• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046695
UUCD1 version UUC-HoS-00448
Ensembl Protein ID ENSP00000378529.2
UniProt Accession Q9UM11; O75869; Q86U66; Q96NW8; Q9UI96; Q9ULH8; Q9UM10; Q9UNQ1; Q9Y2T8; FZR1_HUMAN
Genbank Protein ID AAD26624.1; AAD26623.1; BAA86954.1; BAA86955.1; AAF20266.1; AAD52030.1; AAL28117.1; AAP35779.1; AAC62835.1; AAC62836.1; BAA86556.1; AAH13413.1
Protein Name Fizzy-related protein homolog; CDC20-like protein 1; Cdh1/Hct1 homolog
Genbank Nucleotide ID AF102508; AF102507; AB013462; AB013463; AF080397; AF083810; AF433157; BT007115; AC005787; AC005786; AB033068; BC013413
Gene Name FZR1; CDH1; FYR; FZR; KIAA1242
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000105325.13 ENST00000441788.6 ENSP00000410369.1
ENSG00000105325.13 ENST00000591290.5 ENSP00000467967.1
ENSG00000105325.13 ENST00000395095.7 ENSP00000378529.2
ENSG00000105325.13 ENST00000313639.8 ENSP00000321800.7
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
miRecordsRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 19098431; 19477924; 16810178; 16675394; 11741538; 19336465; 19270695; 18662541; 17726374; 18573889; 17631504; 17376772; 16287863; 14701726; 15144564; 20530197; 21199005; 21186356; 20966048; 20424596; 17618083; 12023018; 21439932; 21270054; 21177849; 20802534; 20729194; 20006513; 20348135; 20064487; 19101468
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/APC_C/CDC20 1.80e-150 502.0 175 479
E3 adaptor/Cullin RING/DCX/DWD 2.40e-26 92.3 311 341
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/APC_C/CDC20
   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrt 91
           p+kvldapel+ddfylnL+dWss nvl+v+Lg++vylwsa+t++v++l+dl  e+d+vtsv w+e+g+l+avGt+kg v+i+D+++ kk+++
   Q: 175  PFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLsVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSM 266
           689************************************************99*************************************** PP
   S: 92   ltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelkl.stlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaav 182
           l+gh+arvgaL+Wnae+lssGsrd++il+rd+r++ l+  ++lq+h+qevCGlkw++d++lLasGGnDn++ vw++ss +P+++++eh aav
   Q: 267  LEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSeRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAV 358
           ***************************************99*************************************************** PP
   S: 183  kaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlsla 274
           kaiawsP+q++lLasGGGtaDrci+fwntltg+ l++idtgsqvc+l+wsk+++elvsthG+++n+i +wkypsl++va+l+gh++Rvl+la
   Q: 359  KAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA 450
           ******************************************************************************************** PP
   S: 275  lspdgeaivtaagDetlrfwklfdkkkak 303
           +spdgeaivt+agDetlrfw++f+k++++
   Q: 451  MSPDGEAIVTGAGDETLRFWNVFSKTRST 479
           ************************99875 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH  +v++l++ +d  ll+sG++D+++ vW+
   Q: 311  GHRQEVCGLKWsTDhQLLASGGNDNKLLVWN 341
           8**********98889**************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).
 Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).
Protein Sequence
(Fasta)
MDQDYERRLL RQIVIQNENT MPRVTEMRRT LTPASSPVSS PSKHGDRFIP SRAGANWSVN 60
FHRINENEKS PSQNRKAKDA TSDNGKDGLA YSALLKNELL GAGIEKVQDP QTEDRRLQPS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046695|E3,CDC20;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCGGGCGC GCGCGGCGGA GGGAGGGAGC CGGGAGGCAG CGGAGGAGCG ACCGCCGCCA 60
TATTAGGGAC CGCGGAGCCC GGGATCCCGT CAGCGGCGGC CGCGGCCGGG CCTGCGGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046695|E3,CDC20;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0006281--P:DNA repair
GO:0031572--P:G2 DNA damage checkpoint
GO:0070306--P:lens fiber cell differentiation
GO:0007067--P:mitotic nuclear division
GO:0090344--P:negative regulation of cell aging
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0008284--P:positive regulation of cell proliferation
GO:0045732--P:positive regulation of protein catabolic process
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0040020--P:regulation of meiotic nuclear division
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:51343
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000670 Aegilops tauschii 63.38 8.00e-115 407.00
IUUC-Aml-002003 Ailuropoda melanoleuca 94.96 0.00e+00 939.00
IUUC-Atr-002753 Amborella trichopoda 57.40 2.00e-132 466.00
IUUC-Apl-003212 Anas platyrhynchos 97.38 0.00e+00 977.00
IUUC-Aly-005442 Arabidopsis lyrata 56.29 3.00e-139 488.00
IUUC-Ath-006938 Arabidopsis thaliana 56.64 1.00e-137 483.00
IUUC-Ago-007784 Ashbya gossypii 49.28 3.00e-95 342.00
IUUC-Acl-008269 Aspergillus clavatus 49.79 1.00e-132 466.00
IUUC-Afl-008432 Aspergillus flavus 50.21 6.00e-132 464.00
IUUC-Afu-008829 Aspergillus fumigatus 50.62 4.00e-133 468.00
IUUC-Ani-009471 Aspergillus nidulans 49.79 1.00e-131 463.00
IUUC-Ang-009711 Aspergillus niger 51.06 1.00e-130 460.00
IUUC-Aor-010118 Aspergillus oryzae 50.21 6.00e-132 464.00
IUUC-Ate-010534 Aspergillus terreus 50.62 1.00e-131 463.00
IUUC-Ame-011011 Astyanax mexicanus 92.00 0.00e+00 879.00
IUUC-Bgr-012013 Blumeria graminis 51.14 1.00e-130 460.00
IUUC-Bta-012586 Bos taurus 98.39 0.00e+00 982.00
IUUC-Bci-013807 Botrytis cinerea 51.65 7.00e-126 444.00
IUUC-Bdi-014981 Brachypodium distachyon 70.49 3.00e-129 455.00
IUUC-Bol-016301 Brassica oleracea 57.01 1.00e-137 483.00
IUUC-Bra-017453 Brassica rapa 57.01 1.00e-137 483.00
IUUC-Cel-018472 Caenorhabditis elegans 64.72 7.00e-142 497.00
IUUC-Cja-019929 Callithrix jacchus 99.80 0.00e+00 1023.00
IUUC-Cfa-020977 Canis familiaris 98.79 0.00e+00 1014.00
IUUC-Cpo-021537 Cavia porcellus 98.19 0.00e+00 980.00
IUUC-Csa-023389 Chlorocebus sabaeus 99.40 0.00e+00 991.00
IUUC-Cin-025327 Ciona intestinalis 69.20 3.00e-180 624.00
IUUC-Csv-025921 Ciona savignyi 65.73 0.00e+00 657.00
IUUC-Cgl-026631 Colletotrichum gloeosporioides 51.96 6.00e-132 464.00
IUUC-Cne-026933 Cryptococcus neoformans 59.58 2.00e-127 450.00
IUUC-Cme-027143 Cyanidioschyzon merolae 63.70 4.00e-118 419.00
IUUC-Dre-027470 Danio rerio 90.58 0.00e+00 870.00
IUUC-Dno-029629 Dasypus novemcinctus 90.07 0.00e+00 799.00
IUUC-Dor-030187 Dipodomys ordii 87.90 0.00e+00 879.00
IUUC-Dse-031502 Dothistroma septosporum 50.21 2.00e-126 446.00
IUUC-Dme-031858 Drosophila melanogaster 73.95 0.00e+00 677.00
IUUC-Ete-032562 Echinops telfairi 85.08 0.00e+00 825.00
IUUC-Eca-034210 Equus caballus 98.39 0.00e+00 984.00
IUUC-Fca-035839 Felis catus 92.94 0.00e+00 926.00
IUUC-Fal-036895 Ficedula albicollis 97.18 0.00e+00 974.00
IUUC-Fox-037814 Fusarium oxysporum 64.17 7.00e-123 433.00
IUUC-Fso-038420 Fusarium solani 50.00 2.00e-131 462.00
IUUC-Gmo-039544 Gadus morhua 88.58 0.00e+00 851.00
IUUC-Ggr-039774 Gaeumannomyces graminis 50.20 4.00e-132 465.00
IUUC-Gga-041025 Gallus gallus 97.18 0.00e+00 974.00
IUUC-Gac-041279 Gasterosteus aculeatus 88.35 0.00e+00 897.00
IUUC-Gma-042657 Glycine max 56.82 7.00e-135 474.00
IUUC-Ggo-045599 Gorilla gorilla 99.80 0.00e+00 966.00
IUUC-Hvu-047486 Hordeum vulgare 65.95 2.00e-106 378.00
IUUC-Itr-048192 Ictidomys tridecemlineatus 97.58 0.00e+00 977.00
IUUC-Kpa-049239 Komagataella pastoris 60.42 2.00e-120 426.00
IUUC-Lch-049827 Latimeria chalumnae 95.77 0.00e+00 925.00
IUUC-Lpe-051568 Leersia perrieri 50.00 2.00e-111 395.00
IUUC-Loc-052856 Lepisosteus oculatus 93.57 0.00e+00 903.00
IUUC-Laf-054321 Loxodonta africana 91.56 6.00e-110 391.00
IUUC-Mcc-055601 Macaca mulatta 99.40 0.00e+00 991.00
IUUC-Meu-056276 Macropus eugenii 67.88 3.00e-169 588.00
IUUC-Mor-057113 Magnaporthe oryzae 51.57 1.00e-131 463.00
IUUC-Mpo-057599 Magnaporthe poae 50.39 5.00e-132 464.00
IUUC-Mtr-057689 Medicago truncatula 57.43 4.00e-136 478.00
IUUC-Mla-059048 Melampsora laricipopulina 50.10 1.00e-119 423.00
IUUC-Mga-060097 Meleagris gallopavo 91.20 0.00e+00 903.00
IUUC-Mvi-060465 Microbotryum violaceum 51.76 5.00e-130 457.00
IUUC-Mmr-061151 Microcebus murinus 90.12 0.00e+00 868.00
IUUC-Mdo-063062 Monodelphis domestica 96.98 0.00e+00 974.00
IUUC-Mmu-063731 Mus musculus 97.78 0.00e+00 978.00
IUUC-Mac-065208 Musa acuminata 57.70 3.00e-129 455.00
IUUC-Mpu-066173 Mustela putorius furo 97.98 0.00e+00 981.00
IUUC-Mlu-068030 Myotis lucifugus 98.99 0.00e+00 1014.00
IUUC-Nfi-068536 Neosartorya fischeri 50.62 1.00e-133 470.00
IUUC-Ncr-068734 Neurospora crassa 52.35 1.00e-134 473.00
IUUC-Nle-070163 Nomascus leucogenys 99.40 0.00e+00 991.00
IUUC-Opr-070974 Ochotona princeps 92.12 9.00e-156 542.00
IUUC-Ont-072272 Oreochromis niloticus 90.00 0.00e+00 863.00
IUUC-Oan-073634 Ornithorhynchus anatinus 99.32 1.00e-174 605.00
IUUC-Oba-075417 Oryza barthii 64.67 7.00e-111 394.00
IUUC-Obr-076123 Oryza brachyantha 69.51 5.00e-126 444.00
IUUC-Ogl-077294 Oryza glaberrima 53.88 3.00e-126 445.00
IUUC-Ogu-077996 Oryza glumaepatula 53.66 5.00e-125 441.00
IUUC-Oin-080172 Oryza indica 70.16 4.00e-126 444.00
IUUC-Olo-081068 Oryza longistaminata 70.16 4.00e-126 444.00
IUUC-Ome-081250 Oryza meridionalis 54.34 2.00e-127 449.00
IUUC-Oni-083048 Oryza nivara 53.88 3.00e-126 445.00
IUUC-Opu-083333 Oryza punctata 54.29 1.00e-126 446.00
IUUC-Oru-085001 Oryza rufipogon 53.88 3.00e-126 445.00
IUUC-Osa-086243 Oryza sativa 53.88 3.00e-126 445.00
IUUC-Ola-087094 Oryzias latipes 89.62 0.00e+00 831.00
IUUC-Oga-088911 Otolemur garnettii 98.79 0.00e+00 986.00
IUUC-Oar-089508 Ovis aries 98.39 0.00e+00 982.00
IUUC-Ptr-090967 Pan troglodytes 87.56 0.00e+00 665.00
IUUC-Pan-092147 Papio anubis 100.00 0.00e+00 1025.00
IUUC-Psi-093702 Pelodiscus sinensis 96.99 0.00e+00 973.00
IUUC-Pma-094581 Petromyzon marinus 83.37 0.00e+00 792.00
IUUC-Pno-095139 Phaeosphaeria nodorum 59.76 8.00e-113 401.00
IUUC-Ppa-095952 Physcomitrella patens 57.88 5.00e-141 494.00
IUUC-Pfo-096309 Poecilia formosa 90.38 0.00e+00 864.00
IUUC-Pab-098762 Pongo abelii 82.66 0.00e+00 777.00
IUUC-Pop-098924 Populus trichocarpa 55.98 1.00e-132 466.00
IUUC-Pca-100565 Procavia capensis 92.81 0.00e+00 878.00
IUUC-Ppe-101924 Prunus persica 56.76 1.00e-136 479.00
IUUC-Pva-102602 Pteropus vampyrus 96.17 0.00e+00 946.00
IUUC-Pgr-103466 Puccinia graminis 50.86 4.00e-118 418.00
IUUC-Ptt-103888 Puccinia triticina 53.71 2.00e-107 382.00
IUUC-Pte-104097 Pyrenophora teres 48.93 1.00e-128 454.00
IUUC-Pyt-104445 Pyrenophora triticirepentis 45.21 2.00e-111 396.00
IUUC-Rno-105028 Rattus norvegicus 97.38 0.00e+00 972.00
IUUC-Sce-106240 Saccharomyces cerevisiae 39.16 1.00e-95 343.00
IUUC-Sha-107107 Sarcophilus harrisii 83.80 0.00e+00 824.00
IUUC-Sja-107900 Schizosaccharomyces japonicus 48.75 3.00e-114 405.00
IUUC-Spo-108056 Schizosaccharomyces pombe 48.73 7.00e-114 404.00
IUUC-Ssl-108391 Sclerotinia sclerotiorum 52.49 1.00e-128 453.00
IUUC-Smo-108878 Selaginella moellendorffii 59.06 4.00e-144 504.00
IUUC-Sit-110550 Setaria italica 55.38 1.00e-127 450.00
IUUC-Sly-111446 Solanum lycopersicum 56.42 1.00e-134 473.00
IUUC-Stu-112491 Solanum tuberosum 56.22 1.00e-133 469.00
IUUC-Sar-112962 Sorex araneus 80.53 2.00e-119 421.00
IUUC-Sbi-114489 Sorghum bicolor 54.32 1.00e-123 436.00
IUUC-Sre-115222 Sporisorium reilianum 48.02 3.00e-133 468.00
IUUC-Ssc-116171 Sus scrofa 98.19 0.00e+00 982.00
IUUC-Tgu-116878 Taeniopygia guttata 85.91 0.00e+00 837.00
IUUC-Tru-118222 Takifugu rubripes 90.18 0.00e+00 867.00
IUUC-Tni-119863 Tetraodon nigroviridis 89.98 0.00e+00 857.00
IUUC-Tca-121599 Theobroma cacao 54.58 9.00e-135 473.00
IUUC-Tre-122249 Trichoderma reesei 51.12 7.00e-133 467.00
IUUC-Tvi-122675 Trichoderma virens 51.31 1.00e-132 466.00
IUUC-Tae-123028 Triticum aestivum 58.59 5.00e-126 444.00
IUUC-Tur-126545 Triticum urartu 60.32 1.00e-103 369.00
IUUC-Tme-127151 Tuber melanosporum 54.73 3.00e-144 505.00
IUUC-Tbe-128056 Tupaia belangeri 89.38 4.00e-168 583.00
IUUC-Ttr-129055 Tursiops truncatus 98.19 0.00e+00 982.00
IUUC-Uma-129555 Ustilago maydis 47.83 1.00e-132 466.00
IUUC-Vda-130027 Verticillium dahliae 50.40 3.00e-133 469.00
IUUC-Vvi-131749 Vitis vinifera 55.53 7.00e-134 470.00
IUUC-Xtr-132808 Xenopus tropicalis 91.33 0.00e+00 920.00
IUUC-Xma-133183 Xiphophorus maculatus 90.38 0.00e+00 864.00
IUUC-Yli-134584 Yarrowia lipolytica 64.18 6.00e-130 457.00
IUUC-Zma-135640 Zea mays 68.04 4.00e-125 441.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved