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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106153
UUCD1 version UUC-SaC-00225
Ensembl Protein ID YDR059C
UniProt Accession P15732; D6VS45; UBC5_YEAST
Genbank Protein ID CAA35529.1; CAA89088.1; CAA58975.1; CAA98877.1; DAA11905.1
Protein Name Ubiquitin-conjugating enzyme E2-16 kDa; E2 ubiquitin-conjugating enzyme 5; Ubiquitin carrier protein; Ubiquitin-protein ligase
Genbank Nucleotide ID X17494; Z49209; X84162; Z74355; BK006938
Gene Name UBC5; YDR059C; D4234; YD9609.13C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDR059C YDR059C YDR059C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 16275324; 19578373; 19204001
Classification
Family E-value Score Start End
E2/UBC 2.20e-55 184.7 6 140
UBD/UBC-like/UBD_UBC 2.10e-76 253.1 6 143
Active Site
Position(s) Description Evidence
86 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesvl 102
           R++kel++l +dpp+++sa+pv + dl++w++ i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv+f+tki+hPn++++G++Cl+ilk  ++Wspal++++vl
   Q: 6    RIAKELSDLGRDPPASCSAGPVGD-DLYHWQASIMGPSDSPYAGGVFFLSIHFPTDYPFKPPKVNFTTKIYHPNINSSGNICLDILK--DQWSPALTLSKVL 104
           89**********************.9************************************************************9..************* PP
   S: 103  lsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lsi+sll+++np++pl  e+a+++k+++++y+ +++
   Q: 105  LSICSLLTDANPDDPLVPEIAQIYKTDKAKYEATAK 140
           ********************************9987 PP
   

   UBD/UBC-like/UBD_UBC
   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaaltlskvllsl 102
           ri kel+dl rd++a +sa++v+ddl++++a i+gp+dspy ggvffl i++ptdypfkppkv+f+tkiyhpnins+g icldil++qws+altlskvlls+
   Q: 6    RIAKELSDLGRDPPASCSAGPVGDDLYHWQASIMGPSDSPYAGGVFFLSIHFPTDYPFKPPKVNFTTKIYHPNINSSGNICLDILKDQWSPALTLSKVLLSI 107
           89**************************************************************************************************** PP
   S: 103  cslladaepddplvaeiariyktdkekykriarewt 138
           csll+da+pddplv+eia+iyktdk ky+ +a+ewt
   Q: 108  CSLLTDANPDDPLVPEIAQIYKTDKAKYEATAKEWT 143
           ***********************************8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
Protein Sequence
(Fasta)
MSSSKRIAKE LSDLGRDPPA SCSAGPVGDD LYHWQASIMG PSDSPYAGGV FFLSIHFPTD 60
YPFKPPKVNF TTKIYHPNIN SSGNICLDIL KDQWSPALTL SKVLLSICSL LTDANPDDPL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106153|E2,E2/UBC;UBD,UBD_UBC|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCTTCCT CCAAGCGTAT TGCCAAGGAA TTAAGTGATT TAGGGAGGTA TGTTAAAAAT 60
AAAATGAATG ATTTTTCTTG ATCTGTAAAG AAAAAGGATT ACTAACATGA GTTTCTTTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106153|E2,E2/UBC;UBD,UBD_UBC|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0346--Stress response
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0000502--C:proteasome complex
GO:0005524--F:ATP binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034605--P:cellular response to heat
GO:0000209--P:protein polyubiquitination
KEGG sce:YDR059C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001563 Ailuropoda melanoleuca 80.56 2.00e-69 251.00
IUUC-Apl-004043 Anas platyrhynchos 80.28 2.00e-69 252.00
IUUC-Aca-005236 Anolis carolinensis 80.56 9.00e-71 256.00
IUUC-Aor-010157 Aspergillus oryzae 84.03 3.00e-75 271.00
IUUC-Ame-011657 Astyanax mexicanus 81.94 6.00e-71 257.00
IUUC-Bgr-012238 Blumeria graminis 79.17 9.00e-71 256.00
IUUC-Bta-013158 Bos taurus 80.56 9.00e-71 256.00
IUUC-Cel-018362 Caenorhabditis elegans 80.56 8.00e-71 256.00
IUUC-Cja-019886 Callithrix jacchus 80.56 9.00e-71 256.00
IUUC-Cfa-020436 Canis familiaris 80.56 9.00e-71 256.00
IUUC-Cpo-021714 Cavia porcellus 80.56 3.00e-70 254.00
IUUC-Csa-023668 Chlorocebus sabaeus 80.56 2.00e-69 251.00
IUUC-Cho-024987 Choloepus hoffmanni 80.56 2.00e-69 251.00
IUUC-Cin-025379 Ciona intestinalis 77.78 3.00e-68 248.00
IUUC-Csv-026311 Ciona savignyi 76.39 4.00e-65 237.00
IUUC-Cgl-026490 Colletotrichum gloeosporioides 84.03 2.00e-75 272.00
IUUC-Cme-027220 Cyanidioschyzon merolae 80.56 9.00e-71 256.00
IUUC-Dre-028804 Danio rerio 81.94 3.00e-71 258.00
IUUC-Dno-028952 Dasypus novemcinctus 80.71 4.00e-69 251.00
IUUC-Dse-031397 Dothistroma septosporum 83.33 2.00e-75 271.00
IUUC-Dme-031594 Drosophila melanogaster 81.94 2.00e-71 258.00
IUUC-Ete-032540 Echinops telfairi 80.56 2.00e-69 251.00
IUUC-Eca-034167 Equus caballus 80.56 2.00e-69 251.00
IUUC-Eeu-034766 Erinaceus europaeus 80.71 4.00e-67 244.00
IUUC-Gga-041015 Gallus gallus 81.25 8.00e-71 256.00
IUUC-Gac-041400 Gasterosteus aculeatus 81.25 1.00e-70 256.00
IUUC-Hsa-045885 Homo sapiens 80.56 9.00e-71 256.00
IUUC-Itr-048743 Ictidomys tridecemlineatus 80.56 2.00e-69 251.00
IUUC-Kpa-049290 Komagataella pastoris 92.47 9.00e-79 283.00
IUUC-Lch-050109 Latimeria chalumnae 79.17 3.00e-68 248.00
IUUC-Lma-053121 Leptosphaeria maculans 83.33 2.00e-75 272.00
IUUC-Laf-053580 Loxodonta africana 80.71 6.00e-69 250.00
IUUC-Mor-057235 Magnaporthe oryzae 84.03 4.00e-75 271.00
IUUC-Mpo-057596 Magnaporthe poae 79.19 3.00e-70 254.00
IUUC-Mmr-060889 Microcebus murinus 81.25 8.00e-71 256.00
IUUC-Mmu-063796 Mus musculus 81.25 8.00e-71 256.00
IUUC-Mpu-065724 Mustela putorius furo 80.56 2.00e-69 251.00
IUUC-Mlu-067573 Myotis lucifugus 80.00 4.00e-67 244.00
IUUC-Opr-070191 Ochotona princeps 80.58 3.00e-68 248.00
IUUC-Ont-071403 Oreochromis niloticus 81.94 7.00e-71 256.00
IUUC-Ocu-074315 Oryctolagus cuniculus 80.56 9.00e-71 256.00
IUUC-Ola-086493 Oryzias latipes 81.25 5.00e-70 254.00
IUUC-Olu-087615 Ostreococcus lucimarinus 75.51 2.00e-65 238.00
IUUC-Ptr-090707 Pan troglodytes 80.56 9.00e-71 256.00
IUUC-Pan-092143 Papio anubis 80.56 9.00e-71 256.00
IUUC-Pma-094405 Petromyzon marinus 78.01 5.00e-66 241.00
IUUC-Pno-094765 Phaeosphaeria nodorum 83.33 2.00e-75 272.00
IUUC-Pfo-096323 Poecilia formosa 81.94 1.00e-70 255.00
IUUC-Pab-097764 Pongo abelii 80.56 9.00e-71 256.00
IUUC-Pca-100678 Procavia capensis 80.56 2.00e-69 251.00
IUUC-Pva-102770 Pteropus vampyrus 80.56 2.00e-69 251.00
IUUC-Pgr-103381 Puccinia graminis 80.56 6.00e-69 251.00
IUUC-Ptt-103723 Puccinia triticina 78.57 2.00e-63 232.00
IUUC-Pte-104015 Pyrenophora teres 82.64 5.00e-75 270.00
IUUC-Pyt-104701 Pyrenophora triticirepentis 82.64 5.00e-75 270.00
IUUC-Sha-106489 Sarcophilus harrisii 76.87 1.00e-67 246.00
IUUC-Sja-107729 Schizosaccharomyces japonicus 84.03 6.00e-75 270.00
IUUC-Sar-113302 Sorex araneus 80.58 2.00e-68 248.00
IUUC-Tru-118628 Takifugu rubripes 81.25 3.00e-70 254.00
IUUC-Tni-120056 Tetraodon nigroviridis 79.86 8.00e-70 253.00
IUUC-Ttr-128363 Tursiops truncatus 80.56 2.00e-69 251.00
IUUC-Vda-129695 Verticillium dahliae 84.03 2.00e-75 272.00
IUUC-Vpa-130446 Vicugna pacos 80.00 2.00e-67 246.00
IUUC-Xtr-132284 Xenopus tropicalis 81.94 1.00e-70 256.00
IUUC-Xma-133673 Xiphophorus maculatus 80.56 2.00e-70 255.00
IUUC-Yli-134353 Yarrowia lipolytica 82.64 1.00e-72 263.00
Created Date 25-Jun-2017

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