• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106240
UUCD1 version UUC-SaC-00039
Ensembl Protein ID YGL003C
UniProt Accession P53197; D6VUD5; CDH1_YEAST
Genbank Protein ID CAA96703.1; AAT93097.1; DAA08096.1
Protein Name APC/C activator protein CDH1; CDC20 homolog 1; Homolog of CDC twenty 1
Genbank Nucleotide ID Z72525; AY693078; BK006941
Gene Name CDH1; HCT1; YGL003C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGL003C YGL003C YGL003C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 18500339; 17406666; 19285942; 18172166; 19336465; 17535428; 12456658; 12737808
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.00e-20 70.0 384 413
E3 adaptor/Cullin RING/APC_C/CDC20 1.00e-138 460.1 251 551
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           Ht +v++l++   d+ l+sG++D++++v++
   Q: 384  HTQEVCGLKWnvADNKLASGGNDNVVHVYE 413
           9*********99779*************98 PP
   

   E3 adaptor/Cullin RING/APC_C/CDC20
   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltghsarvgaL 102
           p++vldap+l+ddfy++L+dWss++vlavaLg+s++l++++tgdv++l+d+ e+++ ts+swi +g++lavG+++g veiyDv+++k++rtl+gh++rv++L
   Q: 251  PYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDT-ENEY-TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACL 350
           79************************************************9.6777.9******************************************** PP
   S: 103  sWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavkaiawsPwqkslLasGGGtaDr 204
           sWn++vl+sGsrd++ilhrdvr+++  ++t+++h+qevCGlkwn ++++LasGGnDn+v+v++ +s++P+ +f+ehkaavka+awsP+++++La+GGGtaDr
   Q: 351  SWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADR 452
           ****************************************************************************************************** PP
   S: 205  cikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaagDetlrfwklfdkkkak 303
           ++k+wn++t+ ++++id+gsq+c+++wsk+++elv++hG++++++tlw+++s++ +a lkgh++Rvl+l+ls+dg+++v++agDetlr+wklfdk kak
   Q: 453  RLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDKPKAK 551
           **********************************************************************************************98865 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.
 Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.
Protein Sequence
(Fasta)
MSTNLNPFMN NTPSSSPLKG SESKRVSKRP ISSSSSASLL SSPSRRSRPS TVYGDRYIPS 60
RTDIDFNSIV SISSMASVPA LNPSSTEDQV EYQKERQAHE TYNTLLKNEL FGEMLSKDTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106240|E3,CDC20;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCCACAA ACCTGAACCC ATTCATGAAT AATACGCCTT CCTCCTCCCC ACTCAAGGGT 60
TCTGAAAGTA AGAGGGTATC GAAAAGGCCA ATATCTAGTT CTTCGTCCGC CTCACTATTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106240|E3,CDC20;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0010997--F:anaphase-promoting complex binding
GO:0030332--F:cyclin binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0051301--P:cell division
GO:1902426--P:deactivation of mitotic spindle assembly checkpoint
GO:0007067--P:mitotic nuclear division
GO:0010697--P:negative regulation of spindle pole body separation
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
KEGG sce:YGL003C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000670 Aegilops tauschii 45.94 2.00e-85 307.00
IUUC-Aml-002003 Ailuropoda melanoleuca 48.85 4.00e-95 339.00
IUUC-Atr-002753 Amborella trichopoda 44.30 6.00e-90 322.00
IUUC-Apl-003212 Anas platyrhynchos 38.92 8.00e-96 342.00
IUUC-Aca-004920 Anolis carolinensis 45.45 8.00e-79 285.00
IUUC-Aly-005442 Arabidopsis lyrata 48.80 6.00e-96 342.00
IUUC-Ath-006938 Arabidopsis thaliana 48.20 7.00e-95 338.00
IUUC-Ago-007784 Ashbya gossypii 62.99 0.00e+00 721.00
IUUC-Acl-008269 Aspergillus clavatus 42.32 2.00e-116 410.00
IUUC-Afl-008432 Aspergillus flavus 41.65 3.00e-116 410.00
IUUC-Afu-008829 Aspergillus fumigatus 43.25 2.00e-117 414.00
IUUC-Ani-009471 Aspergillus nidulans 42.35 1.00e-116 411.00
IUUC-Ang-009711 Aspergillus niger 41.57 4.00e-112 396.00
IUUC-Aor-010118 Aspergillus oryzae 41.65 3.00e-116 410.00
IUUC-Ate-010534 Aspergillus terreus 41.87 4.00e-116 409.00
IUUC-Ame-011773 Astyanax mexicanus 47.54 1.00e-95 341.00
IUUC-Bgr-012013 Blumeria graminis 42.20 5.00e-113 399.00
IUUC-Bta-012586 Bos taurus 38.92 7.00e-96 342.00
IUUC-Bci-013807 Botrytis cinerea 41.81 1.00e-107 381.00
IUUC-Bdi-014981 Brachypodium distachyon 50.83 4.00e-93 333.00
IUUC-Bol-016301 Brassica oleracea 48.19 8.00e-96 342.00
IUUC-Bra-017453 Brassica rapa 48.19 1.00e-95 341.00
IUUC-Cel-018472 Caenorhabditis elegans 47.85 5.00e-93 333.00
IUUC-Cja-019929 Callithrix jacchus 39.16 4.00e-96 343.00
IUUC-Cfa-020977 Canis familiaris 39.16 4.00e-96 343.00
IUUC-Cpo-021537 Cavia porcellus 38.92 3.00e-96 343.00
IUUC-Cre-022701 Chlamydomonas reinhardtii 44.65 9.00e-82 295.00
IUUC-Csa-023389 Chlorocebus sabaeus 38.92 3.00e-96 343.00
IUUC-Cho-024920 Choloepus hoffmanni 48.21 4.00e-31 127.00
IUUC-Cin-025327 Ciona intestinalis 46.24 2.00e-89 320.00
IUUC-Csv-025921 Ciona savignyi 45.92 4.00e-91 326.00
IUUC-Cgl-026631 Colletotrichum gloeosporioides 43.11 2.00e-116 410.00
IUUC-Cne-026933 Cryptococcus neoformans 44.88 8.00e-103 365.00
IUUC-Cme-027143 Cyanidioschyzon merolae 47.54 5.00e-92 330.00
IUUC-Dre-027470 Danio rerio 48.50 1.00e-91 327.00
IUUC-Dno-029629 Dasypus novemcinctus 49.50 9.00e-84 302.00
IUUC-Dor-030187 Dipodomys ordii 47.99 3.00e-93 333.00
IUUC-Dse-031502 Dothistroma septosporum 40.28 3.00e-105 373.00
IUUC-Dme-031858 Drosophila melanogaster 39.08 2.00e-97 347.00
IUUC-Ete-032387 Echinops telfairi 40.38 3.00e-71 260.00
IUUC-Eca-034210 Equus caballus 39.11 2.00e-96 343.00
IUUC-Eeu-035059 Erinaceus europaeus 38.99 8.00e-63 232.00
IUUC-Fca-035839 Felis catus 48.55 4.00e-95 339.00
IUUC-Fal-036895 Ficedula albicollis 38.92 6.00e-96 342.00
IUUC-Fox-037814 Fusarium oxysporum 52.72 2.00e-103 367.00
IUUC-Fso-038420 Fusarium solani 42.86 9.00e-113 398.00
IUUC-Gmo-039544 Gadus morhua 48.07 2.00e-91 327.00
IUUC-Ggr-039774 Gaeumannomyces graminis 44.27 3.00e-117 413.00
IUUC-Gga-041025 Gallus gallus 38.92 6.00e-96 342.00
IUUC-Gac-041279 Gasterosteus aculeatus 48.42 2.00e-94 337.00
IUUC-Gma-042657 Glycine max 47.46 9.00e-92 328.00
IUUC-Ggo-045599 Gorilla gorilla 48.81 2.00e-92 330.00
IUUC-Hsa-046695 Homo sapiens 39.16 3.00e-96 343.00
IUUC-Hvu-047476 Hordeum vulgare 42.73 1.00e-82 298.00
IUUC-Itr-048192 Ictidomys tridecemlineatus 38.54 6.00e-96 342.00
IUUC-Kpa-049239 Komagataella pastoris 44.26 3.00e-126 443.00
IUUC-Lch-049827 Latimeria chalumnae 48.80 6.00e-93 332.00
IUUC-Lpe-051568 Leersia perrieri 45.85 2.00e-80 290.00
IUUC-Loc-052856 Lepisosteus oculatus 48.50 3.00e-92 330.00
IUUC-Laf-053742 Loxodonta africana 44.97 4.00e-78 283.00
IUUC-Mcc-055601 Macaca mulatta 38.92 3.00e-96 343.00
IUUC-Meu-056276 Macropus eugenii 44.89 1.00e-83 301.00
IUUC-Mor-057113 Magnaporthe oryzae 41.96 1.00e-111 394.00
IUUC-Mpo-057599 Magnaporthe poae 44.51 9.00e-115 405.00
IUUC-Mtr-057689 Medicago truncatula 48.06 4.00e-92 329.00
IUUC-Mla-059048 Melampsora laricipopulina 38.99 1.00e-91 328.00
IUUC-Mga-060097 Meleagris gallopavo 37.24 3.00e-86 310.00
IUUC-Mvi-060465 Microbotryum violaceum 51.00 4.00e-107 379.00
IUUC-Mmr-061615 Microcebus murinus 45.51 7.00e-79 285.00
IUUC-Mdo-063062 Monodelphis domestica 38.92 8.00e-96 342.00
IUUC-Mmu-063731 Mus musculus 39.11 4.00e-96 342.00
IUUC-Mac-064942 Musa acuminata 48.87 7.00e-92 328.00
IUUC-Mpu-066173 Mustela putorius furo 38.92 2.00e-96 343.00
IUUC-Mlu-068030 Myotis lucifugus 39.16 5.00e-96 342.00
IUUC-Nfi-068536 Neosartorya fischeri 43.06 3.00e-117 413.00
IUUC-Ncr-068734 Neurospora crassa 42.17 4.00e-113 399.00
IUUC-Nle-070163 Nomascus leucogenys 38.92 3.00e-96 343.00
IUUC-Opr-070974 Ochotona princeps 47.60 3.00e-72 262.00
IUUC-Ont-072507 Oreochromis niloticus 38.77 2.00e-97 347.00
IUUC-Oan-073677 Ornithorhynchus anatinus 41.53 1.00e-80 291.00
IUUC-Ocu-073797 Oryctolagus cuniculus 44.55 4.00e-78 283.00
IUUC-Oba-075417 Oryza barthii 47.18 2.00e-81 294.00
IUUC-Obr-076123 Oryza brachyantha 50.17 1.00e-90 325.00
IUUC-Ogl-077294 Oryza glaberrima 49.83 4.00e-90 323.00
IUUC-Ogu-077996 Oryza glumaepatula 49.83 4.00e-90 323.00
IUUC-Oin-080172 Oryza indica 49.83 4.00e-90 322.00
IUUC-Olo-081068 Oryza longistaminata 49.83 4.00e-90 322.00
IUUC-Ome-081250 Oryza meridionalis 49.83 4.00e-90 323.00
IUUC-Oni-083048 Oryza nivara 49.83 4.00e-90 323.00
IUUC-Opu-083333 Oryza punctata 49.51 3.00e-90 323.00
IUUC-Oru-085001 Oryza rufipogon 49.83 4.00e-90 323.00
IUUC-Osa-086243 Oryza sativa 49.83 4.00e-90 323.00
IUUC-Ola-087094 Oryzias latipes 47.79 1.00e-91 327.00
IUUC-Olu-087647 Ostreococcus lucimarinus 47.19 2.00e-88 317.00
IUUC-Oga-088911 Otolemur garnettii 38.92 6.00e-96 342.00
IUUC-Oar-089508 Ovis aries 38.92 7.00e-96 342.00
IUUC-Ptr-090935 Pan troglodytes 45.28 1.00e-78 284.00
IUUC-Pan-092147 Papio anubis 39.16 3.00e-96 343.00
IUUC-Psi-093702 Pelodiscus sinensis 38.85 4.00e-95 339.00
IUUC-Pma-094581 Petromyzon marinus 48.86 3.00e-94 337.00
IUUC-Pno-095139 Phaeosphaeria nodorum 45.77 3.00e-88 317.00
IUUC-Ppa-095518 Physcomitrella patens 40.28 3.00e-101 360.00
IUUC-Pfo-096309 Poecilia formosa 48.07 1.00e-91 327.00
IUUC-Pab-098603 Pongo abelii 45.28 1.00e-78 285.00
IUUC-Pop-098924 Populus trichocarpa 47.58 6.00e-91 325.00
IUUC-Pca-100565 Procavia capensis 48.67 6.00e-93 332.00
IUUC-Ppe-101924 Prunus persica 38.77 4.00e-92 329.00
IUUC-Pva-102602 Pteropus vampyrus 48.41 3.00e-91 327.00
IUUC-Pgr-103466 Puccinia graminis 40.43 6.00e-97 346.00
IUUC-Ptt-103888 Puccinia triticina 44.63 5.00e-83 299.00
IUUC-Pte-104097 Pyrenophora teres 37.97 2.00e-107 380.00
IUUC-Pyt-104445 Pyrenophora triticirepentis 36.72 2.00e-96 344.00
IUUC-Rno-105028 Rattus norvegicus 39.11 3.00e-96 343.00
IUUC-Sha-106538 Sarcophilus harrisii 43.19 1.00e-85 308.00
IUUC-Sja-107785 Schizosaccharomyces japonicus 39.01 3.00e-105 373.00
IUUC-Spo-108369 Schizosaccharomyces pombe 41.21 6.00e-102 362.00
IUUC-Ssl-108391 Sclerotinia sclerotiorum 43.06 3.00e-111 393.00
IUUC-Smo-108878 Selaginella moellendorffii 40.87 1.00e-101 361.00
IUUC-Sit-110563 Setaria italica 49.84 3.00e-86 310.00
IUUC-Sly-111560 Solanum lycopersicum 47.69 8.00e-90 322.00
IUUC-Stu-112835 Solanum tuberosum 47.44 7.00e-89 318.00
IUUC-Sar-113092 Sorex araneus 43.03 1.00e-71 261.00
IUUC-Sbi-114489 Sorghum bicolor 48.40 5.00e-86 309.00
IUUC-Sre-115222 Sporisorium reilianum 40.41 2.00e-109 387.00
IUUC-Ssc-116171 Sus scrofa 38.92 6.00e-96 342.00
IUUC-Tgu-117100 Taeniopygia guttata 45.00 7.00e-85 305.00
IUUC-Tru-118222 Takifugu rubripes 48.38 1.00e-91 328.00
IUUC-Tsy-118931 Tarsius syrichta 36.18 3.00e-49 187.00
IUUC-Tni-119863 Tetraodon nigroviridis 48.07 2.00e-91 327.00
IUUC-Tca-121599 Theobroma cacao 50.16 2.00e-91 327.00
IUUC-Tre-122249 Trichoderma reesei 43.08 5.00e-115 405.00
IUUC-Tvi-122675 Trichoderma virens 42.66 7.00e-115 405.00
IUUC-Tae-123489 Triticum aestivum 50.49 2.00e-94 337.00
IUUC-Tur-126193 Triticum urartu 43.20 7.00e-81 292.00
IUUC-Tme-127151 Tuber melanosporum 42.23 2.00e-119 420.00
IUUC-Tbe-128056 Tupaia belangeri 45.51 6.00e-72 261.00
IUUC-Ttr-129055 Tursiops truncatus 39.31 1.00e-95 341.00
IUUC-Uma-129555 Ustilago maydis 39.55 5.00e-107 379.00
IUUC-Vda-130027 Verticillium dahliae 42.89 2.00e-112 397.00
IUUC-Vpa-130775 Vicugna pacos 37.93 2.00e-50 191.00
IUUC-Vvi-131749 Vitis vinifera 44.24 4.00e-92 329.00
IUUC-Xtr-132808 Xenopus tropicalis 39.73 4.00e-96 343.00
IUUC-Xma-133183 Xiphophorus maculatus 48.07 1.00e-91 327.00
IUUC-Yli-134584 Yarrowia lipolytica 43.79 2.00e-124 437.00
IUUC-Zma-135717 Zea mays 48.40 1.00e-85 308.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved