iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018702

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

BTB and MATH domain-containing protein 42

Genbank Nucleotide ID

FO080718

Gene Name

bath-42; C50C3.8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00016803	C50C3.8	C50C3.8

Annotation

mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	19223395; 13679922

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.30e-17	64.2	219	284
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.70e-07	30.5	321	352

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkld 66
           +D++++vg+++++ah+++L   S+vF+++f++    e + k++++i+d +++++ra+++F+Ytg  +
   Q: 219  TDCVIHVGNKHIKAHRCILGQNSPVFKSMFSSPNMiEAQ-KGEIHIEDAKYDSVRAMVEFMYTGATE 284
           7*****************************666665**9.************************876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l N+++i +f+d+y++++Lk+a+++f+ +h++
   Q: 321  LKNVTQIAMFSDTYTADYLKSAVIRFLTTHHR 352
           57****************************86 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MSSRSSWSST EQINRTISSR ADDLPPQPRR LEVVSKQATR VTALSTKLEW KIEQFEKLMK 60
LIKNGSNLIS RMFSVPDAPT VCWELHVYPN GKRDEDVNNV SFFLRQVGLA RGEEPIMTEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATAACCTCT TGCTCGCTCA ACTTATCAAC AGAGGTAAAA CTTATTCGCA ATATAATATG 60
TCTTCACGTT CCTCGTGGTC ATCCACGGAG CAGATTAATC GCACAATCAG TTCCAGAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like

PROSITE

PS50097--BTB
PS50144--MATH

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00061--MATH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

cel:CELE_C50C3.8

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ang-009714	Aspergillus niger	25.00	3.50e-02	31.20
IUUC-Cre-022654	Chlamydomonas reinhardtii	27.47	2.00e-03	34.30
IUUC-Fso-038419	Fusarium solani	33.33	5.00e-05	40.40
IUUC-Kpa-049253	Komagataella pastoris	25.90	2.00e+00	26.90
IUUC-Mla-058948	Melampsora laricipopulina	29.20	2.00e-06	47.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence