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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106164
UUCD1 version UUC-SaC-00081
Ensembl Protein ID YCR084C
UniProt Accession P16649; D6VR85; P17995; P18323; TUP1_YEAST
Genbank Protein ID AAA35182.1; AAA34413.1; CAA34411.1; CAA42259.1; DAA07554.1
Protein Name General transcriptional corepressor TUP1; Flocculation suppressor protein; Glucose repression regulatory protein TUP1; Repressor AER2
Genbank Nucleotide ID M31733; M35861; X16365; X59720; BK006937
Gene Name TUP1; AAR1; AER2; AMM1; CYC9; FLK1; SFL2; UMR7; YCR084C; YCR84C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YCR084C YCR084C YCR084C
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.40e-46 151.3 483 519
UBD/Beta-Prp 2.30e-108 360.3 341 712
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH+ ++++l++ ++ + lvsGs+D t+++WDlrtg +
   Q: 483  GHEQDIYSLDYfPSgDKLVSGSGDRTVRIWDLRTGQC 519
           8*********77666********************98 PP
   

   UBD/Beta-Prp
   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae..................................................... 54
            +h+sv++cvkfs+d+++latg+ ++t++v++v++g+l+++ls+++a+                                                     
   Q: 341  LDHTSVVCCVKFSNDGEYLATGC-NKTTQVYRVSDGSLVARLSDDSAAnnhrnsitenntttstdnntmtttttttitttamtsaaelakdvenlntsssp 440
           589********************.***************************************************************************** PP
   S: 55   .....vtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgn 150
                +++v+fspdgk+l+tg+eDr+i++wd++++k+v++l+ghe++++sl+++psgdklvsGs drt+r+wdl+tgqc+  tls++dgv++++v+++dg+
   Q: 441  ssdlyIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSL-TLSIEDGVTTVAVSPGDGK 540
           *********************************************************************************.******************* PP
   S: 151  llvsGslDrtvrlWdlktgkllrtl.......tgghtdsvyslsfdsngkelvsgsldgtvklwdlq............tgecvrtlnghtdnvksvrfsp 232
           ++++GslDr+vr+Wd++tg+l+++l       tg h+dsvys+ f+++g+++vsgsld++vklw+lq            +g+c +t++gh+d+v+sv++++
   Q: 541  YIAAGSLDRAVRVWDSETGFLVERLdsenesgTG-HKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQnannksdsktpnSGTCEVTYIGHKDFVLSVATTQ 640
           ******************************9777.****************************************************************** PP
   S: 233  nderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav.....lsfgdnvlvlgsedskvniwklkknep 299
           nde+++sgs+D+ + +Wd++sg++l +lq+h++svisvav     l++++nv+++gs+d+k++iwk+kk++p
   Q: 641  NDEYILSGSKDRGVLFWDKKSGNPLLMLQGHRNSVISVAVangspLGPEYNVFATGSGDCKARIWKYKKIAP 712
           ********************************************************************9886 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
 Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
Protein Sequence
(Fasta)
MTASVSNTQN KLNELLDAIR QEFLQVSQEA NTYRLQNQKD YDFKMNQQLA EMQQIRNTVY 60
ELELTHRKMK DAYEEEIKHL KLGLEQRDHQ IASLTVQQQR QQQQQQQVQQ HLQQQQQQLA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106164|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGACTGCCA GCGTTTCGAA TACGCAGAAT AAGCTGAATG AGCTTCTCGA TGCCATCAGA 60
CAGGAGTTTC TCCAAGTCTC ACAAGAGGCA AATACCTACC GTCTTCAAAA CCAAAAGGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106164|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013890--Tscrpt_rep_Tup1_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08581--Tup_N
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005634--C:nucleus
GO:0017053--C:transcriptional repressor complex
GO:0042393--F:histone binding
GO:0042826--F:histone deacetylase binding
GO:0036033--F:mediator complex binding
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0043486--P:histone exchange
GO:0035955--P:negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
GO:0001198--P:negative regulation of mating-type specific transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0000433--P:negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0007070--P:negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle
GO:0016584--P:nucleosome positioning
GO:2000531--P:regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
GO:2000217--P:regulation of invasive growth in response to glucose limitation
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006351--P:transcription, DNA-templated
KEGG sce:YCR084C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000502 Aegilops tauschii 28.81 8.00e-27 112.00
IUUC-Ago-007787 Ashbya gossypii 74.48 3.00e-180 622.00
IUUC-Acl-008112 Aspergillus clavatus 49.39 1.00e-100 358.00
IUUC-Afl-008410 Aspergillus flavus 47.88 6.00e-101 359.00
IUUC-Afu-008822 Aspergillus fumigatus 46.86 9.00e-100 355.00
IUUC-Ani-009447 Aspergillus nidulans 48.58 6.00e-101 359.00
IUUC-Ang-009633 Aspergillus niger 47.64 9.00e-101 358.00
IUUC-Aor-010122 Aspergillus oryzae 47.88 9.00e-101 358.00
IUUC-Ate-010265 Aspergillus terreus 47.64 3.00e-100 357.00
IUUC-Bgr-012206 Blumeria graminis 56.93 6.00e-84 302.00
IUUC-Bci-013662 Botrytis cinerea 60.97 6.00e-93 332.00
IUUC-Cgl-026593 Colletotrichum gloeosporioides 58.15 3.00e-89 319.00
IUUC-Cne-026944 Cryptococcus neoformans 45.39 2.00e-102 364.00
IUUC-Dse-031198 Dothistroma septosporum 46.96 2.00e-109 387.00
IUUC-Fox-037829 Fusarium oxysporum 48.92 3.00e-111 393.00
IUUC-Fso-038383 Fusarium solani 48.44 3.00e-111 393.00
IUUC-Ggr-039887 Gaeumannomyces graminis 49.51 5.00e-113 399.00
IUUC-Kpa-049111 Komagataella pastoris 61.10 2.00e-144 503.00
IUUC-Lma-053115 Leptosphaeria maculans 48.28 2.00e-103 367.00
IUUC-Mor-057042 Magnaporthe oryzae 47.63 4.00e-109 386.00
IUUC-Mpo-057414 Magnaporthe poae 49.76 2.00e-113 400.00
IUUC-Mla-058997 Melampsora laricipopulina 43.88 4.00e-91 327.00
IUUC-Mvi-060368 Microbotryum violaceum 41.97 2.00e-84 305.00
IUUC-Nfi-068326 Neosartorya fischeri 49.63 2.00e-100 357.00
IUUC-Ncr-068753 Neurospora crassa 49.64 2.00e-111 394.00
IUUC-Pno-095046 Phaeosphaeria nodorum 44.56 5.00e-89 319.00
IUUC-Ppe-101341 Prunus persica 31.20 2.00e-36 144.00
IUUC-Pgr-103412 Puccinia graminis 41.91 1.00e-91 327.00
IUUC-Ptt-103788 Puccinia triticina 38.23 4.00e-41 160.00
IUUC-Pte-104272 Pyrenophora teres 48.90 1.00e-105 374.00
IUUC-Pyt-104514 Pyrenophora triticirepentis 48.90 2.00e-105 374.00
IUUC-Sja-107934 Schizosaccharomyces japonicus 43.42 6.00e-93 332.00
IUUC-Spo-108357 Schizosaccharomyces pombe 43.50 1.00e-95 341.00
IUUC-Sre-115049 Sporisorium reilianum 43.13 2.00e-93 334.00
IUUC-Tre-121975 Trichoderma reesei 49.88 8.00e-111 392.00
IUUC-Tvi-122338 Trichoderma virens 49.41 6.00e-113 399.00
IUUC-Tme-127064 Tuber melanosporum 49.39 2.00e-114 404.00
IUUC-Uma-129593 Ustilago maydis 43.87 8.00e-94 336.00
IUUC-Vda-129718 Verticillium dahliae 48.66 4.00e-105 373.00
IUUC-Vvi-131269 Vitis vinifera 31.23 1.00e-35 141.00
IUUC-Yli-134621 Yarrowia lipolytica 64.15 3.00e-98 350.00
Created Date 25-Jun-2017

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