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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106396
UUCD1 version UUC-SaC-00015
Ensembl Protein ID YLR032W
UniProt Accession P32849; D6VY34; RAD5_YEAST
Genbank Protein ID AAA34951.1; CAA97556.1; AAB23590.1; DAA09350.1
Protein Name DNA repair protein RAD5; Radiation sensitivity protein 5; Revertibility protein 2
Genbank Nucleotide ID M96644; Z73204; S46103; BK006945
Gene Name RAD5; REV2; SNM2; YLR032W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YLR032W YLR032W YLR032W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18757916
Classification
Family E-value Score Start End
E3 activity/RING/RING 7.00e-06 24.9 914 961
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC +++   ++  l++ CgH f+++Cl  +   +ns++   +CP Cr
   Q: 914  CSICTTEPmdlDK-ALFTECGHSFCEKCLFEYIEFQNSKNLGLKCPNCR 961
           9***997756566.667************88866677799999*****8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with the DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs. Recruits the UBC13-MMS2 dimer to chromatin for DNA repair.
 Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with the DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs. Recruits the UBC13-MMS2 dimer to chromatin for DNA repair.
Protein Sequence
(Fasta)
MSHIEQEERK RFFNDDLDTS ETSLNFKSEN KESFLFANSH NDDDDDVVVS VSDTTEGEGD 60
RSIVPVRREI EEEGQNQFIT ELLRIIPEMP KDLVMELNEK FGSQEEGLSL ALSHYFDHNS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106396|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGTCATA TTGAACAGGA AGAAAGGAAG AGGTTTTTTA ACGATGACCT TGACACTTCA 60
GAAACATCGT TAAACTTCAA ATCTGAGAAT AAAGAGTCGT TTTTATTTGC AAATAGTCAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106396|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014905--HIRAN
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00271--Helicase_C
PF08797--HIRAN
PF00176--SNF2_N
PF13639--zf-RING_2
SMART

SM00487--DEXDc
SM00490--HELICc
SM00910--HIRAN
SM00184--RING
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005524--F:ATP binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0000400--F:four-way junction DNA binding
GO:0009378--F:four-way junction helicase activity
GO:0000403--F:Y-form DNA binding
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0042276--P:error-prone translesion synthesis
GO:0010994--P:free ubiquitin chain polymerization
GO:0006301--P:postreplication repair
GO:0000209--P:protein polyubiquitination
KEGG sce:YLR032W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000167 Aegilops tauschii 30.72 6.00e-112 396.00
IUUC-Atr-003139 Amborella trichopoda 29.20 1.00e-110 392.00
IUUC-Aly-005600 Arabidopsis lyrata 33.29 4.00e-115 407.00
IUUC-Ath-007079 Arabidopsis thaliana 33.25 8.00e-112 396.00
IUUC-Ago-007997 Ashbya gossypii 47.87 0.00e+00 962.00
IUUC-Acl-008022 Aspergillus clavatus 32.58 1.00e-145 508.00
IUUC-Afl-008514 Aspergillus flavus 33.46 3.00e-148 517.00
IUUC-Afu-009055 Aspergillus fumigatus 33.59 6.00e-144 503.00
IUUC-Ani-009340 Aspergillus nidulans 32.77 5.00e-147 513.00
IUUC-Ang-009785 Aspergillus niger 34.01 6.00e-154 536.00
IUUC-Aor-010158 Aspergillus oryzae 33.46 4.00e-148 517.00
IUUC-Ate-010536 Aspergillus terreus 32.30 3.00e-129 454.00
IUUC-Ame-011743 Astyanax mexicanus 30.41 3.00e-71 261.00
IUUC-Bgr-012147 Blumeria graminis 33.82 7.00e-144 503.00
IUUC-Bta-013391 Bos taurus 31.05 1.00e-78 286.00
IUUC-Bci-013741 Botrytis cinerea 33.33 3.00e-147 514.00
IUUC-Bdi-014646 Brachypodium distachyon 30.73 6.00e-112 396.00
IUUC-Bol-015995 Brassica oleracea 34.05 1.00e-114 405.00
IUUC-Bra-017004 Brassica rapa 33.74 5.00e-113 400.00
IUUC-Cpo-021361 Cavia porcellus 30.79 5.00e-69 253.00
IUUC-Cre-022824 Chlamydomonas reinhardtii 23.80 6.00e-42 164.00
IUUC-Cho-024891 Choloepus hoffmanni 31.44 3.00e-53 201.00
IUUC-Cgl-026606 Colletotrichum gloeosporioides 34.21 3.00e-153 534.00
IUUC-Cne-026886 Cryptococcus neoformans 30.61 1.00e-114 405.00
IUUC-Cme-027110 Cyanidioschyzon merolae 30.22 1.00e-93 336.00
IUUC-Dno-029517 Dasypus novemcinctus 31.98 8.00e-72 263.00
IUUC-Dse-031471 Dothistroma septosporum 34.23 2.00e-150 524.00
IUUC-Dme-031815 Drosophila melanogaster 27.81 3.00e-51 195.00
IUUC-Fox-038039 Fusarium oxysporum 34.58 1.00e-152 532.00
IUUC-Fso-038179 Fusarium solani 34.11 7.00e-152 529.00
IUUC-Ggr-039735 Gaeumannomyces graminis 34.29 1.00e-146 511.00
IUUC-Gac-042401 Gasterosteus aculeatus 31.99 2.00e-83 301.00
IUUC-Gma-042995 Glycine max 30.34 2.00e-114 404.00
IUUC-Ggo-045628 Gorilla gorilla 31.83 8.00e-79 286.00
IUUC-Hsa-045930 Homo sapiens 31.83 8.00e-79 286.00
IUUC-Hvu-047747 Hordeum vulgare 31.33 3.00e-114 404.00
IUUC-Kpa-049087 Komagataella pastoris 39.89 0.00e+00 692.00
IUUC-Lch-050617 Latimeria chalumnae 32.43 1.00e-80 292.00
IUUC-Lpe-051123 Leersia perrieri 29.30 2.00e-110 392.00
IUUC-Loc-052785 Lepisosteus oculatus 31.99 4.00e-82 297.00
IUUC-Lma-052956 Leptosphaeria maculans 33.99 9.00e-153 532.00
IUUC-Laf-054309 Loxodonta africana 32.37 1.00e-71 263.00
IUUC-Mor-057210 Magnaporthe oryzae 35.10 6.00e-158 549.00
IUUC-Mpo-057407 Magnaporthe poae 34.17 5.00e-149 520.00
IUUC-Mtr-058194 Medicago truncatula 31.24 4.00e-104 370.00
IUUC-Mla-058867 Melampsora laricipopulina 30.05 3.00e-73 267.00
IUUC-Mvi-060322 Microbotryum violaceum 29.78 4.00e-80 291.00
IUUC-Mmr-061043 Microcebus murinus 31.66 6.00e-72 263.00
IUUC-Mmu-064338 Mus musculus 31.59 3.00e-77 281.00
IUUC-Nfi-068354 Neosartorya fischeri 33.56 1.00e-144 505.00
IUUC-Ncr-068844 Neurospora crassa 33.71 5.00e-151 526.00
IUUC-Oba-075316 Oryza barthii 29.26 8.00e-108 383.00
IUUC-Obr-076403 Oryza brachyantha 33.46 2.00e-108 385.00
IUUC-Ogl-077573 Oryza glaberrima 29.80 2.00e-110 392.00
IUUC-Ogu-078083 Oryza glumaepatula 29.36 3.00e-109 387.00
IUUC-Oin-079146 Oryza indica 29.80 3.00e-110 390.00
IUUC-Olo-080615 Oryza longistaminata 30.15 6.00e-114 403.00
IUUC-Ome-081448 Oryza meridionalis 28.72 4.00e-96 344.00
IUUC-Oni-082773 Oryza nivara 29.64 1.00e-109 389.00
IUUC-Opu-083675 Oryza punctata 29.93 1.00e-113 402.00
IUUC-Oru-084543 Oryza rufipogon 29.64 4.00e-109 387.00
IUUC-Osa-085686 Oryza sativa 32.46 7.00e-106 376.00
IUUC-Oar-089293 Ovis aries 31.32 2.00e-78 285.00
IUUC-Pno-094916 Phaeosphaeria nodorum 35.53 4.00e-153 533.00
IUUC-Ppa-095877 Physcomitrella patens 34.24 2.00e-110 391.00
IUUC-Pfo-096540 Poecilia formosa 30.69 4.00e-81 294.00
IUUC-Pop-099537 Populus trichocarpa 32.55 1.00e-112 398.00
IUUC-Pca-100648 Procavia capensis 31.08 1.00e-77 282.00
IUUC-Ppe-102107 Prunus persica 29.90 2.00e-107 382.00
IUUC-Pgr-103454 Puccinia graminis 28.57 3.00e-79 288.00
IUUC-Ptt-103829 Puccinia triticina 30.33 1.00e-82 300.00
IUUC-Pte-104242 Pyrenophora teres 32.67 1.00e-146 512.00
IUUC-Pyt-104728 Pyrenophora triticirepentis 34.04 3.00e-148 517.00
IUUC-Rno-106130 Rattus norvegicus 31.38 3.00e-79 288.00
IUUC-Sja-107985 Schizosaccharomyces japonicus 36.78 8.00e-155 539.00
IUUC-Spo-108026 Schizosaccharomyces pombe 34.63 1.00e-152 531.00
IUUC-Ssl-108388 Sclerotinia sclerotiorum 33.46 4.00e-148 517.00
IUUC-Smo-109465 Selaginella moellendorffii 27.72 5.00e-76 277.00
IUUC-Sit-110076 Setaria italica 29.94 2.00e-107 381.00
IUUC-Sly-111031 Solanum lycopersicum 33.17 2.00e-113 401.00
IUUC-Stu-112600 Solanum tuberosum 33.17 3.00e-115 407.00
IUUC-Sar-113719 Sorex araneus 32.26 7.00e-80 290.00
IUUC-Sbi-113927 Sorghum bicolor 30.17 3.00e-106 377.00
IUUC-Sre-115131 Sporisorium reilianum 39.02 4.00e-56 211.00
IUUC-Tgu-117188 Taeniopygia guttata 28.28 2.00e-25 110.00
IUUC-Tni-120618 Tetraodon nigroviridis 31.61 8.00e-84 303.00
IUUC-Tca-121146 Theobroma cacao 30.62 2.00e-115 408.00
IUUC-Tre-121896 Trichoderma reesei 33.62 4.00e-148 517.00
IUUC-Tvi-122597 Trichoderma virens 32.30 2.00e-151 528.00
IUUC-Tae-124722 Triticum aestivum 30.54 7.00e-111 393.00
IUUC-Tur-125999 Triticum urartu 34.30 6.00e-110 390.00
IUUC-Tme-126953 Tuber melanosporum 31.81 1.00e-140 491.00
IUUC-Tbe-127642 Tupaia belangeri 33.46 2.00e-33 135.00
IUUC-Uma-129629 Ustilago maydis 29.40 2.00e-116 412.00
IUUC-Vda-129849 Verticillium dahliae 32.55 3.00e-139 487.00
IUUC-Vvi-131508 Vitis vinifera 32.22 2.00e-112 398.00
IUUC-Xma-133384 Xiphophorus maculatus 30.42 7.00e-80 290.00
IUUC-Yli-134588 Yarrowia lipolytica 32.21 5.00e-132 463.00
IUUC-Zma-135801 Zea mays 31.44 2.00e-97 348.00
Created Date 25-Jun-2017

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