iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	12816948

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	9.80e-17	61.6	457	492

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraannnleaAveyLld 40
           + ++ l+ MG+++++a+qaL +a +nl+ A+  Ll+
   Q: 457  ENVNTLRGMGYSTQAAKQALHQARGNLDDALKVLLS 492
           56999****************************997 PP

Organism

Mus musculus

Functional Description
(View)

Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation (By similarity).

Protein Sequence
(Fasta)

MKTNGGLCRI RALGRSQLAR QWRRMAQKKY LQAKLTQFLR EDRIQLWKPP YTKENKEVGL 60
AVKDLAKKYS ERLECCENEV ENIIEEIRRK AIERGTGNEH YRTTGIATIE VFLPPRLRKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTTTTAGC CTTGCCTTTC CACCTAACAG CTCCACCTAC AGTCGGCCCT TGCCTCCATC 60
TTCCTCCTCG CCCGGTCCCA CATCCGCTCC ACCGCAAACT ACCAGCCCCG CCCACAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011990--TPR-like_helical_dom
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50030--UBA

Pfam

PF00627--UBA

SMART

SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:53312

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000706	Aegilops tauschii	31.69	4.00e-23	102.00
IUUC-Aml-002011	Ailuropoda melanoleuca	89.92	0.00e+00	1003.00
IUUC-Atr-002685	Amborella trichopoda	26.20	5.00e-28	119.00
IUUC-Apl-003818	Anas platyrhynchos	62.54	2.00e-179	622.00
IUUC-Aca-004439	Anolis carolinensis	62.78	0.00e+00	656.00
IUUC-Aly-005796	Arabidopsis lyrata	24.94	5.00e-29	122.00
IUUC-Ath-007419	Arabidopsis thaliana	25.06	1.00e-27	117.00
IUUC-Ani-009253	Aspergillus nidulans	26.88	1.00e-01	31.60
IUUC-Ame-011290	Astyanax mexicanus	45.12	3.00e-108	385.00
IUUC-Bta-013446	Bos taurus	85.04	0.00e+00	951.00
IUUC-Bdi-014400	Brachypodium distachyon	31.09	4.00e-25	109.00
IUUC-Bol-015407	Brassica oleracea	24.23	3.00e-25	110.00
IUUC-Bra-017386	Brassica rapa	25.47	5.00e-23	102.00
IUUC-Cja-018982	Callithrix jacchus	84.74	0.00e+00	882.00
IUUC-Cfa-020919	Canis familiaris	90.24	0.00e+00	1006.00
IUUC-Cpo-021709	Cavia porcellus	85.46	0.00e+00	973.00
IUUC-Cre-023004	Chlamydomonas reinhardtii	23.56	4.00e-04	41.60
IUUC-Csa-023986	Chlorocebus sabaeus	85.83	0.00e+00	961.00
IUUC-Cho-024391	Choloepus hoffmanni	95.35	7.00e-97	347.00
IUUC-Cin-025227	Ciona intestinalis	33.33	5.00e-71	262.00
IUUC-Csv-026213	Ciona savignyi	27.31	4.00e-13	68.20
IUUC-Dre-028258	Danio rerio	40.59	1.00e-93	337.00
IUUC-Dno-029732	Dasypus novemcinctus	88.62	0.00e+00	967.00
IUUC-Dor-030896	Dipodomys ordii	80.52	0.00e+00	871.00
IUUC-Dme-031789	Drosophila melanogaster	29.10	3.00e-43	170.00
IUUC-Ete-032810	Echinops telfairi	79.55	0.00e+00	818.00
IUUC-Eca-033649	Equus caballus	86.83	0.00e+00	978.00
IUUC-Fca-035979	Felis catus	89.23	0.00e+00	996.00
IUUC-Fal-036708	Ficedula albicollis	62.03	0.00e+00	634.00
IUUC-Gmo-039174	Gadus morhua	40.56	8.00e-75	274.00
IUUC-Gga-040165	Gallus gallus	63.50	0.00e+00	646.00
IUUC-Gac-042269	Gasterosteus aculeatus	41.56	6.00e-90	325.00
IUUC-Gma-043420	Glycine max	27.41	8.00e-26	112.00
IUUC-Ggo-045525	Gorilla gorilla	86.36	0.00e+00	948.00
IUUC-Hsa-046456	Homo sapiens	85.51	0.00e+00	969.00
IUUC-Hvu-047099	Hordeum vulgare	31.15	3.00e-23	102.00
IUUC-Itr-048763	Ictidomys tridecemlineatus	89.59	0.00e+00	988.00
IUUC-Lch-049579	Latimeria chalumnae	46.55	9.00e-124	437.00
IUUC-Lpe-051485	Leersia perrieri	29.72	7.00e-26	112.00
IUUC-Loc-051974	Lepisosteus oculatus	44.21	9.00e-113	400.00
IUUC-Laf-053661	Loxodonta africana	88.46	0.00e+00	993.00
IUUC-Mcc-054599	Macaca mulatta	87.18	0.00e+00	947.00
IUUC-Meu-055935	Macropus eugenii	75.90	0.00e+00	838.00
IUUC-Mtr-058497	Medicago truncatula	27.74	3.00e-27	116.00
IUUC-Mga-059711	Meleagris gallopavo	62.87	0.00e+00	627.00
IUUC-Mmr-061079	Microcebus murinus	88.73	0.00e+00	1006.00
IUUC-Mdo-062991	Monodelphis domestica	81.76	0.00e+00	888.00
IUUC-Mac-064485	Musa acuminata	27.96	1.00e-26	114.00
IUUC-Mpu-066376	Mustela putorius furo	88.94	0.00e+00	993.00
IUUC-Mlu-067808	Myotis lucifugus	87.80	0.00e+00	1011.00
IUUC-Nle-069384	Nomascus leucogenys	85.67	0.00e+00	964.00
IUUC-Opr-071209	Ochotona princeps	83.33	3.00e-116	412.00
IUUC-Ont-071237	Oreochromis niloticus	43.07	2.00e-96	346.00
IUUC-Oan-073241	Ornithorhynchus anatinus	72.52	0.00e+00	767.00
IUUC-Ocu-074372	Oryctolagus cuniculus	87.32	0.00e+00	934.00
IUUC-Oba-075604	Oryza barthii	28.26	8.00e-26	111.00
IUUC-Obr-076272	Oryza brachyantha	30.04	3.00e-27	116.00
IUUC-Ogl-077860	Oryza glaberrima	28.26	8.00e-26	111.00
IUUC-Ogu-078907	Oryza glumaepatula	28.26	7.00e-26	112.00
IUUC-Oin-079073	Oryza indica	28.26	8.00e-26	111.00
IUUC-Olo-080884	Oryza longistaminata	28.26	8.00e-26	111.00
IUUC-Ome-081393	Oryza meridionalis	27.90	1.00e-25	110.00
IUUC-Oni-082606	Oryza nivara	28.26	7.00e-26	112.00
IUUC-Opu-083514	Oryza punctata	28.26	8.00e-26	112.00
IUUC-Oru-084709	Oryza rufipogon	28.62	2.00e-26	113.00
IUUC-Ola-086447	Oryzias latipes	42.64	3.00e-92	332.00
IUUC-Olu-087599	Ostreococcus lucimarinus	33.33	3.40e-02	32.70
IUUC-Oga-087931	Otolemur garnettii	89.11	0.00e+00	979.00
IUUC-Oar-090452	Ovis aries	85.20	0.00e+00	964.00
IUUC-Ptr-091538	Pan troglodytes	85.06	0.00e+00	920.00
IUUC-Pan-092411	Papio anubis	86.72	0.00e+00	945.00
IUUC-Psi-093867	Pelodiscus sinensis	63.02	1.00e-168	587.00
IUUC-Pma-094370	Petromyzon marinus	40.30	8.00e-93	334.00
IUUC-Ppa-096000	Physcomitrella patens	27.91	4.00e-36	146.00
IUUC-Pfo-097368	Poecilia formosa	43.19	6.00e-99	354.00
IUUC-Pab-097956	Pongo abelii	86.60	0.00e+00	949.00
IUUC-Pop-099788	Populus trichocarpa	25.27	3.00e-26	113.00
IUUC-Pca-100209	Procavia capensis	78.87	3.00e-98	352.00
IUUC-Ppe-101943	Prunus persica	28.16	8.00e-20	91.70
IUUC-Pva-102894	Pteropus vampyrus	79.06	0.00e+00	858.00
IUUC-Rno-105948	Rattus norvegicus	95.11	0.00e+00	1035.00
IUUC-Sha-106803	Sarcophilus harrisii	79.21	5.00e-118	417.00
IUUC-Smo-109087	Selaginella moellendorffii	29.52	5.00e-35	142.00
IUUC-Sit-110238	Setaria italica	33.53	2.00e-20	94.00
IUUC-Sly-111808	Solanum lycopersicum	29.36	2.00e-30	127.00
IUUC-Stu-112555	Solanum tuberosum	26.36	5.00e-27	115.00
IUUC-Sar-113510	Sorex araneus	73.79	3.00e-110	392.00
IUUC-Sbi-113830	Sorghum bicolor	32.09	3.00e-25	110.00
IUUC-Ssc-116283	Sus scrofa	85.42	0.00e+00	849.00
IUUC-Tgu-116651	Taeniopygia guttata	62.03	0.00e+00	636.00
IUUC-Tru-118492	Takifugu rubripes	43.11	4.00e-101	362.00
IUUC-Tsy-119635	Tarsius syrichta	81.49	0.00e+00	855.00
IUUC-Tni-120691	Tetraodon nigroviridis	43.01	1.00e-97	350.00
IUUC-Tca-121143	Theobroma cacao	25.50	1.00e-28	120.00
IUUC-Tae-123939	Triticum aestivum	31.69	2.00e-23	104.00
IUUC-Tbe-127414	Tupaia belangeri	85.23	0.00e+00	933.00
IUUC-Ttr-128330	Tursiops truncatus	80.94	0.00e+00	807.00
IUUC-Vpa-130210	Vicugna pacos	79.12	0.00e+00	739.00
IUUC-Vvi-131180	Vitis vinifera	24.23	8.00e-21	95.10
IUUC-Xtr-132695	Xenopus tropicalis	58.44	2.00e-168	585.00
IUUC-Xma-134255	Xiphophorus maculatus	43.19	3.00e-99	355.00
IUUC-Zma-135571	Zea mays	32.62	2.00e-26	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence