iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	3.10e-10	40.8	111	147

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyL 38
            + +++ + +MGFd+e++++a +++   n ea ++ L
   Q: 111  KSKAIDHFLAMGFDEEKVVKAIQEHgEDNMEAIANAL 147
           5679*********************666666666655 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation (RdDM) (PubMed:12121623, PubMed:12151602, PubMed:14680640). Acts as major DNA methyltransferase in the RdDM pathway, and is essential for RNA-directed de novo DNA methylation of cytosines in all sequence contexts (PubMed:21060858, PubMed:21212233). Associates with long non-coding RNA (lncRNA) produced by RNA polymerase V (Pol V). This association is dependent on AGO4 and IDN2, and results in DNA methylation of RdDM target loci (PubMed:24862207).

Protein Sequence
(Fasta)

MVIWNNDDDD FLEIDNFQSS PRSSPIHAMQ CRVENLAGVA VTTSSLSSPT ETTDLVQMGF 60
SDEVFATLFD MGFPVEMISR AIKETGPNVE TSVIIDTISK YSSDCEAGSS KSKAIDHFLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTCCTCCT CCAGTAAACT GACGACGATA CAAGCTCTCT CACCAACGGC GACAGTATCT 60
TTGCCGGCGG CGGGAGCGCT TCTGCTTAAT CTGTAGCTCA AACTAAAAAT TCTCTGGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase

Interpro

IPR029063--SAM-dependent_MTases
IPR030380--SAM_MeTfrase_DRM
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS51680--SAM_MT_DRM
PS50030--UBA

Pfam

PF00145--DNA_methylase

SMART

SM00165--UBA

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003886--F:DNA (cytosine-5-)-methyltransferase activity
GO:0003677--F:DNA binding
GO:0009008--F:DNA-methyltransferase activity
GO:0050832--P:defense response to fungus
GO:0006306--P:DNA methylation
GO:0016458--P:gene silencing
GO:0051567--P:histone H3-K9 methylation

KEGG

ath:AT5G14620

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000447	Aegilops tauschii	51.61	4.00e-142	498.00
IUUC-Aly-006478	Arabidopsis lyrata	91.87	0.00e+00	1108.00
IUUC-Bta-012720	Bos taurus	24.75	2.10e-02	33.10
IUUC-Bol-016452	Brassica oleracea	72.95	0.00e+00	821.00
IUUC-Bra-017647	Brassica rapa	72.19	0.00e+00	804.00
IUUC-Cja-019955	Callithrix jacchus	30.16	3.60e-02	32.70
IUUC-Hvu-047206	Hordeum vulgare	51.00	3.00e-144	504.00
IUUC-Lpe-051697	Leersia perrieri	49.20	5.00e-148	518.00
IUUC-Mpu-066241	Mustela putorius furo	30.16	4.90e-02	32.00
IUUC-Oba-075087	Oryza barthii	52.66	2.00e-157	548.00
IUUC-Obr-076453	Oryza brachyantha	51.25	5.00e-151	527.00
IUUC-Ogl-077238	Oryza glaberrima	50.43	3.00e-157	548.00
IUUC-Ogu-078621	Oryza glumaepatula	52.66	1.00e-157	549.00
IUUC-Oin-080056	Oryza indica	52.69	3.00e-156	545.00
IUUC-Olo-080578	Oryza longistaminata	56.49	9.00e-153	533.00
IUUC-Ome-081140	Oryza meridionalis	47.08	5.00e-125	441.00
IUUC-Opu-083378	Oryza punctata	51.64	3.00e-154	538.00
IUUC-Oru-084947	Oryza rufipogon	52.66	4.00e-157	547.00
IUUC-Osa-085973	Oryza sativa	48.19	1.00e-77	282.00
IUUC-Pfo-096166	Poecilia formosa	24.75	1.40e-02	33.90
IUUC-Spo-108263	Schizosaccharomyces pombe	37.21	3.70e-02	32.70
IUUC-Sit-110358	Setaria italica	53.64	3.00e-159	554.00
IUUC-Sbi-114163	Sorghum bicolor	49.66	3.00e-149	521.00
IUUC-Tni-120603	Tetraodon nigroviridis	24.75	3.00e-02	32.70
IUUC-Tae-125889	Triticum aestivum	49.82	5.00e-144	504.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence