iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000213186.7	ENST00000309784.8	ENSP00000311219.4
ENSG00000213186.7	ENST00000496222.1	ENSP00000418856.1
ENSG00000213186.7	ENST00000468542.1	ENSP00000420451.1
ENSG00000213186.7	ENST00000543469.1	ENSP00000444313.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17314412

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	8.00e-06	27.5	6	89
E3 activity/RING/RING	6.30e-09	37.9	10	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...........tcPvtrqpl.....teedlvPnltlrrliqawcee 71
           ee+ CpI + +++dP vlp+ +t+ r+++e  l+ +g+           +cP +r+ +       e+l  n +lr++i+++ +e
   Q: 6    EELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNfyiwrplriplKCPNCRSITeiaptGIESLPVNFALRAIIEKYQQE 89
           7999*****************************999999**********99999975533221456777799999999999776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefr..........CPlCr 46
           C+iC++ f+d p+vlpC H+f+++Cl+++     ++s++f+          CP Cr
   Q: 10   CPICYSIFED-PRVLPCSHTFCRNCLENI----LQASGNFYiwrplriplkCPNCR 60
           **********.***************999....567777766666666777****8 PP

Organism

Homo sapiens

Functional Description
(View)

May serve as a multifunctional regulator for innate immune signaling pathways.

Protein Sequence
(Fasta)

MHNFEEELTC PICYSIFEDP RVLPCSHTFC RNCLENILQA SGNFYIWRPL RIPLKCPNCR 60
SITEIAPTGI ESLPVNFALR AIIEKYQQED HPDIVTCPEH YRQPLNVYCL LDKKLVCGHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCGATTCT CCTGCCTCAG CCTCGTGAGT AGCTGGGGTT ACAGGCGCCC GCTACCACAC 60
CCGGCTAATT TTTGTATTTT TAGTAGAGAC GAGGTTTCAC CATGTTGGTC AGGCTGGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005813--C:centrosome
GO:0005929--C:cilium
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0030992--C:intraciliary transport particle B
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0060271--P:cilium assembly
GO:0045087--P:innate immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046597--P:negative regulation of viral entry into host cell

KEGG

hsa:286827

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002249	Ailuropoda melanoleuca	88.56	0.00e+00	740.00
IUUC-Apl-003996	Anas platyrhynchos	58.77	8.00e-124	437.00
IUUC-Aca-005141	Anolis carolinensis	57.53	7.00e-133	467.00
IUUC-Bta-013440	Bos taurus	89.50	0.00e+00	671.00
IUUC-Cfa-021168	Canis familiaris	88.78	0.00e+00	738.00
IUUC-Cpo-021702	Cavia porcellus	75.12	3.00e-176	611.00
IUUC-Csa-024141	Chlorocebus sabaeus	94.54	0.00e+00	719.00
IUUC-Dno-029180	Dasypus novemcinctus	87.59	0.00e+00	724.00
IUUC-Eca-034357	Equus caballus	88.09	0.00e+00	705.00
IUUC-Fca-036287	Felis catus	89.33	0.00e+00	742.00
IUUC-Gga-040739	Gallus gallus	58.13	2.00e-136	478.00
IUUC-Ggo-045307	Gorilla gorilla	98.26	0.00e+00	782.00
IUUC-Itr-048230	Ictidomys tridecemlineatus	90.07	0.00e+00	751.00
IUUC-Laf-054522	Loxodonta africana	84.86	0.00e+00	706.00
IUUC-Mcc-055145	Macaca mulatta	94.54	0.00e+00	752.00
IUUC-Meu-056214	Macropus eugenii	47.48	5.00e-61	228.00
IUUC-Mmr-061197	Microcebus murinus	91.32	0.00e+00	759.00
IUUC-Mdo-062631	Monodelphis domestica	60.25	1.00e-135	476.00
IUUC-Mmu-064217	Mus musculus	82.84	0.00e+00	665.00
IUUC-Mpu-065691	Mustela putorius furo	90.57	0.00e+00	754.00
IUUC-Mlu-067742	Myotis lucifugus	85.54	0.00e+00	685.00
IUUC-Nle-069722	Nomascus leucogenys	95.53	0.00e+00	789.00
IUUC-Oan-073382	Ornithorhynchus anatinus	61.79	1.00e-140	493.00
IUUC-Oar-089206	Ovis aries	87.59	0.00e+00	731.00
IUUC-Pan-092189	Papio anubis	94.79	0.00e+00	755.00
IUUC-Psi-093523	Pelodiscus sinensis	62.56	4.00e-144	504.00
IUUC-Pma-094162	Petromyzon marinus	32.10	1.00e-46	180.00
IUUC-Pva-103089	Pteropus vampyrus	87.78	0.00e+00	702.00
IUUC-Pgr-103338	Puccinia graminis	36.23	1.00e-06	47.00
IUUC-Rno-105440	Rattus norvegicus	84.08	0.00e+00	677.00
IUUC-Ssc-115809	Sus scrofa	86.85	0.00e+00	696.00
IUUC-Tru-118402	Takifugu rubripes	44.07	3.00e-94	338.00
IUUC-Ttr-128921	Tursiops truncatus	88.03	0.00e+00	709.00
IUUC-Vpa-130397	Vicugna pacos	88.09	0.00e+00	738.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence