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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105300
UUCD1 version UUC-RaN-00902
Ensembl Protein ID ENSRNOP00000016699.3
UniProt Accession Q6AXU4; RN181_RAT
Genbank Protein ID AAH79313.1
Protein Name E3 ubiquitin-protein ligase RNF181; RING finger protein 181; RING-type E3 ubiquitin transferase RNF181
Genbank Nucleotide ID BC079313
Gene Name Rnf181
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000012035.6 ENSRNOT00000016699.6 ENSRNOP00000016699.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 8.30e-10 39.4 88 129
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl +f+++  ++ +pC H+fh +C+  w       sk+ +CPlCr
   Q: 88   CPVCLLEFEEEetVIEMPCHHLFHSNCILPW------LSKTNSCPLCR 129
           ********44444888***************......**********8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MASYFDEHDC EPLNPEREAR NNMLLELARR VRGAWSWAPG SRSLFNRMDF EDLGLVDWEH 60
HLPPPAAKAV VESLPRTVIR SSKAELKCPV CLLEFEEEET VIEMPCHHLF HSNCILPWLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105300|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCCTTCAAG GTCATAGGAA GGATCACTCA TGGGCTGGCA CGATGGTTTG GCAGGTAAAG 60
GTGCTTGTTG CTAACGATTA CTGGTTGGGG CTCTGTATGT GTGTGTTGCC AATTTGACAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105300|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG rno:297337
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002024 Ailuropoda melanoleuca 79.53 5.00e-70 256.00
IUUC-Atr-002553 Amborella trichopoda 43.88 3.00e-18 86.70
IUUC-Ame-011175 Astyanax mexicanus 61.54 4.00e-48 183.00
IUUC-Bta-012728 Bos taurus 81.93 1.00e-71 261.00
IUUC-Bol-015156 Brassica oleracea 45.83 3.00e-19 89.70
IUUC-Bra-017773 Brassica rapa 45.83 4.00e-19 89.40
IUUC-Cja-019559 Callithrix jacchus 82.53 6.00e-73 265.00
IUUC-Cfa-020880 Canis familiaris 82.53 2.00e-72 263.00
IUUC-Cpo-022238 Cavia porcellus 80.95 4.00e-72 263.00
IUUC-Csa-023787 Chlorocebus sabaeus 81.93 4.00e-72 263.00
IUUC-Cin-025410 Ciona intestinalis 41.51 2.00e-21 94.40
IUUC-Dre-028637 Danio rerio 62.87 1.00e-52 198.00
IUUC-Dno-029183 Dasypus novemcinctus 81.33 7.00e-72 262.00
IUUC-Dor-030499 Dipodomys ordii 81.33 5.00e-69 252.00
IUUC-Dme-031824 Drosophila melanogaster 34.38 2.00e-17 81.30
IUUC-Ete-032501 Echinops telfairi 87.90 3.00e-59 219.00
IUUC-Eca-033768 Equus caballus 81.93 6.00e-72 262.00
IUUC-Eeu-035209 Erinaceus europaeus 78.38 1.00e-58 218.00
IUUC-Fca-036074 Felis catus 79.53 8.00e-70 255.00
IUUC-Gmo-038882 Gadus morhua 59.76 2.00e-44 171.00
IUUC-Gac-042217 Gasterosteus aculeatus 61.63 9.00e-51 192.00
IUUC-Gma-044323 Glycine max 51.69 2.00e-21 97.40
IUUC-Ggo-044890 Gorilla gorilla 81.93 2.00e-72 263.00
IUUC-Hsa-045980 Homo sapiens 81.33 8.00e-72 262.00
IUUC-Itr-048618 Ictidomys tridecemlineatus 81.33 8.00e-72 262.00
IUUC-Lch-049758 Latimeria chalumnae 63.16 1.00e-51 195.00
IUUC-Lpe-051295 Leersia perrieri 45.24 1.00e-18 88.60
IUUC-Loc-052244 Lepisosteus oculatus 59.77 1.00e-49 188.00
IUUC-Laf-054225 Loxodonta africana 85.54 3.00e-77 280.00
IUUC-Meu-056718 Macropus eugenii 62.87 9.00e-56 208.00
IUUC-Mtr-058205 Medicago truncatula 43.88 1.00e-17 84.30
IUUC-Mmr-061195 Microcebus murinus 78.92 9.00e-69 251.00
IUUC-Mdo-062131 Monodelphis domestica 65.88 2.00e-58 218.00
IUUC-Mmu-063803 Mus musculus 94.21 2.00e-62 231.00
IUUC-Mac-065058 Musa acuminata 49.43 1.00e-18 87.40
IUUC-Mpu-066689 Mustela putorius furo 79.87 9.00e-62 228.00
IUUC-Mlu-067441 Myotis lucifugus 81.44 6.00e-74 269.00
IUUC-Nle-069091 Nomascus leucogenys 78.18 1.00e-68 251.00
IUUC-Opr-070653 Ochotona princeps 82.53 1.00e-72 265.00
IUUC-Ont-071833 Oreochromis niloticus 58.68 1.00e-49 188.00
IUUC-Oan-073246 Ornithorhynchus anatinus 65.88 4.00e-55 206.00
IUUC-Ocu-074317 Oryctolagus cuniculus 82.53 1.00e-72 264.00
IUUC-Obr-076852 Oryza brachyantha 33.56 3.00e-18 87.40
IUUC-Ogl-077246 Oryza glaberrima 52.05 2.00e-17 82.80
IUUC-Ogu-078441 Oryza glumaepatula 47.62 1.00e-19 91.30
IUUC-Oin-079290 Oryza indica 47.62 1.00e-19 90.10
IUUC-Olo-080680 Oryza longistaminata 43.88 3.00e-19 90.10
IUUC-Ome-081782 Oryza meridionalis 51.25 1.00e-17 84.00
IUUC-Oni-082821 Oryza nivara 43.43 6.00e-20 89.70
IUUC-Opu-083695 Oryza punctata 51.25 6.00e-19 90.50
IUUC-Oru-084216 Oryza rufipogon 47.62 1.00e-19 90.90
IUUC-Osa-086033 Oryza sativa 47.62 1.00e-19 90.90
IUUC-Ola-087215 Oryzias latipes 61.08 4.00e-48 183.00
IUUC-Oga-088998 Otolemur garnettii 77.71 4.00e-55 206.00
IUUC-Oar-089622 Ovis aries 81.33 6.00e-72 262.00
IUUC-Ptr-091537 Pan troglodytes 81.93 2.00e-72 263.00
IUUC-Pan-091865 Papio anubis 82.53 2.00e-72 264.00
IUUC-Pfo-097473 Poecilia formosa 63.53 2.00e-52 197.00
IUUC-Pab-097986 Pongo abelii 81.93 2.00e-72 263.00
IUUC-Pop-099046 Populus trichocarpa 41.90 4.00e-18 85.90
IUUC-Pca-100492 Procavia capensis 81.93 3.00e-72 263.00
IUUC-Ppe-101517 Prunus persica 39.52 8.00e-20 91.30
IUUC-Pva-102641 Pteropus vampyrus 81.33 4.00e-72 263.00
IUUC-Sha-106578 Sarcophilus harrisii 66.86 3.00e-54 203.00
IUUC-Sit-110240 Setaria italica 51.14 2.00e-20 94.40
IUUC-Sly-110977 Solanum lycopersicum 50.00 1.00e-19 90.90
IUUC-Stu-112415 Solanum tuberosum 48.75 3.00e-19 89.40
IUUC-Sar-112952 Sorex araneus 74.80 3.00e-44 169.00
IUUC-Sbi-114270 Sorghum bicolor 48.98 4.00e-19 88.60
IUUC-Ssc-115694 Sus scrofa 81.93 6.00e-72 262.00
IUUC-Tsy-119580 Tarsius syrichta 87.50 2.00e-32 129.00
IUUC-Tni-120075 Tetraodon nigroviridis 63.53 5.00e-52 196.00
IUUC-Tca-121683 Theobroma cacao 41.12 4.00e-19 89.70
IUUC-Ttr-129081 Tursiops truncatus 80.72 3.00e-71 260.00
IUUC-Vpa-130305 Vicugna pacos 83.47 5.00e-52 195.00
IUUC-Xtr-132897 Xenopus tropicalis 64.12 6.00e-46 176.00
IUUC-Xma-133809 Xiphophorus maculatus 63.53 2.00e-52 197.00
Created Date 25-Jun-2017

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