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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046871
Ensembl Protein ID ENSP00000418447.1
UniProt Accession P67775; P05323; P13197; PP2AA_HUMAN
Genbank Protein ID CAA31176.1; AAB38019.1; AAA36466.1; AAH00400.1; AAH02657.1; AAH19275.1; AAH31696.1
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; Replication protein C
Genbank Nucleotide ID X12646; J03804; M60483; BC000400; BC002657; BC019275; BC031696
Gene Name PPP2CA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000113575.9 ENST00000481195.5 ENSP00000418447.1
ENSG00000113575.9 ENST00000523082.1 ENSP00000428816.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 20092282
Organism Homo sapiens
Functional Description
(View)

Functional Description


     PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
 PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Protein Sequence
(Fasta)
MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046871|UBD,UIM|Homo sapiens
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Nucleotide Sequence
(Fasta)
CTTTTCCCCT CCGCTCCCCG CCGCCTCCTG ACGCCGGGCG TGACGTCACC ACGCCCGGCG 60
GCCGCCATTA CAGAGAGCCG AGCTCTGGAG CCTCAGCGAG CGGAGGAGGA GGCGCAGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046871|UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0464--Manganese
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR004843--Calcineurin-like_PHP_ApaH
IPR029052--Metallo-depent_PP-like
IPR006186--Ser/Thr-sp_prot-phosphatase
PROSITE

PS00125--SER_THR_PHOSPHATASE
Pfam

PF00149--Metallophos
PRINTS

PR00114--STPHPHTASE
SMART

SM00156--PP2Ac
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0015630--C:microtubule cytoskeleton
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000159--C:protein phosphatase type 2A complex
GO:0000922--C:spindle pole
GO:0046872--F:metal ion binding
GO:0004721--F:phosphoprotein phosphatase activity
GO:0006915--P:apoptotic process
GO:0006672--P:ceramide metabolic process
GO:0000188--P:inactivation of MAPK activity
GO:0051321--P:meiotic cell cycle
GO:0007498--P:mesoderm development
GO:0007084--P:mitotic nuclear envelope reassembly
GO:0030308--P:negative regulation of cell growth
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0006470--P:protein dephosphorylation
GO:0030155--P:regulation of cell adhesion
GO:0045595--P:regulation of cell differentiation
GO:0006275--P:regulation of DNA replication
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0030111--P:regulation of Wnt signaling pathway
GO:0010033--P:response to organic substance
GO:0008380--P:RNA splicing
GO:0019932--P:second-messenger-mediated signaling
KEGG hsa:5515
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000073 Aegilops tauschii 81.40 1.00e-153 535.00
IUUC-Aml-001862 Ailuropoda melanoleuca 100.00 0.00e+00 649.00
IUUC-Atr-002565 Amborella trichopoda 82.39 5.00e-155 540.00
IUUC-Apl-004163 Anas platyrhynchos 97.42 0.00e+00 633.00
IUUC-Aca-005038 Anolis carolinensis 99.03 0.00e+00 645.00
IUUC-Aly-005921 Arabidopsis lyrata 80.20 1.00e-153 535.00
IUUC-Ath-007164 Arabidopsis thaliana 80.20 2.00e-153 534.00
IUUC-Ame-010907 Astyanax mexicanus 99.03 0.00e+00 645.00
IUUC-Bgr-012186 Blumeria graminis 84.04 6.00e-159 553.00
IUUC-Bta-013583 Bos taurus 100.00 0.00e+00 649.00
IUUC-Bci-013884 Botrytis cinerea 85.02 8.00e-161 559.00
IUUC-Bdi-014993 Brachypodium distachyon 81.40 1.00e-153 535.00
IUUC-Bra-017702 Brassica rapa 80.20 2.00e-154 537.00
IUUC-Cja-019549 Callithrix jacchus 100.00 0.00e+00 649.00
IUUC-Cfa-020295 Canis familiaris 100.00 0.00e+00 649.00
IUUC-Cpo-022311 Cavia porcellus 100.00 0.00e+00 649.00
IUUC-Cre-022625 Chlamydomonas reinhardtii 78.43 8.00e-148 516.00
IUUC-Csa-023283 Chlorocebus sabaeus 100.00 0.00e+00 649.00
IUUC-Cin-025581 Ciona intestinalis 93.07 2.00e-173 601.00
IUUC-Csv-026026 Ciona savignyi 91.91 8.00e-152 529.00
IUUC-Cgl-026758 Colletotrichum gloeosporioides 84.69 1.00e-160 559.00
IUUC-Cne-026997 Cryptococcus neoformans 85.38 2.00e-160 558.00
IUUC-Cme-027101 Cyanidioschyzon merolae 82.52 5.00e-158 550.00
IUUC-Dre-027487 Danio rerio 97.41 0.00e+00 640.00
IUUC-Dno-028872 Dasypus novemcinctus 100.00 0.00e+00 649.00
IUUC-Ete-032859 Echinops telfairi 100.00 0.00e+00 649.00
IUUC-Fca-036395 Felis catus 100.00 0.00e+00 649.00
IUUC-Fal-036826 Ficedula albicollis 100.00 1.00e-166 578.00
IUUC-Fox-037783 Fusarium oxysporum 84.36 5.00e-161 560.00
IUUC-Fso-038215 Fusarium solani 84.69 4.00e-161 560.00
IUUC-Gmo-038520 Gadus morhua 96.43 9.00e-180 622.00
IUUC-Ggr-039745 Gaeumannomyces graminis 84.69 2.00e-160 558.00
IUUC-Gga-040663 Gallus gallus 99.03 0.00e+00 645.00
IUUC-Gac-042221 Gasterosteus aculeatus 96.44 0.00e+00 632.00
IUUC-Gma-042753 Glycine max 81.73 2.00e-154 538.00
IUUC-Ggo-044960 Gorilla gorilla 100.00 0.00e+00 649.00
IUUC-Itr-048646 Ictidomys tridecemlineatus 100.00 0.00e+00 649.00
IUUC-Kpa-049311 Komagataella pastoris 76.49 1.00e-143 502.00
IUUC-Lch-050295 Latimeria chalumnae 99.03 0.00e+00 646.00
IUUC-Lpe-051261 Leersia perrieri 81.40 8.00e-155 539.00
IUUC-Loc-052336 Lepisosteus oculatus 99.35 0.00e+00 647.00
IUUC-Lma-053211 Leptosphaeria maculans 84.69 3.00e-161 560.00
IUUC-Laf-053835 Loxodonta africana 100.00 0.00e+00 649.00
IUUC-Mcc-055756 Macaca mulatta 100.00 0.00e+00 649.00
IUUC-Meu-056068 Macropus eugenii 75.40 3.00e-130 457.00
IUUC-Mor-057272 Magnaporthe oryzae 84.69 9.00e-161 559.00
IUUC-Mpo-057478 Magnaporthe poae 84.69 1.00e-160 558.00
IUUC-Mtr-057736 Medicago truncatula 80.40 3.00e-152 530.00
IUUC-Mla-059001 Melampsora laricipopulina 85.15 2.00e-161 561.00
IUUC-Mga-059904 Meleagris gallopavo 97.24 3.00e-170 590.00
IUUC-Mvi-060467 Microbotryum violaceum 85.86 5.00e-162 563.00
IUUC-Mmr-060867 Microcebus murinus 100.00 0.00e+00 649.00
IUUC-Mdo-062353 Monodelphis domestica 100.00 0.00e+00 649.00
IUUC-Mmu-064204 Mus musculus 99.68 0.00e+00 648.00
IUUC-Mac-064924 Musa acuminata 82.72 7.00e-156 543.00
IUUC-Mpu-066183 Mustela putorius furo 100.00 0.00e+00 649.00
IUUC-Mlu-067115 Myotis lucifugus 99.68 0.00e+00 647.00
IUUC-Ncr-068958 Neurospora crassa 85.02 4.00e-161 560.00
IUUC-Nle-069365 Nomascus leucogenys 100.00 0.00e+00 649.00
IUUC-Opr-071012 Ochotona princeps 100.00 0.00e+00 649.00
IUUC-Ont-071469 Oreochromis niloticus 97.09 0.00e+00 635.00
IUUC-Oan-072869 Ornithorhynchus anatinus 95.55 1.00e-167 582.00
IUUC-Ocu-074394 Oryctolagus cuniculus 100.00 0.00e+00 649.00
IUUC-Oba-075432 Oryza barthii 81.06 7.00e-154 536.00
IUUC-Ogl-077436 Oryza glaberrima 82.39 9.00e-155 539.00
IUUC-Ogu-078351 Oryza glumaepatula 81.06 7.00e-154 536.00
IUUC-Oin-080218 Oryza indica 82.39 1.00e-154 538.00
IUUC-Olo-080223 Oryza longistaminata 82.39 9.00e-155 539.00
IUUC-Ome-081581 Oryza meridionalis 82.39 1.00e-154 538.00
IUUC-Oni-082094 Oryza nivara 82.39 1.00e-154 538.00
IUUC-Opu-083544 Oryza punctata 82.06 1.00e-154 538.00
IUUC-Oru-084975 Oryza rufipogon 82.39 1.00e-154 538.00
IUUC-Osa-085945 Oryza sativa 82.39 1.00e-154 538.00
IUUC-Ola-087141 Oryzias latipes 96.76 0.00e+00 634.00
IUUC-Oga-087919 Otolemur garnettii 100.00 0.00e+00 649.00
IUUC-Oar-089240 Ovis aries 100.00 1.00e-166 578.00
IUUC-Ptr-091367 Pan troglodytes 99.35 0.00e+00 643.00
IUUC-Pan-091956 Papio anubis 100.00 0.00e+00 649.00
IUUC-Psi-094099 Pelodiscus sinensis 98.05 0.00e+00 631.00
IUUC-Pma-094369 Petromyzon marinus 90.70 5.00e-89 319.00
IUUC-Pno-094872 Phaeosphaeria nodorum 78.00 6.00e-138 483.00
IUUC-Ppa-095520 Physcomitrella patens 84.05 1.00e-158 552.00
IUUC-Pfo-097359 Poecilia formosa 97.41 0.00e+00 636.00
IUUC-Pop-099210 Populus trichocarpa 81.73 1.00e-154 538.00
IUUC-Pca-100122 Procavia capensis 86.73 6.00e-155 540.00
IUUC-Ppe-101822 Prunus persica 81.40 2.00e-153 535.00
IUUC-Pva-102237 Pteropus vampyrus 89.64 2.00e-163 567.00
IUUC-Pgr-103259 Puccinia graminis 84.49 3.00e-160 557.00
IUUC-Pte-104116 Pyrenophora teres 84.69 5.00e-161 560.00
IUUC-Pyt-104768 Pyrenophora triticirepentis 84.69 5.00e-161 560.00
IUUC-Rno-104853 Rattus norvegicus 99.68 0.00e+00 648.00
IUUC-Sce-106338 Saccharomyces cerevisiae 76.16 1.00e-144 506.00
IUUC-Sha-107562 Sarcophilus harrisii 100.00 0.00e+00 650.00
IUUC-Sja-107705 Schizosaccharomyces japonicus 81.40 5.00e-154 536.00
IUUC-Spo-108240 Schizosaccharomyces pombe 80.07 3.00e-152 531.00
IUUC-Smo-109421 Selaginella moellendorffii 84.44 1.00e-158 552.00
IUUC-Sit-110313 Setaria italica 81.73 1.00e-154 538.00
IUUC-Sly-111492 Solanum lycopersicum 82.06 9.00e-155 539.00
IUUC-Stu-112108 Solanum tuberosum 82.06 9.00e-155 539.00
IUUC-Sar-113253 Sorex araneus 95.11 3.00e-174 604.00
IUUC-Sbi-114125 Sorghum bicolor 81.40 8.00e-154 536.00
IUUC-Sre-115054 Sporisorium reilianum 86.38 2.00e-161 561.00
IUUC-Tgu-117419 Taeniopygia guttata 99.03 0.00e+00 645.00
IUUC-Tru-117531 Takifugu rubripes 96.76 0.00e+00 633.00
IUUC-Tsy-119543 Tarsius syrichta 100.00 0.00e+00 649.00
IUUC-Tni-120904 Tetraodon nigroviridis 96.44 0.00e+00 630.00
IUUC-Tca-120941 Theobroma cacao 82.45 9.00e-155 539.00
IUUC-Tre-121939 Trichoderma reesei 83.06 3.00e-158 550.00
IUUC-Tvi-122516 Trichoderma virens 83.06 1.00e-158 552.00
IUUC-Tae-124897 Triticum aestivum 81.40 1.00e-153 535.00
IUUC-Tbe-127639 Tupaia belangeri 100.00 0.00e+00 649.00
IUUC-Ttr-128718 Tursiops truncatus 99.68 0.00e+00 649.00
IUUC-Uma-129470 Ustilago maydis 86.38 2.00e-161 561.00
IUUC-Vvi-131390 Vitis vinifera 81.73 3.00e-154 537.00
IUUC-Xtr-132784 Xenopus tropicalis 99.03 0.00e+00 645.00
IUUC-Xma-133450 Xiphophorus maculatus 96.44 0.00e+00 630.00
Created Date 25-Jun-2017

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