• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046737
Ensembl Protein ID ENSP00000364550.3
UniProt Accession P41229; B0QZ44; B4E3I2; F5H3T1; Q5JUX3; Q5JUX4; Q5JUX5; Q7Z5S5; KDM5C_HUMAN
Genbank Protein ID AAA61302.1; BAG65494.1; CAI39836.1; CAI39837.1; CAI39838.1; EAW93145.1; AAH54499.1; CAA82758.1
Protein Name Lysine-specific demethylase 5C; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169
Genbank Nucleotide ID L25270; AK304732; AL139396; AL139396; AL139396; CH471154; BC054499; Z29650
Gene Name KDM5C; DXS1272E; JARID1C; SMCX; XE169
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000126012.11 ENST00000375401.7 ENSP00000364550.3
ENSG00000126012.11 ENST00000404049.7 ENSP00000385394.3
ENSG00000126012.11 ENST00000375379.7 ENSP00000364528.3
ENSG00000126012.11 ENST00000375383.7 ENSP00000364532.3
ENSG00000126012.11 ENST00000429877.5 ENSP00000409757.1
ENSG00000126012.11 ENST00000428012.1 ENSP00000407277.1
ENSG00000126012.11 ENST00000349663.6 ENSP00000344004.6
ENSG00000126012.11 ENST00000452825.7 ENSP00000445176.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 4.00e-14 54.2 326 372
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           vC +C +g+ed+ +l+ C+ C++++H  Cl ++  +e p+   w CpkC 
   Q: 326  VCRMCSRGDEDD-KLLLCDGCDDNYHIFCLLPP-LPEIPKGV-WRCPKCV 372
           8*********88.6*******************.*******8.******6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Protein Sequence
(Fasta)
MEPGSDDFLP PPECPVFEPS WAEFRDPLGY IAKIRPIAEK SGICKIRPPA DWQPPFAVEV 60
DNFRFTPRIQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL KIPNVERRIL DLYSLSKIVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046737|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTGTTCCTC CGCCGTTGCA ATGAACTATT TTCTCTCAGT CCGGGGTGGT ACTTTTGAGT 60
AACCCCTTCC AAATAGAAAC CCATACCAGC CTATTTAGCT CGGTCTCCAC TATATGAAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046737|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0225--Disease mutation
KW-0408--Iron
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
SMART

SM00501--BRIGHT
SM00558--JmjC
SM00545--JmjN
SM00249--PHD
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0034720--P:histone H3-K4 demethylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0009636--P:response to toxic substance
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated
KEGG hsa:8242
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001327 Ailuropoda melanoleuca 97.81 0.00e+00 2670.00
IUUC-Aca-004712 Anolis carolinensis 80.02 0.00e+00 2008.00
IUUC-Afl-008625 Aspergillus flavus 30.22 4.00e-112 400.00
IUUC-Afu-008796 Aspergillus fumigatus 31.43 7.00e-116 412.00
IUUC-Aor-010155 Aspergillus oryzae 30.22 4.00e-112 400.00
IUUC-Bta-013099 Bos taurus 96.26 0.00e+00 2610.00
IUUC-Bci-013992 Botrytis cinerea 30.51 6.00e-108 386.00
IUUC-Cja-018723 Callithrix jacchus 95.24 0.00e+00 2615.00
IUUC-Cfa-020954 Canis familiaris 97.98 0.00e+00 2603.00
IUUC-Cpo-021718 Cavia porcellus 97.96 0.00e+00 1371.00
IUUC-Csa-023946 Chlorocebus sabaeus 98.61 0.00e+00 2638.00
IUUC-Dre-028238 Danio rerio 63.09 0.00e+00 1857.00
IUUC-Dno-029435 Dasypus novemcinctus 94.61 0.00e+00 2611.00
IUUC-Dor-030226 Dipodomys ordii 90.58 0.00e+00 1803.00
IUUC-Dse-031479 Dothistroma septosporum 29.85 2.00e-119 424.00
IUUC-Eca-033834 Equus caballus 97.10 0.00e+00 2700.00
IUUC-Eeu-034692 Erinaceus europaeus 95.12 0.00e+00 2025.00
IUUC-Fca-035766 Felis catus 94.83 0.00e+00 2515.00
IUUC-Fox-037694 Fusarium oxysporum 32.28 1.00e-100 361.00
IUUC-Fso-038127 Fusarium solani 30.67 8.00e-116 412.00
IUUC-Gac-041825 Gasterosteus aculeatus 64.24 0.00e+00 1781.00
IUUC-Ggo-045492 Gorilla gorilla 99.81 0.00e+00 2766.00
IUUC-Itr-048348 Ictidomys tridecemlineatus 97.81 0.00e+00 2762.00
IUUC-Lch-050517 Latimeria chalumnae 75.07 0.00e+00 2098.00
IUUC-Laf-054098 Loxodonta africana 88.91 0.00e+00 2369.00
IUUC-Mcc-055740 Macaca mulatta 99.29 0.00e+00 2748.00
IUUC-Meu-056643 Macropus eugenii 84.85 0.00e+00 2281.00
IUUC-Mtr-058113 Medicago truncatula 32.79 3.00e-97 351.00
IUUC-Mmr-061032 Microcebus murinus 98.38 0.00e+00 2639.00
IUUC-Mdo-062754 Monodelphis domestica 81.37 0.00e+00 2205.00
IUUC-Mmu-063943 Mus musculus 95.16 0.00e+00 2678.00
IUUC-Mpu-066800 Mustela putorius furo 97.03 0.00e+00 2671.00
IUUC-Mlu-067109 Myotis lucifugus 96.44 0.00e+00 2645.00
IUUC-Nfi-068430 Neosartorya fischeri 31.33 3.00e-113 404.00
IUUC-Ncr-068763 Neurospora crassa 28.40 9.00e-141 495.00
IUUC-Nle-069569 Nomascus leucogenys 99.56 0.00e+00 2628.00
IUUC-Ont-072274 Oreochromis niloticus 65.94 0.00e+00 1837.00
IUUC-Oan-073160 Ornithorhynchus anatinus 86.42 0.00e+00 2276.00
IUUC-Ocu-074440 Oryctolagus cuniculus 98.00 0.00e+00 2667.00
IUUC-Oin-079273 Oryza indica 37.84 1.00e-13 69.30
IUUC-Ola-087059 Oryzias latipes 66.21 0.00e+00 1871.00
IUUC-Oga-088191 Otolemur garnettii 97.54 0.00e+00 2708.00
IUUC-Oar-090027 Ovis aries 96.32 0.00e+00 2611.00
IUUC-Pan-091829 Papio anubis 98.84 0.00e+00 2733.00
IUUC-Pma-094137 Petromyzon marinus 52.11 0.00e+00 1379.00
IUUC-Pno-094879 Phaeosphaeria nodorum 29.69 4.00e-114 407.00
IUUC-Pfo-096645 Poecilia formosa 65.37 0.00e+00 1794.00
IUUC-Pab-097582 Pongo abelii 96.20 0.00e+00 2400.00
IUUC-Pca-100446 Procavia capensis 93.68 0.00e+00 2608.00
IUUC-Ppe-101504 Prunus persica 32.56 2.00e-103 371.00
IUUC-Pva-102553 Pteropus vampyrus 94.28 0.00e+00 1637.00
IUUC-Sha-106769 Sarcophilus harrisii 88.13 0.00e+00 2129.00
IUUC-Ssl-108489 Sclerotinia sclerotiorum 30.72 1.00e-118 422.00
IUUC-Sre-115161 Sporisorium reilianum 30.42 4.00e-133 470.00
IUUC-Ssc-116354 Sus scrofa 98.07 0.00e+00 2738.00
IUUC-Tru-117667 Takifugu rubripes 65.40 0.00e+00 1655.00
IUUC-Tni-119920 Tetraodon nigroviridis 64.50 0.00e+00 1790.00
IUUC-Tca-121478 Theobroma cacao 32.40 3.00e-106 381.00
IUUC-Tre-122213 Trichoderma reesei 29.45 1.00e-109 392.00
IUUC-Tbe-128040 Tupaia belangeri 99.28 0.00e+00 1085.00
IUUC-Ttr-128979 Tursiops truncatus 97.68 0.00e+00 2687.00
IUUC-Vpa-130433 Vicugna pacos 99.36 0.00e+00 1809.00
IUUC-Vvi-131071 Vitis vinifera 32.27 7.00e-86 313.00
IUUC-Xtr-132324 Xenopus tropicalis 68.45 0.00e+00 1908.00
IUUC-Xma-134315 Xiphophorus maculatus 64.68 0.00e+00 1843.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved