iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Drug and target
Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19897738; 19273587; 18787112; 17620341; 17344412; 19008353; 19001089; 19218424; 21098119; 15620356; 18988848
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	19897738; 19273587; 17344412; 19008353; 19218424; 21098119
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-43	141.9	461	495
E3 adaptor/Cullin RING/SCF/F-box	0.0061	15.1	272	319
UBD/Beta-Prp	6.70e-91	303.0	374	703

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDlr 31
           gH++ v+cl+     + +++v+Gs+D+t++vW l 
   Q: 461  GHNSTVRCLDIveyKNiKYIVTGSRDNTLHVWKLP 495
           8*********9999889***************985 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 100  aglldrlpeeilveilklldkeellraarvcrrwq.elasqkalwktv 146
           ++l+++lp ei ++i+++l+ e++++   v+++w+  + ++++lwk++
   Q: 272  RDLITSLPFEISLKIFNYLQFEDIINSLGVSQNWNkIIRKSTSLWKKL 319
           678899*****************************5555589999986 PP

UBD/Beta-Prp

   S: 2    iktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
            +tl+gh++svitc++f  ++++++tg +d++i+v+d  ++k+l +lsgh+++v+a+k+ + g ilv+gs+Drt++vwd+++g+c+h++kgh+++v++l++
   Q: 374  RTTLRGHMTSVITCLQF--EDNYVITGADDKMIRVYDSINKKFLLQLSGHDGGVWALKYAHGG-ILVSGSTDRTVRVWDIKKGCCTHVFKGHNSTVRCLDI 471
           689**************..*******************************************9.************************************* PP
   S: 103  sp..sgdklvsGshdrtirvwdletgqclee......................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltggh 179
            +  + +++v+Gs+d+t++vw+l++++ + +                      +l+gh+++v++v+ h+  n++vsGs+D+t+ +Wd++++k+l+ l+g h
   Q: 472  VEykNIKYIVTGSRDNTLHVWKLPKESSVPDhgeehdyplvfhtpeenpyfvgVLRGHMASVRTVSGHG--NIVVSGSYDNTLIVWDVAQMKCLYILSG-H 569
           **7666***************************************************************..***************************9.* PP
   S: 180  tdsvyslsfdsngkelvsgsldgtvklwdlq....tgec................vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktl 260
           td++ys+++d+++k+++s+s+d+t+++wdl+    +gec                ++tl+ght+ v  +r+s  d++lvs+++Dgsir Wd   +d+ +++
   Q: 570  TDRIYSTIYDHERKRCISASMDTTIRIWDLEniwnNGECsyatnsaspcakilgaMYTLQGHTALVGLLRLS--DKFLVSAAADGSIRGWD--ANDYSRKF 666
           ***********************************9************************************..****************8..9******* PP
   S: 261  qlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++h+++++++++++++dn+lv+gse+ ++ni++l++ +
   Q: 667  SYHHTNLSAITTFYVSDNILVSGSEN-QFNIYNLRSGK 703
           *************************6.*******9876 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition.

Protein Sequence
(Fasta)

MGSFPLAEFP LRDIPVPYSY RVSGGIASSG SVTALVTAAG THRNSSTAKT VETEDGEEDI 60
DEYQRKRAAG SGESTPERSD FKRVKHDNHK TLHPVNLQNT GAASVDNDGL HNLTDISNDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTCGT TTCCCTTAGC TGAGTTTCCA TTACGTGATA TCCCTGTTCC TTATAGCTAC 60
CGTGTGTCTG GCGGTATAGC TTCCTCAGGT AGTGTTACTG CGCTTGTTAC TGCCGCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0749--Sporulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR031740--Cdc4_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF16856--CDC4_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0016363--C:nuclear matrix
GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0050815--F:phosphoserine binding
GO:0043130--F:ubiquitin binding
GO:0051301--P:cell division
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0007126--P:meiotic nuclear division
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0030435--P:sporulation resulting in formation of a cellular spore

KEGG

sce:YFL009W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003489	Anas platyrhynchos	29.39	3.00e-61	228.00
IUUC-Ago-007888	Ashbya gossypii	58.12	0.00e+00	668.00
IUUC-Acl-008250	Aspergillus clavatus	41.50	5.00e-83	300.00
IUUC-Afl-008413	Aspergillus flavus	40.76	1.00e-80	293.00
IUUC-Afu-009106	Aspergillus fumigatus	39.38	2.00e-82	298.00
IUUC-Ani-009352	Aspergillus nidulans	40.88	6.00e-85	306.00
IUUC-Ang-009529	Aspergillus niger	36.18	9.00e-91	326.00
IUUC-Aor-010182	Aspergillus oryzae	41.21	3.00e-82	298.00
IUUC-Ate-010332	Aspergillus terreus	42.21	6.00e-84	303.00
IUUC-Ame-010898	Astyanax mexicanus	29.78	2.00e-62	231.00
IUUC-Bgr-011997	Blumeria graminis	40.77	3.00e-84	304.00
IUUC-Bta-012391	Bos taurus	29.39	8.00e-61	226.00
IUUC-Bci-013601	Botrytis cinerea	41.56	2.00e-87	315.00
IUUC-Cel-018495	Caenorhabditis elegans	28.17	2.00e-60	224.00
IUUC-Cja-018902	Callithrix jacchus	29.39	3.00e-61	228.00
IUUC-Cfa-020237	Canis familiaris	29.39	3.00e-61	228.00
IUUC-Cpo-022234	Cavia porcellus	29.39	6.00e-61	226.00
IUUC-Csa-023532	Chlorocebus sabaeus	29.39	3.00e-61	227.00
IUUC-Cho-025026	Choloepus hoffmanni	32.36	2.00e-50	191.00
IUUC-Cin-025516	Ciona intestinalis	33.33	1.00e-47	181.00
IUUC-Csv-026312	Ciona savignyi	30.41	5.00e-62	230.00
IUUC-Cgl-026707	Colletotrichum gloeosporioides	41.19	7.00e-90	323.00
IUUC-Cne-027018	Cryptococcus neoformans	32.76	9.00e-88	316.00
IUUC-Dre-028303	Danio rerio	29.98	2.00e-63	235.00
IUUC-Dor-030196	Dipodomys ordii	28.99	4.00e-59	220.00
IUUC-Dse-031358	Dothistroma septosporum	38.44	8.00e-83	300.00
IUUC-Dme-031702	Drosophila melanogaster	30.12	3.00e-66	245.00
IUUC-Ete-032791	Echinops telfairi	29.39	6.00e-61	226.00
IUUC-Eca-033424	Equus caballus	29.39	8.00e-61	226.00
IUUC-Fca-036422	Felis catus	29.39	3.00e-61	227.00
IUUC-Fal-037478	Ficedula albicollis	28.52	1.00e-61	229.00
IUUC-Fox-037701	Fusarium oxysporum	42.12	1.00e-89	322.00
IUUC-Fso-038362	Fusarium solani	40.90	2.00e-89	322.00
IUUC-Gmo-039478	Gadus morhua	27.31	1.00e-49	188.00
IUUC-Ggr-040085	Gaeumannomyces graminis	42.12	4.00e-90	323.00
IUUC-Gga-040170	Gallus gallus	28.52	4.00e-61	227.00
IUUC-Gac-042423	Gasterosteus aculeatus	30.47	5.00e-58	216.00
IUUC-Ggo-044422	Gorilla gorilla	29.39	4.00e-61	227.00
IUUC-Hsa-045898	Homo sapiens	29.39	4.00e-61	227.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	29.39	3.00e-60	223.00
IUUC-Kpa-049097	Komagataella pastoris	40.81	7.00e-115	406.00
IUUC-Lch-050414	Latimeria chalumnae	29.39	8.00e-62	229.00
IUUC-Loc-052348	Lepisosteus oculatus	29.59	6.00e-62	229.00
IUUC-Lma-053123	Leptosphaeria maculans	41.79	4.00e-87	314.00
IUUC-Laf-054054	Loxodonta africana	29.39	2.00e-61	228.00
IUUC-Mcc-055056	Macaca mulatta	29.39	3.00e-61	227.00
IUUC-Mor-057133	Magnaporthe oryzae	41.29	2.00e-90	325.00
IUUC-Mpo-057542	Magnaporthe poae	41.63	1.00e-89	322.00
IUUC-Mla-058993	Melampsora laricipopulina	34.48	2.00e-82	297.00
IUUC-Mga-059255	Meleagris gallopavo	29.39	3.00e-61	227.00
IUUC-Mvi-060490	Microbotryum violaceum	38.14	6.00e-71	261.00
IUUC-Mmr-061292	Microcebus murinus	29.39	3.00e-61	228.00
IUUC-Mdo-062304	Monodelphis domestica	29.59	3.00e-61	228.00
IUUC-Mmu-063610	Mus musculus	29.39	1.00e-61	229.00
IUUC-Mpu-065931	Mustela putorius furo	29.39	3.00e-61	228.00
IUUC-Mlu-066976	Myotis lucifugus	29.39	1.00e-61	229.00
IUUC-Nfi-068570	Neosartorya fischeri	39.38	2.00e-82	298.00
IUUC-Ncr-068778	Neurospora crassa	42.65	1.00e-89	322.00
IUUC-Nle-070174	Nomascus leucogenys	29.39	4.00e-61	227.00
IUUC-Ont-071997	Oreochromis niloticus	30.18	2.00e-61	228.00
IUUC-Oan-072936	Ornithorhynchus anatinus	29.39	2.00e-61	228.00
IUUC-Ocu-074742	Oryctolagus cuniculus	29.39	4.00e-61	227.00
IUUC-Obr-076806	Oryza brachyantha	27.66	1.00e-21	96.70
IUUC-Oin-079809	Oryza indica	27.05	2.00e-21	96.30
IUUC-Osa-086141	Oryza sativa	27.05	1.00e-21	96.70
IUUC-Ola-087098	Oryzias latipes	29.41	2.00e-61	228.00
IUUC-Oga-088884	Otolemur garnettii	32.25	2.00e-52	197.00
IUUC-Oar-090220	Ovis aries	29.19	3.00e-62	231.00
IUUC-Ptr-090492	Pan troglodytes	29.39	4.00e-61	227.00
IUUC-Pan-091770	Papio anubis	29.39	3.00e-61	227.00
IUUC-Psi-093207	Pelodiscus sinensis	29.39	4.00e-61	226.00
IUUC-Pma-094749	Petromyzon marinus	30.27	2.00e-60	224.00
IUUC-Pno-095026	Phaeosphaeria nodorum	40.19	1.00e-84	305.00
IUUC-Pfo-096493	Poecilia formosa	29.78	1.00e-61	228.00
IUUC-Pab-098141	Pongo abelii	29.39	9.00e-61	226.00
IUUC-Pva-102988	Pteropus vampyrus	29.39	2.00e-61	228.00
IUUC-Pgr-103612	Puccinia graminis	38.15	2.00e-75	275.00
IUUC-Ptt-103698	Puccinia triticina	37.62	3.00e-50	191.00
IUUC-Pte-104253	Pyrenophora teres	40.86	1.00e-86	312.00
IUUC-Pyt-104635	Pyrenophora triticirepentis	42.08	8.00e-87	313.00
IUUC-Sha-107653	Sarcophilus harrisii	29.59	2.00e-61	228.00
IUUC-Sja-107764	Schizosaccharomyces japonicus	35.78	3.00e-85	307.00
IUUC-Spo-108063	Schizosaccharomyces pombe	35.28	1.00e-83	302.00
IUUC-Sar-113600	Sorex araneus	29.22	5.00e-53	200.00
IUUC-Sbi-113820	Sorghum bicolor	26.33	3.00e-21	95.50
IUUC-Sre-114901	Sporisorium reilianum	31.43	6.00e-44	171.00
IUUC-Tgu-117510	Taeniopygia guttata	29.39	3.00e-61	228.00
IUUC-Tru-117819	Takifugu rubripes	29.98	8.00e-63	233.00
IUUC-Tsy-118828	Tarsius syrichta	29.39	2.00e-61	228.00
IUUC-Tni-120468	Tetraodon nigroviridis	29.98	3.00e-62	230.00
IUUC-Tre-121989	Trichoderma reesei	42.86	3.00e-82	297.00
IUUC-Tvi-122620	Trichoderma virens	42.34	2.00e-81	295.00
IUUC-Tme-127195	Tuber melanosporum	41.31	2.00e-80	292.00
IUUC-Tbe-127925	Tupaia belangeri	29.39	5.00e-61	226.00
IUUC-Ttr-128899	Tursiops truncatus	29.39	2.00e-61	228.00
IUUC-Uma-129449	Ustilago maydis	31.55	1.00e-43	170.00
IUUC-Vda-129936	Verticillium dahliae	42.93	9.00e-90	323.00
IUUC-Xma-133646	Xiphophorus maculatus	29.78	1.00e-62	232.00
IUUC-Yli-134479	Yarrowia lipolytica	36.83	6.00e-99	353.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence