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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046594
UUCD1 version UUC-HoS-00471
Ensembl Protein ID ENSP00000385085.3
UniProt Accession Q9Y575; B3KPA3; D6W5B4; D6W5B5; G8JLA9; Q2TAI4; Q53TN0; Q53TN8; Q9NVZ2; ASB3_HUMAN
Genbank Protein ID AAD41895.1; BAA91455.1; BAA91599.1; BAG51615.1; AAY24350.1; AAX93180.1; EAX00167.1; EAX00168.1; EAX00169.1; EAX00170.1; AAH06488.1; AAH09569.1; AAI10916.1
Protein Name Ankyrin repeat and SOCS box protein 3
Genbank Nucleotide ID AF156778; AK000985; AK001283; AK056069; AC007883; AC008064; AC008068; CH471053; CH471053; CH471053; BC006488; BC009569; BC110915
Gene Name ASB3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000270898.5 ENST00000406625.5 ENSP00000385085.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmiRTarBasemicroRNA
TRANSFACTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
Mentha
Disease-associated Information
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMPhosphositePlus
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 15899873
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 7.60e-20 72.2 485 541
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrse...prSLqhLCRlaIrrclgsqrl...kaidkLPLPksLkdYLlyedy 52
           s++w+l+++   ++SL+hLCRl+Ir++l+s+rl   ++i++LPLP+sL++YLlyed+
   Q: 485  SNAWILQQHiatVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYEDV 541
           799****************************************************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.
Protein Sequence
(Fasta)
MAMMPLVLHH PERQAELGSG LRDGGGAALR PPGRLVKQMD FTEAYADTCS TVGLAAREGN 60
VKVLRKLLKK GRSVDVADNR GWMPIHEAAY HNSVECLQML INADSSENYI KMKTFEGFCA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046594|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAACTGCGA GCCTGAAAAA CCTGGCTCAA GCGCCCCTCG TGAGGCGGGC AGCGGGAGTG 60
GCCGGGCTCT GGGCCCCAGG AGGCAGGCGA CGGAGGCGCG GAGGGTGCGG GGCGCAGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046594|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF13606--Ank_3
PF07525--SOCS_box
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
KEGG hsa:100302652; hsa:51130
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001348 Ailuropoda melanoleuca 91.15 0.00e+00 804.00
IUUC-Apl-004038 Anas platyrhynchos 64.79 0.00e+00 687.00
IUUC-Aca-005213 Anolis carolinensis 69.11 4.00e-135 474.00
IUUC-Ame-011115 Astyanax mexicanus 46.17 1.00e-93 336.00
IUUC-Bta-012822 Bos taurus 87.67 0.00e+00 929.00
IUUC-Bdi-014410 Brachypodium distachyon 29.33 4.00e-19 89.40
IUUC-Cja-019017 Callithrix jacchus 91.94 0.00e+00 1042.00
IUUC-Cfa-020833 Canis familiaris 88.65 0.00e+00 943.00
IUUC-Cpo-021675 Cavia porcellus 78.99 0.00e+00 831.00
IUUC-Csa-023300 Chlorocebus sabaeus 97.14 0.00e+00 1035.00
IUUC-Cho-024842 Choloepus hoffmanni 85.77 0.00e+00 962.00
IUUC-Cme-027144 Cyanidioschyzon merolae 30.20 8.00e-22 99.80
IUUC-Dre-028406 Danio rerio 45.93 2.00e-117 416.00
IUUC-Dor-030407 Dipodomys ordii 73.56 0.00e+00 729.00
IUUC-Ete-032393 Echinops telfairi 68.98 0.00e+00 722.00
IUUC-Eca-033744 Equus caballus 89.17 0.00e+00 961.00
IUUC-Eeu-035003 Erinaceus europaeus 88.96 1.00e-169 589.00
IUUC-Fca-036117 Felis catus 85.82 0.00e+00 929.00
IUUC-Fal-037324 Ficedula albicollis 60.89 0.00e+00 642.00
IUUC-Ggr-040007 Gaeumannomyces graminis 28.41 3.00e-26 115.00
IUUC-Gga-040483 Gallus gallus 64.02 0.00e+00 647.00
IUUC-Gma-043361 Glycine max 27.85 2.00e-16 80.50
IUUC-Ggo-045011 Gorilla gorilla 98.86 0.00e+00 1028.00
IUUC-Hvu-047391 Hordeum vulgare 30.51 8.00e-17 81.60
IUUC-Itr-048681 Ictidomys tridecemlineatus 88.68 0.00e+00 941.00
IUUC-Lch-050315 Latimeria chalumnae 62.09 0.00e+00 671.00
IUUC-Lpe-050794 Leersia perrieri 28.37 3.00e-18 86.30
IUUC-Loc-052906 Lepisosteus oculatus 60.08 3.00e-175 608.00
IUUC-Laf-053858 Loxodonta africana 85.12 0.00e+00 846.00
IUUC-Mcc-055512 Macaca mulatta 96.95 0.00e+00 1070.00
IUUC-Meu-055966 Macropus eugenii 67.20 9.00e-102 363.00
IUUC-Mga-059959 Meleagris gallopavo 63.82 0.00e+00 648.00
IUUC-Mmr-061498 Microcebus murinus 90.85 0.00e+00 877.00
IUUC-Mdo-061876 Monodelphis domestica 72.41 0.00e+00 775.00
IUUC-Mmu-063243 Mus musculus 80.82 0.00e+00 896.00
IUUC-Mac-065606 Musa acuminata 27.23 3.00e-14 72.80
IUUC-Mpu-066885 Mustela putorius furo 89.38 0.00e+00 956.00
IUUC-Mlu-067517 Myotis lucifugus 85.41 0.00e+00 916.00
IUUC-Nle-069096 Nomascus leucogenys 97.85 0.00e+00 1076.00
IUUC-Opr-070318 Ochotona princeps 85.09 0.00e+00 896.00
IUUC-Ont-071807 Oreochromis niloticus 41.38 1.00e-106 380.00
IUUC-Ocu-074380 Oryctolagus cuniculus 88.68 0.00e+00 969.00
IUUC-Obr-076187 Oryza brachyantha 28.37 1.00e-18 87.80
IUUC-Ogl-077822 Oryza glaberrima 27.62 2.00e-17 84.00
IUUC-Ogu-078020 Oryza glumaepatula 27.62 2.00e-17 84.00
IUUC-Oin-079995 Oryza indica 27.62 1.00e-17 84.00
IUUC-Ome-081528 Oryza meridionalis 28.10 2.00e-18 86.70
IUUC-Oni-082930 Oryza nivara 27.62 2.00e-17 84.00
IUUC-Opu-083946 Oryza punctata 27.14 1.00e-17 84.30
IUUC-Oru-084572 Oryza rufipogon 27.62 2.00e-17 84.00
IUUC-Osa-085743 Oryza sativa 27.62 2.00e-17 84.00
IUUC-Oga-088296 Otolemur garnettii 89.12 0.00e+00 924.00
IUUC-Oar-089334 Ovis aries 87.14 0.00e+00 947.00
IUUC-Ptr-091065 Pan troglodytes 99.61 0.00e+00 1049.00
IUUC-Pan-092439 Papio anubis 97.31 0.00e+00 1027.00
IUUC-Psi-093809 Pelodiscus sinensis 66.54 0.00e+00 693.00
IUUC-Pfo-097038 Poecilia formosa 39.92 2.00e-92 333.00
IUUC-Pab-098233 Pongo abelii 97.85 0.00e+00 1096.00
IUUC-Pop-099715 Populus trichocarpa 28.43 2.00e-14 73.90
IUUC-Pca-100412 Procavia capensis 73.44 1.00e-73 270.00
IUUC-Ppe-101736 Prunus persica 30.00 1.00e-17 84.30
IUUC-Pva-102254 Pteropus vampyrus 81.64 0.00e+00 879.00
IUUC-Rno-105588 Rattus norvegicus 82.66 0.00e+00 859.00
IUUC-Sha-106478 Sarcophilus harrisii 75.24 0.00e+00 797.00
IUUC-Sit-109748 Setaria italica 28.37 9.00e-18 85.10
IUUC-Sly-111895 Solanum lycopersicum 31.96 1.00e-15 77.80
IUUC-Sar-113706 Sorex araneus 80.69 2.00e-123 436.00
IUUC-Sbi-114008 Sorghum bicolor 29.81 6.00e-20 92.00
IUUC-Ssc-115429 Sus scrofa 88.42 0.00e+00 960.00
IUUC-Tgu-116719 Taeniopygia guttata 59.62 5.00e-153 534.00
IUUC-Tsy-119128 Tarsius syrichta 82.25 0.00e+00 895.00
IUUC-Tae-123509 Triticum aestivum 27.88 3.00e-16 79.70
IUUC-Tbe-127415 Tupaia belangeri 76.25 0.00e+00 793.00
IUUC-Ttr-128239 Tursiops truncatus 86.81 0.00e+00 955.00
IUUC-Vpa-130131 Vicugna pacos 87.76 0.00e+00 930.00
IUUC-Vvi-130914 Vitis vinifera 27.24 2.00e-16 80.50
IUUC-Xtr-132585 Xenopus tropicalis 58.43 4.00e-167 581.00
IUUC-Xma-133565 Xiphophorus maculatus 40.58 1.00e-95 343.00
Created Date 25-Jun-2017

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