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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106170
UUCD1 version UUC-SaC-00269
Ensembl Protein ID YJL197W
UniProt Accession P39538; D6VVZ5; UBP12_YEAST
Genbank Protein ID CAA54762.1; CAA89492.1; DAA08611.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-specific-processing protease 12
Genbank Nucleotide ID X77688; Z49472; BK006943
Gene Name UBP12; YJL197W; J0340
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YJL197W YJL197W YJL197W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.30e-99 330.3 364 1109
Active Site
Position(s) Description Evidence
373 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
1068 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw......kskkkavsprellkalkkeaeefsgyeqqDaq 93
           tGl NlgNtCYmNS+LQcL++ip+lr+++l   ++ ++neenp + +g +++++ +l+++l        +++ a+ p+++++++++++++fsgy+qqD+q
   Q: 364  TGLVNLGNTCYMNSALQCLVHIPQLRDYFLYdGYEDEINEENPLGYHGYVARAFSDLVQKLFqnrmsiMQRNAAFPPSMFKSTIGHFNSMFSGYMQQDSQ 463
           7*****************************989****************************855666677777*************************** PP
   S: 94   Eflaflldqleeelkkeknkpkeeeeeedkselsde............aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkee 181
           Eflaflld+l+e+l++  +k+++e+ + +    +d              +e + k+n s+i+dlF g +ks++ c+ec+nvs +++p +d++lp+p ++ 
   Q: 464  EFLAFLLDSLHEDLNRIIKKEYTEKPSLSP--GDDVndwnvvkkladdTWEMHLKRNCSVITDLFVGMYKSTLYCPECQNVSITFDPYNDVTLPLPVDTV 561
           **************9988888888866652..2222568999999999***************************************************9 PP
   S: 182  tkke................................................................................................ 185
            +k+                                                                                                
   Q: 562  WDKTikifpmnspplllevelsksstymdlknyvgkmsgldpntlfgceifsnqiyvnyestesnaqfltlqelikpaddvifyelpvtndnevivpvln 661
           9999************************************************************************************************ PP
   S: 186  .................................................................................................... 185
                                                                                                               
   Q: 662  triekgyknamlfgvpffitlkedelnnpgairmklqnrfvhlsggyipfpepvgnrtdfadafpllvekypdvefeqykdilqytsikvtdkdksffsi 761
           **************************************************************************************************** PP
   S: 186  .................................................................................................... 185
                                                                                                               
   Q: 762  kilsvekeqqfasnnrtgpnfwtpisqlnldkatdiddkledvvkdiynysslvdcaegvlmqvddegdtegseaknfskpfqsgddeenketvtnnenv 861
           **************************************************************************************************** PP
   S: 186  .................................................................................................... 185
                                                                                                               
   Q: 862  nntndrdedmeltddveedastepeltdkpealdkikdsltstpfailsmndiivcewselgsneafsddkiynwenpatlpnkelenaklersnakert 961
           **************************************************************************************************** PP
   S: 186  .slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiav 283
            +l+dcL+ f+k+e l   + +yc++ck++++a+k+++l++ P++L +hLkRf  +++++++ ki+  v+fp++ Ldls++++ +++      +Y+L+av
   Q: 962  iTLDDCLQLFSKPEILGLTDSWYCPTCKEHRQATKQIQLWNTPDILLIHLKRF--ESQRSFSDKIDATVNFPITdLDLSRYVVYKDDPR--GLIYDLYAV 1057
           *****************************************************..66778999*******************9977666..9******** PP
   S: 284  vvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +H+G+l++GHY+ayvkn  ++kW++fdDs+Vte+  e+       +aY+lfY r
   Q: 1058 DNHYGGLGGGHYTAYVKNfADNKWYYFDDSRVTETAPENSIA---GSAYLLFYIR 1109
           ******************44556************8877777...8*******87 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Ubiquitin carboxyl-terminal hydrolase that recognizes ubiquitin chains that stabilize FZO1 and promote mitochondrial fusion. UBP12 deubiquitylates FZO1 only after oligomerization.
 Ubiquitin carboxyl-terminal hydrolase that recognizes ubiquitin chains that stabilize FZO1 and promote mitochondrial fusion. UBP12 deubiquitylates FZO1 only after oligomerization.
Protein Sequence
(Fasta)
MGSSDVSSRE CSLVYNEDPD FTDGTTPCDR LGVDLMNVLD DKDEIKQESV PVSDREIEDT 60
ESDASAVSSF ASANELIAEP HAASETNLGT NGQDGRNVLE QQRDVVARLI EENKETQKEG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106170|DUB,USP|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGTTCTT CAGATGTTTC AAGTCGTGAA TGTTCATTGG TTTATAATGA AGATCCCGAT 60
TTCACCGATG GCACAACACC ATGTGATCGG TTGGGAGTGG ACTTGATGAA TGTTCTAGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106170|DUB,USP|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028134--USP4/12
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
SMART

SM00695--DUSP
Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG sce:YJL197W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000058 Aegilops tauschii 43.39 1.00e-47 182.00
IUUC-Aml-001852 Ailuropoda melanoleuca 36.97 4.00e-61 228.00
IUUC-Atr-002955 Amborella trichopoda 38.05 1.00e-51 196.00
IUUC-Apl-003249 Anas platyrhynchos 37.06 2.00e-61 228.00
IUUC-Aca-004532 Anolis carolinensis 34.81 1.00e-62 233.00
IUUC-Aly-005456 Arabidopsis lyrata 35.08 9.00e-47 180.00
IUUC-Ath-007343 Arabidopsis thaliana 37.01 4.00e-50 191.00
IUUC-Ago-007911 Ashbya gossypii 44.50 0.00e+00 905.00
IUUC-Acl-008284 Aspergillus clavatus 38.81 5.00e-61 228.00
IUUC-Afl-008507 Aspergillus flavus 39.57 2.00e-64 239.00
IUUC-Afu-008878 Aspergillus fumigatus 39.08 5.00e-62 231.00
IUUC-Ani-009479 Aspergillus nidulans 38.75 8.00e-63 234.00
IUUC-Ang-009562 Aspergillus niger 40.00 5.00e-65 241.00
IUUC-Aor-009949 Aspergillus oryzae 39.30 2.00e-63 236.00
IUUC-Ate-010323 Aspergillus terreus 39.61 1.00e-61 230.00
IUUC-Ame-010757 Astyanax mexicanus 38.38 3.00e-61 228.00
IUUC-Bgr-012277 Blumeria graminis 44.29 3.00e-67 249.00
IUUC-Bta-013284 Bos taurus 38.19 1.00e-61 229.00
IUUC-Bci-013993 Botrytis cinerea 37.87 9.00e-70 257.00
IUUC-Bdi-014013 Brachypodium distachyon 41.75 4.00e-59 221.00
IUUC-Bol-016299 Brassica oleracea 29.90 1.00e-51 196.00
IUUC-Bra-017213 Brassica rapa 30.13 1.00e-51 196.00
IUUC-Cel-018203 Caenorhabditis elegans 43.93 3.00e-47 181.00
IUUC-Cja-019222 Callithrix jacchus 36.97 3.00e-61 228.00
IUUC-Cfa-020035 Canis familiaris 36.97 4.00e-61 228.00
IUUC-Cpo-022071 Cavia porcellus 36.97 4.00e-61 227.00
IUUC-Csa-023882 Chlorocebus sabaeus 36.97 3.00e-61 228.00
IUUC-Cho-024595 Choloepus hoffmanni 38.70 2.00e-57 215.00
IUUC-Cin-025292 Ciona intestinalis 34.76 2.00e-51 196.00
IUUC-Csv-026109 Ciona savignyi 34.46 8.00e-48 183.00
IUUC-Cgl-026741 Colletotrichum gloeosporioides 38.03 2.00e-69 256.00
IUUC-Cne-026852 Cryptococcus neoformans 35.56 1.00e-63 236.00
IUUC-Cme-027338 Cyanidioschyzon merolae 33.74 1.00e-45 176.00
IUUC-Dre-027869 Danio rerio 39.21 2.00e-62 231.00
IUUC-Dno-029025 Dasypus novemcinctus 36.97 2.00e-61 229.00
IUUC-Dor-030384 Dipodomys ordii 35.80 2.00e-61 229.00
IUUC-Dse-031432 Dothistroma septosporum 44.01 8.00e-63 234.00
IUUC-Dme-032094 Drosophila melanogaster 33.44 1.00e-38 154.00
IUUC-Ete-032970 Echinops telfairi 45.30 5.00e-51 194.00
IUUC-Eca-033271 Equus caballus 35.82 3.00e-61 228.00
IUUC-Eeu-034488 Erinaceus europaeus 36.70 4.00e-60 224.00
IUUC-Fca-036012 Felis catus 38.48 6.00e-62 230.00
IUUC-Fal-036618 Ficedula albicollis 37.06 6.00e-62 230.00
IUUC-Fox-037986 Fusarium oxysporum 39.04 4.00e-69 254.00
IUUC-Fso-038291 Fusarium solani 47.39 3.00e-74 271.00
IUUC-Gmo-038866 Gadus morhua 38.81 1.00e-62 233.00
IUUC-Ggr-039740 Gaeumannomyces graminis 39.01 1.00e-72 266.00
IUUC-Gga-041146 Gallus gallus 37.33 3.00e-62 231.00
IUUC-Gac-041679 Gasterosteus aculeatus 37.78 4.00e-61 228.00
IUUC-Gma-042830 Glycine max 39.87 1.00e-52 199.00
IUUC-Ggo-045002 Gorilla gorilla 36.97 4.00e-61 227.00
IUUC-Hsa-046052 Homo sapiens 36.97 3.00e-61 228.00
IUUC-Hvu-047108 Hordeum vulgare 39.73 4.00e-49 187.00
IUUC-Itr-048306 Ictidomys tridecemlineatus 36.97 4.00e-61 227.00
IUUC-Kpa-049332 Komagataella pastoris 41.36 3.00e-115 408.00
IUUC-Lch-050107 Latimeria chalumnae 38.04 2.00e-63 236.00
IUUC-Lpe-051047 Leersia perrieri 40.24 4.00e-56 211.00
IUUC-Loc-051800 Lepisosteus oculatus 37.19 8.00e-62 230.00
IUUC-Lma-052981 Leptosphaeria maculans 43.55 5.00e-66 245.00
IUUC-Laf-053645 Loxodonta africana 37.23 6.00e-61 227.00
IUUC-Mcc-055586 Macaca mulatta 36.97 3.00e-61 228.00
IUUC-Meu-056749 Macropus eugenii 38.19 3.00e-62 230.00
IUUC-Mor-056985 Magnaporthe oryzae 44.78 9.00e-71 260.00
IUUC-Mpo-057486 Magnaporthe poae 38.52 2.00e-71 262.00
IUUC-Mtr-058489 Medicago truncatula 39.56 7.00e-54 203.00
IUUC-Mla-058848 Melampsora laricipopulina 38.98 3.00e-61 229.00
IUUC-Mga-060162 Meleagris gallopavo 37.33 4.00e-62 231.00
IUUC-Mvi-060324 Microbotryum violaceum 35.41 2.00e-59 223.00
IUUC-Mmr-061105 Microcebus murinus 37.04 1.00e-61 229.00
IUUC-Mdo-062107 Monodelphis domestica 36.96 4.00e-60 224.00
IUUC-Mmu-063960 Mus musculus 36.59 9.00e-56 209.00
IUUC-Mac-064956 Musa acuminata 39.58 1.00e-57 216.00
IUUC-Mpu-065868 Mustela putorius furo 36.97 4.00e-61 227.00
IUUC-Mlu-066961 Myotis lucifugus 38.19 5.00e-62 230.00
IUUC-Nfi-068330 Neosartorya fischeri 39.35 2.00e-63 236.00
IUUC-Ncr-068879 Neurospora crassa 42.41 2.00e-72 266.00
IUUC-Nle-069874 Nomascus leucogenys 36.97 3.00e-61 228.00
IUUC-Opr-071212 Ochotona princeps 36.97 1.00e-61 229.00
IUUC-Ont-071847 Oreochromis niloticus 38.29 2.00e-59 222.00
IUUC-Oan-073387 Ornithorhynchus anatinus 35.54 5.00e-59 220.00
IUUC-Ocu-074573 Oryctolagus cuniculus 36.97 3.00e-61 228.00
IUUC-Oba-075427 Oryza barthii 36.25 9.00e-52 196.00
IUUC-Obr-076902 Oryza brachyantha 38.67 5.00e-56 210.00
IUUC-Ogl-077583 Oryza glaberrima 37.21 9.00e-49 186.00
IUUC-Ogu-078422 Oryza glumaepatula 36.25 8.00e-52 196.00
IUUC-Oin-079453 Oryza indica 38.62 9.00e-57 213.00
IUUC-Olo-080315 Oryza longistaminata 38.32 1.00e-56 212.00
IUUC-Ome-081271 Oryza meridionalis 38.62 6.00e-57 214.00
IUUC-Oni-082834 Oryza nivara 36.86 7.00e-52 197.00
IUUC-Opu-083691 Oryza punctata 35.81 4.00e-53 201.00
IUUC-Oru-084820 Oryza rufipogon 36.86 7.00e-52 197.00
IUUC-Osa-086139 Oryza sativa 38.62 1.00e-56 213.00
IUUC-Ola-086553 Oryzias latipes 39.52 8.00e-62 230.00
IUUC-Olu-087717 Ostreococcus lucimarinus 36.94 2.00e-49 188.00
IUUC-Oga-088424 Otolemur garnettii 38.44 2.00e-62 231.00
IUUC-Oar-089732 Ovis aries 37.90 2.00e-61 228.00
IUUC-Ptr-091319 Pan troglodytes 36.97 2.00e-61 228.00
IUUC-Pan-091968 Papio anubis 36.97 3.00e-61 228.00
IUUC-Psi-093849 Pelodiscus sinensis 37.30 1.00e-61 229.00
IUUC-Pma-094268 Petromyzon marinus 38.95 2.00e-61 228.00
IUUC-Pno-094890 Phaeosphaeria nodorum 36.91 3.00e-66 245.00
IUUC-Ppa-095584 Physcomitrella patens 29.62 6.00e-23 101.00
IUUC-Pfo-097110 Poecilia formosa 38.95 6.00e-62 230.00
IUUC-Pab-098664 Pongo abelii 36.97 3.00e-61 228.00
IUUC-Pop-099801 Populus trichocarpa 43.89 4.00e-56 211.00
IUUC-Pca-100161 Procavia capensis 36.28 3.00e-54 204.00
IUUC-Ppe-101637 Prunus persica 36.41 1.00e-56 212.00
IUUC-Pva-103244 Pteropus vampyrus 36.68 3.00e-62 231.00
IUUC-Pgr-103546 Puccinia graminis 39.58 1.00e-56 213.00
IUUC-Ptt-103847 Puccinia triticina 40.07 4.00e-56 211.00
IUUC-Pte-104102 Pyrenophora teres 46.78 4.00e-60 225.00
IUUC-Pyt-104812 Pyrenophora triticirepentis 46.15 7.00e-61 228.00
IUUC-Rno-106081 Rattus norvegicus 36.59 3.00e-56 211.00
IUUC-Sha-107502 Sarcophilus harrisii 38.19 8.00e-62 229.00
IUUC-Sja-107752 Schizosaccharomyces japonicus 33.66 1.00e-74 273.00
IUUC-Spo-108291 Schizosaccharomyces pombe 31.48 1.00e-75 276.00
IUUC-Smo-108686 Selaginella moellendorffii 43.56 7.00e-53 199.00
IUUC-Sit-109930 Setaria italica 40.79 2.00e-57 215.00
IUUC-Sly-111891 Solanum lycopersicum 37.78 4.00e-50 191.00
IUUC-Stu-112671 Solanum tuberosum 39.80 5.00e-54 204.00
IUUC-Sar-113498 Sorex araneus 37.23 6.00e-61 227.00
IUUC-Sbi-114549 Sorghum bicolor 40.85 5.00e-55 207.00
IUUC-Sre-115130 Sporisorium reilianum 35.51 4.00e-60 224.00
IUUC-Ssc-115285 Sus scrofa 36.97 3.00e-61 228.00
IUUC-Tgu-116529 Taeniopygia guttata 37.06 6.00e-62 230.00
IUUC-Tru-118298 Takifugu rubripes 39.50 1.00e-62 233.00
IUUC-Tsy-119414 Tarsius syrichta 38.44 3.00e-61 228.00
IUUC-Tni-120093 Tetraodon nigroviridis 39.17 4.00e-63 234.00
IUUC-Tca-121670 Theobroma cacao 38.87 9.00e-56 209.00
IUUC-Tre-121888 Trichoderma reesei 41.01 8.00e-77 280.00
IUUC-Tvi-122422 Trichoderma virens 41.13 7.00e-74 271.00
IUUC-Tae-125401 Triticum aestivum 39.64 2.00e-57 215.00
IUUC-Tur-126392 Triticum urartu 40.17 4.00e-42 164.00
IUUC-Tme-127062 Tuber melanosporum 42.36 2.00e-74 272.00
IUUC-Tbe-127672 Tupaia belangeri 36.97 4.00e-62 231.00
IUUC-Ttr-128441 Tursiops truncatus 36.96 5.00e-61 227.00
IUUC-Uma-129498 Ustilago maydis 33.06 1.00e-53 203.00
IUUC-Vda-129781 Verticillium dahliae 40.61 2.00e-72 266.00
IUUC-Vpa-130469 Vicugna pacos 36.97 6.00e-61 227.00
IUUC-Vvi-131066 Vitis vinifera 39.56 5.00e-52 197.00
IUUC-Xtr-132305 Xenopus tropicalis 38.97 1.00e-61 229.00
IUUC-Xma-133550 Xiphophorus maculatus 38.66 3.00e-61 228.00
IUUC-Yli-134392 Yarrowia lipolytica 36.73 4.00e-77 281.00
IUUC-Zma-135361 Zea mays 40.24 2.00e-56 212.00
Created Date 25-Jun-2017

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