iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000066258.13	ENSMUST00000106837.7	ENSMUSP00000102450.1
ENSMUSG00000066258.13	ENSMUST00000106839.8	ENSMUSP00000102452.2
ENSMUSG00000066258.13	ENSMUST00000070943.6	ENSMUSP00000065008.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	7.70e-07	30.2	10	76
E3 activity/RING/RING	9.50e-08	33.6	15	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggk.....tcPvtrqplteedlvPnltlrrl 64
            ee  Cp+ l+lM  Pv + +G+t+ + +I  +++s +       cPv+r + + ++l Pn  + ++
   Q: 10   KEEVTCPVCLNLMVKPVSADCGHTFCQGCITLYFESIKCdkkvfICPVCRISYQFSNLRPNRNVANI 76
           68999*****************************77766677999****************987665 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ + + p++ +CgH+f++ C+  ++ + +  +k f+CP+Cr
   Q: 15   CPVCLNLMVK-PVSADCGHTFCQGCITLYFESIKCDKKVFICPVCR 59
           **********.9*9***************9***************8 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MASQFMKNLK EEVTCPVCLN LMVKPVSADC GHTFCQGCIT LYFESIKCDK KVFICPVCRI 60
SYQFSNLRPN RNVANIVERL KMFKPSPEEE QKVFNCARHG KKLQLFCRKD MMAICWLCER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCAAACTT TCCTTTCTCT AGATTTTAGC CGGAAATACC TTGAAGTTCT GGATTGGTGA 60
GTTAATTCTC CCTGGTTTAC AACTTTCTGG CGTCTGATAA AGGGCTGAGC AATTTTAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032917--TRIM5
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response

KEGG

mmu:76681

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Itr-048793	Ictidomys tridecemlineatus	57.92	9.00e-87	313.00
IUUC-Sly-111157	Solanum lycopersicum	33.33	3.00e-08	52.40

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence