iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	9.80e-143	475.8	164	465
E3 adaptor/Cullin RING/DCX/DWD	2.00e-24	85.5	298	328

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltghsar 98
           p+kvldap l+ddfylnL+dWs++nvlav+Lg++vylw+a++++v+kl+dl  +d+v+sv w  +gt+lavGt++g+v+i+D++++k++rt++gh  r
   Q: 164  PYKVLDAPALQDDFYLNLVDWSAQNVLAVGLGNCVYLWNACSSKVTKLCDLGAEDSVCSVGWALRGTHLAVGTSTGKVQIWDASRCKRTRTMEGHRLR 261
           79************************************************************************************************ PP
   S: 99   vgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavkaiawsPwqkslLa 196
           vgaL+W + vlssGsrd++il+rd+r++e ++s+l++h++evCGlkw+ d+++LasGGnDn + vw+++s++P+ k++eh+aavkaiawsP+ ++lLa
   Q: 262  VGALAWGSSVLSSGSRDKSILQRDIRCQEDHVSKLAGHKSEVCGLKWSYDNRELASGGNDNRLFVWNQHSTQPVLKYSEHTAAVKAIAWSPHVHGLLA 359
           ************************************************************************************************** PP
   S: 197  sGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaagDetlrfw 294
           sGGGtaDrci+fwnt+t + l++idt sqvc+l+wsk+ +elvsthG+++n+i++wkyp++sk+a+l+gh++Rvl+la+spdg++ivt+agDetlrfw
   Q: 360  SGGGTADRCIRFWNTTTNTHLSSIDTCSQVCNLAWSKNVNELVSTHGYSQNQIIVWKYPTMSKIATLTGHTYRVLYLAVSPDGQTIVTGAGDETLRFW 457
           ************************************************************************************************** PP
   S: 295  klfdkkka 302
           ++f + k+
   Q: 458  NVFPSPKS 465
           ***87665 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWD 29
           gH+++v++l++  +++ l+sG++D+ + vW+
   Q: 298  GHKSEVCGLKWsyDNRELASGGNDNRLFVWN 328
           8**********964499*************9 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). Necessary and sufficient for endoreduplication and correct cell expansion. Controls meristem size by stimulating endoreduplication in the elongation zone.

Protein Sequence
(Fasta)

MEEEDPTASN VITNSNSSSM RNLSPAMNTP VVSLESRINR LINANQSQSP SPSSLSRSIY 60
SDRFIPSRSG SNFALFDLSP SPSKDGKEDG AGSYATLLRA AMFGPETPEK RDITGFSSSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAAACAGA CATTAATCCA TAACTATTTA GGCCCATCTT CAAGCCCATT AAACCTTTTC 60
CTCTTAATCC AACGATTAAG ATTGAATCAG AAGCTTAAAC CTCACGGTCC TCACCTGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0051301--P:cell division
GO:0016049--P:cell growth
GO:0042023--P:DNA endoreduplication
GO:0007067--P:mitotic nuclear division
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination
GO:0010091--P:trichome branching

KEGG

ath:AT4G22910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000670	Aegilops tauschii	79.50	6.00e-154	536.00
IUUC-Aml-002003	Ailuropoda melanoleuca	55.65	5.00e-135	473.00
IUUC-Atr-002753	Amborella trichopoda	75.17	0.00e+00	627.00
IUUC-Apl-003212	Anas platyrhynchos	57.44	5.00e-138	483.00
IUUC-Aly-005442	Arabidopsis lyrata	97.31	0.00e+00	941.00
IUUC-Ago-007784	Ashbya gossypii	47.84	3.00e-96	345.00
IUUC-Acl-008269	Aspergillus clavatus	48.01	1.00e-128	452.00
IUUC-Afl-008432	Aspergillus flavus	49.69	1.00e-128	452.00
IUUC-Afu-008829	Aspergillus fumigatus	49.06	5.00e-128	450.00
IUUC-Ani-009471	Aspergillus nidulans	49.06	1.00e-128	452.00
IUUC-Ang-009711	Aspergillus niger	64.94	3.00e-127	448.00
IUUC-Aor-010118	Aspergillus oryzae	49.69	1.00e-128	452.00
IUUC-Ate-010534	Aspergillus terreus	48.74	7.00e-128	450.00
IUUC-Ame-011011	Astyanax mexicanus	57.18	8.00e-137	479.00
IUUC-Bgr-012013	Blumeria graminis	64.61	4.00e-123	434.00
IUUC-Bta-012586	Bos taurus	57.57	1.00e-137	482.00
IUUC-Bci-013807	Botrytis cinerea	48.68	3.00e-120	425.00
IUUC-Bdi-014981	Brachypodium distachyon	74.07	0.00e+00	631.00
IUUC-Bol-016301	Brassica oleracea	91.68	0.00e+00	852.00
IUUC-Bra-017453	Brassica rapa	91.27	0.00e+00	855.00
IUUC-Cel-018472	Caenorhabditis elegans	61.77	4.00e-121	428.00
IUUC-Cja-019929	Callithrix jacchus	56.39	4.00e-138	484.00
IUUC-Cfa-020977	Canis familiaris	56.39	5.00e-138	483.00
IUUC-Cpo-021537	Cavia porcellus	57.34	2.00e-137	481.00
IUUC-Cre-022944	Chlamydomonas reinhardtii	48.08	2.00e-108	385.00
IUUC-Csa-023389	Chlorocebus sabaeus	57.57	4.00e-138	484.00
IUUC-Cin-025327	Ciona intestinalis	56.01	8.00e-131	459.00
IUUC-Csv-025921	Ciona savignyi	53.53	4.00e-130	457.00
IUUC-Cgl-026631	Colletotrichum gloeosporioides	49.19	2.00e-123	435.00
IUUC-Cne-026933	Cryptococcus neoformans	56.63	1.00e-123	436.00
IUUC-Cme-027143	Cyanidioschyzon merolae	62.62	1.00e-120	427.00
IUUC-Dre-027470	Danio rerio	56.43	4.00e-135	474.00
IUUC-Dno-029629	Dasypus novemcinctus	54.46	6.00e-118	417.00
IUUC-Dor-030187	Dipodomys ordii	55.45	8.00e-128	449.00
IUUC-Dse-031502	Dothistroma septosporum	47.48	5.00e-116	410.00
IUUC-Dme-031858	Drosophila melanogaster	55.98	1.00e-137	482.00
IUUC-Ete-032562	Echinops telfairi	71.92	1.00e-85	310.00
IUUC-Eca-034210	Equus caballus	57.57	1.00e-137	482.00
IUUC-Fca-035839	Felis catus	57.51	1.00e-134	472.00
IUUC-Fal-036895	Ficedula albicollis	57.44	4.00e-138	484.00
IUUC-Fox-037814	Fusarium oxysporum	61.63	6.00e-122	429.00
IUUC-Fso-038420	Fusarium solani	61.63	7.00e-123	433.00
IUUC-Gmo-039544	Gadus morhua	56.72	1.00e-134	472.00
IUUC-Ggr-039774	Gaeumannomyces graminis	49.20	7.00e-125	440.00
IUUC-Gga-041025	Gallus gallus	57.67	1.00e-138	485.00
IUUC-Gac-041596	Gasterosteus aculeatus	56.62	4.00e-134	470.00
IUUC-Gma-042657	Glycine max	76.53	0.00e+00	718.00
IUUC-Ggo-045599	Gorilla gorilla	55.80	3.00e-136	478.00
IUUC-Hsa-046695	Homo sapiens	56.39	3.00e-138	484.00
IUUC-Itr-048192	Ictidomys tridecemlineatus	57.11	7.00e-138	483.00
IUUC-Kpa-049239	Komagataella pastoris	54.01	4.00e-118	417.00
IUUC-Lch-049827	Latimeria chalumnae	57.05	1.00e-136	479.00
IUUC-Loc-052856	Lepisosteus oculatus	56.53	3.00e-136	478.00
IUUC-Mcc-055601	Macaca mulatta	57.57	4.00e-138	484.00
IUUC-Meu-056276	Macropus eugenii	55.12	2.00e-121	428.00
IUUC-Mor-057113	Magnaporthe oryzae	48.99	7.00e-124	437.00
IUUC-Mpo-057599	Magnaporthe poae	49.40	5.00e-125	441.00
IUUC-Mla-059048	Melampsora laricipopulina	46.11	2.00e-106	379.00
IUUC-Mga-060097	Meleagris gallopavo	54.30	1.00e-126	446.00
IUUC-Mvi-060465	Microbotryum violaceum	47.98	2.00e-123	435.00
IUUC-Mmr-061151	Microcebus murinus	50.55	2.00e-112	398.00
IUUC-Mdo-063062	Monodelphis domestica	57.44	2.00e-138	484.00
IUUC-Mmu-063731	Mus musculus	57.34	4.00e-137	480.00
IUUC-Mac-065208	Musa acuminata	79.45	0.00e+00	650.00
IUUC-Mpu-066173	Mustela putorius furo	57.34	7.00e-138	483.00
IUUC-Mlu-068030	Myotis lucifugus	56.39	6.00e-138	483.00
IUUC-Nfi-068536	Neosartorya fischeri	49.06	4.00e-128	451.00
IUUC-Ncr-068734	Neurospora crassa	49.37	2.00e-125	442.00
IUUC-Nle-070163	Nomascus leucogenys	57.57	9.00e-138	483.00
IUUC-Opr-070974	Ochotona princeps	65.97	4.00e-106	377.00
IUUC-Ont-072272	Oreochromis niloticus	56.85	1.00e-134	472.00
IUUC-Oan-073634	Ornithorhynchus anatinus	68.88	3.00e-115	407.00
IUUC-Obr-076123	Oryza brachyantha	76.96	1.00e-166	579.00
IUUC-Ogl-077294	Oryza glaberrima	69.85	1.00e-177	615.00
IUUC-Ogu-077996	Oryza glumaepatula	69.85	2.00e-177	615.00
IUUC-Oin-080172	Oryza indica	78.05	2.00e-167	581.00
IUUC-Olo-081068	Oryza longistaminata	77.81	1.00e-164	571.00
IUUC-Ome-081250	Oryza meridionalis	69.93	4.00e-178	616.00
IUUC-Oni-083048	Oryza nivara	69.85	1.00e-177	615.00
IUUC-Opu-083333	Oryza punctata	69.78	0.00e+00	625.00
IUUC-Oru-085001	Oryza rufipogon	69.85	1.00e-177	615.00
IUUC-Osa-086243	Oryza sativa	69.85	1.00e-177	615.00
IUUC-Ola-087094	Oryzias latipes	54.73	2.00e-131	462.00
IUUC-Oga-088911	Otolemur garnettii	57.57	8.00e-138	483.00
IUUC-Oar-089508	Ovis aries	57.57	1.00e-137	482.00
IUUC-Pan-092147	Papio anubis	56.39	3.00e-138	484.00
IUUC-Psi-093702	Pelodiscus sinensis	56.62	6.00e-138	483.00
IUUC-Pma-094581	Petromyzon marinus	53.33	2.00e-126	445.00
IUUC-Pno-095139	Phaeosphaeria nodorum	60.94	5.00e-117	414.00
IUUC-Ppa-095366	Physcomitrella patens	68.94	4.00e-179	620.00
IUUC-Pfo-096309	Poecilia formosa	57.08	1.00e-134	472.00
IUUC-Pop-098924	Populus trichocarpa	75.20	0.00e+00	702.00
IUUC-Pca-100565	Procavia capensis	54.82	2.00e-133	468.00
IUUC-Ppe-101924	Prunus persica	81.76	0.00e+00	728.00
IUUC-Pva-102602	Pteropus vampyrus	56.98	2.00e-132	464.00
IUUC-Pgr-103466	Puccinia graminis	48.50	1.00e-106	379.00
IUUC-Ptt-103888	Puccinia triticina	55.17	7.00e-97	347.00
IUUC-Pte-104097	Pyrenophora teres	48.70	3.00e-125	441.00
IUUC-Pyt-104445	Pyrenophora triticirepentis	44.78	1.00e-106	379.00
IUUC-Rno-105028	Rattus norvegicus	57.34	2.00e-137	481.00
IUUC-Sce-106240	Saccharomyces cerevisiae	48.20	3.00e-94	338.00
IUUC-Sha-106538	Sarcophilus harrisii	49.89	2.00e-119	422.00
IUUC-Sja-107785	Schizosaccharomyces japonicus	46.29	5.00e-114	404.00
IUUC-Spo-108369	Schizosaccharomyces pombe	44.47	8.00e-109	386.00
IUUC-Ssl-108391	Sclerotinia sclerotiorum	48.07	5.00e-121	427.00
IUUC-Smo-109041	Selaginella moellendorffii	70.22	0.00e+00	626.00
IUUC-Sit-110563	Setaria italica	72.71	2.00e-174	605.00
IUUC-Sly-111446	Solanum lycopersicum	79.50	0.00e+00	686.00
IUUC-Stu-112491	Solanum tuberosum	79.73	0.00e+00	686.00
IUUC-Sbi-114489	Sorghum bicolor	72.71	3.00e-177	613.00
IUUC-Sre-115222	Sporisorium reilianum	52.05	4.00e-117	414.00
IUUC-Ssc-116171	Sus scrofa	57.57	1.00e-137	482.00
IUUC-Tgu-116878	Taeniopygia guttata	50.46	3.00e-111	394.00
IUUC-Tru-118222	Takifugu rubripes	55.70	5.00e-135	473.00
IUUC-Tni-119863	Tetraodon nigroviridis	57.44	2.00e-135	474.00
IUUC-Tca-121599	Theobroma cacao	84.79	0.00e+00	753.00
IUUC-Tre-122249	Trichoderma reesei	49.09	3.00e-125	441.00
IUUC-Tvi-122675	Trichoderma virens	64.00	2.00e-124	439.00
IUUC-Tae-123489	Triticum aestivum	72.20	0.00e+00	632.00
IUUC-Tme-127151	Tuber melanosporum	52.89	1.00e-138	485.00
IUUC-Tbe-128056	Tupaia belangeri	61.54	6.00e-98	349.00
IUUC-Ttr-129055	Tursiops truncatus	56.51	5.00e-138	483.00
IUUC-Uma-129555	Ustilago maydis	52.29	3.00e-118	418.00
IUUC-Vda-130027	Verticillium dahliae	63.86	1.00e-124	439.00
IUUC-Vvi-131749	Vitis vinifera	82.54	0.00e+00	733.00
IUUC-Xtr-132808	Xenopus tropicalis	56.88	4.00e-139	487.00
IUUC-Xma-133183	Xiphophorus maculatus	57.08	1.00e-134	472.00
IUUC-Yli-134584	Yarrowia lipolytica	62.03	2.00e-125	442.00
IUUC-Zma-135717	Zea mays	71.83	2.00e-175	607.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence