0000228--C:nuclear chromosome
GO:0055087--C:Ski complex
GO:0051607--P:defense response to virus
GO:0070478--P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO:0034427--P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0070481--P:nuclear-transcribed mRNA catabolic process, non-stop decay
GO:0006461--P:protein complex assembly
GO:0065004--P:protein-DNA complex assembly
GO:0007131--P:reciprocal meiotic recombination
KEGG sce:YGL213C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007993 Ashbya gossypii 51.07 1.00e-125 441.00
IUUC-Acl-008297 Aspergillus clavatus 25.91 6.00e-18 83.20
IUUC-Afl-008528 Aspergillus flavus 26.49 1.00e-18 85.10
IUUC-Afu-008800 Aspergillus fumigatus 32.24 1.00e-18 84.30
IUUC-Ani-009288 Aspergillus nidulans 24.94 2.00e-20 90.90
IUUC-Ang-009702 Aspergillus niger 26.17 2.00e-21 94.40
IUUC-Aor-009969 Aspergillus oryzae 25.97 6.00e-19 86.30
IUUC-Bgr-012189 Blumeria graminis 26.75 1.00e-20 91.70
IUUC-Bci-013644 Botrytis cinerea 25.84 8.00e-19 85.50
IUUC-Cgl-026446 Colletotrichum gloeosporioides 28.21 4.00e-23 99.80
IUUC-Dse-031348 Dothistroma septosporum 25.43 7.00e-24 102.00
IUUC-Fox-038047 Fusarium oxysporum 26.20 2.00e-17 80.90
IUUC-Fso-038168 Fusarium solani 24.15 2.00e-13 67.80
IUUC-Ggr-039743 Gaeumannomyces graminis 29.65 4.00e-12 63.50
IUUC-Kpa-049292 Komagataella pastoris 37.41 1.00e-57 214.00
IUUC-Lma-052992 Leptosphaeria maculans 23.26 1.00e-14 72.00
IUUC-Mor-056971 Magnaporthe oryzae 33.81 1.00e-18 85.10
IUUC-Mpo-057485 Magnaporthe poae 30.00 4.00e-12 63.50
IUUC-Nfi-068346 Neosartorya fischeri 27.01 3.00e-20 90.10
IUUC-Ncr-068641 Neurospora crassa 23.94 1.00e-12 65.10
IUUC-Pte-104236 Pyrenophora teres 24.55 3.00e-14 70.50
IUUC-Pyt-104717 Pyrenophora triticirepentis 24.47 2.00e-14 70.90
IUUC-Spo-108244 Schizosaccharomyces pombe 23.80 2.00e-15 74.30
IUUC-Tre-122038 Trichoderma reesei 26.77 5.00e-19 86.30
IUUC-Tvi-122302 Trichoderma virens 26.45 7.00e-19 85.50
IUUC-Tme-127066 Tuber melanosporum 38.26 5.00e-18 83.20
IUUC-Vda-129720 Verticillium dahliae 27.34 2.00e-16 78.20
IUUC-Yli-134554 Yarrowia lipolytica 27.14 9.00e-31 125.00
Created Date 25-Jun-2017

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