iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19996097; 19581926

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.00014	23.6	3	81

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 69   aakpkaglrseaaaapapapaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelas...qkalwkt 145
           a  p ag  s  a +     a + +      ag + rlp  +l  ++++l+ +el ++a+vc++w+++ +   ++++w++
   Q: 3    APAPGAGAASGGAGCS-GGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCALVCKHWYRCLHgdeNSEVWRS 81
           5556666666554433.3334444455566789999******************************88875545667765 PP

Organism

Homo sapiens

Functional Description
(View)

Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.

Protein Sequence
(Fasta)

MAAPAPGAGA ASGGAGCSGG GAGAGAGSGS GAAGAGGRLP SRVLELVFSY LELSELRSCA 60
LVCKHWYRCL HGDENSEVWR SLCARSLAEE ALRTDILCNL PSYKAKIRAF QHAFSTNDCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAGTCAC ATCCGGGGCC GAGAGGAACC GCGAACGAGC TGGGCGTGCG CCCTTGCTTC 60
GTGCCCTCAA CCCGCATGGC GGAGCCGCTG GCGCGCCGCG GAGAGGCCGG GCGAGTCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001810--F-box_dom
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50181--FBOX

Pfam

PF12937--F-box-like
PF00622--SPRY

SMART

SM00256--FBOX
SM00449--SPRY

Gene Ontology

GO:0030054--C:cell junction
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0042734--C:presynaptic membrane
GO:0021960--P:anterior commissure morphogenesis
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021799--P:cerebral cortex radially oriented cell migration
GO:0021800--P:cerebral cortex tangential migration
GO:0021957--P:corticospinal tract morphogenesis
GO:0001764--P:neuron migration
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060386--P:synapse assembly involved in innervation

KEGG

hsa:200933

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000793	Aegilops tauschii	44.19	1.00e-04	37.40
IUUC-Aml-001815	Ailuropoda melanoleuca	99.20	7.00e-149	519.00
IUUC-Atr-003027	Amborella trichopoda	44.19	3.00e-03	35.80
IUUC-Apl-003739	Anas platyrhynchos	99.21	1.00e-71	261.00
IUUC-Aca-005393	Anolis carolinensis	94.38	4.00e-132	463.00
IUUC-Ame-011341	Astyanax mexicanus	83.53	2.00e-128	451.00
IUUC-Bta-013136	Bos taurus	99.20	6.00e-148	516.00
IUUC-Bdi-014438	Brachypodium distachyon	46.51	1.00e-05	40.80
IUUC-Cel-018377	Caenorhabditis elegans	55.42	7.00e-78	284.00
IUUC-Cja-019860	Callithrix jacchus	100.00	9.00e-150	522.00
IUUC-Cfa-020372	Canis familiaris	97.19	9.00e-145	505.00
IUUC-Cpo-022254	Cavia porcellus	99.20	7.00e-149	519.00
IUUC-Csa-023427	Chlorocebus sabaeus	100.00	1.00e-150	525.00
IUUC-Cho-024723	Choloepus hoffmanni	86.67	1.00e-89	321.00
IUUC-Cin-025644	Ciona intestinalis	62.65	4.00e-97	347.00
IUUC-Csv-025822	Ciona savignyi	63.45	3.00e-97	348.00
IUUC-Dre-028352	Danio rerio	86.75	2.00e-131	461.00
IUUC-Dno-029763	Dasypus novemcinctus	99.20	5.00e-149	520.00
IUUC-Dor-030984	Dipodomys ordii	99.20	4.00e-149	520.00
IUUC-Dse-031450	Dothistroma septosporum	50.00	7.50e-02	31.60
IUUC-Dme-032049	Drosophila melanogaster	71.31	8.00e-104	369.00
IUUC-Ete-033197	Echinops telfairi	96.88	1.00e-50	193.00
IUUC-Eca-034006	Equus caballus	99.55	2.00e-133	467.00
IUUC-Eeu-035294	Erinaceus europaeus	98.89	2.00e-106	377.00
IUUC-Fca-035599	Felis catus	98.80	3.00e-148	517.00
IUUC-Fal-037304	Ficedula albicollis	95.06	2.00e-131	461.00
IUUC-Gmo-038969	Gadus morhua	85.54	3.00e-129	454.00
IUUC-Gga-040625	Gallus gallus	100.00	3.00e-61	226.00
IUUC-Gac-041926	Gasterosteus aculeatus	84.74	1.00e-128	452.00
IUUC-Ggo-045114	Gorilla gorilla	100.00	7.00e-140	489.00
IUUC-Hvu-047420	Hordeum vulgare	44.19	1.00e-04	37.40
IUUC-Itr-049037	Ictidomys tridecemlineatus	99.20	5.00e-150	523.00
IUUC-Lch-049702	Latimeria chalumnae	89.96	3.00e-136	477.00
IUUC-Loc-052199	Lepisosteus oculatus	88.35	2.00e-134	471.00
IUUC-Laf-054069	Loxodonta africana	99.20	4.00e-149	520.00
IUUC-Mcc-055362	Macaca mulatta	100.00	9.00e-150	522.00
IUUC-Meu-056400	Macropus eugenii	95.21	4.00e-106	377.00
IUUC-Mla-058812	Melampsora laricipopulina	37.50	1.70e-01	31.20
IUUC-Mga-059682	Meleagris gallopavo	94.83	3.00e-125	440.00
IUUC-Mmr-061545	Microcebus murinus	99.60	1.00e-149	522.00
IUUC-Mdo-063044	Monodelphis domestica	99.20	3.00e-149	520.00
IUUC-Mmu-063211	Mus musculus	99.20	5.00e-149	520.00
IUUC-Mac-065336	Musa acuminata	51.61	5.00e-04	37.70
IUUC-Mpu-065969	Mustela putorius furo	99.22	5.00e-153	533.00
IUUC-Mlu-067484	Myotis lucifugus	95.77	2.00e-119	421.00
IUUC-Nle-069299	Nomascus leucogenys	100.00	1.00e-149	521.00
IUUC-Ont-071824	Oreochromis niloticus	85.94	7.00e-130	456.00
IUUC-Ocu-074917	Oryctolagus cuniculus	99.59	1.00e-146	511.00
IUUC-Oba-075891	Oryza barthii	46.51	7.00e-05	38.50
IUUC-Obr-076186	Oryza brachyantha	50.00	1.30e-02	34.30
IUUC-Ogl-077596	Oryza glaberrima	46.51	7.00e-05	38.50
IUUC-Ogu-078277	Oryza glumaepatula	46.51	4.00e-05	39.30
IUUC-Oin-079470	Oryza indica	46.51	7.00e-05	38.50
IUUC-Oni-082654	Oryza nivara	46.51	7.00e-05	38.50
IUUC-Opu-083861	Oryza punctata	47.37	1.00e-03	34.30
IUUC-Oru-084548	Oryza rufipogon	46.51	6.00e-05	38.90
IUUC-Osa-085983	Oryza sativa	46.51	6.00e-05	38.90
IUUC-Ola-087014	Oryzias latipes	84.34	2.00e-128	451.00
IUUC-Oga-089176	Otolemur garnettii	98.80	2.00e-148	518.00
IUUC-Oar-089517	Ovis aries	97.54	5.00e-141	493.00
IUUC-Ptr-091318	Pan troglodytes	100.00	4.00e-107	379.00
IUUC-Pan-092627	Papio anubis	100.00	9.00e-150	522.00
IUUC-Psi-093937	Pelodiscus sinensis	98.89	2.00e-106	377.00
IUUC-Pfo-097200	Poecilia formosa	84.36	6.00e-125	440.00
IUUC-Ppe-101651	Prunus persica	35.00	7.00e-03	35.00
IUUC-Pva-102717	Pteropus vampyrus	99.20	6.00e-149	519.00
IUUC-Pte-104263	Pyrenophora teres	48.57	6.00e-04	38.10
IUUC-Pyt-104608	Pyrenophora triticirepentis	48.57	3.00e-04	38.90
IUUC-Rno-105956	Rattus norvegicus	92.53	4.00e-132	463.00
IUUC-Sha-107117	Sarcophilus harrisii	99.44	6.00e-107	379.00
IUUC-Sja-107898	Schizosaccharomyces japonicus	46.15	6.30e-02	33.50
IUUC-Sit-110696	Setaria italica	48.84	1.00e-05	40.80
IUUC-Sar-113757	Sorex araneus	98.89	2.00e-106	377.00
IUUC-Sbi-113995	Sorghum bicolor	48.84	1.00e-05	40.80
IUUC-Tgu-117169	Taeniopygia guttata	97.80	4.00e-106	376.00
IUUC-Tru-118146	Takifugu rubripes	85.94	2.00e-129	454.00
IUUC-Tni-120858	Tetraodon nigroviridis	85.54	3.00e-128	451.00
IUUC-Tae-123886	Triticum aestivum	44.19	1.00e-04	37.40
IUUC-Tbe-128110	Tupaia belangeri	92.74	6.00e-127	446.00
IUUC-Ttr-128569	Tursiops truncatus	100.00	7.00e-150	523.00
IUUC-Vpa-130507	Vicugna pacos	100.00	1.00e-149	521.00
IUUC-Xtr-132793	Xenopus tropicalis	94.38	8.00e-143	499.00
IUUC-Xma-133910	Xiphophorus maculatus	84.36	6.00e-125	440.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence