iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-031942

UUCD1 version

UUC-DrM-00565

Ensembl Protein ID

FBpp0075690

UniProt Accession

Q9VTY6; UBE2C_DROME

Genbank Protein ID

AAL02117.1; AAF49909.1; ABI34153.1

Protein Name

Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; Ubiquitin carrier protein C; Ubiquitin carrier protein vihar; Ubiquitin-protein ligase C

Genbank Nucleotide ID

AF410850; AE014296; BT028772

Gene Name

vih; Ubch10; CG10682

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0264848	FBtr0075958	FBpp0075690

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.50e-45	154.4	36	167

Active Site

Position(s)	Description	Evidence
116	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           Rl+kel++l+  +  gisa p+ e ++++w  +i Gp +t+Y g++++l+++fp++YP+ +P vkflt++fhPnv+ +G++Cl+ilk  +kWs+ ++v
   Q: 36   RLHKELMNLMMANERGISAFPDGE-NIFKWVGTIAGPRNTVYSGQTYRLSLDFPNSYPYAAPVVKFLTSCFHPNVDLQGAICLDILK--DKWSALYDV 130
           99**********************.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkk 136
           +++llsiqsll epn+espln++aa ++++++e ykk 
   Q: 131  RTILLSIQSLLGEPNNESPLNAQAAMMWNDQKE-YKKY 167
           **************************9998887.9986 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Protein Sequence
(Fasta)

MAQNISPEQS GGAGGGGSKH SDDSMPVKDN HAVSKRLHKE LMNLMMANER GISAFPDGEN 60
IFKWVGTIAG PRNTVYSGQT YRLSLDFPNS YPYAAPVVKF LTSCFHPNVD LQGAICLDIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTGCCCAA ACACAGTTTC TTCTCGTTCT CCTTCCATTT TGTTTTCACA CAAAAGTGAA 60
AAAAAAAATA TCTGAAAAAG CAACAGACGC GTATTCCGAC CGATCAAACT AAATTTCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0010458--P:exit from mitosis
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0000209--P:protein polyubiquitination

KEGG

dme:Dmel_CG10682

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001924	Ailuropoda melanoleuca	65.52	8.00e-54	201.00
IUUC-Atr-002538	Amborella trichopoda	64.29	2.00e-51	193.00
IUUC-Aly-006086	Arabidopsis lyrata	63.45	1.00e-53	201.00
IUUC-Ath-006897	Arabidopsis thaliana	61.54	1.00e-54	204.00
IUUC-Acl-008223	Aspergillus clavatus	56.29	4.00e-41	159.00
IUUC-Afl-008675	Aspergillus flavus	57.62	1.00e-42	164.00
IUUC-Afu-008997	Aspergillus fumigatus	51.69	7.00e-43	165.00
IUUC-Ani-009470	Aspergillus nidulans	56.95	4.00e-42	162.00
IUUC-Ang-009648	Aspergillus niger	60.26	6.00e-44	169.00
IUUC-Aor-009977	Aspergillus oryzae	59.69	5.00e-36	142.00
IUUC-Ate-010318	Aspergillus terreus	57.62	9.00e-43	165.00
IUUC-Ame-011302	Astyanax mexicanus	57.56	5.00e-58	215.00
IUUC-Bta-013101	Bos taurus	67.13	1.00e-55	208.00
IUUC-Bci-013787	Botrytis cinerea	50.99	5.00e-43	166.00
IUUC-Bdi-014144	Brachypodium distachyon	62.94	3.00e-54	202.00
IUUC-Bol-015613	Brassica oleracea	60.26	3.00e-54	203.00
IUUC-Bra-017562	Brassica rapa	60.26	3.00e-54	203.00
IUUC-Cfa-020588	Canis familiaris	67.13	1.00e-55	207.00
IUUC-Cpo-021384	Cavia porcellus	66.43	1.00e-55	207.00
IUUC-Csa-023437	Chlorocebus sabaeus	67.13	5.00e-56	209.00
IUUC-Cho-024330	Choloepus hoffmanni	69.57	2.00e-46	176.00
IUUC-Cin-025365	Ciona intestinalis	67.47	9.00e-32	128.00
IUUC-Csv-025933	Ciona savignyi	61.49	5.00e-59	219.00
IUUC-Cgl-026494	Colletotrichum gloeosporioides	52.32	1.00e-43	168.00
IUUC-Cme-027266	Cyanidioschyzon merolae	53.97	5.00e-38	149.00
IUUC-Dre-027375	Danio rerio	59.88	1.00e-58	217.00
IUUC-Dno-029921	Dasypus novemcinctus	64.58	2.00e-53	200.00
IUUC-Dor-030209	Dipodomys ordii	63.64	6.00e-52	195.00
IUUC-Dse-031516	Dothistroma septosporum	49.68	2.00e-39	154.00
IUUC-Eca-034073	Equus caballus	67.13	1.00e-55	207.00
IUUC-Eeu-034854	Erinaceus europaeus	69.31	3.00e-38	150.00
IUUC-Fca-035666	Felis catus	67.13	1.00e-55	207.00
IUUC-Fal-037652	Ficedula albicollis	67.00	1.00e-37	146.00
IUUC-Fox-037793	Fusarium oxysporum	54.30	9.00e-46	175.00
IUUC-Fso-038151	Fusarium solani	53.64	3.00e-45	173.00
IUUC-Gmo-038894	Gadus morhua	68.46	4.00e-51	192.00
IUUC-Ggr-039730	Gaeumannomyces graminis	52.00	1.00e-37	148.00
IUUC-Gga-040537	Gallus gallus	64.12	3.00e-50	189.00
IUUC-Gac-041346	Gasterosteus aculeatus	67.63	2.00e-54	204.00
IUUC-Gma-043989	Glycine max	62.07	8.00e-54	201.00
IUUC-Ggo-045594	Gorilla gorilla	65.52	4.00e-54	202.00
IUUC-Hsa-046216	Homo sapiens	66.43	1.00e-55	207.00
IUUC-Hvu-047797	Hordeum vulgare	64.93	3.00e-51	193.00
IUUC-Itr-048402	Ictidomys tridecemlineatus	67.13	1.00e-55	207.00
IUUC-Kpa-049294	Komagataella pastoris	56.86	2.00e-48	184.00
IUUC-Lch-049761	Latimeria chalumnae	59.31	1.00e-50	191.00
IUUC-Lpe-051089	Leersia perrieri	65.03	2.00e-55	207.00
IUUC-Loc-052297	Lepisosteus oculatus	64.08	5.00e-56	210.00
IUUC-Lma-053214	Leptosphaeria maculans	52.94	1.00e-44	171.00
IUUC-Laf-054468	Loxodonta africana	65.75	1.00e-54	204.00
IUUC-Mcc-055338	Macaca mulatta	67.13	5.00e-56	209.00
IUUC-Meu-056147	Macropus eugenii	64.63	2.00e-55	207.00
IUUC-Mor-057239	Magnaporthe oryzae	52.98	1.00e-43	168.00
IUUC-Mpo-057491	Magnaporthe poae	52.98	1.00e-44	171.00
IUUC-Mtr-058382	Medicago truncatula	64.83	2.00e-55	207.00
IUUC-Mla-058880	Melampsora laricipopulina	56.77	6.00e-52	195.00
IUUC-Mga-059929	Meleagris gallopavo	70.97	4.00e-37	144.00
IUUC-Mvi-060528	Microbotryum violaceum	53.21	3.00e-44	170.00
IUUC-Mmr-060747	Microcebus murinus	70.31	4.00e-52	196.00
IUUC-Mdo-062343	Monodelphis domestica	65.97	6.00e-55	205.00
IUUC-Mmu-063563	Mus musculus	66.43	1.00e-54	204.00
IUUC-Mac-064777	Musa acuminata	64.54	3.00e-53	200.00
IUUC-Mpu-066541	Mustela putorius furo	66.43	1.00e-54	204.00
IUUC-Mlu-067388	Myotis lucifugus	65.52	3.00e-53	200.00
IUUC-Nfi-068577	Neosartorya fischeri	56.95	6.00e-41	159.00
IUUC-Ncr-068803	Neurospora crassa	52.78	4.00e-36	142.00
IUUC-Opr-070902	Ochotona princeps	66.43	3.00e-55	206.00
IUUC-Ont-071672	Oreochromis niloticus	66.67	2.00e-54	203.00
IUUC-Ocu-074566	Oryctolagus cuniculus	66.43	2.00e-54	203.00
IUUC-Oba-075538	Oryza barthii	65.15	6.00e-51	191.00
IUUC-Obr-076757	Oryza brachyantha	66.67	7.00e-37	144.00
IUUC-Ogu-078467	Oryza glumaepatula	62.76	1.00e-54	204.00
IUUC-Oin-079533	Oryza indica	65.15	9.00e-51	191.00
IUUC-Olo-080673	Oryza longistaminata	65.15	5.00e-51	191.00
IUUC-Ome-081483	Oryza meridionalis	62.76	1.00e-54	204.00
IUUC-Oni-082321	Oryza nivara	62.76	1.00e-54	204.00
IUUC-Opu-083245	Oryza punctata	62.76	5.00e-54	202.00
IUUC-Oru-084641	Oryza rufipogon	59.48	2.00e-52	197.00
IUUC-Osa-085992	Oryza sativa	62.76	1.00e-54	204.00
IUUC-Ola-086807	Oryzias latipes	69.23	2.00e-58	217.00
IUUC-Olu-087834	Ostreococcus lucimarinus	66.17	2.00e-49	187.00
IUUC-Oga-088699	Otolemur garnettii	65.75	2.00e-54	203.00
IUUC-Oar-089542	Ovis aries	66.21	3.00e-54	203.00
IUUC-Ptr-091069	Pan troglodytes	66.43	1.00e-55	207.00
IUUC-Pan-092533	Papio anubis	66.21	1.00e-54	204.00
IUUC-Psi-093206	Pelodiscus sinensis	70.30	4.00e-39	151.00
IUUC-Pma-094607	Petromyzon marinus	62.21	6.00e-59	218.00
IUUC-Pno-094829	Phaeosphaeria nodorum	57.53	1.00e-45	174.00
IUUC-Ppa-095861	Physcomitrella patens	64.83	3.00e-56	209.00
IUUC-Pfo-096836	Poecilia formosa	66.20	4.00e-57	212.00
IUUC-Pab-098707	Pongo abelii	66.43	1.00e-55	207.00
IUUC-Pop-099870	Populus trichocarpa	62.18	1.00e-56	211.00
IUUC-Pca-100661	Procavia capensis	66.67	7.00e-56	208.00
IUUC-Ppe-101289	Prunus persica	60.38	2.00e-54	204.00
IUUC-Pva-103235	Pteropus vampyrus	69.84	5.00e-50	189.00
IUUC-Pte-104292	Pyrenophora teres	55.24	7.00e-44	168.00
IUUC-Rno-105501	Rattus norvegicus	67.83	4.00e-56	209.00
IUUC-Sce-106133	Saccharomyces cerevisiae	54.19	6.00e-41	158.00
IUUC-Sha-107205	Sarcophilus harrisii	64.44	1.00e-49	188.00
IUUC-Sja-108009	Schizosaccharomyces japonicus	58.97	3.00e-50	189.00
IUUC-Spo-108136	Schizosaccharomyces pombe	56.60	1.00e-49	187.00
IUUC-Ssl-108394	Sclerotinia sclerotiorum	50.99	5.00e-43	166.00
IUUC-Smo-109459	Selaginella moellendorffii	59.01	3.00e-55	206.00
IUUC-Sit-110754	Setaria italica	62.07	6.00e-54	202.00
IUUC-Sly-111137	Solanum lycopersicum	62.59	3.00e-51	193.00
IUUC-Stu-112305	Solanum tuberosum	58.06	5.00e-53	199.00
IUUC-Sbi-114299	Sorghum bicolor	58.50	3.00e-50	190.00
IUUC-Ssc-115625	Sus scrofa	67.13	1.00e-55	207.00
IUUC-Tru-118289	Takifugu rubripes	79.07	4.00e-37	144.00
IUUC-Tni-120070	Tetraodon nigroviridis	66.67	4.00e-52	195.00
IUUC-Tca-121158	Theobroma cacao	63.45	2.00e-54	203.00
IUUC-Tre-121973	Trichoderma reesei	54.97	1.00e-45	174.00
IUUC-Tvi-122496	Trichoderma virens	54.97	7.00e-46	175.00
IUUC-Tae-123596	Triticum aestivum	62.07	5.00e-54	202.00
IUUC-Tur-126818	Triticum urartu	64.55	3.00e-41	159.00
IUUC-Tme-127044	Tuber melanosporum	57.89	4.00e-43	166.00
IUUC-Ttr-128548	Tursiops truncatus	70.30	4.00e-39	153.00
IUUC-Vda-129840	Verticillium dahliae	54.97	1.00e-45	174.00
IUUC-Vvi-131685	Vitis vinifera	62.07	3.00e-52	196.00
IUUC-Xtr-132953	Xenopus tropicalis	57.71	6.00e-56	209.00
IUUC-Xma-134093	Xiphophorus maculatus	65.49	1.00e-56	211.00
IUUC-Yli-134548	Yarrowia lipolytica	57.62	1.00e-49	187.00
IUUC-Zma-135182	Zea mays	60.00	1.00e-52	198.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence