iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	20392747

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.15	12.1	266	301

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqela 137
           +l  lp+e+ +ei+++ldk++l  +arv r+++  +
   Q: 266  SLLGLPDELYFEIFRYLDKSQLNVVARVNRHLHFYS 301
           56789*************************998555 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability.

Protein Sequence
(Fasta)

MSDTKSEIEG FIAIPTTSGE QQQQQPQQQQ NEQQVVGTKD IKAPDQVGKK QRPRLIQEKS 60
TQETNPLILE HATLEWVPQH MDKLLNQYQE CRKMPAAEWL HLLTYLVALE CGFVEEETFA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAGTAGTG TTGCATAGTA GCTGCCAGCC AGCTGATTAT TCGCTAAATA ACCAATTGTT 60
TTTTCGCGAA TTTTTCAATT TTCTGTGATT TTTGCGGCTA CAAAATCGAA AACTATATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome

Interpro

IPR001810--F-box_dom

PROSITE

PS50181--FBOX

Pfam

PF00646--F-box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007291--P:sperm individualization

KEGG

dme:Dmel_CG10855

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002765	Amborella trichopoda	33.33	1.00e-01	31.60
IUUC-Ang-009611	Aspergillus niger	36.11	2.90e-02	32.00
IUUC-Lma-053285	Leptosphaeria maculans	30.19	7.00e-02	31.60
IUUC-Mor-057219	Magnaporthe oryzae	53.85	7.30e-02	32.00
IUUC-Mla-059138	Melampsora laricipopulina	33.33	7.80e-02	29.60
IUUC-Mlu-067607	Myotis lucifugus	32.35	1.30e+00	27.70
IUUC-Ola-086629	Oryzias latipes	33.85	5.80e-01	28.50
IUUC-Pma-094225	Petromyzon marinus	25.00	4.80e-02	32.00
IUUC-Pyt-104506	Pyrenophora triticirepentis	43.59	4.70e-02	31.60
IUUC-Sbi-114635	Sorghum bicolor	30.00	1.00e-03	37.70
IUUC-Sre-115194	Sporisorium reilianum	30.65	3.00e-03	34.70
IUUC-Uma-129611	Ustilago maydis	30.65	2.00e-03	35.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence