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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046746
UUCD1 version UUC-HoS-01247
Ensembl Protein ID ENSP00000351147.2
UniProt Accession Q8WV16; B4DUT6; G3V522; Q86U31; Q8IV10; Q96K22; Q9Y4P5; DCAF4_HUMAN
Genbank Protein ID CAD62301.1; BAB55337.1; BAG62448.1; AAH18979.1; AAH35901.1; CAB45748.1
Protein Name DDB1- and CUL4-associated factor 4; WD repeat-containing protein 21A
Genbank Nucleotide ID BX247962; AK027745; AK300786; AC007160; BC035901; AL080157
Gene Name DCAF4; WDR21; WDR21A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000119599.16 ENST00000358377.6 ENSP00000351147.2
ENSG00000119599.16 ENST00000353777.7 ENSP00000345176.3
ENSG00000119599.16 ENST00000509320.5 ENSP00000422270.1
ENSG00000119599.16 ENST00000509153.5 ENSP00000426178.1
ENSG00000119599.16 ENST00000555042.5 ENSP00000452131.1
ENSG00000119599.16 ENST00000553457.1 ENSP00000451186.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.00e-07 32.8 369 406
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H + vt+++  +d  +l ++   g+ik+WDlrt ++++
   Q: 369  HDSAVTSVRIlQDeQYLMASDMAGKIKLWDLRTTKCVR 406
           999******998889****9999************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MNKSRWQSRR RHGRRSHQQN PWFRLRDSED RSDSRAAQPA HDSGHGDDES PSTSSGTAGT 60
SSVPELPGFY FDPEKKRYFR LLPGHNNCNP LTKESIRQKE MESKRLRLLQ EEDRRKKIAR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046746|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGATCGT CCCTATTGAC GTCGACAGAC AGAAGCCGCG TCCAGTGAGA AGGAAAGAAC 60
GGCCGCTATA GCCCTATCGG CTGCTACAAC ACCAAAACGC ATCCACCTAA CTGGCTGACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046746|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0016567--P:protein ubiquitination
GO:0008380--P:RNA splicing
KEGG hsa:26094
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001176 Aegilops tauschii 42.55 2.00e-13 68.90
IUUC-Aml-001929 Ailuropoda melanoleuca 87.47 0.00e+00 828.00
IUUC-Atr-002556 Amborella trichopoda 30.59 3.00e-14 73.20
IUUC-Apl-003177 Anas platyrhynchos 70.84 1.00e-175 609.00
IUUC-Aca-004610 Anolis carolinensis 65.80 0.00e+00 630.00
IUUC-Aly-005883 Arabidopsis lyrata 23.29 7.00e-17 82.00
IUUC-Ath-006668 Arabidopsis thaliana 23.48 4.00e-17 83.20
IUUC-Afl-008573 Aspergillus flavus 21.78 6.00e-07 48.90
IUUC-Aor-010226 Aspergillus oryzae 21.29 7.00e-05 42.00
IUUC-Ate-010340 Aspergillus terreus 22.40 2.00e-10 60.50
IUUC-Ame-010690 Astyanax mexicanus 60.47 1.00e-156 546.00
IUUC-Bta-012668 Bos taurus 81.50 0.00e+00 739.00
IUUC-Bdi-014848 Brachypodium distachyon 34.01 2.00e-14 73.60
IUUC-Bol-016035 Brassica oleracea 33.14 2.00e-15 77.00
IUUC-Bra-016687 Brassica rapa 32.00 2.00e-14 73.60
IUUC-Cja-019560 Callithrix jacchus 89.94 1.00e-83 301.00
IUUC-Cfa-020441 Canis familiaris 87.27 0.00e+00 802.00
IUUC-Cpo-021299 Cavia porcellus 78.43 0.00e+00 786.00
IUUC-Csa-023185 Chlorocebus sabaeus 97.06 0.00e+00 919.00
IUUC-Cho-024353 Choloepus hoffmanni 80.25 0.00e+00 794.00
IUUC-Dno-029890 Dasypus novemcinctus 80.81 0.00e+00 746.00
IUUC-Dor-030618 Dipodomys ordii 79.20 1.00e-84 307.00
IUUC-Ete-032557 Echinops telfairi 68.31 4.00e-135 474.00
IUUC-Eca-033466 Equus caballus 85.12 0.00e+00 834.00
IUUC-Eeu-034995 Erinaceus europaeus 73.22 4.00e-147 514.00
IUUC-Fca-036199 Felis catus 86.58 0.00e+00 806.00
IUUC-Fal-036717 Ficedula albicollis 69.20 1.00e-172 599.00
IUUC-Gmo-039201 Gadus morhua 60.46 1.00e-152 533.00
IUUC-Gga-040398 Gallus gallus 71.13 1.00e-162 566.00
IUUC-Gac-042391 Gasterosteus aculeatus 60.50 3.00e-160 558.00
IUUC-Gma-042906 Glycine max 28.30 2.00e-11 63.90
IUUC-Ggo-045348 Gorilla gorilla 99.58 0.00e+00 936.00
IUUC-Hvu-047825 Hordeum vulgare 33.99 3.00e-15 76.60
IUUC-Itr-048472 Ictidomys tridecemlineatus 84.27 0.00e+00 819.00
IUUC-Lch-050272 Latimeria chalumnae 59.41 1.00e-151 530.00
IUUC-Lpe-051618 Leersia perrieri 28.00 1.00e-13 71.20
IUUC-Loc-051772 Lepisosteus oculatus 62.09 1.00e-164 573.00
IUUC-Laf-054577 Loxodonta africana 71.40 0.00e+00 632.00
IUUC-Mcc-055284 Macaca mulatta 82.18 0.00e+00 737.00
IUUC-Meu-056721 Macropus eugenii 62.69 8.00e-88 317.00
IUUC-Mga-059238 Meleagris gallopavo 70.84 4.00e-165 574.00
IUUC-Mmr-061642 Microcebus murinus 90.45 0.00e+00 720.00
IUUC-Mdo-062030 Monodelphis domestica 74.25 0.00e+00 641.00
IUUC-Mmu-063420 Mus musculus 81.63 0.00e+00 800.00
IUUC-Mac-065231 Musa acuminata 35.77 2.00e-17 83.60
IUUC-Mpu-065692 Mustela putorius furo 87.68 0.00e+00 829.00
IUUC-Mlu-067428 Myotis lucifugus 82.97 0.00e+00 790.00
IUUC-Nle-070145 Nomascus leucogenys 98.74 0.00e+00 953.00
IUUC-Opr-071081 Ochotona princeps 78.99 0.00e+00 716.00
IUUC-Ont-071302 Oreochromis niloticus 62.44 2.00e-156 546.00
IUUC-Oan-073494 Ornithorhynchus anatinus 56.06 3.00e-127 448.00
IUUC-Ocu-073925 Oryctolagus cuniculus 79.37 0.00e+00 770.00
IUUC-Oba-075797 Oryza barthii 30.26 8.00e-13 68.60
IUUC-Obr-076014 Oryza brachyantha 31.58 4.00e-14 73.20
IUUC-Ogl-077201 Oryza glaberrima 30.26 1.00e-12 68.20
IUUC-Ogu-078056 Oryza glumaepatula 30.26 1.00e-12 68.60
IUUC-Oin-080062 Oryza indica 30.26 8.00e-13 68.60
IUUC-Olo-080869 Oryza longistaminata 30.26 4.00e-13 70.50
IUUC-Ome-081820 Oryza meridionalis 30.26 3.00e-13 69.70
IUUC-Oni-082497 Oryza nivara 30.26 8.00e-13 68.60
IUUC-Opu-083780 Oryza punctata 38.82 2.00e-11 65.10
IUUC-Oru-085091 Oryza rufipogon 30.26 8.00e-13 68.60
IUUC-Osa-085725 Oryza sativa 30.26 8.00e-13 68.60
IUUC-Ola-087033 Oryzias latipes 61.06 1.00e-144 506.00
IUUC-Oga-088861 Otolemur garnettii 85.56 0.00e+00 800.00
IUUC-Oar-090048 Ovis aries 83.58 0.00e+00 788.00
IUUC-Ptr-091658 Pan troglodytes 99.58 0.00e+00 937.00
IUUC-Pan-092873 Papio anubis 95.38 0.00e+00 932.00
IUUC-Psi-093421 Pelodiscus sinensis 70.45 3.00e-176 611.00
IUUC-Pma-094216 Petromyzon marinus 45.23 4.00e-94 338.00
IUUC-Ppa-095186 Physcomitrella patens 49.25 4.00e-10 59.70
IUUC-Pfo-096178 Poecilia formosa 61.01 2.00e-147 516.00
IUUC-Pop-099334 Populus trichocarpa 34.16 5.00e-16 77.80
IUUC-Pca-100845 Procavia capensis 70.95 0.00e+00 683.00
IUUC-Pva-103203 Pteropus vampyrus 85.12 0.00e+00 820.00
IUUC-Rno-105675 Rattus norvegicus 82.56 0.00e+00 777.00
IUUC-Sha-107389 Sarcophilus harrisii 73.10 0.00e+00 646.00
IUUC-Sja-107847 Schizosaccharomyces japonicus 24.46 5.00e-14 72.40
IUUC-Spo-108190 Schizosaccharomyces pombe 24.75 3.00e-12 66.20
IUUC-Sit-110421 Setaria italica 40.34 6.00e-15 75.10
IUUC-Sly-110888 Solanum lycopersicum 24.23 1.00e-07 51.20
IUUC-Sar-113185 Sorex araneus 65.01 4.00e-162 564.00
IUUC-Sbi-114182 Sorghum bicolor 43.42 5.00e-14 70.90
IUUC-Ssc-116005 Sus scrofa 86.16 0.00e+00 825.00
IUUC-Tgu-117023 Taeniopygia guttata 67.04 5.00e-166 577.00
IUUC-Tru-118221 Takifugu rubripes 59.10 3.00e-153 535.00
IUUC-Tsy-118784 Tarsius syrichta 75.63 0.00e+00 632.00
IUUC-Tni-120072 Tetraodon nigroviridis 60.31 2.00e-154 538.00
IUUC-Tca-121267 Theobroma cacao 26.06 1.00e-17 85.10
IUUC-Tae-124900 Triticum aestivum 33.33 2.00e-15 75.90
IUUC-Tur-126655 Triticum urartu 33.33 3.00e-15 75.90
IUUC-Tbe-127243 Tupaia belangeri 76.41 0.00e+00 693.00
IUUC-Ttr-129237 Tursiops truncatus 76.89 0.00e+00 721.00
IUUC-Vvi-131184 Vitis vinifera 27.54 4.00e-10 59.70
IUUC-Xtr-132006 Xenopus tropicalis 51.03 1.00e-122 432.00
Created Date 25-Jun-2017

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