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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046894
UUCD1 version UUC-HoS-00234
Ensembl Protein ID ENSP00000335091.4
UniProt Accession Q8ND25; D3DUJ9; Q9H083; ZNRF1_HUMAN
Genbank Protein ID AAK69753.1; CAB66837.1; CAD39100.1; EAW95668.1; EAW95670.1; EAW95671.1; AAH07235.1
Protein Name E3 ubiquitin-protein ligase ZNRF1; Nerve injury-induced gene 283 protein; RING-type E3 ubiquitin transferase ZNRF1; Zinc/RING finger protein 1
Genbank Nucleotide ID AF378524; AL136903; AL834440; AC092383; CH471114; CH471114; BC007235
Gene Name ZNRF1; NIN283
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000186187.11 ENST00000335325.8 ENSP00000335091.4
ENSG00000186187.11 ENST00000320619.10 ENSP00000323362.6
ENSG00000186187.11 ENST00000566250.5 ENSP00000456168.1
ENSG00000186187.11 ENST00000568351.1 ENSP00000457606.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19648646; 20107048
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.002 20.3 184 222
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCP 43
           C iCle++   ++    lpC  ++h++C+  w         + +CP
   Q: 184  CVICLEELlqgDT-IARLPCLCIYHKSCIDSW------FEVNRSCP 222
           ********88444.777***************......66666677 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
 E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Protein Sequence
(Fasta)
MGGKQSTAAR SRGPFPGVST DDSAVPPPGG APHFGHYRTG GGAMGLRSRS VSSVAGMGMD 60
PSTAGGVPFG LYTPASRGTG DSERAPGGGG SASDSTYAHG NGYQETGGGH HRDGMLYLGS 120
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Protein Fasta Sequence


>IUUC-Hsa-046894|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
TCCACGGCGG CGAGGAGCGC CGGCGAGCGC AGCCCGGGAC CGAGCGGGGC GGCGCGGCTG 60
GCGGGGCCGG CGGCGGCTGA AGCGAGAGCG CGACGCGACG CGACCGCGGC TTCCCGAGCT 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046894|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0005764--C:lysosome
GO:0016020--C:membrane
GO:0030672--C:synaptic vesicle membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
KEGG hsa:84937
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004093 Anas platyrhynchos 95.45 3.00e-60 222.00
IUUC-Bta-012934 Bos taurus 97.36 4.00e-129 453.00
IUUC-Cja-019419 Callithrix jacchus 99.12 4.00e-131 459.00
IUUC-Cfa-020388 Canis familiaris 100.00 5.00e-107 379.00
IUUC-Cpo-021584 Cavia porcellus 99.12 3.00e-131 460.00
IUUC-Cgl-026728 Colletotrichum gloeosporioides 54.00 4.00e-09 56.60
IUUC-Dre-027713 Danio rerio 76.21 6.00e-95 339.00
IUUC-Dse-031322 Dothistroma septosporum 46.81 8.00e-09 55.50
IUUC-Eca-033414 Equus caballus 100.00 1.00e-65 241.00
IUUC-Fca-036570 Felis catus 99.56 1.00e-131 461.00
IUUC-Fal-037096 Ficedula albicollis 96.30 2.00e-76 277.00
IUUC-Fox-038020 Fusarium oxysporum 33.04 3.00e-10 60.50
IUUC-Fso-038176 Fusarium solani 51.02 2.00e-08 55.10
IUUC-Ggr-039766 Gaeumannomyces graminis 46.77 1.00e-08 55.50
IUUC-Gga-041242 Gallus gallus 86.84 2.00e-95 341.00
IUUC-Itr-048339 Ictidomys tridecemlineatus 100.00 6.00e-49 184.00
IUUC-Kpa-049401 Komagataella pastoris 31.68 9.00e-09 53.50
IUUC-Lch-049749 Latimeria chalumnae 69.72 3.00e-40 157.00
IUUC-Loc-052268 Lepisosteus oculatus 79.74 9.00e-96 342.00
IUUC-Laf-054263 Loxodonta africana 98.68 2.00e-130 457.00
IUUC-Mpo-057355 Magnaporthe poae 46.77 8.00e-09 55.80
IUUC-Mla-059140 Melampsora laricipopulina 33.33 6.00e-05 42.00
IUUC-Mga-059226 Meleagris gallopavo 98.82 2.00e-48 183.00
IUUC-Mmu-064275 Mus musculus 99.12 3.00e-131 460.00
IUUC-Mpu-066334 Mustela putorius furo 99.56 1.00e-131 461.00
IUUC-Mlu-067491 Myotis lucifugus 97.81 3.00e-124 437.00
IUUC-Ont-071907 Oreochromis niloticus 71.37 2.00e-82 298.00
IUUC-Oan-072941 Ornithorhynchus anatinus 88.10 5.00e-39 151.00
IUUC-Ocu-074256 Oryctolagus cuniculus 99.12 3.00e-127 447.00
IUUC-Ola-087551 Oryzias latipes 90.80 1.00e-46 176.00
IUUC-Pfo-097234 Poecilia formosa 73.68 2.00e-90 325.00
IUUC-Pab-098719 Pongo abelii 100.00 3.00e-132 463.00
IUUC-Rno-105985 Rattus norvegicus 98.68 8.00e-131 459.00
IUUC-Sja-107832 Schizosaccharomyces japonicus 34.26 1.00e-09 56.60
IUUC-Sre-115192 Sporisorium reilianum 38.78 2.00e-15 78.60
IUUC-Tgu-116682 Taeniopygia guttata 87.57 1.00e-82 298.00
IUUC-Tre-122233 Trichoderma reesei 32.32 1.00e-06 48.50
IUUC-Tme-127002 Tuber melanosporum 56.25 2.00e-10 60.80
IUUC-Uma-129459 Ustilago maydis 37.62 6.00e-15 77.40
IUUC-Vda-129847 Verticillium dahliae 54.00 5.00e-10 59.30
IUUC-Xtr-132972 Xenopus tropicalis 63.88 2.00e-62 231.00
IUUC-Xma-134213 Xiphophorus maculatus 73.57 1.00e-89 322.00
IUUC-Yli-134502 Yarrowia lipolytica 29.48 1.00e-12 66.60
Created Date 25-Jun-2017

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