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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063869
UUCD1 version UUC-MuM-01079
Ensembl Protein ID ENSMUSP00000089728.6
UniProt Accession Q9JMA1; Q543U5; Q923F2; Q9D0L0; UBP14_MOUSE
Genbank Protein ID BAA93551.1; BAB27544.1; BAC26713.1; BAC32528.1; AAH05571.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14
Genbank Nucleotide ID AB034633; AK011322; AK029977; AK045909; BC005571
Gene Name Usp14
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000047879.16 ENSMUST00000092096.12 ENSMUSP00000089728.6
ENSMUSG00000047879.16 ENSMUST00000116669.1 ENSMUSP00000112368.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Protein 3D Structure
PDBMMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 10933821
Classification
Family E-value Score Start End
DUB/USP 6.50e-65 220.6 105 479
ULD/UDP/UBQ/UBQ_Other 1.40e-08 35.6 5 74
Active Site
Position(s) Description Evidence
114 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
434 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+  ++        + +++ s++a+  +++k+ksli++ F++++++++kc e +++ +++ + ++l
   Q: 192  qgQYLQQDANECWIQMMRVLQQKLEAIEDD-------SGRETDSSSAPAVTPSKKKSLIDQYFGVEFETTMKCTESEEEEVTKGKENQL 273
           999*********************442222.......22223344578889**************************999999888888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 274  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 355
           8888877754..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts.....................peekqke.............................kkkYeLiavvvHsG.slssGHYvayv 299
            + ct                      +     +                             +  Y+L av+ H+G s+ssGHYv++v
   Q: 356  YELCTPelqekmvsfrskfkdledkkvN-----QqpnandknsppkeikyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSWV 439
           ******6666666666666666555550.....055555556677777777777777777777************************** PP
   S: 300  knekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           + ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 440  RRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 479
           *************************988************ PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k+g+t++++ +
   Q: 5    SVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKMKNGMTVLMMGS 74
           69********99*************************************999.9**************965 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Maintains the cellular levels of monomeric ubiquitin in cells. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor cxcr4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1.
 Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Maintains the cellular levels of monomeric ubiquitin in cells. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor cxcr4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1.
Protein Sequence
(Fasta)
MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKMKNGMTVL MMGSADALPE EPSAKTVFVE DMTEEQLATA MELPCGLTNL GNTCYMNATV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063869|DUB,USP;ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGAAACCACT GTCTCCTGCA TGAGATATGC TTCGACCCGG AGCTCCACCA TTAAACTACC 60
TCGTGTTCTT ACATCAAGTT GGTCGTCTGT TCGTGATTCT TGGGTGCACG TTGAATCGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063869|DUB,USP;ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
SMART

SM00213--UBQ
Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0070628--F:proteasome binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:59025
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000893 Aegilops tauschii 43.41 8.00e-38 151.00
IUUC-Aml-002053 Ailuropoda melanoleuca 96.13 0.00e+00 914.00
IUUC-Atr-002725 Amborella trichopoda 42.54 5.00e-101 361.00
IUUC-Apl-004031 Anas platyrhynchos 89.43 0.00e+00 883.00
IUUC-Aca-004361 Anolis carolinensis 88.28 0.00e+00 898.00
IUUC-Aly-006078 Arabidopsis lyrata 41.48 7.00e-111 394.00
IUUC-Ath-007623 Arabidopsis thaliana 42.46 1.00e-111 396.00
IUUC-Ago-007796 Ashbya gossypii 33.26 1.00e-59 224.00
IUUC-Acl-008258 Aspergillus clavatus 37.19 3.00e-66 246.00
IUUC-Afl-008732 Aspergillus flavus 32.99 8.00e-78 284.00
IUUC-Afu-008755 Aspergillus fumigatus 37.90 3.00e-67 249.00
IUUC-Ani-009148 Aspergillus nidulans 39.61 5.00e-72 265.00
IUUC-Ang-009878 Aspergillus niger 37.75 4.00e-66 245.00
IUUC-Aor-010239 Aspergillus oryzae 33.16 4.00e-72 265.00
IUUC-Ate-010243 Aspergillus terreus 38.33 6.00e-66 245.00
IUUC-Ame-011327 Astyanax mexicanus 50.20 1.00e-127 449.00
IUUC-Bgr-012231 Blumeria graminis 37.63 2.00e-67 250.00
IUUC-Bta-012553 Bos taurus 96.36 0.00e+00 947.00
IUUC-Bci-013606 Botrytis cinerea 39.95 3.00e-70 259.00
IUUC-Bdi-014567 Brachypodium distachyon 42.71 1.00e-111 396.00
IUUC-Bol-016127 Brassica oleracea 42.20 1.00e-113 403.00
IUUC-Bra-017501 Brassica rapa 42.00 6.00e-113 400.00
IUUC-Cel-018140 Caenorhabditis elegans 41.75 4.00e-101 362.00
IUUC-Cja-019516 Callithrix jacchus 95.35 0.00e+00 940.00
IUUC-Cfa-020808 Canis familiaris 96.76 0.00e+00 950.00
IUUC-Cpo-021688 Cavia porcellus 95.55 0.00e+00 933.00
IUUC-Cre-022663 Chlamydomonas reinhardtii 38.08 2.00e-82 299.00
IUUC-Csa-023429 Chlorocebus sabaeus 96.55 0.00e+00 921.00
IUUC-Cho-024347 Choloepus hoffmanni 95.74 0.00e+00 941.00
IUUC-Cin-025198 Ciona intestinalis 55.33 5.00e-152 530.00
IUUC-Csv-026007 Ciona savignyi 53.41 7.00e-155 540.00
IUUC-Cgl-026757 Colletotrichum gloeosporioides 38.70 3.00e-64 239.00
IUUC-Cne-026963 Cryptococcus neoformans 34.47 9.00e-75 274.00
IUUC-Cme-027240 Cyanidioschyzon merolae 31.65 7.00e-61 228.00
IUUC-Dre-027647 Danio rerio 82.04 0.00e+00 830.00
IUUC-Dno-029967 Dasypus novemcinctus 95.34 0.00e+00 915.00
IUUC-Dor-030886 Dipodomys ordii 90.68 0.00e+00 749.00
IUUC-Dse-031466 Dothistroma septosporum 35.56 8.00e-58 218.00
IUUC-Dme-032079 Drosophila melanogaster 56.06 2.00e-160 558.00
IUUC-Ete-032351 Echinops telfairi 85.02 0.00e+00 847.00
IUUC-Eca-033461 Equus caballus 95.55 0.00e+00 984.00
IUUC-Eeu-035220 Erinaceus europaeus 72.69 0.00e+00 688.00
IUUC-Fca-036210 Felis catus 96.96 0.00e+00 951.00
IUUC-Fal-037528 Ficedula albicollis 89.05 0.00e+00 864.00
IUUC-Fox-037805 Fusarium oxysporum 40.16 3.00e-71 262.00
IUUC-Fso-038177 Fusarium solani 38.34 2.00e-68 253.00
IUUC-Gmo-038953 Gadus morhua 77.96 0.00e+00 768.00
IUUC-Ggr-039972 Gaeumannomyces graminis 33.94 2.00e-75 276.00
IUUC-Gga-040462 Gallus gallus 88.66 0.00e+00 876.00
IUUC-Gac-041312 Gasterosteus aculeatus 81.07 0.00e+00 801.00
IUUC-Gma-043255 Glycine max 41.68 2.00e-108 386.00
IUUC-Ggo-045458 Gorilla gorilla 79.96 0.00e+00 783.00
IUUC-Hsa-045706 Homo sapiens 96.76 0.00e+00 924.00
IUUC-Hvu-047821 Hordeum vulgare 46.22 1.00e-57 216.00
IUUC-Itr-048654 Ictidomys tridecemlineatus 95.95 0.00e+00 947.00
IUUC-Lch-050464 Latimeria chalumnae 81.22 0.00e+00 818.00
IUUC-Lpe-051419 Leersia perrieri 42.47 3.00e-108 385.00
IUUC-Loc-052732 Lepisosteus oculatus 80.61 0.00e+00 845.00
IUUC-Lma-053177 Leptosphaeria maculans 41.28 4.00e-71 262.00
IUUC-Laf-053822 Loxodonta africana 95.74 0.00e+00 940.00
IUUC-Mcc-055893 Macaca mulatta 96.75 0.00e+00 922.00
IUUC-Meu-056307 Macropus eugenii 81.39 0.00e+00 783.00
IUUC-Mor-057171 Magnaporthe oryzae 39.90 1.00e-68 253.00
IUUC-Mpo-057415 Magnaporthe poae 41.49 6.00e-71 261.00
IUUC-Mtr-057901 Medicago truncatula 43.08 2.00e-112 399.00
IUUC-Mla-058897 Melampsora laricipopulina 39.36 2.00e-75 276.00
IUUC-Mga-060016 Meleagris gallopavo 89.43 0.00e+00 882.00
IUUC-Mvi-060562 Microbotryum violaceum 39.30 5.00e-68 251.00
IUUC-Mmr-060624 Microcebus murinus 95.95 0.00e+00 989.00
IUUC-Mdo-061809 Monodelphis domestica 91.53 0.00e+00 885.00
IUUC-Mac-064876 Musa acuminata 39.40 2.00e-95 343.00
IUUC-Mpu-066480 Mustela putorius furo 96.36 0.00e+00 947.00
IUUC-Mlu-067866 Myotis lucifugus 95.34 0.00e+00 949.00
IUUC-Nfi-068393 Neosartorya fischeri 37.65 1.00e-65 244.00
IUUC-Ncr-068815 Neurospora crassa 36.02 4.00e-83 301.00
IUUC-Nle-070121 Nomascus leucogenys 96.84 1.00e-138 485.00
IUUC-Opr-070712 Ochotona princeps 76.40 8.00e-175 607.00
IUUC-Ont-071544 Oreochromis niloticus 80.65 0.00e+00 764.00
IUUC-Oan-073635 Ornithorhynchus anatinus 90.42 0.00e+00 743.00
IUUC-Ocu-074926 Oryctolagus cuniculus 95.75 0.00e+00 915.00
IUUC-Oba-075633 Oryza barthii 41.86 3.00e-108 385.00
IUUC-Obr-076423 Oryza brachyantha 42.83 8.00e-112 397.00
IUUC-Ogl-077913 Oryza glaberrima 42.42 1.00e-110 393.00
IUUC-Ogu-078435 Oryza glumaepatula 41.86 3.00e-108 385.00
IUUC-Oin-080072 Oryza indica 41.82 2.00e-108 385.00
IUUC-Olo-080535 Oryza longistaminata 38.40 7.00e-92 330.00
IUUC-Ome-081309 Oryza meridionalis 41.86 3.00e-108 385.00
IUUC-Oni-083113 Oryza nivara 41.86 3.00e-108 385.00
IUUC-Opu-083168 Oryza punctata 40.91 7.00e-103 367.00
IUUC-Oru-084253 Oryza rufipogon 41.86 3.00e-108 385.00
IUUC-Osa-085554 Oryza sativa 42.42 1.00e-110 393.00
IUUC-Ola-086998 Oryzias latipes 78.96 0.00e+00 789.00
IUUC-Olu-087818 Ostreococcus lucimarinus 36.23 7.00e-71 261.00
IUUC-Oga-088571 Otolemur garnettii 95.95 0.00e+00 940.00
IUUC-Oar-089526 Ovis aries 96.34 0.00e+00 943.00
IUUC-Ptr-091433 Pan troglodytes 96.75 0.00e+00 922.00
IUUC-Pan-091966 Papio anubis 96.55 0.00e+00 921.00
IUUC-Psi-093458 Pelodiscus sinensis 87.72 0.00e+00 839.00
IUUC-Pma-094343 Petromyzon marinus 68.51 3.00e-121 427.00
IUUC-Pno-095109 Phaeosphaeria nodorum 39.00 9.00e-67 248.00
IUUC-Ppa-095756 Physcomitrella patens 44.29 2.00e-111 395.00
IUUC-Pfo-096514 Poecilia formosa 80.08 0.00e+00 780.00
IUUC-Pab-098477 Pongo abelii 85.11 0.00e+00 730.00
IUUC-Pop-099221 Populus trichocarpa 40.76 2.00e-103 369.00
IUUC-Pca-100791 Procavia capensis 79.21 2.00e-177 615.00
IUUC-Ppe-101812 Prunus persica 41.82 3.00e-108 385.00
IUUC-Pva-102462 Pteropus vampyrus 90.91 0.00e+00 760.00
IUUC-Pgr-103623 Puccinia graminis 40.69 7.00e-75 275.00
IUUC-Ptt-103767 Puccinia triticina 38.81 3.00e-68 252.00
IUUC-Pte-104109 Pyrenophora teres 39.04 6.00e-71 261.00
IUUC-Pyt-104766 Pyrenophora triticirepentis 39.64 4.00e-71 262.00
IUUC-Rno-105351 Rattus norvegicus 98.38 0.00e+00 923.00
IUUC-Sce-106168 Saccharomyces cerevisiae 33.13 9.00e-63 234.00
IUUC-Sha-107491 Sarcophilus harrisii 91.31 0.00e+00 902.00
IUUC-Sja-107769 Schizosaccharomyces japonicus 34.58 2.00e-78 286.00
IUUC-Spo-108174 Schizosaccharomyces pombe 37.05 3.00e-80 292.00
IUUC-Ssl-108659 Sclerotinia sclerotiorum 35.45 4.00e-86 312.00
IUUC-Smo-108805 Selaginella moellendorffii 43.83 2.00e-110 392.00
IUUC-Sit-110361 Setaria italica 42.94 1.00e-113 404.00
IUUC-Sly-110965 Solanum lycopersicum 40.40 6.00e-108 384.00
IUUC-Sar-113355 Sorex araneus 96.88 5.00e-165 573.00
IUUC-Sbi-114778 Sorghum bicolor 43.43 2.00e-112 399.00
IUUC-Sre-115011 Sporisorium reilianum 36.90 8.00e-63 234.00
IUUC-Ssc-116273 Sus scrofa 95.52 0.00e+00 927.00
IUUC-Tgu-117063 Taeniopygia guttata 88.62 0.00e+00 861.00
IUUC-Tru-118381 Takifugu rubripes 78.86 0.00e+00 791.00
IUUC-Tsy-119076 Tarsius syrichta 79.05 1.00e-114 406.00
IUUC-Tni-119941 Tetraodon nigroviridis 79.18 0.00e+00 779.00
IUUC-Tca-121246 Theobroma cacao 41.07 1.00e-109 390.00
IUUC-Tre-121969 Trichoderma reesei 39.49 3.00e-69 256.00
IUUC-Tvi-122543 Trichoderma virens 33.16 3.00e-68 252.00
IUUC-Tae-125484 Triticum aestivum 42.25 7.00e-110 390.00
IUUC-Tur-126128 Triticum urartu 40.89 1.00e-38 154.00
IUUC-Tbe-128030 Tupaia belangeri 88.93 0.00e+00 844.00
IUUC-Ttr-128701 Tursiops truncatus 94.81 0.00e+00 771.00
IUUC-Uma-129657 Ustilago maydis 37.92 1.00e-65 244.00
IUUC-Vda-129723 Verticillium dahliae 35.49 9.00e-61 228.00
IUUC-Vpa-130284 Vicugna pacos 68.85 0.00e+00 627.00
IUUC-Vvi-131037 Vitis vinifera 42.21 1.00e-108 386.00
IUUC-Xtr-132235 Xenopus tropicalis 84.88 0.00e+00 877.00
IUUC-Xma-133840 Xiphophorus maculatus 81.67 0.00e+00 804.00
IUUC-Yli-134453 Yarrowia lipolytica 37.18 6.00e-83 301.00
IUUC-Zma-135669 Zea mays 36.69 4.00e-95 342.00
Created Date 25-Jun-2017

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