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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063582
UUCD1 version UUC-MuM-01203
Ensembl Protein ID ENSMUSP00000026710.5
UniProt Accession Q99LG0; G5E860; Q99KM0; UBP16_MOUSE
Genbank Protein ID BAE35580.1; EDK98336.1; AAH03278.1; AAH04577.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID AK160038; AC154631; BC003278; BC004577
Gene Name Usp16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025616.14 ENSMUST00000026710.11 ENSMUSP00000026710.5
ENSMUSG00000025616.14 ENSMUST00000119504.7 ENSMUSP00000114058.1
ENSMUSG00000025616.14 ENSMUST00000144759.7 ENSMUSP00000116323.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 10077596
Classification
Family E-value Score Start End
DUB/USP 1.60e-91 308.1 195 823
Active Site
Position(s) Description Evidence
204 Nucleophile ECO:0000255|HAMAP-Rule:MF_03062}
759 Proton acceptor ECO:0000255|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.............kkkeklneenp.........kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e                                  ep g+l+ ++ ++++e++++kk++
   Q: 195  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppD---------LalteplevnLEPPGPLTLAMSQFLSEMQENKKRV 274
           5******************************86666666654441.........04444455558899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a +f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk  +s+++++F+g+l+
   Q: 275  VTPKELFSQVCKKATRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEEvknkvKDYEKKKAIPSFVDRIFGGELT 363
           ************************************************************99999999999999999************ PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 364  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknvkmtmeeedkdseeekddsymksrsdlpsgtskhlqkkakkqakkqaknq 452
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 453  rrqqkiqerflhfnelcatdytednereadtalagevevdtdsthgsqeeatqielsvnqkdldgqesmiertpdvqespedlgvksan 541
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 542  tesdlgivtpapecprdfngafleertsgeldiinglknlnlnaavdpdeinieipndshsapkvyevmnedpetafctlanreafstd 630
           ***************************************************************************************** PP
   S: 186  ..slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
             s+q+cL +ft++e+l+++nk+ ce c ++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++f
   Q: 631  ecSIQHCLYQFTRNEKLQDANKLLCEVCSRRQCngpkanikgdrrhvytnAKKQMLVSLAPPVLTLHLKRF--QQAGFNLRKVNKHIKF 717
           *****************************888899999999999999999*********************..9999************ PP
   S: 256  pleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtev 317
           p+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k+                        +kg+W++++D++V++v
   Q: 718  PEILDLAPFCTLKCKNVAEestRVLYSLYGVVEHSGTMRSGHYTAYAKErtaschlsnlvlhgdipqdcemesTKGQWFHISDTHVQAV 806
           ************9999888888999************************9999999999999999999999888999************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           + ++vl+   s+aY+lfY+r
   Q: 807  PITKVLN---SQAYLLFYER 823
           *******...********98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRTKGRS APDTVASESA EPVCRHLRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
PEEEAEDPSV WLCLKCGHQG CGRDSQEQHA LKHYTTPRSE PHYLVLSLDN WSVWCYKCDE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063582|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAAAGAACA CTCACATTTA TAAGCGAGTG GGACAGGATT AGGGGAAAGG AGAGACGTGT 60
GTAATTACGT CGCTCTCTTG GCCATCCTGC AGAAATAACG TATTTAAGAG AGGTAGCCAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063582|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016578--P:histone deubiquitination
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:74112
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 28.78 1.00e-28 122.00
IUUC-Aml-001931 Ailuropoda melanoleuca 81.30 0.00e+00 1245.00
IUUC-Atr-003015 Amborella trichopoda 31.67 4.00e-36 147.00
IUUC-Apl-004145 Anas platyrhynchos 60.05 0.00e+00 875.00
IUUC-Aca-004314 Anolis carolinensis 57.97 0.00e+00 860.00
IUUC-Aly-006422 Arabidopsis lyrata 28.92 3.00e-31 131.00
IUUC-Ath-006732 Arabidopsis thaliana 31.00 7.00e-34 139.00
IUUC-Bta-013362 Bos taurus 81.06 0.00e+00 1233.00
IUUC-Bdi-014624 Brachypodium distachyon 29.54 6.00e-28 119.00
IUUC-Bol-015941 Brassica oleracea 31.33 3.00e-35 144.00
IUUC-Bra-016751 Brassica rapa 30.84 5.00e-33 137.00
IUUC-Cja-019177 Callithrix jacchus 82.03 0.00e+00 1298.00
IUUC-Cfa-020051 Canis familiaris 81.91 0.00e+00 1266.00
IUUC-Cpo-021886 Cavia porcellus 73.04 0.00e+00 1164.00
IUUC-Csa-024103 Chlorocebus sabaeus 82.39 0.00e+00 1306.00
IUUC-Cho-024315 Choloepus hoffmanni 68.88 2.00e-113 403.00
IUUC-Cin-025775 Ciona intestinalis 49.65 5.00e-39 152.00
IUUC-Csv-026075 Ciona savignyi 50.00 3.00e-57 216.00
IUUC-Cme-027348 Cyanidioschyzon merolae 37.84 8.00e-20 92.00
IUUC-Dre-028388 Danio rerio 52.64 2.00e-114 407.00
IUUC-Dno-029409 Dasypus novemcinctus 78.17 0.00e+00 1234.00
IUUC-Dor-030443 Dipodomys ordii 71.95 5.00e-171 594.00
IUUC-Ete-032807 Echinops telfairi 76.56 0.00e+00 635.00
IUUC-Eca-033479 Equus caballus 81.66 0.00e+00 1280.00
IUUC-Eeu-034835 Erinaceus europaeus 72.02 7.00e-164 571.00
IUUC-Fca-036320 Felis catus 81.79 0.00e+00 1295.00
IUUC-Fal-037029 Ficedula albicollis 57.18 0.00e+00 805.00
IUUC-Gmo-039480 Gadus morhua 51.49 1.00e-111 397.00
IUUC-Gga-040527 Gallus gallus 61.05 0.00e+00 872.00
IUUC-Gac-042343 Gasterosteus aculeatus 49.18 2.00e-109 390.00
IUUC-Gma-044402 Glycine max 29.70 9.00e-34 139.00
IUUC-Ggo-045598 Gorilla gorilla 82.15 0.00e+00 1296.00
IUUC-Hsa-046598 Homo sapiens 82.00 0.00e+00 1291.00
IUUC-Hvu-047146 Hordeum vulgare 28.48 4.00e-28 120.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 81.79 0.00e+00 1277.00
IUUC-Lch-050536 Latimeria chalumnae 51.81 0.00e+00 722.00
IUUC-Lpe-050703 Leersia perrieri 29.01 4.00e-29 123.00
IUUC-Loc-051814 Lepisosteus oculatus 54.93 2.00e-121 430.00
IUUC-Laf-053732 Loxodonta africana 78.61 0.00e+00 1256.00
IUUC-Mcc-054661 Macaca mulatta 82.63 0.00e+00 1307.00
IUUC-Meu-055967 Macropus eugenii 69.93 5.00e-148 518.00
IUUC-Mtr-057945 Medicago truncatula 30.61 1.00e-33 139.00
IUUC-Mga-059551 Meleagris gallopavo 61.07 0.00e+00 889.00
IUUC-Mvi-060391 Microbotryum violaceum 33.16 3.00e-20 94.40
IUUC-Mmr-061747 Microcebus murinus 82.37 0.00e+00 1268.00
IUUC-Mdo-062220 Monodelphis domestica 66.14 0.00e+00 1012.00
IUUC-Mac-064941 Musa acuminata 33.64 6.00e-38 152.00
IUUC-Mpu-066339 Mustela putorius furo 81.18 0.00e+00 1269.00
IUUC-Mlu-067511 Myotis lucifugus 77.44 0.00e+00 1200.00
IUUC-Nle-069252 Nomascus leucogenys 82.63 0.00e+00 1305.00
IUUC-Opr-070969 Ochotona princeps 79.80 0.00e+00 1216.00
IUUC-Ont-071786 Oreochromis niloticus 49.18 3.00e-111 396.00
IUUC-Ocu-074704 Oryctolagus cuniculus 80.61 0.00e+00 1270.00
IUUC-Oba-075094 Oryza barthii 29.27 4.00e-30 127.00
IUUC-Obr-076743 Oryza brachyantha 30.86 1.00e-31 132.00
IUUC-Ogl-077739 Oryza glaberrima 29.57 2.00e-30 127.00
IUUC-Ogu-078851 Oryza glumaepatula 29.27 4.00e-30 127.00
IUUC-Oin-079402 Oryza indica 29.27 4.00e-30 127.00
IUUC-Olo-080431 Oryza longistaminata 29.57 4.00e-30 127.00
IUUC-Ome-081580 Oryza meridionalis 29.27 5.00e-30 126.00
IUUC-Oni-082644 Oryza nivara 29.27 4.00e-30 127.00
IUUC-Opu-083452 Oryza punctata 28.40 1.00e-29 125.00
IUUC-Oru-084546 Oryza rufipogon 29.27 4.00e-30 127.00
IUUC-Osa-085858 Oryza sativa 29.27 4.00e-30 127.00
IUUC-Oga-088713 Otolemur garnettii 80.82 0.00e+00 1272.00
IUUC-Oar-089887 Ovis aries 81.66 0.00e+00 1245.00
IUUC-Ptr-091670 Pan troglodytes 82.03 0.00e+00 1294.00
IUUC-Pan-092293 Papio anubis 82.63 0.00e+00 1307.00
IUUC-Psi-093101 Pelodiscus sinensis 64.55 0.00e+00 900.00
IUUC-Ppa-095622 Physcomitrella patens 31.74 3.00e-36 147.00
IUUC-Pfo-097202 Poecilia formosa 49.65 5.00e-111 395.00
IUUC-Pab-098773 Pongo abelii 81.76 0.00e+00 1014.00
IUUC-Pop-099136 Populus trichocarpa 30.23 9.00e-40 159.00
IUUC-Pca-101069 Procavia capensis 63.65 0.00e+00 1024.00
IUUC-Ppe-101794 Prunus persica 31.67 4.00e-36 146.00
IUUC-Pva-103092 Pteropus vampyrus 73.47 2.00e-163 569.00
IUUC-Rno-105237 Rattus norvegicus 91.65 0.00e+00 1420.00
IUUC-Sha-106889 Sarcophilus harrisii 68.44 0.00e+00 1054.00
IUUC-Ssl-108648 Sclerotinia sclerotiorum 27.75 3.00e-11 63.90
IUUC-Sit-110283 Setaria italica 30.64 1.00e-28 122.00
IUUC-Sly-111491 Solanum lycopersicum 28.50 1.00e-36 149.00
IUUC-Stu-112820 Solanum tuberosum 29.34 4.00e-39 157.00
IUUC-Sar-113530 Sorex araneus 76.39 0.00e+00 1187.00
IUUC-Sbi-113785 Sorghum bicolor 38.71 8.00e-25 109.00
IUUC-Ssc-116091 Sus scrofa 80.41 0.00e+00 1242.00
IUUC-Tgu-117478 Taeniopygia guttata 58.64 0.00e+00 840.00
IUUC-Tru-118640 Takifugu rubripes 51.81 3.00e-113 402.00
IUUC-Tsy-119042 Tarsius syrichta 70.23 0.00e+00 801.00
IUUC-Tni-120015 Tetraodon nigroviridis 50.49 1.00e-110 394.00
IUUC-Tca-121701 Theobroma cacao 28.75 1.00e-39 159.00
IUUC-Tae-125351 Triticum aestivum 29.01 6.00e-27 116.00
IUUC-Tur-126788 Triticum urartu 28.40 1.00e-26 115.00
IUUC-Tbe-127309 Tupaia belangeri 69.43 0.00e+00 974.00
IUUC-Ttr-128271 Tursiops truncatus 79.71 0.00e+00 1257.00
IUUC-Vpa-130674 Vicugna pacos 78.82 0.00e+00 1140.00
IUUC-Xtr-131869 Xenopus tropicalis 51.48 0.00e+00 748.00
IUUC-Xma-134195 Xiphophorus maculatus 51.31 7.00e-112 398.00
IUUC-Zma-135157 Zea mays 29.94 8.00e-27 116.00
Created Date 25-Jun-2017

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