iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
JASPAR	TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	16604062

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Positive trans-acting factor capable of stimulating the transcription of the MET genes from the methionine biosynthetic pathway. MET4, MET28 and CBF1 are required for full induction of MET25 and MET16 gene transcription. MET4 controls as well the derepression of MET6. Required for the transcription of genes necessary for sulfur amino acid biosynthesis. Involved in the transcription activation of MET28 and MET30. Required for MET3 gene expression via assembly of the MET4-MET28-MET31 and MET4-MET28-MET32 complexes. Involved in response to cadmium and arsenic. Cadmium-activated MET4 also induces glutathione biosynthesis.

Protein Sequence
(Fasta)

MKQEQSHEGD SYSTEFINLF GKDTATHPSS NNGANNNGMG STNSLDQFVA TASSSSSLVT 60
SSENRRPLIG DVTNRGNTNL YDHAVTPEIL LEQLAYVDNF IPSLDNEFSN VDWNVNTTHN 120

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Nucleotide Sequence
(Fasta)

ATGAAGCAGG AGCAGTCCCA CGAAGGCGAC TCATACAGCA CGGAATTCAT AAATCTCTTT 60
GGCAAAGATA CCGCAACACA CCCTAGCAGC AACAACGGTG CTAATAATAA TGGCATGGGG 120

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Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0028--Amino-acid biosynthesis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0198--Cysteine biosynthesis
KW-0238--DNA-binding
KW-0486--Methionine biosynthesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Gene Ontology

GO:0089713--C:Cbf1-Met4-Met28 complex
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0003713--F:transcription coactivator activity
GO:0019344--P:cysteine biosynthetic process
GO:0009086--P:methionine biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0046685--P:response to arsenic-containing substance
GO:0046686--P:response to cadmium ion
GO:0000096--P:sulfur amino acid metabolic process
GO:0006351--P:transcription, DNA-templated

KEGG

sce:YNL103W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000176	Aegilops tauschii	31.58	3.00e-03	35.40
IUUC-Aml-001217	Ailuropoda melanoleuca	50.00	7.90e-02	29.60
IUUC-Ago-007929	Ashbya gossypii	34.35	6.00e-41	159.00
IUUC-Acl-008145	Aspergillus clavatus	46.67	5.00e-03	33.10
IUUC-Afl-008664	Aspergillus flavus	41.67	6.00e-03	32.70
IUUC-Afu-009015	Aspergillus fumigatus	36.36	1.00e-03	35.00
IUUC-Ang-009517	Aspergillus niger	38.10	3.00e-03	33.50
IUUC-Aor-010136	Aspergillus oryzae	46.67	4.00e-03	32.30
IUUC-Ate-010447	Aspergillus terreus	41.51	2.00e-04	38.10
IUUC-Bol-015745	Brassica oleracea	31.91	2.20e-02	31.60
IUUC-Cpo-022020	Cavia porcellus	55.00	2.30e-02	31.60
IUUC-Cgl-026582	Colletotrichum gloeosporioides	45.71	5.00e-04	36.20
IUUC-Itr-048129	Ictidomys tridecemlineatus	55.00	3.80e-02	30.80
IUUC-Kpa-049276	Komagataella pastoris	36.67	3.00e-09	54.30
IUUC-Laf-054316	Loxodonta africana	54.55	1.30e-02	32.30
IUUC-Nfi-068432	Neosartorya fischeri	36.36	1.00e-03	34.70
IUUC-Ocu-073784	Oryctolagus cuniculus	42.31	1.50e-02	30.80
IUUC-Ppe-101884	Prunus persica	39.39	2.50e-02	31.60
IUUC-Tae-123218	Triticum aestivum	31.58	3.00e-03	35.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence