iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-12	47.2	77	133

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            e++ +ly+y++  d++L+++kGd ++++  ++ + +W++  ++ +g+ G +P nFv+k
   Q: 77   RETLVALYPYDSRADGDLSFQKGDAMYLL--DHSNCDWWYVRHQRTGQTGYVPRNFVAK 133
           57889************************..9999**********************87 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine (PubMed:12110172, PubMed:12527374, PubMed:19210548). May be dispensable for pharyngeal muscle organization in the adult (PubMed:19210548). Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion (PubMed:16024786, PubMed:16251208). Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of axon cone of AVM, ALM, CAN and PVM neurons (PubMed:16251208). Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).

Protein Sequence
(Fasta)

MGCLFSKERR SGGSDMGVSE RIDVSRYPRR FQTPQQQTVF HVNNGGNEGT ISQLNGTSDG 60
MMGNGRGGGG GGGAQERETL VALYPYDSRA DGDLSFQKGD AMYLLDHSNC DWWYVRHQRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAAAACC TCGAAAATAA GAAGAAGAAG CAACCATTCC ATATGCATGC TCAATAATTG 60
TTGTTTGCAC AAAAATACTG GTGTCTTGTG TGAGTTTTTT TGGAAAATTC AGAAAATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0460--Magnesium
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0042995--C:cell projection
GO:0043292--C:contractile fiber
GO:0001891--C:phagocytic cup
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:1990890--F:netrin receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0071679--P:commissural neuron axon guidance
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0048557--P:embryonic digestive tract morphogenesis
GO:0001714--P:endodermal cell fate specification
GO:0000132--P:establishment of mitotic spindle orientation
GO:0035262--P:gonad morphogenesis
GO:0070986--P:left/right axis specification
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0040019--P:positive regulation of embryonic development
GO:0040017--P:positive regulation of locomotion
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0046777--P:protein autophosphorylation

KEGG

cel:CELE_Y92H12A.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002778	Amborella trichopoda	32.16	4.00e-23	102.00
IUUC-Aly-005712	Arabidopsis lyrata	31.46	5.00e-19	88.60
IUUC-Ath-007146	Arabidopsis thaliana	31.47	4.00e-22	99.00
IUUC-Ame-011816	Astyanax mexicanus	55.92	4.00e-147	513.00
IUUC-Bdi-014324	Brachypodium distachyon	32.67	5.00e-22	98.60
IUUC-Bol-016049	Brassica oleracea	30.73	3.00e-17	82.80
IUUC-Bra-017486	Brassica rapa	30.88	1.00e-21	97.10
IUUC-Dre-028216	Danio rerio	56.14	3.00e-148	517.00
IUUC-Eca-033970	Equus caballus	56.02	7.00e-146	509.00
IUUC-Eeu-035173	Erinaceus europaeus	41.43	2.00e-87	315.00
IUUC-Fal-036786	Ficedula albicollis	55.26	8.00e-147	512.00
IUUC-Gma-043938	Glycine max	33.33	2.00e-23	103.00
IUUC-Hvu-047310	Hordeum vulgare	30.32	4.00e-17	82.40
IUUC-Lpe-051166	Leersia perrieri	31.68	1.00e-21	97.40
IUUC-Mtr-058733	Medicago truncatula	32.52	5.00e-22	98.60
IUUC-Mac-064539	Musa acuminata	31.55	2.00e-19	89.70
IUUC-Ont-072127	Oreochromis niloticus	55.92	2.00e-146	511.00
IUUC-Oba-075747	Oryza barthii	33.17	4.00e-20	92.80
IUUC-Obr-076676	Oryza brachyantha	33.66	4.00e-21	95.50
IUUC-Ogl-077331	Oryza glaberrima	32.18	7.00e-23	101.00
IUUC-Ogu-078962	Oryza glumaepatula	32.18	8.00e-23	101.00
IUUC-Oin-079172	Oryza indica	32.18	6.00e-23	101.00
IUUC-Olo-080286	Oryza longistaminata	32.18	7.00e-23	101.00
IUUC-Ome-081788	Oryza meridionalis	30.53	3.00e-24	105.00
IUUC-Oni-082734	Oryza nivara	32.18	1.00e-22	100.00
IUUC-Oru-084741	Oryza rufipogon	32.18	6.00e-23	101.00
IUUC-Osa-085779	Oryza sativa	32.39	6.00e-23	101.00
IUUC-Pop-099554	Populus trichocarpa	31.71	2.00e-22	99.80
IUUC-Ppe-102072	Prunus persica	32.35	4.00e-24	105.00
IUUC-Sit-110213	Setaria italica	29.67	8.00e-20	90.90
IUUC-Sly-111528	Solanum lycopersicum	33.00	4.00e-23	102.00
IUUC-Stu-112831	Solanum tuberosum	33.50	1.00e-23	103.00
IUUC-Sbi-114480	Sorghum bicolor	30.35	1.00e-20	93.60
IUUC-Tru-117596	Takifugu rubripes	51.77	1.00e-147	515.00
IUUC-Tca-121389	Theobroma cacao	32.34	4.00e-23	102.00
IUUC-Tae-123414	Triticum aestivum	28.85	7.00e-19	88.20
IUUC-Vvi-131057	Vitis vinifera	33.00	2.00e-22	100.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence