iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106413

UUCD1 version

UUC-SaC-00249

Ensembl Protein ID

YHR171W

UniProt Accession

P38862; D3DLC0; ATG7_YEAST

Genbank Protein ID

BAA33474.1; AAB68016.1; DAA06864.1

Protein Name

Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; Cytoplasm to vacuole targeting protein 2

Genbank Nucleotide ID

AB017925; U00027; BK006934

Gene Name

ATG7; APG7; CVT2; YHR171W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YHR171W	YHR171W	YHR171W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	20723759

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.

Protein Sequence
(Fasta)

MSSERVLSYA PAFKSFLDTS FFQELSRLKL DVLKLDSTCQ PLTVNLDLHN IPKSADQVPL 60
FLTNRSFEKH NNKRTNEVPL QGSIFNFNVL DEFKNLDKQL FLHQRALECW EDGIKDINKC 120

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Nucleotide Sequence
(Fasta)

ATGTCGTCAG AAAGGGTCTT AAGTTATGCA CCAGCTTTTA AATCATTTCT GGATACATCT 60
TTTTTCCAAG AATTATCGAG ATTGAAACTC GATGTTCTGA AATTAGATTC AACATGCCAA 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0097632--C:extrinsic component of pre-autophagosomal structure membrane
GO:0016020--C:membrane
GO:0000407--C:pre-autophagosomal structure
GO:0019778--F:Atg12 activating enzyme activity
GO:0019779--F:Atg8 activating enzyme activity
GO:0006914--P:autophagy
GO:0006501--P:C-terminal protein lipidation
GO:0032258--P:CVT pathway
GO:0050832--P:defense response to fungus
GO:0044805--P:late nucleophagy
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0032446--P:protein modification by small protein conjugation

KEGG

sce:YHR171W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	29.59	4.00e-66	244.00
IUUC-Aml-002316	Ailuropoda melanoleuca	38.70	3.00e-110	390.00
IUUC-Atr-002579	Amborella trichopoda	39.04	3.00e-120	423.00
IUUC-Apl-003805	Anas platyrhynchos	37.63	6.00e-118	416.00
IUUC-Aca-004618	Anolis carolinensis	39.10	6.00e-107	379.00
IUUC-Aly-005670	Arabidopsis lyrata	37.95	3.00e-102	363.00
IUUC-Ath-007499	Arabidopsis thaliana	38.51	1.00e-104	372.00
IUUC-Ago-007838	Ashbya gossypii	51.19	0.00e+00	624.00
IUUC-Acl-008093	Aspergillus clavatus	50.33	3.00e-113	400.00
IUUC-Afl-008663	Aspergillus flavus	45.83	4.00e-115	406.00
IUUC-Afu-008926	Aspergillus fumigatus	55.20	1.00e-114	405.00
IUUC-Ani-009156	Aspergillus nidulans	40.99	2.00e-118	417.00
IUUC-Ang-009853	Aspergillus niger	47.46	5.00e-56	208.00
IUUC-Aor-010055	Aspergillus oryzae	46.36	9.00e-113	399.00
IUUC-Ate-010281	Aspergillus terreus	43.74	3.00e-98	350.00
IUUC-Ame-010939	Astyanax mexicanus	37.18	6.00e-120	422.00
IUUC-Bgr-012006	Blumeria graminis	39.33	3.00e-118	416.00
IUUC-Bta-012336	Bos taurus	36.51	7.00e-107	379.00
IUUC-Bci-013598	Botrytis cinerea	52.32	3.00e-118	417.00
IUUC-Bdi-014170	Brachypodium distachyon	44.13	1.00e-69	256.00
IUUC-Bol-015357	Brassica oleracea	37.80	4.00e-110	390.00
IUUC-Bra-016835	Brassica rapa	37.87	1.00e-111	395.00
IUUC-Cel-018172	Caenorhabditis elegans	36.72	1.00e-107	382.00
IUUC-Cja-019544	Callithrix jacchus	37.99	3.00e-117	413.00
IUUC-Cfa-021043	Canis familiaris	37.04	1.00e-114	405.00
IUUC-Cpo-022366	Cavia porcellus	37.36	3.00e-116	410.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	48.98	9.00e-68	249.00
IUUC-Csa-023373	Chlorocebus sabaeus	37.30	7.00e-116	409.00
IUUC-Cho-024965	Choloepus hoffmanni	59.85	7.00e-43	166.00
IUUC-Cin-025710	Ciona intestinalis	38.34	9.00e-124	435.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	40.73	3.00e-129	453.00
IUUC-Cne-027083	Cryptococcus neoformans	39.90	8.00e-115	405.00
IUUC-Dre-028740	Danio rerio	35.10	9.00e-101	358.00
IUUC-Dno-029637	Dasypus novemcinctus	38.38	1.00e-111	395.00
IUUC-Dor-030492	Dipodomys ordii	37.39	1.00e-116	412.00
IUUC-Dse-031267	Dothistroma septosporum	42.91	4.00e-108	384.00
IUUC-Dme-032084	Drosophila melanogaster	37.22	6.00e-110	389.00
IUUC-Ete-032616	Echinops telfairi	34.77	2.00e-99	354.00
IUUC-Eca-033991	Equus caballus	37.66	1.00e-116	411.00
IUUC-Eeu-035126	Erinaceus europaeus	50.75	2.00e-55	208.00
IUUC-Fca-035472	Felis catus	37.54	5.00e-116	409.00
IUUC-Fal-037178	Ficedula albicollis	36.97	4.00e-115	406.00
IUUC-Fox-037901	Fusarium oxysporum	40.38	1.00e-120	424.00
IUUC-Fso-038279	Fusarium solani	39.94	1.00e-120	424.00
IUUC-Gmo-039329	Gadus morhua	38.44	3.00e-117	413.00
IUUC-Ggr-040061	Gaeumannomyces graminis	38.47	3.00e-112	397.00
IUUC-Gga-040244	Gallus gallus	37.45	2.00e-120	424.00
IUUC-Gac-041880	Gasterosteus aculeatus	50.98	1.00e-98	352.00
IUUC-Gma-043235	Glycine max	37.43	3.00e-111	393.00
IUUC-Ggo-045428	Gorilla gorilla	36.96	2.00e-115	407.00
IUUC-Hsa-046183	Homo sapiens	36.96	2.00e-115	407.00
IUUC-Hvu-047509	Hordeum vulgare	41.28	4.00e-66	244.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	38.15	9.00e-110	389.00
IUUC-Kpa-049142	Komagataella pastoris	45.70	3.00e-144	503.00
IUUC-Lch-049601	Latimeria chalumnae	33.39	2.00e-75	275.00
IUUC-Lpe-051496	Leersia perrieri	45.00	9.00e-72	263.00
IUUC-Loc-051751	Lepisosteus oculatus	36.57	3.00e-117	413.00
IUUC-Lma-053203	Leptosphaeria maculans	38.90	6.00e-92	329.00
IUUC-Laf-053424	Loxodonta africana	37.97	7.00e-119	419.00
IUUC-Mcc-054633	Macaca mulatta	37.45	2.00e-116	410.00
IUUC-Meu-056523	Macropus eugenii	35.06	2.00e-100	357.00
IUUC-Mor-056983	Magnaporthe oryzae	38.96	5.00e-126	442.00
IUUC-Mpo-057615	Magnaporthe poae	39.09	5.00e-120	423.00
IUUC-Mtr-058366	Medicago truncatula	36.24	1.00e-106	378.00
IUUC-Mla-058826	Melampsora laricipopulina	40.22	6.00e-135	472.00
IUUC-Mga-059447	Meleagris gallopavo	37.45	2.00e-120	424.00
IUUC-Mvi-060537	Microbotryum violaceum	42.92	6.00e-134	469.00
IUUC-Mmr-060676	Microcebus murinus	37.68	2.00e-117	414.00
IUUC-Mdo-062967	Monodelphis domestica	37.50	5.00e-113	399.00
IUUC-Mmu-063217	Mus musculus	37.91	6.00e-117	412.00
IUUC-Mac-065527	Musa acuminata	38.83	1.00e-105	375.00
IUUC-Mpu-066417	Mustela putorius furo	38.01	2.00e-115	407.00
IUUC-Mlu-067195	Myotis lucifugus	37.70	7.00e-121	425.00
IUUC-Nfi-068576	Neosartorya fischeri	52.88	2.00e-112	398.00
IUUC-Ncr-068867	Neurospora crassa	53.99	4.00e-117	413.00
IUUC-Nle-069447	Nomascus leucogenys	44.66	3.00e-84	303.00
IUUC-Opr-070737	Ochotona princeps	49.44	1.00e-94	338.00
IUUC-Ont-071260	Oreochromis niloticus	36.89	7.00e-117	412.00
IUUC-Oan-073622	Ornithorhynchus anatinus	36.21	2.00e-72	264.00
IUUC-Ocu-074584	Oryctolagus cuniculus	37.54	5.00e-119	419.00
IUUC-Oba-075483	Oryza barthii	42.29	6.00e-72	263.00
IUUC-Obr-076786	Oryza brachyantha	44.20	1.00e-70	259.00
IUUC-Ogl-077388	Oryza glaberrima	42.29	8.00e-72	263.00
IUUC-Ogu-078618	Oryza glumaepatula	42.29	1.00e-71	262.00
IUUC-Oin-080007	Oryza indica	42.00	2.00e-71	261.00
IUUC-Olo-080994	Oryza longistaminata	44.83	5.00e-71	260.00
IUUC-Ome-081735	Oryza meridionalis	42.29	2.00e-71	261.00
IUUC-Oni-082153	Oryza nivara	42.00	2.00e-71	261.00
IUUC-Opu-083146	Oryza punctata	45.00	1.00e-71	263.00
IUUC-Oru-084919	Oryza rufipogon	42.00	2.00e-71	261.00
IUUC-Osa-086182	Oryza sativa	42.00	4.00e-71	261.00
IUUC-Ola-086441	Oryzias latipes	37.23	2.00e-121	427.00
IUUC-Olu-087664	Ostreococcus lucimarinus	36.79	8.00e-106	375.00
IUUC-Oga-089074	Otolemur garnettii	38.56	7.00e-111	392.00
IUUC-Oar-090159	Ovis aries	36.81	7.00e-107	379.00
IUUC-Ptr-091105	Pan troglodytes	38.30	5.00e-104	369.00
IUUC-Pan-092446	Papio anubis	37.30	8.00e-116	409.00
IUUC-Psi-093372	Pelodiscus sinensis	39.11	2.00e-114	404.00
IUUC-Pma-094661	Petromyzon marinus	39.30	3.00e-107	380.00
IUUC-Pno-094813	Phaeosphaeria nodorum	37.16	9.00e-98	348.00
IUUC-Ppa-095224	Physcomitrella patens	37.01	9.00e-108	382.00
IUUC-Pfo-096565	Poecilia formosa	37.43	8.00e-114	402.00
IUUC-Pop-099702	Populus trichocarpa	37.54	1.00e-116	411.00
IUUC-Pca-100324	Procavia capensis	32.58	2.00e-54	205.00
IUUC-Ppe-101416	Prunus persica	37.43	1.00e-108	385.00
IUUC-Pva-102589	Pteropus vampyrus	35.43	6.00e-103	366.00
IUUC-Pgr-103497	Puccinia graminis	38.37	4.00e-128	450.00
IUUC-Ptt-103718	Puccinia triticina	37.85	4.00e-128	449.00
IUUC-Pte-104206	Pyrenophora teres	38.16	9.00e-86	308.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	40.03	4.00e-103	367.00
IUUC-Rno-105911	Rattus norvegicus	37.63	1.00e-114	405.00
IUUC-Sha-106679	Sarcophilus harrisii	37.20	5.00e-116	409.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	39.14	7.00e-122	429.00
IUUC-Spo-108107	Schizosaccharomyces pombe	38.99	2.00e-113	400.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	41.25	2.00e-134	470.00
IUUC-Smo-109677	Selaginella moellendorffii	37.19	1.00e-104	371.00
IUUC-Sit-110319	Setaria italica	44.02	1.00e-73	269.00
IUUC-Sly-111215	Solanum lycopersicum	37.68	1.00e-110	391.00
IUUC-Stu-112442	Solanum tuberosum	38.81	6.00e-108	382.00
IUUC-Sar-113370	Sorex araneus	45.90	1.00e-90	325.00
IUUC-Sbi-114261	Sorghum bicolor	43.44	3.00e-71	261.00
IUUC-Sre-114997	Sporisorium reilianum	36.89	6.00e-121	426.00
IUUC-Ssc-115304	Sus scrofa	39.04	2.00e-114	404.00
IUUC-Tgu-117235	Taeniopygia guttata	37.08	2.00e-115	407.00
IUUC-Tru-118374	Takifugu rubripes	37.34	3.00e-116	410.00
IUUC-Tsy-118966	Tarsius syrichta	31.66	7.00e-81	293.00
IUUC-Tni-120269	Tetraodon nigroviridis	37.05	7.00e-103	365.00
IUUC-Tca-121245	Theobroma cacao	37.55	3.00e-116	410.00
IUUC-Tre-121966	Trichoderma reesei	39.61	4.00e-121	426.00
IUUC-Tvi-122360	Trichoderma virens	42.00	1.00e-118	418.00
IUUC-Tae-125251	Triticum aestivum	29.85	5.00e-68	250.00
IUUC-Tur-126294	Triticum urartu	41.28	4.00e-67	247.00
IUUC-Tme-127117	Tuber melanosporum	52.88	4.00e-109	386.00
IUUC-Tbe-127662	Tupaia belangeri	39.05	2.00e-36	145.00
IUUC-Ttr-129054	Tursiops truncatus	37.66	1.00e-115	408.00
IUUC-Uma-129526	Ustilago maydis	51.11	1.00e-117	415.00
IUUC-Vda-129878	Verticillium dahliae	40.47	2.00e-125	441.00
IUUC-Vpa-130264	Vicugna pacos	61.42	6.00e-43	167.00
IUUC-Vvi-131163	Vitis vinifera	37.23	7.00e-112	395.00
IUUC-Xtr-132328	Xenopus tropicalis	29.49	9.00e-69	252.00
IUUC-Xma-133015	Xiphophorus maculatus	35.56	2.00e-104	370.00
IUUC-Yli-134468	Yarrowia lipolytica	39.81	1.00e-124	438.00
IUUC-Zma-134871	Zea mays	30.21	1.00e-72	266.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence