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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045709
UUCD1 version UUC-HoS-00111
Ensembl Protein ID ENSP00000334553.7
UniProt Accession Q13356; Q13357; Q8TAH2; Q9BWR8; PPIL2_HUMAN
Genbank Protein ID AAC50376.1; AAC50377.1; AAC50378.1; CAG30434.1; AAH28385.1; AAH00022.1
Protein Name Peptidyl-prolyl cis-trans isomerase-like 2; CYC4; Cyclophilin-60; RING-type E3 ubiquitin transferase isomerase-like 2; Rotamase PPIL2
Genbank Nucleotide ID U37219; U37220; U37221; CR456548; BC028385; BC000022
Gene Name PPIL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100023.18 ENST00000335025.12 ENSP00000334553.7
ENSG00000100023.18 ENST00000626352.2 ENSP00000486725.1
ENSG00000100023.18 ENST00000458567.5 ENSP00000395181.1
ENSG00000100023.18 ENST00000417788.5 ENSP00000406745.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/U-box U-box 16978875
Classification
Family E-value Score Start End
E3 activity/RING/U-box 9.70e-13 49.6 39 104
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawcee 71
           + +C++sl+++  Pv++p+Gi++d  +I  wl+++g+ +P ++++l+ ++l+  ++ ++   ++++ 
   Q: 39   FDHCSLSLQPFVYPVCTPDGIVFDLLNIVPWLKKYGT-NPSNGEKLDGRSLIKLNFSKNSEGKYHCP 104
           568*********************************9.***********************999985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
 May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
Protein Sequence
(Fasta)
MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV 60
FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045709|E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAAGTGGTC ACGGAACTCG GCTGCGGCTC CATGGTCTGA GTTGTCAGCC GTTGTTTTTT 60
CGTGCTCGCT AGTCGCCGCC GCCGCTCCGC CATGGGGAAG CGACAGCACC AAAAGGACAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045709|E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0413--Isomerase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS51698--U_BOX
Pfam

PF00160--Pro_isomerase
PRINTS

PR00153--CSAPPISMRASE
SMART

SM00504--Ubox
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005796--C:Golgi lumen
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0050900--P:leukocyte migration
GO:0006457--P:protein folding
GO:0072659--P:protein localization to plasma membrane
GO:0000209--P:protein polyubiquitination
KEGG hsa:23759
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000982 Aegilops tauschii 54.15 8.00e-54 205.00
IUUC-Aml-002351 Ailuropoda melanoleuca 86.85 0.00e+00 952.00
IUUC-Atr-002724 Amborella trichopoda 47.08 5.00e-61 229.00
IUUC-Apl-003515 Anas platyrhynchos 81.62 0.00e+00 772.00
IUUC-Aca-004802 Anolis carolinensis 80.88 0.00e+00 872.00
IUUC-Aly-005928 Arabidopsis lyrata 43.68 1.00e-94 340.00
IUUC-Ath-007574 Arabidopsis thaliana 49.76 2.00e-58 220.00
IUUC-Acl-008183 Aspergillus clavatus 44.73 1.00e-105 377.00
IUUC-Afl-008382 Aspergillus flavus 45.34 6.00e-102 365.00
IUUC-Afu-008952 Aspergillus fumigatus 45.02 3.00e-104 372.00
IUUC-Ani-009146 Aspergillus nidulans 42.47 1.00e-106 380.00
IUUC-Ang-009743 Aspergillus niger 43.74 5.00e-101 361.00
IUUC-Aor-010027 Aspergillus oryzae 47.32 3.00e-102 365.00
IUUC-Ate-010569 Aspergillus terreus 43.63 6.00e-107 381.00
IUUC-Ame-010783 Astyanax mexicanus 76.81 0.00e+00 835.00
IUUC-Bgr-012172 Blumeria graminis 35.45 2.00e-74 273.00
IUUC-Bta-012459 Bos taurus 85.56 0.00e+00 939.00
IUUC-Bci-013693 Botrytis cinerea 42.28 7.00e-108 384.00
IUUC-Bdi-014623 Brachypodium distachyon 50.68 1.00e-61 231.00
IUUC-Bol-015781 Brassica oleracea 58.33 1.00e-58 221.00
IUUC-Bra-016624 Brassica rapa 49.76 1.00e-58 221.00
IUUC-Cel-018328 Caenorhabditis elegans 48.12 1.00e-129 456.00
IUUC-Cja-019427 Callithrix jacchus 97.31 0.00e+00 993.00
IUUC-Cfa-020829 Canis familiaris 92.35 0.00e+00 999.00
IUUC-Cpo-022189 Cavia porcellus 93.65 0.00e+00 982.00
IUUC-Cre-022723 Chlamydomonas reinhardtii 46.92 2.00e-56 213.00
IUUC-Csa-024212 Chlorocebus sabaeus 98.82 0.00e+00 1031.00
IUUC-Cin-025720 Ciona intestinalis 60.77 0.00e+00 637.00
IUUC-Csv-026137 Ciona savignyi 59.81 0.00e+00 634.00
IUUC-Cgl-026532 Colletotrichum gloeosporioides 42.96 6.00e-105 374.00
IUUC-Cne-026830 Cryptococcus neoformans 39.52 2.00e-98 352.00
IUUC-Dre-028561 Danio rerio 74.52 0.00e+00 796.00
IUUC-Dno-029029 Dasypus novemcinctus 81.96 0.00e+00 895.00
IUUC-Dor-030683 Dipodomys ordii 78.15 4.00e-106 378.00
IUUC-Dse-031506 Dothistroma septosporum 44.73 8.00e-107 380.00
IUUC-Dme-032058 Drosophila melanogaster 53.63 2.00e-156 545.00
IUUC-Ete-033157 Echinops telfairi 71.59 0.00e+00 705.00
IUUC-Eca-033753 Equus caballus 84.51 3.00e-64 236.00
IUUC-Eeu-034470 Erinaceus europaeus 82.85 1.00e-179 622.00
IUUC-Fca-036571 Felis catus 93.36 0.00e+00 985.00
IUUC-Fal-037613 Ficedula albicollis 82.17 0.00e+00 818.00
IUUC-Fox-037795 Fusarium oxysporum 38.84 3.00e-94 339.00
IUUC-Fso-038213 Fusarium solani 39.34 2.00e-91 330.00
IUUC-Gmo-039609 Gadus morhua 71.10 0.00e+00 729.00
IUUC-Ggr-039825 Gaeumannomyces graminis 41.60 5.00e-93 335.00
IUUC-Gga-041191 Gallus gallus 82.18 0.00e+00 835.00
IUUC-Gac-041524 Gasterosteus aculeatus 74.55 0.00e+00 777.00
IUUC-Gma-042925 Glycine max 53.42 1.00e-63 237.00
IUUC-Ggo-045352 Gorilla gorilla 99.81 0.00e+00 1032.00
IUUC-Hvu-047058 Hordeum vulgare 57.62 1.00e-58 221.00
IUUC-Itr-048483 Ictidomys tridecemlineatus 96.17 0.00e+00 882.00
IUUC-Lch-049681 Latimeria chalumnae 77.33 0.00e+00 761.00
IUUC-Lpe-050799 Leersia perrieri 50.00 1.00e-59 224.00
IUUC-Loc-052566 Lepisosteus oculatus 75.73 2.00e-108 386.00
IUUC-Lma-053028 Leptosphaeria maculans 45.32 8.00e-100 357.00
IUUC-Laf-054547 Loxodonta africana 92.72 0.00e+00 971.00
IUUC-Mcc-054753 Macaca mulatta 93.98 0.00e+00 991.00
IUUC-Meu-056855 Macropus eugenii 60.93 2.00e-115 408.00
IUUC-Mor-056941 Magnaporthe oryzae 41.70 1.00e-97 350.00
IUUC-Mpo-057306 Magnaporthe poae 39.19 1.00e-96 347.00
IUUC-Mtr-058349 Medicago truncatula 51.87 1.00e-62 234.00
IUUC-Mla-058842 Melampsora laricipopulina 41.26 8.00e-106 377.00
IUUC-Mga-060099 Meleagris gallopavo 76.80 0.00e+00 739.00
IUUC-Mvi-060413 Microbotryum violaceum 39.79 2.00e-97 349.00
IUUC-Mmr-061530 Microcebus murinus 95.59 0.00e+00 1023.00
IUUC-Mdo-062668 Monodelphis domestica 90.13 0.00e+00 851.00
IUUC-Mmu-063871 Mus musculus 90.21 0.00e+00 952.00
IUUC-Mac-064559 Musa acuminata 50.93 4.00e-62 232.00
IUUC-Mpu-065919 Mustela putorius furo 92.53 0.00e+00 964.00
IUUC-Mlu-067846 Myotis lucifugus 82.00 0.00e+00 874.00
IUUC-Nfi-068507 Neosartorya fischeri 45.62 7.00e-105 374.00
IUUC-Ncr-068805 Neurospora crassa 53.37 3.00e-42 166.00
IUUC-Nle-070125 Nomascus leucogenys 94.24 0.00e+00 971.00
IUUC-Opr-070486 Ochotona princeps 91.23 0.00e+00 761.00
IUUC-Ont-071597 Oreochromis niloticus 76.05 0.00e+00 818.00
IUUC-Oan-073439 Ornithorhynchus anatinus 84.13 1.00e-28 117.00
IUUC-Ocu-074411 Oryctolagus cuniculus 91.00 0.00e+00 907.00
IUUC-Oba-075040 Oryza barthii 60.78 1.00e-59 224.00
IUUC-Obr-076727 Oryza brachyantha 61.27 8.00e-60 224.00
IUUC-Ogl-077605 Oryza glaberrima 60.78 1.00e-59 224.00
IUUC-Ogu-078177 Oryza glumaepatula 60.78 1.00e-59 224.00
IUUC-Oin-079549 Oryza indica 49.07 6.00e-59 222.00
IUUC-Olo-081090 Oryza longistaminata 60.78 1.00e-59 224.00
IUUC-Ome-081979 Oryza meridionalis 60.78 2.00e-59 224.00
IUUC-Oni-082819 Oryza nivara 60.78 2.00e-59 224.00
IUUC-Opu-083212 Oryza punctata 49.07 6.00e-59 222.00
IUUC-Oru-084412 Oryza rufipogon 60.78 1.00e-59 224.00
IUUC-Osa-085431 Oryza sativa 53.08 3.00e-37 147.00
IUUC-Ola-086602 Oryzias latipes 68.73 0.00e+00 674.00
IUUC-Olu-087682 Ostreococcus lucimarinus 44.42 8.00e-97 347.00
IUUC-Oga-088999 Otolemur garnettii 85.97 0.00e+00 954.00
IUUC-Oar-089338 Ovis aries 77.98 0.00e+00 739.00
IUUC-Ptr-091185 Pan troglodytes 99.81 0.00e+00 1032.00
IUUC-Pan-092321 Papio anubis 98.27 0.00e+00 1053.00
IUUC-Psi-094018 Pelodiscus sinensis 81.61 5.00e-135 473.00
IUUC-Pma-094111 Petromyzon marinus 66.37 3.00e-140 491.00
IUUC-Pno-094782 Phaeosphaeria nodorum 40.00 4.00e-102 365.00
IUUC-Ppa-095335 Physcomitrella patens 50.67 4.00e-67 249.00
IUUC-Pfo-097393 Poecilia formosa 75.90 0.00e+00 812.00
IUUC-Pab-098263 Pongo abelii 94.42 0.00e+00 964.00
IUUC-Pop-099316 Populus trichocarpa 46.25 2.00e-106 379.00
IUUC-Pca-100387 Procavia capensis 72.87 6.00e-87 315.00
IUUC-Ppe-101275 Prunus persica 51.87 3.00e-62 233.00
IUUC-Pva-102150 Pteropus vampyrus 80.55 0.00e+00 829.00
IUUC-Pgr-103378 Puccinia graminis 46.47 2.00e-112 399.00
IUUC-Ptt-103908 Puccinia triticina 39.78 2.00e-98 353.00
IUUC-Pte-104248 Pyrenophora teres 40.66 9.00e-103 367.00
IUUC-Pyt-104645 Pyrenophora triticirepentis 41.04 1.00e-104 373.00
IUUC-Rno-105162 Rattus norvegicus 90.40 0.00e+00 960.00
IUUC-Sha-107123 Sarcophilus harrisii 77.06 4.00e-115 408.00
IUUC-Sja-107828 Schizosaccharomyces japonicus 39.85 7.00e-92 331.00
IUUC-Spo-108368 Schizosaccharomyces pombe 41.15 1.00e-97 350.00
IUUC-Smo-109263 Selaginella moellendorffii 43.05 2.00e-120 426.00
IUUC-Sit-110821 Setaria italica 60.29 5.00e-59 222.00
IUUC-Sly-111803 Solanum lycopersicum 52.27 9.00e-63 234.00
IUUC-Stu-112730 Solanum tuberosum 47.35 2.00e-62 233.00
IUUC-Sar-113618 Sorex araneus 91.09 0.00e+00 898.00
IUUC-Sbi-114487 Sorghum bicolor 56.95 3.00e-59 223.00
IUUC-Sre-115009 Sporisorium reilianum 37.43 1.00e-89 323.00
IUUC-Ssc-115984 Sus scrofa 91.00 0.00e+00 940.00
IUUC-Tgu-117410 Taeniopygia guttata 83.17 0.00e+00 846.00
IUUC-Tru-118537 Takifugu rubripes 71.48 0.00e+00 774.00
IUUC-Tsy-119318 Tarsius syrichta 77.26 9.00e-134 470.00
IUUC-Tni-120514 Tetraodon nigroviridis 70.96 9.00e-171 593.00
IUUC-Tca-121620 Theobroma cacao 51.40 5.00e-62 232.00
IUUC-Tre-121904 Trichoderma reesei 44.65 2.00e-84 306.00
IUUC-Tvi-122585 Trichoderma virens 40.50 8.00e-86 311.00
IUUC-Tae-125342 Triticum aestivum 59.80 1.00e-58 220.00
IUUC-Tme-126960 Tuber melanosporum 42.72 4.00e-110 391.00
IUUC-Tbe-127839 Tupaia belangeri 72.22 6.00e-100 357.00
IUUC-Ttr-129173 Tursiops truncatus 77.01 0.00e+00 780.00
IUUC-Uma-129595 Ustilago maydis 36.03 7.00e-82 298.00
IUUC-Vda-130012 Verticillium dahliae 40.07 2.00e-102 366.00
IUUC-Vvi-131156 Vitis vinifera 48.09 8.00e-66 244.00
IUUC-Xtr-132807 Xenopus tropicalis 72.76 0.00e+00 814.00
IUUC-Xma-133940 Xiphophorus maculatus 71.86 8.00e-65 239.00
IUUC-Yli-134361 Yarrowia lipolytica 32.85 3.00e-49 189.00
IUUC-Zma-135759 Zea mays 57.77 1.00e-57 217.00
Created Date 25-Jun-2017

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