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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063462
UUCD1 version UUC-MuM-00002
Ensembl Protein ID ENSMUSP00000025183.8
UniProt Accession O35730; Q3U242; Q3U333; Q4FK33; Q63ZX8; Q921Z8; RING1_MOUSE
Genbank Protein ID CAA73381.1; AAC69901.1; BAE32956.1; BAE33300.1; CAJ18427.1; AAH09070.1; AAH82771.1
Protein Name E3 ubiquitin-protein ligase RING1; Polycomb complex protein RING1; RING finger protein 1; RING-type E3 ubiquitin transferase RING1; Transcription repressor Ring1A
Genbank Nucleotide ID Y12881; AF100956; AK154962; AK155509; CT010219; BC009070; BC082771
Gene Name Ring1; Ring1A; Rnf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024325.8 ENSMUST00000025183.8 ENSMUSP00000025183.8
Annotation
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18650381; 20921134
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.10e-06 30.1 48 88
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+   +  C H f+ dC+  ++       s++  CP+Cr
   Q: 48   CPICLDMLKNTMTTKECLHRFCSDCIvTAL------RSGNKECPTCR 88
           **********555555**********7777......**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).
 Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).
Protein Sequence
(Fasta)
MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT 60
TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH 120
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Protein Fasta Sequence


>IUUC-Mmu-063462|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AGGGAGGGCG GAAGTGACGT CGAGCCTCGG CGCCCAGGCC ATGGCGGCGG TGGCGGTGGC 60
AGCAAGGGTT GCGGCGTGAG TGGCAGCTGC GGACCGAGCG GACCAGGGCA GCGGAGCCCC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063462|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0016740--F:transferase activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0048593--P:camera-type eye morphogenesis
GO:0035518--P:histone H2A monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:19763
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001831 Ailuropoda melanoleuca 99.41 5.00e-99 354.00
IUUC-Aca-005261 Anolis carolinensis 59.36 1.00e-120 426.00
IUUC-Bta-012493 Bos taurus 99.31 3.00e-83 301.00
IUUC-Cel-018573 Caenorhabditis elegans 50.00 4.00e-15 79.00
IUUC-Cja-019447 Callithrix jacchus 98.82 2.00e-98 352.00
IUUC-Cfa-020721 Canis familiaris 99.41 5.00e-99 354.00
IUUC-Cpo-022273 Cavia porcellus 98.82 1.00e-98 353.00
IUUC-Csa-023422 Chlorocebus sabaeus 98.82 2.00e-98 352.00
IUUC-Dno-028911 Dasypus novemcinctus 99.41 6.00e-99 354.00
IUUC-Dor-030457 Dipodomys ordii 82.35 5.00e-76 278.00
IUUC-Eca-033576 Equus caballus 99.41 5.00e-99 354.00
IUUC-Eeu-034880 Erinaceus europaeus 99.34 3.00e-87 315.00
IUUC-Fca-035789 Felis catus 99.41 5.00e-99 354.00
IUUC-Gmo-038890 Gadus morhua 54.83 2.00e-92 332.00
IUUC-Gac-041845 Gasterosteus aculeatus 56.72 8.00e-105 373.00
IUUC-Gma-044107 Glycine max 44.26 9.00e-24 104.00
IUUC-Ggo-045070 Gorilla gorilla 98.82 2.00e-98 352.00
IUUC-Hsa-045680 Homo sapiens 98.82 2.00e-98 352.00
IUUC-Itr-048166 Ictidomys tridecemlineatus 99.41 5.00e-99 354.00
IUUC-Laf-054431 Loxodonta africana 99.41 5.00e-99 354.00
IUUC-Mcc-055268 Macaca mulatta 98.82 2.00e-98 352.00
IUUC-Meu-056000 Macropus eugenii 90.44 2.00e-154 538.00
IUUC-Mmr-061509 Microcebus murinus 98.82 4.00e-98 351.00
IUUC-Mdo-063069 Monodelphis domestica 90.13 2.00e-147 515.00
IUUC-Mac-064893 Musa acuminata 46.94 2.00e-24 107.00
IUUC-Mpu-066818 Mustela putorius furo 99.41 5.00e-99 354.00
IUUC-Mlu-067266 Myotis lucifugus 99.28 7.00e-79 287.00
IUUC-Nle-069778 Nomascus leucogenys 98.82 2.00e-98 352.00
IUUC-Opr-070456 Ochotona princeps 86.22 1.00e-56 213.00
IUUC-Oga-088881 Otolemur garnettii 99.41 5.00e-99 354.00
IUUC-Oar-089484 Ovis aries 99.41 5.00e-99 354.00
IUUC-Ptr-091151 Pan troglodytes 98.58 2.00e-80 292.00
IUUC-Pan-092254 Papio anubis 98.82 2.00e-98 352.00
IUUC-Pab-098086 Pongo abelii 98.24 6.00e-98 350.00
IUUC-Pca-100649 Procavia capensis 96.47 4.00e-92 331.00
IUUC-Rno-105941 Rattus norvegicus 98.52 9.00e-152 529.00
IUUC-Sha-106734 Sarcophilus harrisii 89.95 9.00e-167 579.00
IUUC-Stu-112805 Solanum tuberosum 51.28 4.00e-20 92.80
IUUC-Ssc-116072 Sus scrofa 99.41 5.00e-99 354.00
IUUC-Ttr-128591 Tursiops truncatus 99.31 6.00e-83 301.00
Created Date 25-Jun-2017

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