iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	21990941; 17493935

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	0.0036	18.5	55	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd...vqpevfrallkFlYtgklde 67
           D ++++g+  f+ hk+ L ++S ++++l++   +   + +++ i d     pe+f+   kF+Y   +d+
   Q: 55   DLLVKIGDMNFHLHKYPLLSRSGKMNRLIYESRD---PDPTILILDdlpGGPEAFELASKFCYGVPVDL 120
           888999***********************76544...3466777644999*************877665 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Signal transducer of the phototropic response and photo-induced movements. Involved in the phot1 pathway under low blue light (LBL) fluence rate and in the phot2 pathway under higher fluence rate of blue light (HBL). Necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Not involved in chloroplast accumulation and translocation.

Protein Sequence
(Fasta)

MMWESESDGG VGVGGGGGRE YGDGVLSSNK HGGVKTDGFE LRGQSWFVAT DIPSDLLVKI 60
GDMNFHLHKY PLLSRSGKMN RLIYESRDPD PTILILDDLP GGPEAFELAS KFCYGVPVDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCACTAAA AAACATACTA CAATGTCAGT AAACTAATAA TGTTTAATGT AAAATCTAAA 60
AAAGACAGAT TGAATTATAT GATAAGAATG GGCAAAATTT ATATCACTAA ATTTCAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0807--Transducer
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR029959--NPH3-like
IPR027356--NPH3_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB
PS51649--NPH3

Pfam

PF03000--NPH3

Gene Ontology

GO:0005886--C:plasma membrane
GO:0004871--F:signal transducer activity
GO:0009638--P:phototropism
GO:0016567--P:protein ubiquitination

KEGG

ath:AT5G64330

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000650	Aegilops tauschii	59.08	2.00e-109	388.00
IUUC-Atr-002432	Amborella trichopoda	66.89	0.00e+00	938.00
IUUC-Bdi-014840	Brachypodium distachyon	60.29	0.00e+00	791.00
IUUC-Bol-015226	Brassica oleracea	87.96	0.00e+00	1120.00
IUUC-Bra-017896	Brassica rapa	88.36	0.00e+00	1122.00
IUUC-Gma-043945	Glycine max	71.88	0.00e+00	949.00
IUUC-Hvu-047460	Hordeum vulgare	55.41	3.00e-122	431.00
IUUC-Lpe-051121	Leersia perrieri	64.72	5.00e-110	391.00
IUUC-Mcc-054999	Macaca mulatta	28.05	3.00e-02	32.00
IUUC-Mtr-058304	Medicago truncatula	70.28	0.00e+00	960.00
IUUC-Mac-064562	Musa acuminata	66.67	3.00e-113	401.00
IUUC-Oba-075302	Oryza barthii	53.70	2.00e-174	605.00
IUUC-Ogl-077256	Oryza glaberrima	58.55	0.00e+00	710.00
IUUC-Ogu-078733	Oryza glumaepatula	57.48	0.00e+00	685.00
IUUC-Oin-079386	Oryza indica	58.55	0.00e+00	704.00
IUUC-Ome-081226	Oryza meridionalis	58.13	0.00e+00	699.00
IUUC-Oni-083044	Oryza nivara	58.55	0.00e+00	704.00
IUUC-Opu-083760	Oryza punctata	56.58	0.00e+00	697.00
IUUC-Oru-084799	Oryza rufipogon	57.38	0.00e+00	685.00
IUUC-Osa-086084	Oryza sativa	58.41	0.00e+00	703.00
IUUC-Ola-086476	Oryzias latipes	23.42	1.70e-01	30.80
IUUC-Ppa-095360	Physcomitrella patens	45.40	8.00e-156	543.00
IUUC-Pop-099008	Populus trichocarpa	72.36	0.00e+00	993.00
IUUC-Ppe-101588	Prunus persica	71.01	0.00e+00	967.00
IUUC-Pgr-103598	Puccinia graminis	20.59	2.00e-02	32.00
IUUC-Smo-108896	Selaginella moellendorffii	48.12	7.00e-176	609.00
IUUC-Sit-109711	Setaria italica	65.16	7.00e-113	400.00
IUUC-Sly-110943	Solanum lycopersicum	71.43	0.00e+00	951.00
IUUC-Stu-112832	Solanum tuberosum	71.01	0.00e+00	945.00
IUUC-Sbi-114436	Sorghum bicolor	57.20	0.00e+00	767.00
IUUC-Tca-121395	Theobroma cacao	74.67	0.00e+00	951.00
IUUC-Tae-124007	Triticum aestivum	59.95	0.00e+00	820.00
IUUC-Tur-126447	Triticum urartu	38.65	3.00e-33	135.00
IUUC-Vvi-131223	Vitis vinifera	72.44	0.00e+00	988.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence