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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046285
Ensembl Protein ID ENSP00000288235.4
UniProt Accession Q12965; Q14778; MYO1E_HUMAN
Genbank Protein ID AAA62667.1; AAA20902.1
Protein Name Unconventional myosin-Ie; Myosin-Ic; Unconventional myosin 1E
Genbank Nucleotide ID U14391; AC092756
Gene Name MYO1E; MYO1C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000157483.8 ENST00000288235.8 ENSP00000288235.4
ENSG00000157483.8 ENST00000559412.1 ENSP00000453936.1
ENSG00000157483.8 ENST00000559269.5 ENSP00000453232.1
ENSG00000157483.8 ENST00000560749.1 ENSP00000454113.1
ENSG00000157483.8 ENST00000559489.1 ENSP00000453178.1
ENSG00000157483.8 ENST00000558571.1 ENSP00000453811.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.40e-15 58.6 1055 1108
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++++ly y+aq++deL++++ d++++i  +e   gW+ g   l+gk+GlfP+n+v+k+
   Q: 1055 QCKALYAYDAQDTDELSFNANDIIDII--KEDPSGWWTG--RLRGKQGLFPNNYVTKI 1108
           79*************************..88889*****..9*************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.
 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.
Protein Sequence
(Fasta)
MGSKGVYQYH WQSHNVKHSG VDDMVLLSKI TENSIVENLK KRYMDDYIFT YIGSVLISVN 60
PFKQMPYFGE KEIEMYQGAA QYENPPHIYA LADNMYRNMI IDRENQCVII SGESGAGKTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046285|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATTTATGGAC AGATTGCCCG GCCCGAGCCG AGACTCAGCC AGAGGAGTAC GGATTAAGTG 60
GCCGAAGAAA GAGGAGTGAG GCAGGGGAGC GAGGCGGACG CTCCGAGCGC ATCGGACTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046285|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0446--Lipid-binding
KW-0505--Motor protein
KW-0518--Myosin
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR001609--Myosin_head_motor_dom
IPR010926--Myosin_TH1
IPR027417--P-loop_NTPase
IPR001452--SH3_domain
PROSITE

PS50096--IQ
PS51456--MYOSIN_MOTOR
PS50002--SH3
PS51757--TH1
Pfam

PF00063--Myosin_head
PF06017--Myosin_TH1
PF00018--SH3_1
PRINTS

PR00193--MYOSINHEAVY
PR00452--SH3DOMAIN
SMART

SM00242--MYSc
SM00326--SH3
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005912--C:adherens junction
GO:0005903--C:brush border
GO:0005911--C:cell-cell junction
GO:0030136--C:clathrin-coated vesicle
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0070062--C:extracellular exosome
GO:0016459--C:myosin complex
GO:0051015--F:actin filament binding
GO:0005524--F:ATP binding
GO:0042623--F:ATPase activity, coupled
GO:0005516--F:calmodulin binding
GO:0000146--F:microfilament motor activity
GO:0003774--F:motor activity
GO:0035091--F:phosphatidylinositol binding
GO:0030048--P:actin filament-based movement
GO:0006897--P:endocytosis
GO:0032836--P:glomerular basement membrane development
GO:0003094--P:glomerular filtration
GO:0072015--P:glomerular visceral epithelial cell development
GO:0001701--P:in utero embryonic development
GO:0006807--P:nitrogen compound metabolic process
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0035166--P:post-embryonic hemopoiesis
GO:0001570--P:vasculogenesis
KEGG hsa:4643
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002000 Ailuropoda melanoleuca 97.11 0.00e+00 2174.00
IUUC-Apl-003276 Anas platyrhynchos 90.80 0.00e+00 1988.00
IUUC-Aca-004926 Anolis carolinensis 87.50 0.00e+00 1944.00
IUUC-Ame-011036 Astyanax mexicanus 74.78 0.00e+00 1710.00
IUUC-Bta-013102 Bos taurus 95.13 0.00e+00 2103.00
IUUC-Cja-019330 Callithrix jacchus 98.10 0.00e+00 2196.00
IUUC-Cfa-020843 Canis familiaris 98.19 0.00e+00 2195.00
IUUC-Cpo-022167 Cavia porcellus 95.03 0.00e+00 2130.00
IUUC-Csa-023357 Chlorocebus sabaeus 98.19 0.00e+00 2192.00
IUUC-Cin-025743 Ciona intestinalis 66.00 2.00e-17 79.70
IUUC-Dre-028794 Danio rerio 80.93 0.00e+00 1825.00
IUUC-Dno-029858 Dasypus novemcinctus 97.11 0.00e+00 2176.00
IUUC-Dor-030253 Dipodomys ordii 83.08 0.00e+00 1504.00
IUUC-Eca-034303 Equus caballus 95.85 0.00e+00 2089.00
IUUC-Eeu-034561 Erinaceus europaeus 73.18 5.00e-122 432.00
IUUC-Gmo-038566 Gadus morhua 81.55 0.00e+00 1547.00
IUUC-Gga-040272 Gallus gallus 91.16 0.00e+00 1992.00
IUUC-Gac-042415 Gasterosteus aculeatus 80.72 0.00e+00 1783.00
IUUC-Ggo-044547 Gorilla gorilla 99.64 0.00e+00 2222.00
IUUC-Kpa-049352 Komagataella pastoris 56.86 4.00e-13 69.70
IUUC-Lch-050042 Latimeria chalumnae 74.86 0.00e+00 1673.00
IUUC-Laf-054148 Loxodonta africana 97.47 0.00e+00 2179.00
IUUC-Mcc-055355 Macaca mulatta 98.29 0.00e+00 2195.00
IUUC-Meu-056504 Macropus eugenii 76.71 0.00e+00 1550.00
IUUC-Mga-059294 Meleagris gallopavo 84.74 0.00e+00 678.00
IUUC-Mvi-060271 Microbotryum violaceum 44.83 3.00e-09 56.60
IUUC-Mdo-062463 Monodelphis domestica 92.63 0.00e+00 2056.00
IUUC-Mmu-063160 Mus musculus 96.12 0.00e+00 2117.00
IUUC-Nle-070144 Nomascus leucogenys 99.19 0.00e+00 2209.00
IUUC-Ont-071404 Oreochromis niloticus 81.24 0.00e+00 1795.00
IUUC-Ocu-074845 Oryctolagus cuniculus 93.82 0.00e+00 2038.00
IUUC-Ola-086687 Oryzias latipes 80.43 0.00e+00 1777.00
IUUC-Oga-088019 Otolemur garnettii 97.56 0.00e+00 2156.00
IUUC-Oar-089527 Ovis aries 95.40 0.00e+00 2108.00
IUUC-Ptr-090485 Pan troglodytes 99.64 0.00e+00 2221.00
IUUC-Pan-092820 Papio anubis 98.20 0.00e+00 2190.00
IUUC-Pma-094458 Petromyzon marinus 74.60 0.00e+00 1682.00
IUUC-Pfo-096486 Poecilia formosa 78.43 0.00e+00 1778.00
IUUC-Pab-098517 Pongo abelii 97.11 0.00e+00 2154.00
IUUC-Pca-100128 Procavia capensis 69.28 0.00e+00 915.00
IUUC-Pva-102994 Pteropus vampyrus 94.77 0.00e+00 2110.00
IUUC-Ptt-103726 Puccinia triticina 40.74 1.00e-08 53.90
IUUC-Rno-104993 Rattus norvegicus 90.69 0.00e+00 1756.00
IUUC-Sha-107065 Sarcophilus harrisii 94.24 0.00e+00 2051.00
IUUC-Ssc-115601 Sus scrofa 96.93 0.00e+00 2172.00
IUUC-Tgu-116572 Taeniopygia guttata 89.19 0.00e+00 1917.00
IUUC-Tru-117568 Takifugu rubripes 80.66 0.00e+00 1811.00
IUUC-Tni-120636 Tetraodon nigroviridis 80.69 0.00e+00 1811.00
IUUC-Tbe-127462 Tupaia belangeri 87.94 0.00e+00 1394.00
IUUC-Ttr-128783 Tursiops truncatus 95.93 0.00e+00 2151.00
IUUC-Xma-133052 Xiphophorus maculatus 80.56 0.00e+00 1776.00
Created Date 25-Jun-2017

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