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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045777
UUCD1 version UUC-HoS-01076
Ensembl Protein ID ENSP00000282185.3
UniProt Accession Q9H0Y0; B2RE09; Q6PIX1; Q9H842; ATG10_HUMAN
Genbank Protein ID AAL55833.1; BAB14778.1; BAG38106.1; CAB66846.1; AAH29268.1
Protein Name Ubiquitin-like-conjugating enzyme ATG10; Autophagy-related protein 10
Genbank Nucleotide ID AF318326; AK024016; AK315752; AL136912; BC004551
Gene Name ATG10; APG10L; PP12616
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000152348.15 ENST00000355178.8 ENSP00000347309.4
ENSG00000152348.15 ENST00000282185.7 ENSP00000282185.3
ENSG00000152348.15 ENST00000504770.5 ENSP00000424236.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/Autophagy_C Autophagy_C 12482611; 18690009
Reviewed
Classification
Family Identity E-value Score Source Orthology
E2/Autophagy_C 40.14 3.00e-21 99.00 IUUC-Ath-006900
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.
 E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.
Protein Sequence
(Fasta)
MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI KNGSVMSHLG 60
ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV LYSCSYQVPV LYFRASFLDG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045777|E2,E2/Autophagy_C|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGCGCACG CTCCGACTCG GCCGTGGCGG ACCTGACTGA AGGAGGCCGC GGACCTGACT 60
GAAGGAGGCC ACGGCCACTT CTGGTTGGCC TCGGGGCGCG CTGGCTCGGC TCTTCCTCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045777|E2,E2/Autophagy_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR007135--Autophagy-rel_prot_3
Pfam

PF03987--Autophagy_act_C
Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0019777--F:Atg12 transferase activity
GO:0016874--F:ligase activity
GO:0006914--P:autophagy
GO:0016236--P:macroautophagy
GO:0034263--P:positive regulation of autophagy in response to ER overload
GO:0031401--P:positive regulation of protein modification process
GO:0006497--P:protein lipidation
GO:0032446--P:protein modification by small protein conjugation
GO:0015031--P:protein transport
KEGG hsa:83734
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001704 Ailuropoda melanoleuca 84.26 9.00e-100 355.00
IUUC-Atr-003167 Amborella trichopoda 37.88 3.00e-19 88.60
IUUC-Apl-003998 Anas platyrhynchos 73.48 3.00e-56 209.00
IUUC-Aca-005112 Anolis carolinensis 63.38 3.00e-78 284.00
IUUC-Aly-005641 Arabidopsis lyrata 43.86 2.00e-21 95.50
IUUC-Ath-006900 Arabidopsis thaliana 40.14 3.00e-22 98.60
IUUC-Ani-009502 Aspergillus nidulans 28.44 3.00e-11 62.00
IUUC-Ang-009573 Aspergillus niger 34.62 2.00e-03 35.00
IUUC-Ame-010764 Astyanax mexicanus 41.40 3.00e-39 155.00
IUUC-Bgr-012190 Blumeria graminis 29.06 3.00e-05 42.40
IUUC-Bta-012967 Bos taurus 84.93 5.00e-113 400.00
IUUC-Bci-013739 Botrytis cinerea 31.40 2.00e-06 45.80
IUUC-Bdi-014516 Brachypodium distachyon 33.15 3.00e-22 98.20
IUUC-Bol-015076 Brassica oleracea 41.09 5.00e-21 94.40
IUUC-Bra-017200 Brassica rapa 40.62 3.00e-21 95.10
IUUC-Cel-018371 Caenorhabditis elegans 29.51 1.00e-12 65.50
IUUC-Cja-019790 Callithrix jacchus 93.15 6.00e-122 429.00
IUUC-Cfa-020853 Canis familiaris 84.47 5.00e-100 357.00
IUUC-Cpo-022106 Cavia porcellus 74.77 2.00e-94 337.00
IUUC-Cre-022874 Chlamydomonas reinhardtii 39.76 2.00e-06 47.40
IUUC-Csa-023343 Chlorocebus sabaeus 94.91 7.00e-123 432.00
IUUC-Cho-024935 Choloepus hoffmanni 80.33 1.00e-87 315.00
IUUC-Cgl-026576 Colletotrichum gloeosporioides 28.30 5.00e-03 34.30
IUUC-Dre-028780 Danio rerio 48.42 3.00e-48 184.00
IUUC-Dno-029692 Dasypus novemcinctus 77.97 4.00e-47 180.00
IUUC-Dor-031022 Dipodomys ordii 69.91 1.00e-85 309.00
IUUC-Dse-031332 Dothistroma septosporum 30.00 5.00e-14 71.20
IUUC-Dme-032024 Drosophila melanogaster 35.83 5.00e-16 77.00
IUUC-Ete-032676 Echinops telfairi 62.67 4.00e-77 280.00
IUUC-Eca-034047 Equus caballus 86.11 1.00e-103 369.00
IUUC-Eeu-035295 Erinaceus europaeus 81.02 3.00e-95 340.00
IUUC-Fal-036966 Ficedula albicollis 58.72 2.00e-74 272.00
IUUC-Gmo-039001 Gadus morhua 52.31 2.00e-36 144.00
IUUC-Ggr-039885 Gaeumannomyces graminis 30.58 1.00e-06 46.60
IUUC-Gga-040185 Gallus gallus 61.64 5.00e-78 283.00
IUUC-Gac-042071 Gasterosteus aculeatus 43.40 7.00e-44 170.00
IUUC-Gma-043181 Glycine max 37.04 6.00e-22 97.80
IUUC-Ggo-044593 Gorilla gorilla 99.54 2.00e-131 460.00
IUUC-Hvu-047482 Hordeum vulgare 51.52 1.00e-03 33.90
IUUC-Itr-048920 Ictidomys tridecemlineatus 83.94 2.00e-104 371.00
IUUC-Lch-049914 Latimeria chalumnae 58.33 1.00e-63 236.00
IUUC-Lpe-051404 Leersia perrieri 45.07 2.00e-12 64.70
IUUC-Loc-051861 Lepisosteus oculatus 51.11 1.00e-12 65.90
IUUC-Laf-053966 Loxodonta africana 86.45 3.00e-109 387.00
IUUC-Mcc-055255 Macaca mulatta 95.11 1.00e-104 371.00
IUUC-Meu-056615 Macropus eugenii 52.29 4.00e-56 210.00
IUUC-Mor-057178 Magnaporthe oryzae 32.65 1.00e-06 47.00
IUUC-Mpo-057422 Magnaporthe poae 29.23 3.00e-08 52.00
IUUC-Mtr-058150 Medicago truncatula 42.54 1.00e-25 109.00
IUUC-Mla-059184 Melampsora laricipopulina 25.00 6.00e-06 44.70
IUUC-Mvi-060243 Microbotryum violaceum 31.34 2.00e-11 62.00
IUUC-Mmr-061555 Microcebus murinus 89.95 4.00e-118 416.00
IUUC-Mdo-062606 Monodelphis domestica 71.04 6.00e-91 327.00
IUUC-Mmu-064359 Mus musculus 80.37 2.00e-92 331.00
IUUC-Mac-065062 Musa acuminata 30.56 4.00e-26 111.00
IUUC-Mpu-066185 Mustela putorius furo 81.94 6.00e-108 382.00
IUUC-Mlu-067633 Myotis lucifugus 88.89 2.00e-116 411.00
IUUC-Ncr-068783 Neurospora crassa 31.03 3.00e-05 42.40
IUUC-Nle-069792 Nomascus leucogenys 96.80 2.00e-127 447.00
IUUC-Opr-070828 Ochotona princeps 78.14 1.00e-93 335.00
IUUC-Ont-072408 Oreochromis niloticus 39.49 5.00e-36 144.00
IUUC-Oan-073123 Ornithorhynchus anatinus 61.54 5.00e-40 156.00
IUUC-Ocu-074327 Oryctolagus cuniculus 81.40 1.00e-87 315.00
IUUC-Oba-075315 Oryza barthii 31.84 1.00e-20 93.20
IUUC-Obr-076063 Oryza brachyantha 33.70 4.00e-17 81.60
IUUC-Ogl-077277 Oryza glaberrima 32.66 7.00e-24 103.00
IUUC-Ogu-078842 Oryza glumaepatula 32.66 2.00e-23 102.00
IUUC-Oin-079297 Oryza indica 32.98 1.00e-23 102.00
IUUC-Olo-081058 Oryza longistaminata 44.64 1.00e-22 102.00
IUUC-Ome-081362 Oryza meridionalis 44.64 2.00e-22 100.00
IUUC-Oni-082277 Oryza nivara 42.86 2.00e-22 99.80
IUUC-Opu-083144 Oryza punctata 38.06 4.00e-22 98.60
IUUC-Oru-084588 Oryza rufipogon 32.98 1.00e-23 103.00
IUUC-Osa-085909 Oryza sativa 42.86 1.00e-22 99.40
IUUC-Ola-086810 Oryzias latipes 43.75 1.00e-47 183.00
IUUC-Oga-088788 Otolemur garnettii 85.91 2.00e-110 391.00
IUUC-Oar-090294 Ovis aries 84.02 3.00e-107 380.00
IUUC-Ptr-091440 Pan troglodytes 99.54 3.00e-131 460.00
IUUC-Pan-092548 Papio anubis 95.37 8.00e-123 432.00
IUUC-Psi-093686 Pelodiscus sinensis 68.52 2.00e-84 305.00
IUUC-Pno-095119 Phaeosphaeria nodorum 31.97 6.00e-11 60.80
IUUC-Pfo-096393 Poecilia formosa 39.13 5.00e-39 154.00
IUUC-Pab-098259 Pongo abelii 99.09 1.00e-130 458.00
IUUC-Pop-099545 Populus trichocarpa 45.45 6.00e-26 110.00
IUUC-Pca-100480 Procavia capensis 80.56 2.00e-72 264.00
IUUC-Ppe-101846 Prunus persica 43.65 2.00e-26 112.00
IUUC-Pva-102978 Pteropus vampyrus 85.65 3.00e-105 374.00
IUUC-Pgr-103285 Puccinia graminis 27.59 1.00e-04 40.00
IUUC-Ptt-103807 Puccinia triticina 24.27 2.00e-08 52.80
IUUC-Rno-105831 Rattus norvegicus 78.97 6.00e-100 356.00
IUUC-Sha-106651 Sarcophilus harrisii 69.37 9.00e-90 322.00
IUUC-Sja-107966 Schizosaccharomyces japonicus 28.21 4.00e-05 41.20
IUUC-Ssl-108417 Sclerotinia sclerotiorum 26.19 1.10e-01 30.80
IUUC-Smo-108811 Selaginella moellendorffii 27.78 6.00e-08 50.80
IUUC-Sit-110057 Setaria italica 38.84 4.00e-21 94.40
IUUC-Sly-111795 Solanum lycopersicum 36.36 2.00e-24 105.00
IUUC-Stu-112168 Solanum tuberosum 37.78 1.00e-23 103.00
IUUC-Sar-113345 Sorex araneus 84.26 9.00e-106 375.00
IUUC-Sbi-114155 Sorghum bicolor 33.49 1.00e-24 106.00
IUUC-Sre-115068 Sporisorium reilianum 21.54 5.00e-04 38.10
IUUC-Ssc-116014 Sus scrofa 85.19 2.00e-37 146.00
IUUC-Tgu-117288 Taeniopygia guttata 61.35 8.00e-75 272.00
IUUC-Tru-117563 Takifugu rubripes 38.22 1.00e-29 122.00
IUUC-Tsy-119051 Tarsius syrichta 63.89 6.00e-78 283.00
IUUC-Tni-120201 Tetraodon nigroviridis 42.52 7.00e-42 163.00
IUUC-Tca-121733 Theobroma cacao 37.12 4.00e-20 91.70
IUUC-Tre-121999 Trichoderma reesei 25.86 3.00e-05 41.60
IUUC-Tvi-122677 Trichoderma virens 26.52 1.00e-05 43.10
IUUC-Tae-123626 Triticum aestivum 33.89 5.00e-23 100.00
IUUC-Tur-126141 Triticum urartu 60.00 1.00e-03 34.70
IUUC-Tbe-127590 Tupaia belangeri 85.84 8.00e-112 395.00
IUUC-Ttr-128638 Tursiops truncatus 83.56 5.00e-110 390.00
IUUC-Uma-129378 Ustilago maydis 22.56 6.00e-05 41.20
IUUC-Vda-129872 Verticillium dahliae 32.14 1.00e-03 36.60
IUUC-Vpa-130149 Vicugna pacos 84.72 8.00e-106 375.00
IUUC-Vvi-131240 Vitis vinifera 38.06 2.00e-22 99.40
IUUC-Xma-133582 Xiphophorus maculatus 36.92 2.00e-36 145.00
IUUC-Yli-134414 Yarrowia lipolytica 33.64 1.00e-09 55.10
Created Date 25-Jun-2017

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