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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045971
UUCD1 version UUC-HoS-00659
Ensembl Protein ID ENSP00000358854.3
UniProt Accession Q15542; A8K5B4; B2RMR0; B7ZKJ6; Q53EM4; Q5SYD5; Q86UZ7; Q9Y4K5; TAF5_HUMAN
Genbank Protein ID CAA64777.1; AAC50902.1; AAC51215.1; BAD97335.1; BAF83918.1; CAI16747.1; EAW49645.1; EAW49646.1; AAH52268.2; AAI36341.1; AAI36349.1
Protein Name Transcription initiation factor TFIID subunit 5; Transcription initiation factor TFIID 100 kDa subunit
Genbank Nucleotide ID X95525; U75309; U80191; AK223615; AK291229; AL591408; CH471066; CH471066; BC052268; BC136340; BC136348
Gene Name TAF5; TAF2D
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000148835.10 ENST00000369839.3 ENSP00000358854.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDABioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-43 146.9 625 663
UBD/Beta-Prp 1.60e-87 295.1 473 794
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH ++v+c +f ++ +++++Gs D t+++WD+  g++++
   Q: 625  GHLADVNCTRFhPNsNYVATGSADRTVRLWDVLNGNCVR 663
           89**********777*****************9999986 PP
   

   UBD/Beta-Prp
   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkl...............................lrslsgheaevtavkfspdgkilvtgseD 73
           +t+v++++d+sl+a g++d+t++vw+vt++kl                               l+ l+gh+++v+  +fspd+++l+++seD
   Q: 473  LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLrsvkqasdlslidkesddvlerimdektaseLKILYGHSGPVYGASFSPDRNYLLSSSED 564
           799***************************************************************************************** PP
   S: 74   rtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWd 165
           +t+++w+l+t++c++ +kgh++ v++++fsp+g+++vsG+hdr++r+w ++++q l+ +++gh + vnc+++hp++n++++Gs+DrtvrlWd
   Q: 565  GTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
           *********************************************************.********************************** PP
   S: 166  lktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW.......d 250
           + +g+++r +tg h+++++sl+f++ng++l++g++dg+v lwd+ +g +v +l+ghtd+v+s+rfs+++e+l+sgs+D+++r+W       d
   Q: 656  VLNGNCVRIFTG-HKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWdaikafeD 746
           ***********9.******************************************************************************* PP
   S: 251  lrsgdllktlqlhn..............ssvisvavlsfgdnvlvlgs 284
           l+++d+++++ + n              +++++v +l+f++++lvl++
   Q: 747  LETDDFTTATGHINlpensqelllgtymTKSTPVVHLHFTRRNLVLAA 794
           *******************************************99986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Homodimer. TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with SV40 Large T antigen.
 Homodimer. TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with SV40 Large T antigen.
Protein Sequence
(Fasta)
MAALAEEQTE VAVKLEPEGP PTLLPPQAGD GAGEGSGGTT NNGPNGGGGN VAASSSTGGD 60
GGTPKPTVAV SAAAPAGAAP VPAAAPDAGA PHDRQTLLAV LQFLRQSKLR EAEEALRREA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045971|UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCGAGGTG GCTCAGCCGC AAGATGGCGG CGCTGGCGGA GGAGCAGACG GAGGTGGCGG 60
TCAAGCTAGA GCCTGAGGGA CCGCCAACGC TGCTACCTCC GCAGGCGGGG GACGGCGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045971|UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR007582--TFIID_NTD2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04494--TFIID_NTD2
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005669--C:transcription factor TFIID complex
GO:0033276--C:transcription factor TFTC complex
GO:0046983--F:protein dimerization activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0006325--P:chromatin organization
GO:0006352--P:DNA-templated transcription, initiation
GO:0016573--P:histone acetylation
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0042795--P:snRNA transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0016032--P:viral process
KEGG hsa:6877
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000851 Aegilops tauschii 51.93 1.00e-68 254.00
IUUC-Aml-001607 Ailuropoda melanoleuca 97.06 0.00e+00 1279.00
IUUC-Atr-003136 Amborella trichopoda 46.48 4.00e-95 342.00
IUUC-Apl-004193 Anas platyrhynchos 92.67 0.00e+00 1134.00
IUUC-Aca-004522 Anolis carolinensis 85.03 0.00e+00 1184.00
IUUC-Aly-006476 Arabidopsis lyrata 38.29 9.00e-115 407.00
IUUC-Ath-006587 Arabidopsis thaliana 47.19 5.00e-88 318.00
IUUC-Ago-007736 Ashbya gossypii 42.82 2.00e-93 337.00
IUUC-Acl-008092 Aspergillus clavatus 36.34 3.00e-78 286.00
IUUC-Afl-008659 Aspergillus flavus 36.60 9.00e-80 291.00
IUUC-Afu-008902 Aspergillus fumigatus 37.96 5.00e-80 292.00
IUUC-Ani-009462 Aspergillus nidulans 38.39 2.00e-81 296.00
IUUC-Aor-010083 Aspergillus oryzae 36.60 1.00e-79 291.00
IUUC-Ate-010271 Aspergillus terreus 37.76 4.00e-80 292.00
IUUC-Ame-010721 Astyanax mexicanus 80.48 0.00e+00 1121.00
IUUC-Bgr-012257 Blumeria graminis 29.65 2.00e-74 273.00
IUUC-Bta-013539 Bos taurus 96.50 0.00e+00 1285.00
IUUC-Bci-013737 Botrytis cinerea 28.98 2.00e-79 290.00
IUUC-Bdi-015041 Brachypodium distachyon 48.94 1.00e-83 304.00
IUUC-Bol-016198 Brassica oleracea 37.58 3.00e-112 399.00
IUUC-Bra-017660 Brassica rapa 36.98 2.00e-110 393.00
IUUC-Cel-018451 Caenorhabditis elegans 33.73 9.00e-87 314.00
IUUC-Cja-018881 Callithrix jacchus 98.88 0.00e+00 1269.00
IUUC-Cfa-020056 Canis familiaris 97.88 0.00e+00 1291.00
IUUC-Cpo-021454 Cavia porcellus 88.03 0.00e+00 1246.00
IUUC-Cre-022736 Chlamydomonas reinhardtii 40.07 5.00e-52 199.00
IUUC-Csa-023045 Chlorocebus sabaeus 100.00 0.00e+00 1168.00
IUUC-Cho-024284 Choloepus hoffmanni 85.98 0.00e+00 946.00
IUUC-Cin-025457 Ciona intestinalis 60.29 3.00e-100 358.00
IUUC-Csv-025882 Ciona savignyi 51.88 7.00e-180 624.00
IUUC-Cgl-026392 Colletotrichum gloeosporioides 28.74 4.00e-77 283.00
IUUC-Cne-026876 Cryptococcus neoformans 39.39 3.00e-73 270.00
IUUC-Cme-027302 Cyanidioschyzon merolae 34.41 2.00e-101 363.00
IUUC-Dre-027980 Danio rerio 78.98 0.00e+00 1078.00
IUUC-Dno-028863 Dasypus novemcinctus 97.62 0.00e+00 1253.00
IUUC-Dor-030561 Dipodomys ordii 98.45 0.00e+00 1242.00
IUUC-Dse-031547 Dothistroma septosporum 30.71 1.00e-78 288.00
IUUC-Dme-031917 Drosophila melanogaster 40.90 1.00e-147 516.00
IUUC-Ete-032319 Echinops telfairi 80.10 0.00e+00 920.00
IUUC-Eca-033927 Equus caballus 91.41 0.00e+00 1244.00
IUUC-Eeu-034449 Erinaceus europaeus 99.19 0.00e+00 962.00
IUUC-Fca-036325 Felis catus 97.88 0.00e+00 1261.00
IUUC-Fal-036604 Ficedula albicollis 94.75 0.00e+00 1164.00
IUUC-Fox-038049 Fusarium oxysporum 33.15 2.00e-49 191.00
IUUC-Gmo-038832 Gadus morhua 75.25 0.00e+00 1014.00
IUUC-Ggr-039878 Gaeumannomyces graminis 29.03 1.00e-71 264.00
IUUC-Gga-041147 Gallus gallus 94.74 0.00e+00 1182.00
IUUC-Gac-041373 Gasterosteus aculeatus 79.21 0.00e+00 1071.00
IUUC-Gma-043230 Glycine max 38.40 7.00e-119 421.00
IUUC-Ggo-045526 Gorilla gorilla 100.00 0.00e+00 869.00
IUUC-Hvu-047695 Hordeum vulgare 49.71 4.00e-87 315.00
IUUC-Itr-048400 Ictidomys tridecemlineatus 97.88 0.00e+00 1269.00
IUUC-Kpa-049402 Komagataella pastoris 43.80 7.00e-95 342.00
IUUC-Lch-049526 Latimeria chalumnae 87.95 0.00e+00 1061.00
IUUC-Lpe-050793 Leersia perrieri 36.72 2.00e-87 317.00
IUUC-Loc-052882 Lepisosteus oculatus 82.45 0.00e+00 1147.00
IUUC-Lma-053212 Leptosphaeria maculans 31.64 2.00e-80 293.00
IUUC-Laf-053859 Loxodonta africana 96.12 0.00e+00 1285.00
IUUC-Mcc-054957 Macaca mulatta 100.00 0.00e+00 998.00
IUUC-Meu-056766 Macropus eugenii 98.34 0.00e+00 675.00
IUUC-Mor-057024 Magnaporthe oryzae 29.01 6.00e-68 252.00
IUUC-Mpo-057520 Magnaporthe poae 29.52 7.00e-72 265.00
IUUC-Mtr-058754 Medicago truncatula 39.02 7.00e-122 431.00
IUUC-Mla-058881 Melampsora laricipopulina 38.21 5.00e-80 292.00
IUUC-Mga-059776 Meleagris gallopavo 94.62 0.00e+00 1189.00
IUUC-Mvi-060208 Microbotryum violaceum 41.75 1.00e-83 304.00
IUUC-Mmr-061783 Microcebus murinus 100.00 0.00e+00 998.00
IUUC-Mdo-062856 Monodelphis domestica 98.54 0.00e+00 1210.00
IUUC-Mmu-064218 Mus musculus 97.88 0.00e+00 1280.00
IUUC-Mac-064886 Musa acuminata 53.05 3.00e-72 266.00
IUUC-Mpu-065735 Mustela putorius furo 97.60 0.00e+00 1271.00
IUUC-Mlu-067544 Myotis lucifugus 99.51 0.00e+00 1215.00
IUUC-Nfi-068502 Neosartorya fischeri 37.96 2.00e-80 293.00
IUUC-Ncr-068891 Neurospora crassa 30.00 4.00e-76 279.00
IUUC-Nle-069389 Nomascus leucogenys 99.38 0.00e+00 1283.00
IUUC-Opr-071042 Ochotona princeps 87.94 0.00e+00 677.00
IUUC-Ont-071455 Oreochromis niloticus 80.20 0.00e+00 1095.00
IUUC-Oan-073181 Ornithorhynchus anatinus 95.28 0.00e+00 1178.00
IUUC-Ocu-073758 Oryctolagus cuniculus 97.00 0.00e+00 1297.00
IUUC-Oba-075739 Oryza barthii 44.89 1.00e-81 297.00
IUUC-Obr-076111 Oryza brachyantha 38.40 3.00e-113 402.00
IUUC-Ogl-077914 Oryza glaberrima 37.03 6.00e-100 358.00
IUUC-Ogu-078190 Oryza glumaepatula 35.12 1.00e-89 324.00
IUUC-Oin-079249 Oryza indica 37.73 1.00e-100 360.00
IUUC-Olo-080645 Oryza longistaminata 52.47 2.00e-69 256.00
IUUC-Ome-081831 Oryza meridionalis 42.20 1.00e-71 264.00
IUUC-Oni-082431 Oryza nivara 36.26 2.00e-98 353.00
IUUC-Opu-083325 Oryza punctata 35.49 2.00e-91 329.00
IUUC-Oru-085154 Oryza rufipogon 52.19 5.00e-81 295.00
IUUC-Osa-086189 Oryza sativa 37.90 7.00e-104 371.00
IUUC-Ola-086574 Oryzias latipes 81.87 0.00e+00 1121.00
IUUC-Olu-087616 Ostreococcus lucimarinus 33.23 1.00e-100 360.00
IUUC-Oga-088827 Otolemur garnettii 97.38 0.00e+00 1304.00
IUUC-Oar-089648 Ovis aries 96.38 0.00e+00 1286.00
IUUC-Ptr-091195 Pan troglodytes 99.88 0.00e+00 1313.00
IUUC-Pan-091978 Papio anubis 98.75 0.00e+00 1277.00
IUUC-Psi-093598 Pelodiscus sinensis 94.95 0.00e+00 1072.00
IUUC-Pno-094823 Phaeosphaeria nodorum 30.53 6.00e-84 305.00
IUUC-Ppa-095455 Physcomitrella patens 45.92 2.00e-95 343.00
IUUC-Pfo-097120 Poecilia formosa 80.76 0.00e+00 1083.00
IUUC-Pab-098771 Pongo abelii 99.75 0.00e+00 1285.00
IUUC-Pop-099542 Populus trichocarpa 45.03 2.00e-95 343.00
IUUC-Pca-100804 Procavia capensis 88.89 0.00e+00 933.00
IUUC-Ppe-101686 Prunus persica 38.63 5.00e-111 395.00
IUUC-Pva-102414 Pteropus vampyrus 93.51 0.00e+00 1197.00
IUUC-Pgr-103603 Puccinia graminis 37.00 2.00e-73 271.00
IUUC-Pte-104359 Pyrenophora teres 30.26 6.00e-83 301.00
IUUC-Pyt-104523 Pyrenophora triticirepentis 29.71 1.00e-83 304.00
IUUC-Rno-105064 Rattus norvegicus 96.25 0.00e+00 1307.00
IUUC-Sce-106186 Saccharomyces cerevisiae 42.75 4.00e-91 329.00
IUUC-Sha-106582 Sarcophilus harrisii 98.37 0.00e+00 1203.00
IUUC-Sja-107683 Schizosaccharomyces japonicus 38.09 1.00e-109 390.00
IUUC-Spo-108142 Schizosaccharomyces pombe 36.12 7.00e-107 381.00
IUUC-Ssl-108456 Sclerotinia sclerotiorum 28.14 2.00e-78 287.00
IUUC-Smo-109111 Selaginella moellendorffii 36.90 8.00e-107 381.00
IUUC-Sit-109804 Setaria italica 38.33 1.00e-106 380.00
IUUC-Sly-111693 Solanum lycopersicum 37.38 5.00e-110 392.00
IUUC-Sar-113412 Sorex araneus 98.58 0.00e+00 806.00
IUUC-Sbi-114849 Sorghum bicolor 37.44 6.00e-105 375.00
IUUC-Sre-114945 Sporisorium reilianum 35.37 1.00e-77 285.00
IUUC-Ssc-115582 Sus scrofa 77.91 0.00e+00 923.00
IUUC-Tgu-116899 Taeniopygia guttata 94.82 0.00e+00 1149.00
IUUC-Tru-118011 Takifugu rubripes 79.94 0.00e+00 1098.00
IUUC-Tni-120598 Tetraodon nigroviridis 80.31 0.00e+00 1087.00
IUUC-Tca-121247 Theobroma cacao 44.73 1.00e-94 341.00
IUUC-Tre-121949 Trichoderma reesei 36.41 8.00e-63 235.00
IUUC-Tvi-122626 Trichoderma virens 33.11 3.00e-64 239.00
IUUC-Tae-123335 Triticum aestivum 50.29 6.00e-89 322.00
IUUC-Tur-126005 Triticum urartu 45.17 9.00e-83 301.00
IUUC-Tme-126904 Tuber melanosporum 42.38 2.00e-91 330.00
IUUC-Tbe-127254 Tupaia belangeri 93.09 0.00e+00 1214.00
IUUC-Ttr-128544 Tursiops truncatus 97.88 0.00e+00 1254.00
IUUC-Uma-129379 Ustilago maydis 34.31 1.00e-77 285.00
IUUC-Vda-129761 Verticillium dahliae 33.67 2.00e-58 221.00
IUUC-Vpa-130485 Vicugna pacos 97.00 0.00e+00 1268.00
IUUC-Vvi-131171 Vitis vinifera 37.48 4.00e-116 412.00
IUUC-Xtr-132762 Xenopus tropicalis 73.04 0.00e+00 979.00
IUUC-Xma-133583 Xiphophorus maculatus 80.62 0.00e+00 1087.00
IUUC-Yli-134446 Yarrowia lipolytica 37.74 5.00e-117 415.00
Created Date 25-Jun-2017

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