iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-39	132.5	233	263
UBD/Beta-Prp	2.00e-61	208.2	56	276

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++++++++ +d t+l+s+s+D+t k+WD+
   Q: 233  HDGGIYAISWsPDsTHLLSASGDKTSKIWDV 263
           99*********999****************7 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkg 92
           +h +++ + k++p++ ++a+g  +g++++wd+t++  + ++  +   ++++++ + +d+k ++ ++e   ++  v+  +tg+ v  ++g
   Q: 56   EHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHILKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDTGSSVGEITG 144
           455666678*************************988777632334566***********9999999988777888888********** PP
   S: 93   hedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgg 178
           h++ + s+++ +++ ++l++Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l  +++
   Q: 145  HNKVINSVDIKQNRpYRLATGSDDNCAAFFEGPPFKFKF-TIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALggSKA 232
           ************999*****************9999998.99********************************************888 PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght 222
           h++ +y +s+++++++l+s+s d+t k+wd+  +++v t+   +
   Q: 233  HDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGS 276
           ***********************************999997655 PP

Organism

Rattus norvegicus

Functional Description
(View)

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).

Protein Sequence
(Fasta)

MPYEIKKVFA SLPQVERGVS KILGGDPKGD NFLYTNGKCV ILRNIDNPAV ADIYTEHAHQ 60
VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHILKYEYQP FAGKIKDIAW TEDSKRIAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCGCCCCC TCCGCGCCCG GCACGCCCGG CGCCGCCTTC CGCGCCGTCC CTGGGCTCGG 60
CCACTGCTAG GTTCTACTCG AGCGGGGCGC CGTAACAAGT AGGCGAGGAT GCCGTACGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0042643--C:actomyosin, actin portion
GO:0042995--C:cell projection
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0002102--C:podosome
GO:0051015--F:actin filament binding
GO:0030042--P:actin filament depolymerization
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0040011--P:locomotion
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0048713--P:regulation of oligodendrocyte differentiation
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

KEGG

rno:360950

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	34.87	3.00e-81	295.00
IUUC-Aml-002368	Ailuropoda melanoleuca	95.51	0.00e+00	1176.00
IUUC-Atr-003160	Amborella trichopoda	36.32	3.00e-113	402.00
IUUC-Apl-004012	Anas platyrhynchos	88.28	0.00e+00	1084.00
IUUC-Aca-004707	Anolis carolinensis	84.32	0.00e+00	1061.00
IUUC-Aly-006465	Arabidopsis lyrata	37.07	5.00e-110	391.00
IUUC-Ath-006740	Arabidopsis thaliana	36.42	3.00e-109	389.00
IUUC-Ago-007920	Ashbya gossypii	28.00	4.00e-73	269.00
IUUC-Acl-008262	Aspergillus clavatus	37.07	5.00e-109	388.00
IUUC-Afl-008471	Aspergillus flavus	30.72	5.00e-69	255.00
IUUC-Afu-008989	Aspergillus fumigatus	38.71	4.00e-98	352.00
IUUC-Ani-009167	Aspergillus nidulans	38.63	5.00e-118	418.00
IUUC-Ang-009595	Aspergillus niger	38.18	2.00e-105	376.00
IUUC-Aor-009908	Aspergillus oryzae	36.82	1.00e-104	373.00
IUUC-Ate-010580	Aspergillus terreus	38.18	4.00e-111	397.00
IUUC-Ame-011269	Astyanax mexicanus	60.00	9.00e-134	470.00
IUUC-Bgr-011996	Blumeria graminis	34.80	1.00e-108	387.00
IUUC-Bta-013278	Bos taurus	95.87	0.00e+00	1215.00
IUUC-Bci-013925	Botrytis cinerea	35.67	9.00e-108	384.00
IUUC-Bdi-014659	Brachypodium distachyon	35.57	6.00e-104	371.00
IUUC-Bol-016043	Brassica oleracea	35.46	3.00e-107	382.00
IUUC-Bra-017139	Brassica rapa	35.83	2.00e-108	386.00
IUUC-Cel-018417	Caenorhabditis elegans	41.56	6.00e-125	441.00
IUUC-Cja-019952	Callithrix jacchus	95.38	0.00e+00	1162.00
IUUC-Cfa-020225	Canis familiaris	95.71	0.00e+00	1189.00
IUUC-Cpo-021900	Cavia porcellus	95.01	0.00e+00	1174.00
IUUC-Csa-023028	Chlorocebus sabaeus	96.37	0.00e+00	1171.00
IUUC-Cho-025030	Choloepus hoffmanni	68.17	0.00e+00	753.00
IUUC-Cin-025152	Ciona intestinalis	55.25	2.00e-80	291.00
IUUC-Csv-025986	Ciona savignyi	37.20	3.00e-92	332.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	38.60	5.00e-113	401.00
IUUC-Cne-026814	Cryptococcus neoformans	34.29	4.00e-98	352.00
IUUC-Dre-027498	Danio rerio	80.00	2.00e-95	341.00
IUUC-Dno-029383	Dasypus novemcinctus	94.55	0.00e+00	1147.00
IUUC-Dor-030633	Dipodomys ordii	95.37	0.00e+00	1100.00
IUUC-Dse-031526	Dothistroma septosporum	38.39	2.00e-118	419.00
IUUC-Dme-031597	Drosophila melanogaster	48.43	4.00e-169	587.00
IUUC-Ete-032780	Echinops telfairi	83.28	0.00e+00	1034.00
IUUC-Eca-034306	Equus caballus	94.01	0.00e+00	1145.00
IUUC-Eeu-034531	Erinaceus europaeus	72.90	2.00e-135	475.00
IUUC-Fca-036301	Felis catus	96.01	0.00e+00	1204.00
IUUC-Fal-037361	Ficedula albicollis	87.77	0.00e+00	1127.00
IUUC-Fox-037924	Fusarium oxysporum	35.18	1.00e-101	363.00
IUUC-Fso-038199	Fusarium solani	35.12	5.00e-99	355.00
IUUC-Gmo-039238	Gadus morhua	71.66	0.00e+00	891.00
IUUC-Ggr-039830	Gaeumannomyces graminis	35.31	2.00e-96	346.00
IUUC-Gga-040235	Gallus gallus	89.11	0.00e+00	1111.00
IUUC-Gac-042363	Gasterosteus aculeatus	72.16	0.00e+00	928.00
IUUC-Gma-044189	Glycine max	36.45	3.00e-112	399.00
IUUC-Ggo-044632	Gorilla gorilla	93.90	0.00e+00	1135.00
IUUC-Hsa-045792	Homo sapiens	95.87	0.00e+00	1192.00
IUUC-Hvu-047517	Hordeum vulgare	35.02	8.00e-108	384.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	96.51	0.00e+00	1181.00
IUUC-Kpa-049183	Komagataella pastoris	33.11	8.00e-87	314.00
IUUC-Lch-050428	Latimeria chalumnae	76.94	0.00e+00	1006.00
IUUC-Lpe-051306	Leersia perrieri	35.78	5.00e-109	388.00
IUUC-Loc-052096	Lepisosteus oculatus	73.05	0.00e+00	909.00
IUUC-Lma-053313	Leptosphaeria maculans	38.63	1.00e-116	416.00
IUUC-Laf-054060	Loxodonta africana	93.40	0.00e+00	1145.00
IUUC-Mcc-055619	Macaca mulatta	94.27	0.00e+00	1142.00
IUUC-Meu-056689	Macropus eugenii	78.39	0.00e+00	633.00
IUUC-Mor-056940	Magnaporthe oryzae	35.33	3.00e-98	352.00
IUUC-Mpo-057557	Magnaporthe poae	28.85	2.00e-58	220.00
IUUC-Mtr-057922	Medicago truncatula	35.52	2.00e-109	389.00
IUUC-Mla-059103	Melampsora laricipopulina	34.04	7.00e-78	285.00
IUUC-Mga-060150	Meleagris gallopavo	88.74	0.00e+00	1100.00
IUUC-Mvi-060448	Microbotryum violaceum	31.45	1.00e-75	277.00
IUUC-Mmr-061226	Microcebus murinus	94.72	0.00e+00	1160.00
IUUC-Mdo-062674	Monodelphis domestica	91.75	0.00e+00	1149.00
IUUC-Mmu-064170	Mus musculus	98.02	0.00e+00	1205.00
IUUC-Mac-065124	Musa acuminata	36.79	9.00e-114	404.00
IUUC-Mpu-066001	Mustela putorius furo	91.73	0.00e+00	1164.00
IUUC-Mlu-067253	Myotis lucifugus	95.01	0.00e+00	1179.00
IUUC-Nfi-068550	Neosartorya fischeri	38.71	1.00e-113	403.00
IUUC-Ncr-068948	Neurospora crassa	36.98	4.00e-116	411.00
IUUC-Nle-070115	Nomascus leucogenys	92.00	0.00e+00	1072.00
IUUC-Opr-070254	Ochotona princeps	92.50	0.00e+00	1105.00
IUUC-Ont-071666	Oreochromis niloticus	75.74	0.00e+00	962.00
IUUC-Oan-073594	Ornithorhynchus anatinus	92.79	1.00e-168	585.00
IUUC-Ocu-074824	Oryctolagus cuniculus	94.22	0.00e+00	1140.00
IUUC-Oba-075010	Oryza barthii	36.17	3.00e-110	392.00
IUUC-Obr-076364	Oryza brachyantha	36.87	2.00e-111	395.00
IUUC-Ogl-077019	Oryza glaberrima	36.17	3.00e-110	392.00
IUUC-Ogu-078496	Oryza glumaepatula	36.17	3.00e-110	392.00
IUUC-Oin-080116	Oryza indica	36.33	1.00e-110	394.00
IUUC-Olo-080290	Oryza longistaminata	36.17	6.00e-110	391.00
IUUC-Ome-081969	Oryza meridionalis	36.17	4.00e-110	392.00
IUUC-Oni-082075	Oryza nivara	36.17	2.00e-110	392.00
IUUC-Opu-083959	Oryza punctata	36.22	4.00e-110	391.00
IUUC-Oru-084711	Oryza rufipogon	36.17	3.00e-110	392.00
IUUC-Osa-085958	Oryza sativa	36.33	1.00e-110	394.00
IUUC-Ola-086968	Oryzias latipes	76.57	0.00e+00	974.00
IUUC-Oga-089108	Otolemur garnettii	94.93	0.00e+00	1211.00
IUUC-Oar-089986	Ovis aries	90.16	0.00e+00	1119.00
IUUC-Ptr-091281	Pan troglodytes	96.00	0.00e+00	1181.00
IUUC-Pan-092585	Papio anubis	96.53	0.00e+00	1174.00
IUUC-Psi-093811	Pelodiscus sinensis	87.71	0.00e+00	1122.00
IUUC-Pma-094396	Petromyzon marinus	70.89	0.00e+00	912.00
IUUC-Pno-095086	Phaeosphaeria nodorum	37.46	3.00e-109	389.00
IUUC-Ppa-095876	Physcomitrella patens	35.74	2.00e-110	393.00
IUUC-Pfo-096973	Poecilia formosa	75.58	0.00e+00	998.00
IUUC-Pab-098391	Pongo abelii	95.87	0.00e+00	1170.00
IUUC-Pop-098850	Populus trichocarpa	36.32	2.00e-110	392.00
IUUC-Pca-100257	Procavia capensis	60.93	5.00e-92	332.00
IUUC-Ppe-101578	Prunus persica	37.91	4.00e-115	408.00
IUUC-Pva-102872	Pteropus vampyrus	89.46	0.00e+00	1126.00
IUUC-Pgr-103593	Puccinia graminis	33.56	1.00e-80	293.00
IUUC-Pte-104365	Pyrenophora teres	39.00	1.00e-111	397.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.67	3.00e-114	405.00
IUUC-Sce-106383	Saccharomyces cerevisiae	29.15	3.00e-68	252.00
IUUC-Sha-107084	Sarcophilus harrisii	89.66	0.00e+00	1010.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	36.18	3.00e-113	402.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.50	8.00e-97	347.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	35.50	2.00e-107	382.00
IUUC-Smo-109255	Selaginella moellendorffii	34.92	6.00e-100	358.00
IUUC-Sit-109962	Setaria italica	37.42	7.00e-113	401.00
IUUC-Sly-110897	Solanum lycopersicum	37.52	7.00e-115	407.00
IUUC-Stu-111971	Solanum tuberosum	37.52	2.00e-114	406.00
IUUC-Sar-113415	Sorex araneus	71.96	6.00e-109	388.00
IUUC-Sbi-114857	Sorghum bicolor	36.93	1.00e-110	394.00
IUUC-Sre-114900	Sporisorium reilianum	33.66	2.00e-92	333.00
IUUC-Tgu-117256	Taeniopygia guttata	87.71	0.00e+00	1123.00
IUUC-Tru-117871	Takifugu rubripes	69.92	0.00e+00	892.00
IUUC-Tsy-119172	Tarsius syrichta	95.83	2.00e-138	486.00
IUUC-Tni-120339	Tetraodon nigroviridis	70.46	0.00e+00	930.00
IUUC-Tca-121609	Theobroma cacao	36.69	1.00e-111	397.00
IUUC-Tre-122076	Trichoderma reesei	35.69	1.00e-94	340.00
IUUC-Tvi-122528	Trichoderma virens	34.48	3.00e-97	348.00
IUUC-Tae-124549	Triticum aestivum	35.35	1.00e-108	387.00
IUUC-Tur-126845	Triticum urartu	34.84	2.00e-80	293.00
IUUC-Tme-127217	Tuber melanosporum	35.56	2.00e-106	380.00
IUUC-Tbe-127526	Tupaia belangeri	92.90	0.00e+00	1157.00
IUUC-Ttr-128898	Tursiops truncatus	87.64	0.00e+00	1097.00
IUUC-Uma-129631	Ustilago maydis	32.46	7.00e-96	344.00
IUUC-Vda-129732	Verticillium dahliae	35.66	1.00e-94	340.00
IUUC-Vvi-131217	Vitis vinifera	37.40	2.00e-112	400.00
IUUC-Xtr-132860	Xenopus tropicalis	74.39	0.00e+00	949.00
IUUC-Xma-133830	Xiphophorus maculatus	75.58	0.00e+00	998.00
IUUC-Yli-134335	Yarrowia lipolytica	34.15	7.00e-79	288.00
IUUC-Zma-135907	Zea mays	37.09	2.00e-111	396.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence