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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046586
UUCD1 version UUC-HoS-00942
Ensembl Protein ID ENSP00000295888.4
UniProt Accession Q8IZQ1; Q4W5K5; Q6P0Q5; Q8N1T2; Q8NAV6; Q96BS7; Q96D33; Q96N85; Q9Y2J7; WDFY3_HUMAN
Genbank Protein ID AAN15137.1; AAY40903.1; BAA76837.2; BAB71020.1; BAC04455.1; AAH13377.1; AAH15214.2; AAH65502.1; AAI19634.1
Protein Name WD repeat and FYVE domain-containing protein 3; Autophagy-linked FYVE protein
Genbank Nucleotide ID AF538685; AC095046; AC104082; AK055806; AK094910; BC013377; BC015214; BC065502; BC119633
Gene Name WDFY3; KIAA0993
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163625.15 ENST00000295888.8 ENSP00000295888.4
ENSG00000163625.15 ENST00000514711.1 ENSP00000424987.1
ENSG00000163625.15 ENST00000514071.1 ENSP00000426813.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-10 42.0 3125 3156
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtc....lafsdtllvsGsdDgtikvWDl 30
           gHtd vtc    la+  +++vsGs+D t+ +WDl
   Q: 3125 GHTDTVTCatasLAY--HIIVSGSRDRTCIIWDL 3156
           8*******6655566..89**************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.
 Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.
Protein Sequence
(Fasta)
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR 60
VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEINQSEEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046586|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCGGCCGCAG AATCGAGCTC GGGCCCCGGC CCCCGGCCCG CGGCGCGGGG CTCCCGGGCC 60
CCGCCGCGGA CGTCGCGCCG GTCGCCCCTT CCCCGTAGCC CGTGCGCCCT CGGCGCGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046586|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000409--BEACH_dom
IPR013320--ConA-like_dom
IPR031570--DUF4704
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50178--ZF_FYVE
Pfam

PF02138--Beach
PF15787--DUF4704
PF01363--FYVE
PF14844--PH_BEACH
SMART

SM01026--Beach
SM00064--FYVE
SM00320--WD40
Gene Ontology

GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097635--C:extrinsic component of autophagosome membrane
GO:0019898--C:extrinsic component of membrane
GO:0016234--C:inclusion body
GO:0005635--C:nuclear envelope
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016605--C:PML body
GO:0005545--F:1-phosphatidylinositol binding
GO:0003831--F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0046872--F:metal ion binding
GO:0035973--P:aggrephagy
KEGG hsa:23001
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000317 Aegilops tauschii 33.33 3.00e-174 607.00
IUUC-Aml-002094 Ailuropoda melanoleuca 98.02 0.00e+00 6952.00
IUUC-Atr-002879 Amborella trichopoda 36.84 2.00e-174 608.00
IUUC-Apl-003581 Anas platyrhynchos 91.84 0.00e+00 5026.00
IUUC-Aca-005386 Anolis carolinensis 91.64 0.00e+00 6582.00
IUUC-Aly-006119 Arabidopsis lyrata 33.48 2.00e-178 622.00
IUUC-Ath-007645 Arabidopsis thaliana 47.13 4.00e-168 587.00
IUUC-Afu-009064 Aspergillus fumigatus 37.29 9.00e-166 579.00
IUUC-Ani-009310 Aspergillus nidulans 36.39 3.00e-160 560.00
IUUC-Aor-010079 Aspergillus oryzae 35.83 1.00e-164 575.00
IUUC-Ame-011607 Astyanax mexicanus 81.81 0.00e+00 5678.00
IUUC-Bta-012997 Bos taurus 97.65 0.00e+00 6856.00
IUUC-Bci-013784 Botrytis cinerea 35.39 2.00e-163 571.00
IUUC-Bdi-015031 Brachypodium distachyon 34.18 6.00e-174 606.00
IUUC-Bol-016599 Brassica oleracea 46.49 4.00e-162 567.00
IUUC-Bra-017709 Brassica rapa 46.33 6.00e-162 566.00
IUUC-Cja-019272 Callithrix jacchus 99.12 0.00e+00 7005.00
IUUC-Cfa-020073 Canis familiaris 97.70 0.00e+00 6901.00
IUUC-Cpo-021455 Cavia porcellus 95.70 0.00e+00 6773.00
IUUC-Csa-023097 Chlorocebus sabaeus 98.31 0.00e+00 6990.00
IUUC-Cgl-026670 Colletotrichum gloeosporioides 34.77 7.00e-142 499.00
IUUC-Dre-027703 Danio rerio 83.60 0.00e+00 5907.00
IUUC-Dno-029515 Dasypus novemcinctus 99.15 0.00e+00 973.00
IUUC-Dor-030567 Dipodomys ordii 87.07 0.00e+00 2109.00
IUUC-Dme-031959 Drosophila melanogaster 47.76 0.00e+00 2799.00
IUUC-Ete-032373 Echinops telfairi 88.15 0.00e+00 3630.00
IUUC-Eca-033575 Equus caballus 97.65 0.00e+00 6945.00
IUUC-Eeu-034853 Erinaceus europaeus 85.81 0.00e+00 2239.00
IUUC-Fca-036304 Felis catus 98.02 0.00e+00 6892.00
IUUC-Fal-037019 Ficedula albicollis 92.77 0.00e+00 6626.00
IUUC-Fox-038015 Fusarium oxysporum 34.19 2.00e-151 530.00
IUUC-Fso-038249 Fusarium solani 33.78 1.00e-148 522.00
IUUC-Gmo-039503 Gadus morhua 79.07 0.00e+00 5617.00
IUUC-Ggr-039900 Gaeumannomyces graminis 39.20 2.00e-151 531.00
IUUC-Gac-041618 Gasterosteus aculeatus 81.72 0.00e+00 5803.00
IUUC-Gma-043242 Glycine max 36.69 3.00e-177 618.00
IUUC-Ggo-044679 Gorilla gorilla 97.17 0.00e+00 6836.00
IUUC-Hvu-047814 Hordeum vulgare 32.96 1.00e-171 599.00
IUUC-Itr-048396 Ictidomys tridecemlineatus 97.17 0.00e+00 5696.00
IUUC-Lpe-050828 Leersia perrieri 34.30 8.00e-180 626.00
IUUC-Loc-052434 Lepisosteus oculatus 87.05 0.00e+00 6214.00
IUUC-Lma-053017 Leptosphaeria maculans 28.68 5.00e-135 477.00
IUUC-Laf-054408 Loxodonta africana 96.94 0.00e+00 6898.00
IUUC-Mcc-055652 Macaca mulatta 99.35 0.00e+00 7060.00
IUUC-Meu-056743 Macropus eugenii 80.36 0.00e+00 2806.00
IUUC-Mor-057120 Magnaporthe oryzae 38.95 6.00e-161 563.00
IUUC-Mtr-058732 Medicago truncatula 37.56 2.00e-176 615.00
IUUC-Mla-058974 Melampsora laricipopulina 32.78 1.00e-137 486.00
IUUC-Mvi-060546 Microbotryum violaceum 31.02 6.00e-160 559.00
IUUC-Mmr-061760 Microcebus murinus 92.24 0.00e+00 6410.00
IUUC-Mdo-062645 Monodelphis domestica 94.70 0.00e+00 6703.00
IUUC-Mmu-063588 Mus musculus 96.37 0.00e+00 6933.00
IUUC-Mac-064551 Musa acuminata 38.87 1.00e-172 602.00
IUUC-Mpu-066073 Mustela putorius furo 97.96 0.00e+00 6892.00
IUUC-Mlu-067641 Myotis lucifugus 97.22 0.00e+00 6899.00
IUUC-Nfi-068471 Neosartorya fischeri 36.04 3.00e-166 580.00
IUUC-Nle-070009 Nomascus leucogenys 99.43 0.00e+00 7044.00
IUUC-Opr-070689 Ochotona princeps 93.71 0.00e+00 5958.00
IUUC-Ont-071427 Oreochromis niloticus 82.92 0.00e+00 5820.00
IUUC-Oan-073118 Ornithorhynchus anatinus 87.30 0.00e+00 6105.00
IUUC-Ocu-074702 Oryctolagus cuniculus 98.04 0.00e+00 6987.00
IUUC-Oba-075831 Oryza barthii 33.99 1.00e-177 619.00
IUUC-Obr-076728 Oryza brachyantha 33.82 2.00e-177 618.00
IUUC-Ogl-077922 Oryza glaberrima 33.99 7.00e-178 619.00
IUUC-Ogu-079001 Oryza glumaepatula 33.99 4.00e-177 617.00
IUUC-Oin-079929 Oryza indica 36.92 9.00e-166 577.00
IUUC-Olo-080662 Oryza longistaminata 36.89 8.00e-178 619.00
IUUC-Ome-081733 Oryza meridionalis 34.15 1.00e-178 622.00
IUUC-Oni-082641 Oryza nivara 34.07 2.00e-177 618.00
IUUC-Opu-083564 Oryza punctata 34.07 7.00e-179 623.00
IUUC-Oru-084403 Oryza rufipogon 34.07 1.00e-177 619.00
IUUC-Ola-086856 Oryzias latipes 79.75 0.00e+00 5648.00
IUUC-Oga-088908 Otolemur garnettii 98.40 0.00e+00 3112.00
IUUC-Oar-089625 Ovis aries 96.60 0.00e+00 6774.00
IUUC-Ptr-091209 Pan troglodytes 99.83 0.00e+00 7074.00
IUUC-Pan-092751 Papio anubis 99.15 0.00e+00 7042.00
IUUC-Psi-092951 Pelodiscus sinensis 92.97 0.00e+00 6693.00
IUUC-Ppa-095361 Physcomitrella patens 33.59 0.00e+00 676.00
IUUC-Pfo-097102 Poecilia formosa 80.90 0.00e+00 5760.00
IUUC-Pab-098485 Pongo abelii 98.95 0.00e+00 7009.00
IUUC-Pop-099807 Populus trichocarpa 37.49 7.00e-180 626.00
IUUC-Pca-100146 Procavia capensis 90.70 0.00e+00 1473.00
IUUC-Ppe-101277 Prunus persica 37.72 0.00e+00 635.00
IUUC-Pva-102502 Pteropus vampyrus 87.51 0.00e+00 3253.00
IUUC-Rno-105592 Rattus norvegicus 94.75 0.00e+00 6816.00
IUUC-Sha-106751 Sarcophilus harrisii 83.76 0.00e+00 5853.00
IUUC-Sja-107759 Schizosaccharomyces japonicus 38.91 1.00e-148 522.00
IUUC-Spo-108108 Schizosaccharomyces pombe 40.34 1.00e-153 538.00
IUUC-Ssl-108524 Sclerotinia sclerotiorum 37.39 9.00e-165 574.00
IUUC-Smo-109485 Selaginella moellendorffii 32.15 0.00e+00 644.00
IUUC-Sit-110811 Setaria italica 43.08 2.00e-172 602.00
IUUC-Sly-110936 Solanum lycopersicum 35.16 7.00e-178 619.00
IUUC-Sar-113013 Sorex araneus 81.49 0.00e+00 1382.00
IUUC-Sbi-114421 Sorghum bicolor 42.65 6.00e-174 606.00
IUUC-Sre-115137 Sporisorium reilianum 32.98 1.00e-133 472.00
IUUC-Ssc-116100 Sus scrofa 96.85 0.00e+00 6888.00
IUUC-Tgu-117182 Taeniopygia guttata 92.38 0.00e+00 6596.00
IUUC-Tru-117859 Takifugu rubripes 82.27 0.00e+00 5730.00
IUUC-Tsy-119315 Tarsius syrichta 97.93 0.00e+00 4325.00
IUUC-Tni-120784 Tetraodon nigroviridis 81.21 0.00e+00 5639.00
IUUC-Tca-121423 Theobroma cacao 37.31 2.00e-174 608.00
IUUC-Tre-121988 Trichoderma reesei 33.98 2.00e-157 551.00
IUUC-Tvi-122476 Trichoderma virens 36.10 9.00e-160 559.00
IUUC-Tur-126221 Triticum urartu 32.79 6.00e-174 607.00
IUUC-Tme-126944 Tuber melanosporum 40.45 3.00e-156 547.00
IUUC-Tbe-127827 Tupaia belangeri 91.54 0.00e+00 2772.00
IUUC-Ttr-128368 Tursiops truncatus 97.62 0.00e+00 6938.00
IUUC-Vda-129813 Verticillium dahliae 39.87 8.00e-151 529.00
IUUC-Vpa-130252 Vicugna pacos 97.39 0.00e+00 4425.00
IUUC-Vvi-131663 Vitis vinifera 38.13 2.00e-177 618.00
IUUC-Xtr-132689 Xenopus tropicalis 87.44 0.00e+00 6350.00
IUUC-Xma-133273 Xiphophorus maculatus 82.86 0.00e+00 4836.00
IUUC-Zma-135580 Zea mays 43.21 2.00e-172 601.00
Created Date 25-Jun-2017

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