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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106182
Ensembl Protein ID YDL120W
UniProt Accession Q07540; D6VRN0; FRDA_YEAST
Genbank Protein ID CAA98688.1; AAS56486.1; DAA11740.1
Protein Name Frataxin homolog, mitochondrial; Frataxin homolog intermediate form
Genbank Nucleotide ID Z74168; AY558160; BK006938
Gene Name YFH1; YDL120W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDL120W YDL120W YDL120W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 49.30 4.00e-14 75.10 IUUC-Hsa-046921
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.
 Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.
Protein Sequence
(Fasta)
MIKRSLASLV RVSSVMGRRY MIAAAGGERA RFCPAVTNKK NHTVNTFQKR FVESSTDGQV 60
VPQEVLNLPL EKYHEEADDY LDHLLDSLEE LSEAHPDCIP DVELSHGVMT LEIPAFGTYV 120
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Protein Fasta Sequence


>IUUC-Sce-106182|UBD,UBD/Other/Other|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGATTAAGC GGTCTCTCGC AAGTTTAGTT CGAGTCAGCT CTGTAATGGG CAGAAGATAT 60
ATGATAGCAG CGGCAGGAGG AGAACGTGCC AGATTTTGTC CAGCTGTAAC AAATAAAAAG 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106182|UBD,UBD/Other/Other|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0350--Heme biosynthesis
KW-0406--Ion transport
KW-0408--Iron
KW-0409--Iron storage
KW-0410--Iron transport
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport
Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS
PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2
Pfam

PF01491--Frataxin_Cyay
SMART

SM01219--Frataxin_Cyay
Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0006879--P:cellular iron ion homeostasis
GO:0034599--P:cellular response to oxidative stress
GO:0006749--P:glutathione metabolic process
GO:0006783--P:heme biosynthetic process
GO:0006811--P:ion transport
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0016226--P:iron-sulfur cluster assembly
GO:0006121--P:mitochondrial electron transport, succinate to ubiquinone
GO:0007005--P:mitochondrion organization
GO:0006626--P:protein targeting to mitochondrion
GO:0010040--P:response to iron(II) ion
GO:0006979--P:response to oxidative stress
KEGG sce:YDL120W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002122 Ailuropoda melanoleuca 42.57 3.00e-17 79.30
IUUC-Apl-003853 Anas platyrhynchos 41.58 1.00e-16 76.30
IUUC-Aca-005026 Anolis carolinensis 40.00 1.00e-16 76.60
IUUC-Aly-006200 Arabidopsis lyrata 38.89 4.00e-15 72.00
IUUC-Ath-007033 Arabidopsis thaliana 42.47 2.00e-15 73.60
IUUC-Ago-007707 Ashbya gossypii 57.27 6.00e-37 143.00
IUUC-Acl-008146 Aspergillus clavatus 38.22 4.00e-24 102.00
IUUC-Afl-008501 Aspergillus flavus 42.57 2.00e-19 87.00
IUUC-Afu-008851 Aspergillus fumigatus 42.74 7.00e-24 101.00
IUUC-Ani-009129 Aspergillus nidulans 37.84 9.00e-19 84.70
IUUC-Ang-009557 Aspergillus niger 40.17 3.00e-23 99.80
IUUC-Ate-010486 Aspergillus terreus 33.33 6.00e-24 101.00
IUUC-Bgr-012108 Blumeria graminis 47.06 3.00e-24 102.00
IUUC-Bta-013437 Bos taurus 41.58 8.00e-17 78.20
IUUC-Bci-013810 Botrytis cinerea 44.80 9.00e-21 91.30
IUUC-Bdi-014226 Brachypodium distachyon 43.56 8.00e-21 91.30
IUUC-Bol-015092 Brassica oleracea 41.10 5.00e-15 72.00
IUUC-Bra-017945 Brassica rapa 41.10 5.00e-15 71.60
IUUC-Cel-018466 Caenorhabditis elegans 40.78 8.00e-18 80.50
IUUC-Cja-019306 Callithrix jacchus 43.82 6.00e-15 71.60
IUUC-Cfa-020063 Canis familiaris 42.57 3.00e-17 79.30
IUUC-Cpo-021325 Cavia porcellus 41.58 4.00e-17 79.00
IUUC-Cre-022889 Chlamydomonas reinhardtii 47.56 2.00e-17 80.10
IUUC-Csa-023739 Chlorocebus sabaeus 42.57 3.00e-17 79.70
IUUC-Cho-024324 Choloepus hoffmanni 43.82 5.00e-14 68.90
IUUC-Cgl-026402 Colletotrichum gloeosporioides 43.55 5.00e-24 102.00
IUUC-Cne-027094 Cryptococcus neoformans 44.58 4.00e-18 82.40
IUUC-Cme-027112 Cyanidioschyzon merolae 41.18 2.00e-17 79.70
IUUC-Dre-028813 Danio rerio 41.24 1.00e-16 77.40
IUUC-Dno-029949 Dasypus novemcinctus 39.81 2.00e-15 72.40
IUUC-Dse-031482 Dothistroma septosporum 43.22 4.00e-24 102.00
IUUC-Dme-031608 Drosophila melanogaster 43.52 4.00e-18 82.00
IUUC-Ete-032937 Echinops telfairi 66.67 8.00e-07 44.30
IUUC-Eca-033899 Equus caballus 43.82 3.00e-15 72.00
IUUC-Fca-036579 Felis catus 44.19 9.00e-15 71.20
IUUC-Fox-037940 Fusarium oxysporum 40.87 6.00e-24 101.00
IUUC-Fso-038465 Fusarium solani 38.15 3.00e-25 105.00
IUUC-Ggr-040089 Gaeumannomyces graminis 45.00 4.00e-26 108.00
IUUC-Gga-040910 Gallus gallus 41.58 9.00e-17 77.40
IUUC-Gma-044349 Glycine max 36.89 2.00e-15 73.20
IUUC-Ggo-044854 Gorilla gorilla 43.82 7.00e-15 71.60
IUUC-Hsa-046921 Homo sapiens 43.82 6.00e-15 71.60
IUUC-Hvu-047142 Hordeum vulgare 42.72 2.00e-19 86.70
IUUC-Kpa-049187 Komagataella pastoris 44.35 2.00e-29 119.00
IUUC-Lch-050614 Latimeria chalumnae 42.16 6.00e-18 81.60
IUUC-Lpe-051184 Leersia perrieri 41.35 2.00e-19 87.00
IUUC-Loc-052083 Lepisosteus oculatus 42.57 1.00e-18 83.20
IUUC-Lma-053209 Leptosphaeria maculans 42.28 7.00e-22 94.70
IUUC-Laf-054090 Loxodonta africana 42.57 2.00e-17 80.10
IUUC-Meu-056814 Macropus eugenii 44.00 8.00e-18 80.90
IUUC-Mor-057169 Magnaporthe oryzae 51.33 2.00e-28 116.00
IUUC-Mpo-057483 Magnaporthe poae 47.79 9.00e-26 107.00
IUUC-Mtr-058166 Medicago truncatula 34.95 2.00e-14 69.70
IUUC-Mla-059015 Melampsora laricipopulina 40.91 2.00e-19 85.90
IUUC-Mvi-060356 Microbotryum violaceum 52.75 2.00e-16 77.00
IUUC-Mdo-062658 Monodelphis domestica 42.00 3.00e-17 79.70
IUUC-Mmu-063470 Mus musculus 42.16 1.00e-17 80.90
IUUC-Mac-065327 Musa acuminata 46.60 2.00e-19 86.70
IUUC-Mpu-065761 Mustela putorius furo 43.82 4.00e-15 71.60
IUUC-Mlu-067175 Myotis lucifugus 33.33 1.00e-17 80.50
IUUC-Nfi-068535 Neosartorya fischeri 42.74 5.00e-24 102.00
IUUC-Ncr-068966 Neurospora crassa 43.48 4.00e-22 95.50
IUUC-Opr-070533 Ochotona princeps 43.40 5.00e-08 48.10
IUUC-Oan-073024 Ornithorhynchus anatinus 44.71 5.00e-15 72.00
IUUC-Ocu-074451 Oryctolagus cuniculus 43.82 6.00e-15 72.40
IUUC-Oba-075540 Oryza barthii 41.58 4.00e-19 85.50
IUUC-Obr-076285 Oryza brachyantha 42.16 1.00e-18 84.70
IUUC-Ogl-077827 Oryza glaberrima 41.58 4.00e-19 85.50
IUUC-Ogu-078491 Oryza glumaepatula 41.58 4.00e-19 85.90
IUUC-Oin-080149 Oryza indica 41.58 5.00e-19 85.10
IUUC-Olo-080318 Oryza longistaminata 39.25 3.00e-17 78.60
IUUC-Oni-083037 Oryza nivara 41.58 5.00e-19 85.10
IUUC-Opu-083448 Oryza punctata 41.58 4.00e-19 85.90
IUUC-Oru-084793 Oryza rufipogon 41.58 7.00e-19 84.70
IUUC-Osa-086032 Oryza sativa 41.58 5.00e-19 85.10
IUUC-Ola-086956 Oryzias latipes 41.44 2.00e-16 76.30
IUUC-Olu-087806 Ostreococcus lucimarinus 40.62 1.00e-15 73.90
IUUC-Oga-089029 Otolemur garnettii 34.46 5.00e-15 72.40
IUUC-Oar-089471 Ovis aries 41.00 8.00e-17 78.20
IUUC-Pan-092091 Papio anubis 42.57 2.00e-17 79.70
IUUC-Psi-093193 Pelodiscus sinensis 43.56 9.00e-18 80.90
IUUC-Pma-094540 Petromyzon marinus 41.58 2.00e-17 79.00
IUUC-Pno-094873 Phaeosphaeria nodorum 44.92 1.00e-23 100.00
IUUC-Ppa-095343 Physcomitrella patens 49.32 2.00e-16 77.00
IUUC-Pfo-097093 Poecilia formosa 43.69 4.00e-18 82.40
IUUC-Pab-098781 Pongo abelii 50.00 1.00e-12 63.50
IUUC-Pop-098983 Populus trichocarpa 36.73 4.00e-15 72.40
IUUC-Pca-100872 Procavia capensis 34.48 1.00e-11 61.20
IUUC-Ppe-101711 Prunus persica 38.04 6.00e-13 65.10
IUUC-Pva-102256 Pteropus vampyrus 42.57 4.00e-16 75.90
IUUC-Pgr-103607 Puccinia graminis 43.33 5.00e-22 95.10
IUUC-Pte-104220 Pyrenophora teres 41.46 7.00e-21 90.90
IUUC-Pyt-104562 Pyrenophora triticirepentis 41.46 2.00e-21 93.20
IUUC-Rno-105021 Rattus norvegicus 35.29 1.00e-13 67.40
IUUC-Sha-107279 Sarcophilus harrisii 41.00 2.00e-16 76.60
IUUC-Sja-107819 Schizosaccharomyces japonicus 40.62 6.00e-23 97.80
IUUC-Spo-108197 Schizosaccharomyces pombe 44.66 5.00e-19 84.70
IUUC-Smo-108810 Selaginella moellendorffii 42.17 6.00e-17 77.00
IUUC-Sit-110256 Setaria italica 39.81 8.00e-19 85.10
IUUC-Sly-111448 Solanum lycopersicum 42.00 2.00e-18 83.20
IUUC-Stu-112702 Solanum tuberosum 42.00 3.00e-18 82.40
IUUC-Sbi-113956 Sorghum bicolor 34.78 2.00e-20 90.10
IUUC-Sre-115024 Sporisorium reilianum 48.65 3.00e-15 73.20
IUUC-Ssc-116034 Sus scrofa 41.58 8.00e-17 78.20
IUUC-Tgu-117503 Taeniopygia guttata 44.55 8.00e-19 84.00
IUUC-Tsy-119166 Tarsius syrichta 37.93 6.60e-02 27.70
IUUC-Tni-120703 Tetraodon nigroviridis 25.64 6.00e-05 38.50
IUUC-Tca-121473 Theobroma cacao 43.53 3.00e-14 69.30
IUUC-Tre-122241 Trichoderma reesei 41.38 2.00e-20 89.00
IUUC-Tvi-122347 Trichoderma virens 40.68 4.00e-19 85.50
IUUC-Tae-124560 Triticum aestivum 41.75 9.00e-20 87.80
IUUC-Tur-126452 Triticum urartu 41.35 1.00e-19 87.00
IUUC-Tme-127205 Tuber melanosporum 48.45 2.00e-21 92.00
IUUC-Ttr-128186 Tursiops truncatus 41.00 7.00e-16 75.10
IUUC-Uma-129523 Ustilago maydis 36.13 6.00e-16 75.10
IUUC-Vda-129793 Verticillium dahliae 35.68 1.00e-25 107.00
IUUC-Vpa-130040 Vicugna pacos 42.57 1.00e-16 76.60
IUUC-Vvi-131588 Vitis vinifera 42.86 3.00e-15 72.80
IUUC-Yli-134631 Yarrowia lipolytica 59.09 4.00e-28 115.00
IUUC-Zma-135478 Zea mays 41.38 3.00e-19 86.30
Created Date 25-Jun-2017

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