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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-104833
UUCD1 version UUC-RaN-00863
Ensembl Protein ID ENSRNOP00000014377.3
UniProt Accession Q5XFW8; SEC13_RAT
Genbank Protein ID AAH84705.1
Protein Name Protein SEC13 homolog; SEC13-like protein 1
Genbank Nucleotide ID BC084705
Gene Name Sec13; Sec13l1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000010628.4 ENSRNOT00000014377.4 ENSRNOP00000014377.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.80e-29 99.9 55 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd..tllvsGsdDgtikvWD 29
           gH+++v+ +a+  +   ++l+s+s+D ++ +W 
   Q: 55   GHEGPVWQVAWahPMygNILASCSYDRKVIIWK 87
           8***********9666699*************8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
Protein Sequence
(Fasta)
MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV 60
WQVAWAHPMY GNILASCSYD RKVIIWKEEN GTWEKTHEHS GHDSSVNSVC WAPHDYGLIL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104833|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCCGAGGCT GTGAGTCGCC GCTGCTGTAG CTATGGTAAG TGATGCGGTC CCTGAGATAG 60
TCGTGGTCTT GGAGCAGACC ACCGCTACGA CCTCAAGGTT TGCGTGTCCT GCCTCTTTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104833|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0012507--C:ER to Golgi transport vesicle membrane
GO:0070062--C:extracellular exosome
GO:0061700--C:GATOR2 complex
GO:0000776--C:kinetochore
GO:0005643--C:nuclear pore
GO:0031080--C:nuclear pore outer ring
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0051028--P:mRNA transport
GO:0032008--P:positive regulation of TOR signaling
GO:0015031--P:protein transport
KEGG rno:297522
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000671 Aegilops tauschii 54.15 3.00e-91 328.00
IUUC-Aml-001832 Ailuropoda melanoleuca 97.52 0.00e+00 649.00
IUUC-Atr-002914 Amborella trichopoda 54.85 2.00e-90 325.00
IUUC-Apl-003992 Anas platyrhynchos 94.12 6.00e-171 592.00
IUUC-Aca-005283 Anolis carolinensis 94.10 3.00e-180 624.00
IUUC-Aly-005654 Arabidopsis lyrata 54.67 5.00e-90 323.00
IUUC-Ath-006816 Arabidopsis thaliana 55.33 2.00e-90 325.00
IUUC-Ago-007827 Ashbya gossypii 49.67 2.00e-82 299.00
IUUC-Acl-008205 Aspergillus clavatus 51.16 7.00e-80 290.00
IUUC-Afl-008748 Aspergillus flavus 50.81 2.00e-82 298.00
IUUC-Afu-008791 Aspergillus fumigatus 51.16 6.00e-80 290.00
IUUC-Ani-009152 Aspergillus nidulans 49.84 2.00e-82 298.00
IUUC-Ang-009765 Aspergillus niger 50.81 9.00e-83 300.00
IUUC-Aor-009927 Aspergillus oryzae 50.67 2.00e-79 288.00
IUUC-Ate-010248 Aspergillus terreus 50.49 2.00e-82 298.00
IUUC-Ame-011478 Astyanax mexicanus 86.96 4.00e-168 583.00
IUUC-Bgr-012276 Blumeria graminis 50.00 3.00e-79 288.00
IUUC-Bta-012700 Bos taurus 96.89 0.00e+00 646.00
IUUC-Bci-013722 Botrytis cinerea 49.17 1.00e-81 295.00
IUUC-Bdi-014818 Brachypodium distachyon 54.49 1.00e-91 329.00
IUUC-Bol-015779 Brassica oleracea 56.12 4.00e-90 324.00
IUUC-Bra-016973 Brassica rapa 55.29 8.00e-90 324.00
IUUC-Cel-018479 Caenorhabditis elegans 41.01 3.00e-69 254.00
IUUC-Cja-019956 Callithrix jacchus 97.57 3.00e-168 584.00
IUUC-Cfa-020752 Canis familiaris 98.45 0.00e+00 654.00
IUUC-Cpo-021871 Cavia porcellus 96.88 0.00e+00 642.00
IUUC-Cre-022797 Chlamydomonas reinhardtii 55.12 3.00e-96 345.00
IUUC-Csa-023393 Chlorocebus sabaeus 97.83 0.00e+00 652.00
IUUC-Cho-024786 Choloepus hoffmanni 76.71 1.00e-135 475.00
IUUC-Cin-025332 Ciona intestinalis 71.10 2.00e-133 468.00
IUUC-Csv-025926 Ciona savignyi 69.48 2.00e-129 455.00
IUUC-Cgl-026413 Colletotrichum gloeosporioides 51.19 2.00e-78 285.00
IUUC-Cne-027054 Cryptococcus neoformans 50.00 2.00e-78 285.00
IUUC-Cme-027165 Cyanidioschyzon merolae 34.94 2.00e-50 194.00
IUUC-Dre-027782 Danio rerio 87.89 6.00e-170 589.00
IUUC-Dno-029628 Dasypus novemcinctus 97.51 0.00e+00 646.00
IUUC-Dor-030650 Dipodomys ordii 80.75 1.00e-146 512.00
IUUC-Dse-031206 Dothistroma septosporum 46.30 1.00e-76 280.00
IUUC-Dme-031854 Drosophila melanogaster 59.74 2.00e-103 369.00
IUUC-Ete-032618 Echinops telfairi 67.60 7.00e-119 420.00
IUUC-Eca-033268 Equus caballus 98.13 0.00e+00 650.00
IUUC-Fca-035918 Felis catus 97.83 0.00e+00 649.00
IUUC-Fal-037551 Ficedula albicollis 93.18 6.00e-160 556.00
IUUC-Fox-037763 Fusarium oxysporum 49.17 3.00e-81 295.00
IUUC-Fso-038341 Fusarium solani 48.52 9.00e-80 290.00
IUUC-Gmo-038638 Gadus morhua 87.23 1.00e-169 588.00
IUUC-Ggr-039865 Gaeumannomyces graminis 48.99 5.00e-78 283.00
IUUC-Gga-040193 Gallus gallus 93.79 7.00e-179 619.00
IUUC-Gma-044311 Glycine max 54.52 8.00e-91 327.00
IUUC-Ggo-045252 Gorilla gorilla 97.52 0.00e+00 650.00
IUUC-Hsa-046565 Homo sapiens 97.20 0.00e+00 648.00
IUUC-Hvu-047835 Hordeum vulgare 55.48 6.00e-93 333.00
IUUC-Itr-048587 Ictidomys tridecemlineatus 98.75 0.00e+00 651.00
IUUC-Kpa-049148 Komagataella pastoris 53.31 3.00e-87 314.00
IUUC-Lch-050421 Latimeria chalumnae 89.75 5.00e-174 603.00
IUUC-Lpe-051187 Leersia perrieri 52.82 1.00e-91 332.00
IUUC-Loc-052167 Lepisosteus oculatus 88.85 2.00e-171 594.00
IUUC-Lma-053250 Leptosphaeria maculans 50.65 4.00e-80 290.00
IUUC-Laf-054304 Loxodonta africana 97.51 0.00e+00 644.00
IUUC-Mcc-055519 Macaca mulatta 97.52 0.00e+00 650.00
IUUC-Meu-056439 Macropus eugenii 95.33 0.00e+00 634.00
IUUC-Mor-057241 Magnaporthe oryzae 48.97 9.00e-78 283.00
IUUC-Mpo-057373 Magnaporthe poae 43.73 3.00e-63 234.00
IUUC-Mtr-058412 Medicago truncatula 54.52 4.00e-89 320.00
IUUC-Mla-058966 Melampsora laricipopulina 49.39 2.00e-86 312.00
IUUC-Mga-060066 Meleagris gallopavo 94.12 6.00e-171 592.00
IUUC-Mvi-060290 Microbotryum violaceum 46.18 4.00e-80 294.00
IUUC-Mmr-060717 Microcebus murinus 98.45 0.00e+00 651.00
IUUC-Mdo-062496 Monodelphis domestica 95.03 0.00e+00 637.00
IUUC-Mmu-063490 Mus musculus 99.69 0.00e+00 660.00
IUUC-Mac-065307 Musa acuminata 54.95 4.00e-88 318.00
IUUC-Mpu-066601 Mustela putorius furo 98.45 0.00e+00 654.00
IUUC-Mlu-067501 Myotis lucifugus 98.13 0.00e+00 650.00
IUUC-Nfi-068360 Neosartorya fischeri 50.00 2.00e-65 242.00
IUUC-Ncr-068928 Neurospora crassa 49.16 3.00e-82 298.00
IUUC-Nle-069028 Nomascus leucogenys 97.20 0.00e+00 650.00
IUUC-Opr-070446 Ochotona princeps 97.71 3.00e-178 617.00
IUUC-Ont-071587 Oreochromis niloticus 86.92 2.00e-170 590.00
IUUC-Oan-073211 Ornithorhynchus anatinus 92.86 2.00e-180 624.00
IUUC-Ocu-074306 Oryctolagus cuniculus 96.58 0.00e+00 640.00
IUUC-Oba-075069 Oryza barthii 54.15 5.00e-91 327.00
IUUC-Obr-076667 Oryza brachyantha 54.49 2.00e-91 328.00
IUUC-Ogl-077208 Oryza glaberrima 54.15 5.00e-91 327.00
IUUC-Ogu-078513 Oryza glumaepatula 54.15 5.00e-91 327.00
IUUC-Oin-079094 Oryza indica 54.15 5.00e-91 327.00
IUUC-Olo-080473 Oryza longistaminata 54.15 5.00e-91 327.00
IUUC-Ome-081643 Oryza meridionalis 54.15 5.00e-91 327.00
IUUC-Oni-082589 Oryza nivara 54.15 5.00e-91 327.00
IUUC-Opu-083677 Oryza punctata 54.15 5.00e-91 327.00
IUUC-Oru-084537 Oryza rufipogon 54.15 5.00e-91 327.00
IUUC-Osa-085449 Oryza sativa 54.15 5.00e-91 327.00
IUUC-Ola-087226 Oryzias latipes 86.65 7.00e-169 586.00
IUUC-Olu-087893 Ostreococcus lucimarinus 51.37 3.00e-79 288.00
IUUC-Oga-088837 Otolemur garnettii 98.45 0.00e+00 654.00
IUUC-Oar-089594 Ovis aries 96.89 0.00e+00 645.00
IUUC-Ptr-091132 Pan troglodytes 97.20 0.00e+00 648.00
IUUC-Psi-093568 Pelodiscus sinensis 94.48 7.00e-173 599.00
IUUC-Pma-094172 Petromyzon marinus 73.25 2.00e-63 234.00
IUUC-Pno-094955 Phaeosphaeria nodorum 49.34 2.00e-78 285.00
IUUC-Ppa-095578 Physcomitrella patens 55.78 4.00e-92 331.00
IUUC-Pfo-096063 Poecilia formosa 87.58 4.00e-170 590.00
IUUC-Pab-098674 Pongo abelii 96.89 0.00e+00 646.00
IUUC-Pop-099402 Populus trichocarpa 54.67 9.00e-91 326.00
IUUC-Pca-100824 Procavia capensis 78.88 7.00e-145 506.00
IUUC-Ppe-101707 Prunus persica 54.52 1.00e-88 319.00
IUUC-Pva-103161 Pteropus vampyrus 94.41 0.00e+00 626.00
IUUC-Pgr-103573 Puccinia graminis 53.25 1.00e-89 322.00
IUUC-Ptt-103700 Puccinia triticina 51.91 9.00e-83 300.00
IUUC-Pte-104267 Pyrenophora teres 49.66 2.00e-77 281.00
IUUC-Pyt-104535 Pyrenophora triticirepentis 48.30 9.00e-70 256.00
IUUC-Sce-106437 Saccharomyces cerevisiae 50.97 8.00e-77 280.00
IUUC-Sha-106611 Sarcophilus harrisii 95.33 0.00e+00 634.00
IUUC-Sja-107654 Schizosaccharomyces japonicus 49.67 2.00e-82 299.00
IUUC-Spo-108362 Schizosaccharomyces pombe 52.25 1.00e-85 309.00
IUUC-Smo-109674 Selaginella moellendorffii 54.61 1.00e-92 332.00
IUUC-Sit-110132 Setaria italica 53.82 4.00e-91 327.00
IUUC-Sly-111254 Solanum lycopersicum 53.00 1.00e-86 312.00
IUUC-Stu-112195 Solanum tuberosum 53.31 5.00e-87 314.00
IUUC-Sbi-114229 Sorghum bicolor 53.67 2.00e-91 328.00
IUUC-Sre-114898 Sporisorium reilianum 49.00 8.00e-91 327.00
IUUC-Ssc-115995 Sus scrofa 98.01 2.00e-86 310.00
IUUC-Tgu-116793 Taeniopygia guttata 93.46 2.00e-167 581.00
IUUC-Tru-117797 Takifugu rubripes 86.92 3.00e-169 587.00
IUUC-Tsy-118967 Tarsius syrichta 95.24 9.00e-30 124.00
IUUC-Tni-120366 Tetraodon nigroviridis 86.60 7.00e-169 586.00
IUUC-Tca-121068 Theobroma cacao 54.61 1.00e-88 319.00
IUUC-Tre-121899 Trichoderma reesei 49.83 2.00e-81 295.00
IUUC-Tvi-122380 Trichoderma virens 50.00 2.00e-81 295.00
IUUC-Tae-123998 Triticum aestivum 55.81 9.00e-94 336.00
IUUC-Tur-126202 Triticum urartu 55.15 1.00e-92 332.00
IUUC-Tme-127181 Tuber melanosporum 53.25 8.00e-89 320.00
IUUC-Ttr-128448 Tursiops truncatus 85.71 8.00e-160 556.00
IUUC-Uma-129661 Ustilago maydis 49.57 1.00e-91 329.00
IUUC-Vda-129666 Verticillium dahliae 51.54 6.00e-79 287.00
IUUC-Vpa-130318 Vicugna pacos 97.83 0.00e+00 650.00
IUUC-Vvi-130868 Vitis vinifera 54.00 2.00e-89 322.00
IUUC-Xtr-131859 Xenopus tropicalis 90.06 2.00e-173 600.00
IUUC-Xma-133898 Xiphophorus maculatus 87.58 2.00e-170 590.00
IUUC-Yli-134559 Yarrowia lipolytica 52.54 2.00e-83 301.00
Created Date 25-Jun-2017

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