iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	13679922

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	7.50e-13	49.0	223	292
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.50e-08	33.2	329	359

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    Dvilvv....g.geeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgkld 66
           D+++v     g +e+f++h + L a+S+vF+ ++  +e++e++ ++++ei d +p+++ra+++F+Y g ++
   Q: 223  DMTIVAgpldGeREQFRVHAYKLRAHSDVFQMMLsHTEMRENQ-EKRIEILDFSPTSVRAMVEFIYAGVIK 292
           7777774444369*********************666788998.**********************99875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N+l+++++A++y+ + L+da++df++++ 
   Q: 329  VNNVLECITHAERYNTDVLYDACVDFAIHNR 359
           68***************************95 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MSDRHLYGSD HSYLSSKPSC SSCRRQSSTS QKNECMTNPG SIVLTQRWTV CNFESLLKLS 60
RPGSCLRSTV FKDDAVPDAC WQLCLYPGGK REENANNVSL FLKMSATSPS KEVVLKAEYR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTAAATCG AATGTCTGAC CGCCACTTGT ACGGATCGGA TCACAGCTAT CTCAGCTCAA 60
AACCGTCATG CTCGAGCTGT CGGCGACAAT CCTCGACATC ACAGAAGAAT GAGTGTATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR008974--TRAF-like

PROSITE

PS50097--BTB
PS50144--MATH

Pfam

PF00651--BTB

SMART

SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

cel:CELE_Y105E8B.4

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ang-009789	Aspergillus niger	28.21	2.40e-01	28.50
IUUC-Bci-013994	Botrytis cinerea	23.16	1.20e-01	32.00
IUUC-Fox-037999	Fusarium oxysporum	29.71	1.00e-09	55.50
IUUC-Kpa-049324	Komagataella pastoris	21.13	2.70e+00	26.90
IUUC-Lma-053168	Leptosphaeria maculans	32.98	7.00e-05	40.40
IUUC-Mvi-060459	Microbotryum violaceum	30.88	2.10e-01	27.30
IUUC-Pno-094887	Phaeosphaeria nodorum	28.57	2.00e-04	39.30
IUUC-Pte-104154	Pyrenophora teres	28.16	4.00e-04	38.90
IUUC-Pyt-104444	Pyrenophora triticirepentis	24.03	7.00e-04	36.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence