iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006723

UUCD1 version

UUC-ArT-01459

Ensembl Protein ID

AT2G19430.1

UniProt Accession

Q8L4M1; O64576; THOC6_ARATH

Genbank Protein ID

AAM14874.1; AAD10142.1; AEC06880.1; AAM20569.1; AAM91279.1

Protein Name

THO complex subunit 6; Protein DWD HYPERSENSITIVE TO ABA 1; WD repeat-containing protein DWA1

Genbank Nucleotide ID

AC003058; AC005917; CP002685; AY099718; AY128879

Gene Name

THO6; DWA1; THOC6; At2g19430; F27F23.25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G19430	AT2G19430.1	AT2G19430.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	20525848

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-16	59.5	199	237

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+d  + +    s+   +++Gs Dgt ++WD +tg+++k
   Q: 199  GHSDYLHTV-VsrSSaSQILTGSEDGTARIWDCKTGKCVK 237
           677777776.44655678********************97 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling. May function as the substrate recognition module within this complex leading to ABI5 degradation. Functionally redundant with DWA2.

Protein Sequence
(Fasta)

MYGDATNWNE DEYRESILKE REIETRTVFR TAWAPPARIS NPDAFVVASS DGTLAFHSLN 60
SLVSQSASFG YSKGQDVMVA EPERVVRAHE GPAYDVKFYG EDEDALLLSC GDDGRVRGWK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAATTTGAT CGACAAAAAA AAAACAAGCT AGTAAAATAT AATTAACAGA ATTACTAAAT 60
CGGCCGGTTT AGGGATTGCT TTCTCTCAGT CGTCAATTGC ACTAAACCAC TGGTGGTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0938--Abscisic acid signaling pathway
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0509--mRNA transport
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0000347--C:THO complex
GO:0003723--F:RNA binding
GO:0009738--P:abscisic acid-activated signaling pathway
GO:0031047--P:gene silencing by RNA
GO:0006397--P:mRNA processing
GO:0051028--P:mRNA transport
GO:0009788--P:negative regulation of abscisic acid-activated signaling pathway
GO:0010267--P:production of ta-siRNAs involved in RNA interference
GO:0016567--P:protein ubiquitination
GO:0008380--P:RNA splicing

KEGG

ath:AT2G19430

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001101	Aegilops tauschii	49.59	3.00e-97	347.00
IUUC-Aml-001693	Ailuropoda melanoleuca	31.17	1.00e-27	116.00
IUUC-Atr-002699	Amborella trichopoda	52.01	9.00e-96	342.00
IUUC-Aca-004231	Anolis carolinensis	32.28	2.00e-32	132.00
IUUC-Aly-006385	Arabidopsis lyrata	95.91	0.00e+00	701.00
IUUC-Ame-010813	Astyanax mexicanus	29.09	7.00e-21	93.20
IUUC-Bta-013458	Bos taurus	30.77	5.00e-27	114.00
IUUC-Bdi-014935	Brachypodium distachyon	52.17	1.00e-101	362.00
IUUC-Bol-015442	Brassica oleracea	86.38	0.00e+00	628.00
IUUC-Bra-017807	Brassica rapa	86.38	0.00e+00	631.00
IUUC-Cja-019061	Callithrix jacchus	31.17	5.00e-28	117.00
IUUC-Cfa-021146	Canis familiaris	31.58	6.00e-28	117.00
IUUC-Cpo-022512	Cavia porcellus	30.36	8.00e-27	113.00
IUUC-Csa-023055	Chlorocebus sabaeus	30.77	2.00e-28	119.00
IUUC-Cho-024693	Choloepus hoffmanni	32.91	4.00e-19	87.00
IUUC-Cin-025181	Ciona intestinalis	26.69	3.00e-26	111.00
IUUC-Csv-025852	Ciona savignyi	28.57	3.00e-26	111.00
IUUC-Dre-028221	Danio rerio	26.48	1.00e-29	122.00
IUUC-Dno-029200	Dasypus novemcinctus	31.97	1.00e-16	78.60
IUUC-Dor-030863	Dipodomys ordii	29.55	1.00e-26	112.00
IUUC-Dme-032016	Drosophila melanogaster	25.49	2.00e-21	95.50
IUUC-Eca-034363	Equus caballus	31.17	1.00e-27	116.00
IUUC-Fca-036546	Felis catus	30.77	4.00e-27	114.00
IUUC-Gmo-038513	Gadus morhua	29.10	3.00e-27	115.00
IUUC-Gac-042606	Gasterosteus aculeatus	30.12	1.00e-32	132.00
IUUC-Gma-043171	Glycine max	64.96	4.00e-128	450.00
IUUC-Ggo-044877	Gorilla gorilla	31.58	4.00e-28	117.00
IUUC-Hsa-045813	Homo sapiens	31.58	5.00e-28	117.00
IUUC-Hvu-047782	Hordeum vulgare	56.35	7.00e-51	192.00
IUUC-Itr-047876	Ictidomys tridecemlineatus	30.77	7.00e-27	114.00
IUUC-Lch-049506	Latimeria chalumnae	31.89	3.00e-34	138.00
IUUC-Lpe-051203	Leersia perrieri	51.34	2.00e-91	328.00
IUUC-Loc-052451	Lepisosteus oculatus	32.60	2.00e-28	119.00
IUUC-Laf-053864	Loxodonta africana	30.77	1.00e-27	116.00
IUUC-Mcc-055705	Macaca mulatta	28.63	1.00e-23	103.00
IUUC-Meu-055926	Macropus eugenii	31.17	3.00e-27	115.00
IUUC-Mtr-058556	Medicago truncatula	62.10	7.00e-133	466.00
IUUC-Mmr-060836	Microcebus murinus	29.96	4.00e-27	114.00
IUUC-Mdo-062534	Monodelphis domestica	31.12	3.00e-26	112.00
IUUC-Mmu-063560	Mus musculus	31.98	3.00e-28	118.00
IUUC-Mac-065134	Musa acuminata	55.86	5.00e-108	383.00
IUUC-Mpu-066031	Mustela putorius furo	31.17	1.00e-27	116.00
IUUC-Mlu-068051	Myotis lucifugus	30.77	6.00e-27	114.00
IUUC-Nle-069080	Nomascus leucogenys	32.39	3.00e-28	118.00
IUUC-Opr-070787	Ochotona princeps	31.17	4.00e-28	117.00
IUUC-Ont-071952	Oreochromis niloticus	28.85	2.00e-31	129.00
IUUC-Oan-073334	Ornithorhynchus anatinus	29.65	5.00e-20	90.90
IUUC-Oba-075175	Oryza barthii	53.66	4.00e-92	330.00
IUUC-Obr-076393	Oryza brachyantha	51.62	2.00e-91	328.00
IUUC-Ogl-077603	Oryza glaberrima	51.70	3.00e-60	224.00
IUUC-Ogu-078211	Oryza glumaepatula	53.66	3.00e-92	331.00
IUUC-Oin-079554	Oryza indica	58.36	7.00e-89	319.00
IUUC-Olo-080922	Oryza longistaminata	46.82	1.00e-62	233.00
IUUC-Ome-081127	Oryza meridionalis	49.31	2.00e-75	275.00
IUUC-Oni-082376	Oryza nivara	53.66	4.00e-92	330.00
IUUC-Opu-083163	Oryza punctata	50.54	2.00e-91	328.00
IUUC-Oru-084311	Oryza rufipogon	53.66	9.00e-92	329.00
IUUC-Osa-085762	Oryza sativa	51.70	6.00e-60	223.00
IUUC-Oga-088804	Otolemur garnettii	29.96	5.00e-27	114.00
IUUC-Oar-090095	Ovis aries	30.36	1.00e-26	113.00
IUUC-Ptr-090731	Pan troglodytes	31.58	5.00e-28	117.00
IUUC-Pan-092595	Papio anubis	31.58	6.00e-29	120.00
IUUC-Psi-093866	Pelodiscus sinensis	32.68	1.00e-33	135.00
IUUC-Pma-094236	Petromyzon marinus	27.36	4.00e-29	121.00
IUUC-Pfo-096095	Poecilia formosa	32.06	3.00e-34	138.00
IUUC-Pab-098385	Pongo abelii	31.58	4.00e-28	117.00
IUUC-Pop-099433	Populus trichocarpa	61.04	2.00e-129	454.00
IUUC-Pca-101119	Procavia capensis	32.94	4.00e-25	107.00
IUUC-Ppe-101677	Prunus persica	64.31	7.00e-136	476.00
IUUC-Pva-102726	Pteropus vampyrus	31.17	3.00e-29	121.00
IUUC-Rno-105576	Rattus norvegicus	31.58	6.00e-28	117.00
IUUC-Sha-106774	Sarcophilus harrisii	31.12	1.00e-26	112.00
IUUC-Sit-109988	Setaria italica	50.00	5.00e-102	363.00
IUUC-Sly-110864	Solanum lycopersicum	58.47	4.00e-97	347.00
IUUC-Sar-113060	Sorex araneus	30.74	2.00e-27	115.00
IUUC-Sbi-114699	Sorghum bicolor	50.27	1.00e-100	358.00
IUUC-Ssc-116445	Sus scrofa	30.77	3.00e-27	115.00
IUUC-Tru-117834	Takifugu rubripes	28.80	1.00e-30	126.00
IUUC-Tni-119651	Tetraodon nigroviridis	27.81	1.00e-30	126.00
IUUC-Tca-121318	Theobroma cacao	64.32	1.00e-131	462.00
IUUC-Tae-124184	Triticum aestivum	49.46	3.00e-98	350.00
IUUC-Tur-126226	Triticum urartu	57.08	8.00e-76	276.00
IUUC-Tbe-128079	Tupaia belangeri	26.47	4.00e-13	67.80
IUUC-Ttr-128391	Tursiops truncatus	29.84	3.00e-23	101.00
IUUC-Vvi-131148	Vitis vinifera	62.80	8.00e-128	449.00
IUUC-Xtr-132743	Xenopus tropicalis	29.21	9.00e-28	116.00
IUUC-Xma-133722	Xiphophorus maculatus	30.43	3.00e-36	145.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence