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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063181
UUCD1 version UUC-MuM-00442
Ensembl Protein ID ENSMUSP00000022720.8
UniProt Accession Q8C4V4; Q80V32; Q8K1W0; Q9QXW1; FBXL3_MOUSE
Genbank Protein ID AAF09131.1; BAC38050.1; AAM92567.1; AAH46330.1
Protein Name F-box/LRR-repeat protein 3; F-box and leucine-rich repeat protein 3A; F-box/LRR-repeat protein 3A; Protein after-hours; Protein overtime
Genbank Nucleotide ID AF176521; AK080863; AE013600; BC046330
Gene Name Fbxl3; Afh; Fbl3a; Fbxl3a; Ovtm
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022124.14 ENSMUST00000022720.14 ENSMUSP00000022720.8
ENSMUSG00000022124.14 ENSMUST00000132004.7 ENSMUSP00000115843.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 97.20 0.00e+00 835.00 IUUC-Hsa-045977
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
 Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
Protein Sequence
(Fasta)
MKRGGRDSDQ DSAEEGTAEK PKRPRTTQER SQPCDWGNLL QDIVLHVFKY LPLLDRAHAS 60
QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK QIIKRHSNHL QYVSFKVDSS 120
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Protein Fasta Sequence


>IUUC-Mmu-063181|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
AGGGGCAAGC GCGCGGCCGC GAACTGCGGG CGCCATTTTG GATTCCCTAA CTGGGCCGAA 60
GCTTCGGGCT CGCTGCTGTC GATCGCTGCT CGCCTAGGGC GTCTCGGGCG GGCGACGAGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063181|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
Pfam

PF00646--F-box
SMART

SM00256--FBOX
Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007623--P:circadian rhythm
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0016567--P:protein ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG mmu:50789
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000400 Aegilops tauschii 35.00 7.00e-04 37.40
IUUC-Aml-001552 Ailuropoda melanoleuca 97.20 0.00e+00 833.00
IUUC-Atr-003025 Amborella trichopoda 26.97 2.00e-05 40.80
IUUC-Apl-003485 Anas platyrhynchos 91.22 0.00e+00 775.00
IUUC-Aca-004566 Anolis carolinensis 90.57 0.00e+00 757.00
IUUC-Ath-007384 Arabidopsis thaliana 31.75 6.00e-03 34.70
IUUC-Ame-011238 Astyanax mexicanus 84.88 0.00e+00 712.00
IUUC-Bta-013292 Bos taurus 99.36 4.00e-176 610.00
IUUC-Cja-019876 Callithrix jacchus 97.20 0.00e+00 835.00
IUUC-Cfa-020674 Canis familiaris 97.20 0.00e+00 835.00
IUUC-Cpo-021869 Cavia porcellus 97.77 0.00e+00 783.00
IUUC-Csa-023044 Chlorocebus sabaeus 96.96 0.00e+00 833.00
IUUC-Cho-024975 Choloepus hoffmanni 86.68 0.00e+00 733.00
IUUC-Cin-025430 Ciona intestinalis 21.21 7.00e-11 61.60
IUUC-Dre-028332 Danio rerio 86.26 0.00e+00 711.00
IUUC-Dno-028870 Dasypus novemcinctus 96.73 0.00e+00 831.00
IUUC-Dor-030514 Dipodomys ordii 97.20 0.00e+00 835.00
IUUC-Ete-032477 Echinops telfairi 96.28 0.00e+00 719.00
IUUC-Eca-034141 Equus caballus 96.50 0.00e+00 826.00
IUUC-Eeu-035046 Erinaceus europaeus 95.79 0.00e+00 805.00
IUUC-Fca-035829 Felis catus 96.96 0.00e+00 834.00
IUUC-Fal-037609 Ficedula albicollis 90.07 0.00e+00 774.00
IUUC-Gmo-039537 Gadus morhua 81.09 0.00e+00 689.00
IUUC-Gga-040363 Gallus gallus 75.69 0.00e+00 671.00
IUUC-Gac-042440 Gasterosteus aculeatus 89.09 0.00e+00 701.00
IUUC-Ggo-045342 Gorilla gorilla 97.20 0.00e+00 837.00
IUUC-Hsa-045977 Homo sapiens 97.20 0.00e+00 836.00
IUUC-Itr-048500 Ictidomys tridecemlineatus 96.73 0.00e+00 810.00
IUUC-Lch-049981 Latimeria chalumnae 86.54 0.00e+00 736.00
IUUC-Loc-052324 Lepisosteus oculatus 87.04 0.00e+00 728.00
IUUC-Laf-053399 Loxodonta africana 96.26 0.00e+00 827.00
IUUC-Mcc-054813 Macaca mulatta 96.96 0.00e+00 834.00
IUUC-Meu-056017 Macropus eugenii 94.39 0.00e+00 803.00
IUUC-Mga-059960 Meleagris gallopavo 76.16 0.00e+00 672.00
IUUC-Mmr-060711 Microcebus murinus 96.50 0.00e+00 830.00
IUUC-Mdo-062234 Monodelphis domestica 95.35 0.00e+00 821.00
IUUC-Mpu-066368 Mustela putorius furo 97.20 0.00e+00 835.00
IUUC-Mlu-067492 Myotis lucifugus 93.22 0.00e+00 795.00
IUUC-Nle-069358 Nomascus leucogenys 96.50 0.00e+00 829.00
IUUC-Opr-070436 Ochotona princeps 95.56 0.00e+00 814.00
IUUC-Ont-072618 Oreochromis niloticus 89.62 0.00e+00 709.00
IUUC-Oan-073386 Ornithorhynchus anatinus 92.82 0.00e+00 788.00
IUUC-Ocu-073808 Oryctolagus cuniculus 96.73 0.00e+00 829.00
IUUC-Oba-075035 Oryza barthii 27.85 3.00e-04 37.70
IUUC-Ogl-077859 Oryza glaberrima 36.17 9.00e-04 39.70
IUUC-Ome-081689 Oryza meridionalis 36.17 9.00e-04 39.70
IUUC-Oni-083118 Oryza nivara 36.17 1.00e-03 39.70
IUUC-Opu-083603 Oryza punctata 36.17 5.00e-04 40.40
IUUC-Oru-085225 Oryza rufipogon 36.17 9.00e-04 39.70
IUUC-Ola-086567 Oryzias latipes 89.85 0.00e+00 709.00
IUUC-Oga-088421 Otolemur garnettii 96.26 0.00e+00 807.00
IUUC-Oar-090329 Ovis aries 98.05 0.00e+00 806.00
IUUC-Ptr-091390 Pan troglodytes 97.20 0.00e+00 836.00
IUUC-Pan-092155 Papio anubis 96.03 0.00e+00 819.00
IUUC-Psi-093540 Pelodiscus sinensis 91.22 0.00e+00 788.00
IUUC-Pfo-096760 Poecilia formosa 89.87 0.00e+00 707.00
IUUC-Pab-097896 Pongo abelii 97.20 0.00e+00 836.00
IUUC-Pca-100935 Procavia capensis 94.22 2.00e-149 521.00
IUUC-Pva-102705 Pteropus vampyrus 97.20 0.00e+00 838.00
IUUC-Pyt-104677 Pyrenophora triticirepentis 23.47 2.50e-02 33.10
IUUC-Rno-104827 Rattus norvegicus 99.07 0.00e+00 848.00
IUUC-Sha-107356 Sarcophilus harrisii 94.42 0.00e+00 813.00
IUUC-Sit-109906 Setaria italica 30.99 1.60e-02 33.50
IUUC-Sar-113189 Sorex araneus 96.84 0.00e+00 796.00
IUUC-Sre-114931 Sporisorium reilianum 29.31 1.00e-03 38.50
IUUC-Ssc-115570 Sus scrofa 96.97 0.00e+00 829.00
IUUC-Tgu-116972 Taeniopygia guttata 90.30 0.00e+00 763.00
IUUC-Tru-117842 Takifugu rubripes 86.71 0.00e+00 708.00
IUUC-Tsy-119232 Tarsius syrichta 96.73 0.00e+00 830.00
IUUC-Tni-120727 Tetraodon nigroviridis 84.21 0.00e+00 711.00
IUUC-Tca-121081 Theobroma cacao 45.71 2.00e-03 38.90
IUUC-Tre-122087 Trichoderma reesei 30.68 1.70e-02 33.50
IUUC-Tur-126585 Triticum urartu 30.00 5.00e-04 38.10
IUUC-Tbe-127552 Tupaia belangeri 93.92 0.00e+00 711.00
IUUC-Ttr-128903 Tursiops truncatus 96.27 0.00e+00 825.00
IUUC-Vpa-130347 Vicugna pacos 96.27 0.00e+00 823.00
IUUC-Xtr-131886 Xenopus tropicalis 89.38 0.00e+00 773.00
Created Date 25-Jun-2017

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